{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:04:57Z","timestamp":1784531097216,"version":"3.55.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK078757"],"award-info":[{"award-number":["DK078757"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK114875"],"award-info":[{"award-number":["DK114875"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL091535"],"award-info":[{"award-number":["HL091535"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0225728","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T13:31:10Z","timestamp":1575466270000},"page":"e0225728","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":56,"title":["Pro-renin receptor suppresses mitochondrial biogenesis and function via AMPK\/SIRT-1\/ PGC-1\u03b1 pathway in diabetic kidney"],"prefix":"10.1371","volume":"14","author":[{"given":"Safia","family":"Akhtar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8121-9052","authenticated-orcid":true,"given":"Helmy M.","family":"Siragy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,12,4]]},"reference":[{"issue":"2","key":"pone.0225728.ref001","first-page":"28","article-title":"Diabetes And End-Stage Renal Disease; A Review Article On New Concepts","volume":"4","author":"Sb Ghaderian","year":"2015","journal-title":"Journal Of Renal Injury Prevention"},{"key":"pone.0225728.ref002","first-page":"Cjn. 01120211","article-title":"Acute Kidney Injury Episodes And Chronic Kidney Disease Risk In Diabetes Mellitus","author":"Cv Thakar","year":"2011","journal-title":"Clinical Journal Of The American Society Of Nephrology"},{"issue":"7","key":"pone.0225728.ref003","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2337\/diabetes.53.7.1831","article-title":"Tumstatin Peptide, An Inhibitor Of Angiogenesis, Prevents Glomerular Hypertrophy In The Early Stage Of Diabetic Nephropathy","volume":"53","author":"Y Yamamoto","year":"2004","journal-title":"Diabetes"},{"issue":"6865","key":"pone.0225728.ref004","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry And Molecular Cell Biology Of Diabetic Complications","volume":"414","author":"M Brownlee","year":"2001","journal-title":"Nature"},{"issue":"4","key":"pone.0225728.ref005","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1046\/j.1523-1755.2001.0590041236.x","article-title":"Clinical And Pathologic Features Of Focal Segmental Glomerulosclerosis With Mitochondrial Trnaleu (Uur) Gene Mutation","volume":"59","author":"O Hotta","year":"2001","journal-title":"Kidney International"},{"issue":"4","key":"pone.0225728.ref006","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1089\/ars.2009.2531","article-title":"Mitochondrial Dysfunction In Diabetes: From Molecular Mechanisms To Functional Significance And Therapeutic Opportunities","volume":"12","author":"Wi Sivitz","year":"2010","journal-title":"Antioxidants & Redox Signaling"},{"issue":"5708","key":"pone.0225728.ref007","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1126\/science.1104343","article-title":"Mitochondrial Dysfunction And Type 2 Diabetes","volume":"307","author":"Bb Lowell","year":"2005","journal-title":"Science"},{"issue":"11","key":"pone.0225728.ref008","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrendo.2016.104","article-title":"Skeletal Muscle Mitochondria As A Target To Prevent Or Treat Type 2 Diabetes Mellitus","volume":"12","author":"Mk Hesselink","year":"2016","journal-title":"Nature Reviews Endocrinology"},{"key":"pone.0225728.ref009","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fendo.2018.00211","article-title":"Mitochondrial Dynamics In Type 2 Diabetes And Cancer","volume":"9","author":"M Williams","year":"2018","journal-title":"Frontiers In Endocrinology"},{"issue":"8","key":"pone.0225728.ref010","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1007\/s00125-010-1764-2","article-title":"Exercise Training Increases Mitochondrial Content And Ex Vivo Mitochondrial Function Similarly In Patients With Type 2 Diabetes And In Control Individuals","volume":"53","author":"E Phielix","year":"2010","journal-title":"Diabetologia"},{"issue":"3","key":"pone.0225728.ref011","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1440-1681.2009.05292.x","article-title":"(Pro) Renin Receptor Contributes To Diabetic Nephropathy By Enhancing Renal Inflammation","volume":"37","author":"Lc Matavelli","year":"2010","journal-title":"Clinical And Experimental Pharmacology And Physiology"},{"issue":"12","key":"pone.0225728.ref012","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1210\/en.2009-0442","article-title":"Glucose Promotes The Production Of Interleukine-1\u03b2 And Cyclooxygenase-2 In Mesangial Cells Via Enhanced (Pro) Renin Receptor Expression","volume":"150","author":"J Huang","year":"2009","journal-title":"Endocrinology"},{"issue":"3","key":"pone.0225728.ref013","doi-asserted-by":"crossref","first-page":"E302","DOI":"10.1152\/ajpendo.00603.2014","article-title":"(Pro) Renin Receptor Regulates Autophagy And Apoptosis In Podocytes Exposed To High Glucose","volume":"309","author":"C Li","year":"2015","journal-title":"American Journal Of Physiology-Endocrinology And Metabolism"},{"issue":"4","key":"pone.0225728.ref014","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1440-1681.2011.05486.x","article-title":"Renal (Pro) Renin Receptor Contributes To Development Of Diabetic Kidney Disease Through Transforming Growth Factor\u2010B1\u2013Connective Tissue Growth Factor Signalling Cascade","volume":"38","author":"J Huang","year":"2011","journal-title":"Clinical And Experimental Pharmacology And