{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:42:17Z","timestamp":1777585337907,"version":"3.51.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014538","name":"LPDP","doi-asserted-by":"crossref","award":["PRJ-2361\/LPDP\/2015"],"award-info":[{"award-number":["PRJ-2361\/LPDP\/2015"]}],"id":[{"id":"10.13039\/501100014538","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0225390","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T19:12:40Z","timestamp":1573845160000},"page":"e0225390","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Pharmacy-based predictors of non-adherence, non-persistence and reinitiation of antihypertensive drugs among patients on oral diabetes drugs in the Netherlands"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-8938","authenticated-orcid":true,"given":"Sofa D.","family":"Alfian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Denig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eelko","family":"Hak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"pone.0225390.ref001","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.2337\/dc19-S010","article-title":"Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes\u20142019","volume":"42","author":"American Diabetes Association","year":"2019","journal-title":"Diabetes Care"},{"key":"pone.0225390.ref002","article-title":"Dutch guideline cardiovascular risk management","author":"WAB Stalman","year":"2006"},{"key":"pone.0225390.ref003","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jash.2013.07.006","article-title":"Perception of uncontrolled blood pressure and non-adherence to anti-hypertensive agents in diabetic hypertensive patients","volume":"7","author":"PS Ledur","year":"2013","journal-title":"J Am Soc Hypertens. Elsevier"},{"key":"pone.0225390.ref004","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1097\/01.hjh.0000226211.95936.f5","article-title":"Discontinuation of antihypertensive drugs among newly diagnosed hypertensive patients in UK general practice","volume":"24","author":"TA Burke","year":"2006","journal-title":"J Hypertens"},{"key":"pone.0225390.ref005","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.clinthera.2009.06.011","article-title":"First-year treatment adherence among outpatients initiating antihypertensive medication in Korea: Results of a retrospective claims review","volume":"31","author":"SK Sung","year":"2009","journal-title":"Clin Ther."},{"key":"pone.0225390.ref006","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/HJH.0b013e3280148a58","article-title":"Rates and determinants of reinitiating antihypertensive therapy after prolonged stoppage: A population-based study","volume":"25","author":"BLG Van Wijk","year":"2007","journal-title":"J Hypertens"},{"key":"pone.0225390.ref007","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1097\/01.hjh.0000187261.40190.2e","article-title":"Rate and determinants of 10-year persistence with antihypertensive drugs","volume":"23","author":"BLG Wijk Van","year":"2005","journal-title":"J Hypertens"},{"key":"pone.0225390.ref008","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/sj.jhh.1001873","article-title":"Persistence and discontinuation patterns of antihypertensive therapy among newly treated patients: a population-based study","volume":"19","author":"C Bourgault","year":"2005","journal-title":"J Hum Hypertens"},{"key":"pone.0225390.ref009","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/sj.jhh.1001418","article-title":"Long-term persistence with antihypertensive drugs in new patients","volume":"16","author":"E Degli Esposti","year":"2002","journal-title":"J Hum Hypertens"},{"key":"pone.0225390.ref010","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1365-2125.2012.04167.x","article-title":"A new taxonomy for describing and defining adherence to medications","volume":"73","author":"B Vrijens","year":"2012","journal-title":"Br J Clin Pharmacol"},{"key":"pone.0225390.ref011","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1161\/01.HYP.0000222373.59104.3d","article-title":"Recommendations for evaluating compliance and persistence with hypertension therapy using retrospective data","volume":"47","author":"MT Halpern","year":"2006","journal-title":"Hypertension"},{"key":"pone.0225390.ref012","doi-asserted-by":"crossref","first-page":"30","DOI":"10.7326\/M18-0543","article-title":"ESPACOMP medication adherence reporting guideline (EMERGE).","volume":"169","author":"S De Geest","year":"2018","journal-title":"Ann Intern Med"},{"key":"pone.0225390.ref013","doi-asserted-by":"crossref","first-page":"981","DOI":"10.2147\/CLEP.S163037","article-title":"Concordance assessment of self-reported medication use in the Netherlands three-generation Lifelines Cohort Study with the pharmacy database IADB.nl: The PharmLines Initiative","volume":"10","author":"R Sediq","year":"2018","journal-title":"Clin Epidemiol."},{"key":"pone.0225390.ref014","unstructured":"Overheid. N. Wet medisch wetenschappelijk onderzoek met mensen. [Internet]. [cited 1 Aug 2019]. Available: http:\/\/wetten.overheid.nl\/BWBR0009408\/2013-09-27\/1"},{"key":"pone.0225390.ref015","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jclinepi.2018.12.003","article-title":"A systematic review finds inconsistency in the measures used to estimate adherence and persistence to multiple cardiometabolic medications.","volume":"108","author":"SD Alfian","year":"2019","journal-title":"J Clin Epidemiol."},{"key":"pone.0225390.ref016","article-title":"Neighbourhood status development in the Netherlands 1998\u20132010\u2014SCP English","author":"K Frans","year":"2012"},{"key":"pone.0225390.ref017","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12875-015-0275-0","article-title":"To what extent does sociodemographic composition of the neighbourhood explain regional differences in demand of primary out-of-hours care: a multilevel study","volume":"16","author":"T Jansen","year":"2015","journal-title":"BMC Fam Pract"},{"key":"pone.0225390.ref018","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12913-016-1361-2","article-title":"Identification of major cardiovascular events in patients with diabetes using primary care data","volume":"16","author":"KB Pouwels","year":"2016","journal-title":"BMC Health Serv Res"},{"key":"pone.0225390.ref019","unstructured":"Nederlands Huisarten Genootschap. Multidisciplinaire Richtlijn Polyfarmacie bij ouderen 2012 [Internet]. 