{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:19:12Z","timestamp":1780330752798,"version":"3.54.1"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0225806","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T18:33:32Z","timestamp":1576175612000},"page":"e0225806","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Toll-like receptor 7-adapter complex modulates interferon-\u03b1 production in HIV-stimulated plasmacytoid dendritic cells"],"prefix":"10.1371","volume":"14","author":[{"given":"Andy A.","family":"Patamawenu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7006-4040","authenticated-orcid":true,"given":"Nathaniel E.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulley","family":"Shofner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura M.","family":"Manion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5731-3054","authenticated-orcid":true,"given":"Nicole","family":"Doria-Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Migueles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bennett","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Rood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Berkley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"Cogliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Jason","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiki","family":"Tesselaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Miedema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Bess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Lifson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2108-8705","authenticated-orcid":true,"given":"Mark","family":"Connors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,12,12]]},"reference":[{"issue":"1","key":"pone.0225806.ref001","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/imr.12082","article-title":"Dendritic cell dysregulation during HIV-1 infection","volume":"254","author":"E Miller","year":"2013","journal-title":"Immunol Rev"},{"issue":"1","key":"pone.0225806.ref002","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1128\/JVI.79.1.17-27.2005","article-title":"Plasmacytoid dendritic cells: linking innate and adaptive immunity","volume":"79","author":"K McKenna","year":"2005","journal-title":"J Virol"},{"issue":"5421","key":"pone.0225806.ref003","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1126\/science.284.5421.1835","article-title":"The nature of the principal type 1 interferon-producing cells in human blood","volume":"284","author":"FP Siegal","year":"1999","journal-title":"Science"},{"issue":"12","key":"pone.0225806.ref004","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/ni1141","article-title":"Plasmacytoid dendritic cells in immunity","volume":"5","author":"M Colonna","year":"2004","journal-title":"Nat Immunol"},{"issue":"4","key":"pone.0225806.ref005","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1084\/jem.20011666","article-title":"Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivo","volume":"195","author":"W Barchet","year":"2002","journal-title":"J Exp Med"},{"issue":"11","key":"pone.0225806.ref006","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1172\/JCI26032","article-title":"Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions","volume":"115","author":"AS Beignon","year":"2005","journal-title":"J Clin Invest"},{"issue":"5663","key":"pone.0225806.ref007","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1126\/science.1093616","article-title":"Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA","volume":"303","author":"SS Diebold","year":"2004","journal-title":"Science"},{"issue":"8","key":"pone.0225806.ref008","first-page":"593","article-title":"Bacterial infections and toll-like receptors","volume":"76","author":"S Akira","year":"2001","journal-title":"Kekkaku"},{"issue":"5","key":"pone.0225806.ref009","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"T Kawai","year":"2010","journal-title":"Nat Immunol"},{"issue":"2","key":"pone.0225806.ref010","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.virol.2005.09.059","article-title":"HIV-infected cells are major inducers of plasmacytoid dendritic cell interferon production, maturation, and migration","volume":"343","author":"B Schmidt","year":"2005","journal-title":"Virology"},{"issue":"1","key":"pone.0225806.ref011","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4049\/jimmunol.1202489","article-title":"Human Plasmacytoid Dendritic Cells Efficiently Capture HIV-1 Envelope Glycoproteins via CD4 for Antigen Presentation","volume":"191","author":"KJ Sandgren","year":"2013","journal-title":"J Immunol"},{"issue":"8","key":"pone.0225806.ref012","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1128\/JVI.01545-07","article-title":"Human immunodeficiency virus viremia induces plasmacytoid dendritic cell activation in vivo and diminished alpha interferon production in vitro","volume":"82","author":"JC Tilton","year":"2008","journal-title":"J Virol"},{"issue":"2","key":"pone.0225806.ref013","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/QAI.0b013e318279734d","article-title":"Transmission