{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T20:02:10Z","timestamp":1776888130737,"version":"3.51.2"},"reference-count":103,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010578","name":"Deutsche Gesellschaft f\u00fcr Kardiologie","doi-asserted-by":"crossref","award":["Stipendium"],"award-info":[{"award-number":["Stipendium"]}],"id":[{"id":"10.13039\/501100010578","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0225937","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T18:28:22Z","timestamp":1575484102000},"page":"e0225937","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Skeletal muscle alterations in tachycardia-induced heart failure are linked to deficient natriuretic peptide signalling and are attenuated by RAS-\/NEP-inhibition"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4091-8620","authenticated-orcid":true,"given":"Alexander","family":"Dietl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Winkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Pietrzyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Paulus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Bruckmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef A.","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Sossalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Luchner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars S.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Birner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,12,4]]},"reference":[{"key":"pone.0225937.ref001","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S0140-6736(14)61889-4","article-title":"The war against heart failure: the Lancet lecture","volume":"385","author":"E Braunwald","year":"2015","journal-title":"Lancet"},{"key":"pone.0225937.ref002","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"18","author":"P Ponikowski","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"pone.0225937.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12947-017-0120-9","article-title":"3D vena contracta area after MitraClip procedure: precise quantification of residual mitral regurgitation and identification of prognostic information","volume":"16","author":"A Dietl","year":"2018","journal-title":"Cardiovasc Ultrasound"},{"key":"pone.0225937.ref004","article-title":"Treatments targeting inotropy","author":"C Maack","year":"2018","journal-title":"Eur Heart J"},{"key":"pone.0225937.ref005","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrcardio.2017.51","article-title":"Muscle wasting and cachexia in heart failure: mechanisms and therapies","volume":"14","author":"S von Haehling","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"pone.0225937.ref006","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S0140-6736(96)07015-8","article-title":"Wasting as independent risk factor for mortality in chronic heart failure","volume":"349","author":"SD Anker","year":"1997","journal-title":"Lancet"},{"key":"pone.0225937.ref007","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.clnu.2009.12.004","article-title":"Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) \u201ccachexia-anorexia in chronic wasting diseases\u201d; and \u201cnutrition in geriatrics.\u201d","volume":"29","author":"M Muscaritoli","year":"2010","journal-title":"Clin Nutr"},{"key":"pone.0225937.ref008","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijcard.2017.03.154","article-title":"Animal models of cachexia and sarcopenia in chronic illness: Cardiac function, body composition changes and therapeutic results","volume":"238","author":"J Ishida","year":"2017","journal-title":"Int J Cardiol"},{"key":"pone.0225937.ref009","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/ejhf.122","article-title":"Interatrial differences of basal molecular set-up and changes in tachycardia-induced heart failure-a proteomic profiling study","volume":"16","author":"A Dietl","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"pone.0225937.ref010","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.cardfail.2012.06.418","article-title":"Proteomic profiling implies mitochondrial dysfunction in tachycardia-induced heart failure","volume":"18","author":"C Birner","year":"2012","journal-title":"J Card Fail"},{"key":"pone.0225937.ref011","doi-asserted-by":"crossref","first-page":"566","DOI":"10.18632\/oncotarget.23075","article-title":"Pathway-focused PCR array profiling of CAL-27 cell with over-expressed ZNF750","volume":"9","author":"L Pan","year":"2018","journal-title":"Oncotarget"},{"key":"pone.0225937.ref012","doi-asserted-by":"crossref","first-page":"e0169743","DOI":"10.1371\/journal.pone.0169743","article-title":"Combined Inhibition of the Renin-Angiotensin System and Neprilysin Positively