2012 [cited 1 Apr 2018]. Available: https:\/\/www.nhg.org\/sites\/default\/files\/content\/nhg_org\/uploads\/polyfarmacie_bij_ouderen.pdf"},{"key":"pone.0225390.ref020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0137451","article-title":"Adherence to antihypertensive therapy and elevated blood pressure: should we consider the use of multiple medications?","volume":"10","author":"K Hedna","year":"2015","journal-title":"PLoS One"},{"key":"pone.0225390.ref021","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.amjmed.2009.08.008","article-title":"Antihypertensive drug persistence and compliance among newly treated elderly hypertensives in Ontario","volume":"123","author":"O Friedman","year":"2010","journal-title":"Am J Med"},{"key":"pone.0225390.ref022","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1377\/hlthaff.2012.0902","article-title":"Value-Based Insurance Design: Quality Improvement But No Cost Savings","volume":"32","author":"JL Lee","year":"2013","journal-title":"Health Aff"},{"key":"pone.0225390.ref023","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1080\/03007995.2017.1417242","article-title":"Pharmacy-based predictors of non-persistence with and non-adherence to statin treatment among patients on oral diabetes medication in the Netherlands","volume":"34","author":"SD Alfian","year":"2018","journal-title":"Curr Med Res Opin"},{"key":"pone.0225390.ref024","first-page":"A5104","article-title":"Summary of the multidisciplinary guideline on cardiovascular risk management (revision 2011).","volume":"156","author":"T Wiersma","year":"2012","journal-title":"Ned Tijdschr Geneeskd"},{"key":"pone.0225390.ref025","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.sapharm.2014.02.002","article-title":"Factors associated with medication adherence and persistence of treatment for hypertension in a Medicaid population","volume":"10","author":"SA Baggarly","year":"2014","journal-title":"Res Soc Adm Pharm. Elsevier Inc"},{"key":"pone.0225390.ref026","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/pds.1156","article-title":"Differences in antihypertensive drug persistence associated with drug class and gender: a PHARMO study","volume":"14","author":"JA Erkens","year":"2005","journal-title":"Pharmacoepidemiol Drug Saf."},{"key":"pone.0225390.ref027","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1161\/CIRCULATIONAHA.110.983874","article-title":"Meta-analysis: impact of drug class on adherence to antihypertensives","volume":"123","author":"IM Kronish","year":"2011","journal-title":"Circulation"},{"key":"pone.0225390.ref028","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.amjmed.2006.06.028","article-title":"Antihypertensive medication adherence in the Department of Veterans Affairs","volume":"120","author":"D Siegel","year":"2007","journal-title":"Am J Med"},{"key":"pone.0225390.ref029","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3122\/jabfm.2007.01.060094","article-title":"Persistence, adherence, and risk of discontinuation associated with commonly prescribed antihypertensive drug monotherapies","volume":"20","author":"WJ Elliott","year":"2007","journal-title":"J Am Board Fam Med"},{"key":"pone.0225390.ref030","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.amjmed.2011.12.013","article-title":"Adherence to drugs that prevent cardiovascular disease: Meta-analysis on 376,162 patients","volume":"125","author":"SH Naderi","year":"2012","journal-title":"Am J Med"},{"key":"pone.0225390.ref031","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.2337\/diacare.27.5.1218","article-title":"A systematic review of adherence with medications for diabetes","volume":"27","author":"JA Cramer","year":"2004","journal-title":"Diabetes Care"},{"key":"pone.0225390.ref032","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cjca.2014.03.017","article-title":"Antihypertensive drug prescribing and persistence among new elderly users: Implications for persistence improvement interventions","volume":"30","author":"K Tu","year":"2014","journal-title":"Can J Cardiol"},{"key":"pone.0225390.ref033","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/03602530902722679","article-title":"Pharmacokinetics and drug metabolism in the elderly","volume":"41","author":"U Klotz","year":"2009","journal-title":"Drug Metab Rev"},{"key":"pone.0225390.ref034","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00228-007-0340-2","article-title":"Persistence with antihypertensive treatments: results of a 3-year follow-up cohort study","volume":"63","author":"J Hasford","year":"2007","journal-title":"Eur J Clin Pharmacol"},{"key":"pone.0225390.ref035","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00228-005-0957-y","article-title":"Initial treatment of hypertension and adherence to therapy in general practice in Italy","volume":"61","author":"E Poluzzi","year":"2005","journal-title":"Eur J Clin Pharmacol"},{"key":"pone.0225390.ref036","unstructured":"Centraal Bureau voor de Statistiek. More and more people with diabetes [Internet]. 2014 [cited 21 May 2019]. Available: https:\/\/www.cbs.nl\/en-gb\/news\/2014\/46\/more-and-more-people-with-diabetes"},{"key":"pone.0225390.ref037","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1023\/A:1015866415552","article-title":"Intentional and unintentional nonadherence: a study of decision making","volume":"25","author":"AL Wroe","year":"2002","journal-title":"J Behav Med."},{"key":"pone.0225390.ref038","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jpsychores.2007.05.004","article-title":"Understanding different beliefs held by adherers, unintentional nonadherers, and intentional nonadherers: Application of the Necessity-Concerns Framework","volume":"64","author":"S Clifford","year":"2008","journal-title":"J Psychosom Res"},{"key":"pone.0225390.ref039","article-title":"Individual patients hold different beliefs to prescription medications to which they persist vs nonpersist and persist vs nonfulfill.","volume":"187","author":"C. McHorney","year":"2010","journal-title":"Patient Prefer Adherence"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T07:12:28Z","timestamp":1590131548000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225390"}},"subtitle":[],"editor":[{"given":"Markus M.","family":"Bachschmid","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":39,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0225390","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,15]]}}}