of risk-group specific HIV-1 strains among Dutch drug users for more than 20 years and their replacement by nonspecific strains after switching to low-harm drug practices","volume":"62","author":"VV Lukashov","year":"2013","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"6","key":"pone.0225806.ref014","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.immuni.2008.10.010","article-title":"Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control","volume":"29","author":"SA Migueles","year":"2008","journal-title":"Immunity"},{"issue":"23","key":"pone.0225806.ref015","doi-asserted-by":"crossref","first-page":"11486","DOI":"10.1128\/JVI.00324-06","article-title":"Diminished production of monocyte proinflammatory cytokines during human immunodeficiency virus viremia is mediated by type I interferons","volume":"80","author":"JC Tilton","year":"2006","journal-title":"J Virol"},{"issue":"10","key":"pone.0225806.ref016","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/nm.1871","article-title":"Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections","volume":"14","author":"JN Mandl","year":"2008","journal-title":"Nat Med"},{"issue":"3","key":"pone.0225806.ref017","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00281-004-0180-4","article-title":"Plasmacytoid dendritic cell precursors\/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9","volume":"26","author":"T Ito","year":"2005","journal-title":"Springer Semin Immunopathol"},{"issue":"5663","key":"pone.0225806.ref018","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1126\/science.1093620","article-title":"Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8","volume":"303","author":"F Heil","year":"2004","journal-title":"Science"},{"issue":"6","key":"pone.0225806.ref019","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.1478-3231.2008.01725.x","article-title":"Association of interferon regulatory factor-7 gene polymorphism with liver cirrhosis in chronic hepatitis C patients","volume":"28","author":"R Sermasathanasawadi","year":"2008","journal-title":"Liver Int"},{"issue":"5","key":"pone.0225806.ref020","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/QAD.0b013e328343c186","article-title":"Polymorphisms in interferon regulatory factor 7 reduce interferon-alpha responses of plasmacytoid dendritic cells to HIV-1","volume":"25","author":"J Chang","year":"2011","journal-title":"Aids"},{"issue":"1","key":"pone.0225806.ref021","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-2893.2007.00898.x","article-title":"Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy","volume":"15","author":"E Schott","year":"2008","journal-title":"J Viral Hepat"},{"issue":"3","key":"pone.0225806.ref022","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/QAD.0b013e32831fb540","article-title":"A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression","volume":"23","author":"DY Oh","year":"2009","journal-title":"Aids"},{"issue":"8","key":"pone.0225806.ref023","doi-asserted-by":"crossref","first-page":"e1003597","DOI":"10.1371\/journal.ppat.1003597","article-title":"Intact type I Interferon production and IRF7 function in sooty mangabeys","volume":"9","author":"SE Bosinger","year":"2013","journal-title":"PLoS Pathog"},{"issue":"7","key":"pone.0225806.ref024","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1084\/jem.20090547","article-title":"Regulation of TLR7\/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction","volume":"206","author":"W Cao","year":"2009","journal-title":"J Exp Med"},{"issue":"6","key":"pone.0225806.ref025","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1084\/jem.20052454","article-title":"Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production","volume":"203","author":"W Cao","year":"2006","journal-title":"J Exp Med"},{"issue":"8622","key":"pone.0225806.ref026","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/S0140-6736(88)90811-2","article-title":"Anti-retroviral effects of interferon-alpha in AIDS-associated Kaposi's sarcoma","volume":"2","author":"HC Lane","year":"1988","journal-title":"Lancet"},{"issue":"7511","key":"pone.0225806.ref027","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nature13554","article-title":"Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression","volume":"511","author":"NG Sandler","year":"2014","journal-title":"Nature"},{"key":"pone.0225806.ref028","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cytogfr.2018.02.002","article-title":"Interferon alpha subtypes in HIV infection","volume":"40","author":"K Sutter","year":"2018","journal-title":"Cytokine & growth factor reviews"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T14:40:25Z","timestamp":1722177625000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225806"}},"subtitle":[],"editor":[{"given":"Cristian","family":"Apetrei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,12,12]]},"references-count":28,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0225806","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,12]]}}}