Physiology"},{"issue":"6","key":"pone.0225728.ref015","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","article-title":"Resveratrol Improves Mitochondrial Function And Protects Against Metabolic Disease By Activating Sirt1 And Pgc-1\u03b1","volume":"127","author":"M Lagouge","year":"2006","journal-title":"Cell"},{"issue":"4","key":"pone.0225728.ref016","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cmet.2007.08.014","article-title":"Et Al. Sirt1 Improves Insulin Sensitivity Under Insulin-Resistant Conditions By Repressing Ptp1b","volume":"6","author":"C Sun","year":"2007","journal-title":"Cell Metabolism"},{"key":"pone.0225728.ref017","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ebiom.2017.03.019","article-title":"Specific Sirt1 Activator-Mediated Improvement In Glucose Homeostasis Requires Sirt1-Independent Activation Of Ampk","volume":"18","author":"S-J Park","year":"2017","journal-title":"Ebiomedicine"},{"issue":"5","key":"pone.0225728.ref018","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13587","article-title":"Buffering Roles Of (Pro) Renin Receptor In Starvation\u2010Induced Autophagy Of Skeletal Muscles","volume":"6","author":"Y Mizuguchi","year":"2018","journal-title":"Physiological Reports"},{"issue":"1","key":"pone.0225728.ref019","first-page":"245","volume":"9","author":"La Velazquez-Villegas","year":"2018","journal-title":"Tgr5 Signalling Promotes Mitochondrial Fission And Beige Remodelling Of White Adipose Tissue. Nature Communications"},{"key":"pone.0225728.ref020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.metabol.2018.03.023","article-title":"A Negative Feedback Loop Between Microrna-378 And Nrf1 Promotes The Development Of Hepatosteatosis In Mice Treated With A High Fat Diet","volume":"85","author":"T Zhang","year":"2018","journal-title":"Metabolism"},{"key":"pone.0225728.ref021","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.yjmcc.2018.01.005","article-title":"Sestrin2 Prevents Age-Related Intolerance To Post Myocardial Infarction Via Ampk\/Pgc-1\u03b1 Pathway","volume":"115","author":"N Quan","year":"2018","journal-title":"Journal Of Molecular And Cellular Cardiology"},{"issue":"1","key":"pone.0225728.ref022","first-page":"98","article-title":"Betulinic Acid Inhibits Stemness And Emt Of Pancreatic Cancer Cells Via Activation Of Ampk Signaling","volume":"54","author":"L Sun","year":"2019","journal-title":"International Journal Of Oncology"},{"issue":"12","key":"pone.0225728.ref023","doi-asserted-by":"crossref","first-page":"E9390","DOI":"10.15252\/emmm.201809390","article-title":"Mitochondrial Glycerol 3\u2010Phosphate Dehydrogenase Promotes Skeletal Muscle Regeneration","volume":"10","author":"X Liu","year":"2018","journal-title":"Embo Molecular Medicine"},{"issue":"3","key":"pone.0225728.ref024","first-page":"3722","article-title":"Liraglutide Repairs The Infarcted Heart: The Role Of The Sirt1\/Parkin\/Mitophagy Pathway","volume":"17","author":"H Qiao","year":"2018","journal-title":"Molecular Medicine Reports"},{"issue":"5","key":"pone.0225728.ref025","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrg1606","article-title":"Mitochondrial Dna Mutations In Human Disease","volume":"6","author":"Rw Taylor","year":"2005","journal-title":"Nature Reviews Genetics"},{"issue":"4","key":"pone.0225728.ref026","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1007\/s00125-007-0594-3","article-title":"Patients With Type 2 Diabetes Have Normal Mitochondrial Function In Skeletal Muscle","volume":"50","author":"R Boushel","year":"2007","journal-title":"Diabetologia"},{"issue":"1","key":"pone.0225728.ref027","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cmet.2007.10.013","article-title":"Mitochondrial Overload And Incomplete Fatty Acid Oxidation Contribute To Skeletal Muscle Insulin Resistance","volume":"7","author":"Tr Koves","year":"2008","journal-title":"Cell Metabolism"},{"issue":"5","key":"pone.0225728.ref028","doi-asserted-by":"crossref","first-page":"E96147","DOI":"10.1371\/journal.pone.0096147","article-title":"Fenofibrate Improves Renal Lipotoxicity Through Activation Of Ampk-Pgc-1\u03b1 In Db\/Db Mice","volume":"9","author":"Ya Hong","year":"2014","journal-title":"Plos One"},{"issue":"1","key":"pone.0225728.ref029","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s00125-012-2747-2","article-title":"Resveratrol Prevents Renal Lipotoxicity And Inhibits Mesangial Cell Glucotoxicity In A Manner Dependent On The Ampk\u2013Sirt1\u2013Pgc1\u03b1 Axis In Db\/Db Mice","volume":"56","author":"M Kim","year":"2013","journal-title":"Diabetologia"},{"issue":"9","key":"pone.0225728.ref030","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/hmg\/ddh109","article-title":"Mitochondrial Transcription Factor A Regulates Mtdna Copy Number In Mammals","volume":"13","author":"Mi Ekstrand","year":"2004","journal-title":"Human Molecular Genetics"},{"issue":"1","key":"pone.0225728.ref031","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/EC-14-0092","article-title":"Mitochondrial Dysfunction And Insulin Resistance: An Update","volume":"4","author":"Mk Montgomery","year":"2015","journal-title":"Endocrine Connections"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T13:31:29Z","timestamp":1575466289000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225728"}},"subtitle":[],"editor":[{"given":"Utpal","family":"Sen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,12,4]]},"references-count":31,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0225728","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,4]]}}}