{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:36:51Z","timestamp":1770907011052,"version":"3.50.1"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Meiji Co., Ltd."}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0225389","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T13:37:29Z","timestamp":1574775449000},"page":"e0225389","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4083-0140","authenticated-orcid":true,"given":"Kentaro","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Tonouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akina","family":"Sasayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taketo","family":"Yamaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinya","family":"Ashida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"issue":"7","key":"pone.0225389.ref001","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1470-2045(08)70153-0","article-title":"Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study","volume":"9","author":"CM Prado","year":"2008","journal-title":"Lancet Oncol"},{"issue":"4","key":"pone.0225389.ref002","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s00520-003-0568-z","article-title":"Cancer: disease and nutrition are key determinants of patients' quality of life","volume":"12","author":"P Ravasco","year":"2004","journal-title":"Support Care Cancer"},{"issue":"4","key":"pone.0225389.ref003","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3181\/0810-RM-301","article-title":"Gastrointestinal microflora and mucins may play a critical role in the development of 5-Fluorouracil-induced gastrointestinal mucositis","volume":"234","author":"AM Stringer","year":"2009","journal-title":"Exp Biol Med (Maywood)"},{"issue":"3","key":"pone.0225389.ref004","doi-asserted-by":"crossref","first-page":"e31808","DOI":"10.1371\/journal.pone.0031808","article-title":"5-Fluorouracil induced intestinal mucositis via nuclear factor-kappaB activation by transcriptomic analysis and in vivo bioluminescence imaging","volume":"7","author":"CT Chang","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"pone.0225389.ref005","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.4161\/cbt.7.7.6207","article-title":"Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs","volume":"7","author":"RM Logan","year":"2008","journal-title":"Cancer Biol Ther"},{"issue":"5","key":"pone.0225389.ref006","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.intimp.2009.02.005","article-title":"Maitake beta-glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cisplatin in mice","volume":"9","author":"Y Masuda","year":"2009","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"pone.0225389.ref007","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/0148607110377338","article-title":"Nutrition modulation of gastrointestinal toxicity related to cancer chemotherapy: from preclinical findings to clinical strategy","volume":"35","author":"H Xue","year":"2011","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"6","key":"pone.0225389.ref008","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1177\/0148607108324203","article-title":"The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of outcome data","volume":"32","author":"A Pontes-Arruda","year":"2008","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"6","key":"pone.0225389.ref009","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.clnu.2013.12.014","article-title":"Protective effect of an immune-modulating diet comprising whey peptides and fermented milk products on indomethacin-induced small-bowel disorders in rats","volume":"33","author":"H Kume","year":"2014","journal-title":"Clin Nutr"},{"issue":"2","key":"pone.0225389.ref010","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.clnu.2011.10.012","article-title":"A newly designed enteral formula containing whey peptides and fermented milk product protects mice against concanavalin A-induced hepatitis by suppressing overproduction of inflammatory cytokines","volume":"31","author":"H Kume","year":"2012","journal-title":"Clin Nutr"},{"issue":"1","key":"pone.0225389.ref011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12938\/bmfh.17-011","article-title":"An immune-modulating formula comprising whey peptides and fermented milk improves inflammation-related remote organ injuries in diet-induced acute pancreatitis in mice","volume":"37","author":"K Nakamura","year":"2018","journal-title":"Biosci Microbiota Food Health"},{"issue":"4","key":"pone.0225389.ref012","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.clnu.2011.01.002","article-title":"A new immune-modulating diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose attenuates gut ischemia-reperfusion injury in mice","volume":"30","author":"K Nakamura","year":"2011","journal-title":"Clin Nutr"},{"issue":"6","key":"pone.0225389.ref013","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1080\/01635581.2015.1053495","article-title":"An immune-modulating diet in combination with chemotherapy prevents cancer cachexia by attenuating systemic inflammation in colon 26 tumor-bearing mice","volume":"67","author":"K Nakamura","year":"2015","journal-title":"Nutr Cancer"},{"issue":"20","key":"pone.0225389.ref014","first-page":"5778","article-title":"Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effect of CPT-11","volume":"62","author":"OC Trifan","year":"2002","journal-title":"Cancer Res"},{"issue":"23","key":"pone.0225389.ref015","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1158\/1078-0432.CCR-07-0823","article-title":"Nutritional modulation of antitumor efficacy and diarrhea toxicity related to irinotecan chemotherapy in rats bearing the ward colon tumor","volume":"13","author":"H Xue","year":"2007","journal-title":"Clin Cancer Res"},{"issue":"2","key":"pone.0225389.ref016","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.clnu.2006.01.020","article-title":"ESPEN Guidelines on Enteral Nutrition: Non-surgical oncology","volume":"25","author":"J Arends","year":"2006","journal-title":"Clin Nutr"},{"issue":"3","key":"pone.0225389.ref017","doi-asserted-by":"crossref","first-page":"720","DOI":"10.4040\/jkan.2000.30.3.720","article-title":"The relationship of anorexia, nausea, vomiting, oral intake and nutritional status in patients receiving chemotherapy","volume":"30","author":"YH Yang","year":"2000","journal-title":"J Korean Acad Nurs"},{"issue":"1","key":"pone.0225389.ref018","doi-asserted-by":"crossref","first-page":"63","DOI":"10.7762\/cnr.2015.4.1.63","article-title":"Nutritional intervention using nutrition care process in a malnourished patient with chemotherapy side effects","volume":"4","author":"H-O Lee","year":"2015","journal-title":"Clin Nutr Res"},{"issue":"354","key":"pone.0225389.ref019","article-title":"New frontiers in the pathobiology and treatment of cancer regimen-related mucosal injury","volume":"8","author":"M Cinausero","year":"2017","journal-title":"Front Pharmacol"},{"key":"pone.0225389.ref020","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fphar.2018.00245","article-title":"Editorial: adverse effects of cancer chemotherapy: Anything new to improve tolerance and reduce sequelae?","volume":"9","author":"K Nurgali","year":"2018","journal-title":"Front Pharmacol"},{"issue":"1","key":"pone.0225389.ref021","first-page":"30","article-title":"Influence of nutritional management using an enteral formula MHN-02 on intestinal tissue structure in rats","volume":"67","author":"H Kume","year":"2018","journal-title":"Milk Sci"},{"issue":"455","key":"pone.0225389.ref022","article-title":"Alteration of gut microbiota and inflammatory cytokine\/chemokine profiles in 5-fluorouracil induced intestinal mucositis","volume":"7","author":"H-L Li","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"issue":"8","key":"pone.0225389.ref023","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/sj.bjc.6603990","article-title":"Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study","volume":"97","author":"P Osterlund","year":"2007","journal-title":"Br J Cancer"},{"issue":"5","key":"pone.0225389.ref024","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1034\/j.1399-302X.2003.00075.x","article-title":"Oral and intestinal microflora in 5-fluorouracil treated rats, translocation to cervical and mesenteric lymph nodes and effects of probiotic bacteria","volume":"18","author":"I Von Bultzingslowen","year":"2003","journal-title":"Oral Microbiol Immunol"},{"issue":"1","key":"pone.0225389.ref025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/ajcn\/87.1.91","article-title":"Molecular analysis of yogurt containing Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus in human intestinal microbiota","volume":"87","author":"R Garcia-Albiach","year":"2008","journal-title":"Am J Clin Nutr"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T13:37:43Z","timestamp":1574775463000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225389"}},"subtitle":[],"editor":[{"given":"Juan J.","family":"Loor","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,11,26]]},"references-count":25,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0225389","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,26]]}}}