Influences Complex Mitochondrial Adaptations in Progressive Experimental Heart Failure","volume":"12","author":"L Grois","year":"2017","journal-title":"PLoS One"},{"key":"pone.0225937.ref013","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-4939-7268-5_2","article-title":"Comparative DIGE Proteomics","author":"K Ohlendieck","year":"2018","journal-title":"Methods in molecular biology (Clifton, NJ)"},{"key":"pone.0225937.ref014","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1172\/JCI64526","article-title":"Natriuretic peptides enhance the oxidative capacity of human skeletal muscle","volume":"122","author":"S Engeli","year":"2012","journal-title":"J Clin Invest"},{"key":"pone.0225937.ref015","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ejhf.656","article-title":"Chronic heart failure as a state of reduced effectiveness of the natriuretic peptide system: implications for therapy","volume":"19","author":"J D\u00edez","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"pone.0225937.ref016","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1161\/hc0802.104282","article-title":"Maximizing the natriuretic peptide system in experimental heart failure: subcutaneous brain natriuretic peptide and acute vasopeptidase inhibition","volume":"105","author":"HH Chen","year":"2002","journal-title":"Circulation"},{"key":"pone.0225937.ref017","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1677\/joe.1.06396","article-title":"Enhancement of muscle glucose uptake by the vasopeptidase inhibitor, omapatrilat, is independent of insulin signaling and the AMP kinase pathway","volume":"190","author":"V Wong","year":"2006","journal-title":"J Endocrinol"},{"key":"pone.0225937.ref018","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/j.1523-1755.2002.kid559.x","article-title":"Vasopeptidase inhibition and Ang-(1\u20137) in the spontaneously hypertensive rat","volume":"62","author":"CM Ferrario","year":"2002","journal-title":"Kidney Int"},{"key":"pone.0225937.ref019","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0895-7061(02)03144-8","article-title":"Effects of omapatrilat on blood pressure and renal injury in L-NAME and L-NAME plus DOCA-treated rats","volume":"16","author":"I Rodriguez-Gomez","year":"2003","journal-title":"Am J Hypertens"},{"key":"pone.0225937.ref020","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1161\/01.HYP.0000099240.89890.94","article-title":"Renal effects of omapatrilat and captopril in salt-loaded, nitric oxide-deficient rats","volume":"42","author":"L Ying","year":"2003","journal-title":"Hypertens (Dallas, Tex 1979)"},{"key":"pone.0225937.ref021","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/laban0708-323","article-title":"A technique for intragastric gavage of radiolabeled liquid cholesterol in rabbits (Oryctolagus cuniculus) using a pediatric feeding tube","author":"G Martinic","year":"2008","journal-title":"Lab Animal"},{"key":"pone.0225937.ref022","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0140-6736(00)02602-7","article-title":"Comparison of vasopeptidase inhibitor, omapatrilat, and lisinopril on exercise tolerance and morbidity in patients with heart failure: IMPRESS randomised trial","volume":"356","author":"JL Rouleau","year":"2000","journal-title":"Lancet (London, England)"},{"key":"pone.0225937.ref023","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00210-012-0791-6","article-title":"Antihypertrophic effects of combined inhibition of the renin-angiotensin system (RAS) and neutral endopeptidase (NEP) in progressive, tachycardia-induced experimental heart failure","volume":"385","author":"C Birner","year":"2012","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"pone.0225937.ref024","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"RM Lang","year":"2015","journal-title":"Eur Hear J\u2014Cardiovasc Imaging"},{"key":"pone.0225937.ref025","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s10554-017-1238-4","article-title":"Comprehensive echocardiographic assessment of biventricular function in the rabbit, animal model in cardiovascular research: feasibility and normal values","volume":"34","author":"SR Ramos","year":"2018","journal-title":"Int J Cardiovasc Imaging"},{"key":"pone.0225937.ref026","article-title":"Tissue triage and freezing for models of skeletal muscle disease","author":"H Meng","year":"2014","journal-title":"J Vis Exp"},{"key":"pone.0225937.ref027","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0014-4886(70)90244-X","article-title":"Procedure for the histochemical demonstration of actomyosin ATPase","volume":"28","author":"L Guth","year":"1970","journal-title":"Exp Neurol"},{"key":"pone.0225937.ref028","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1159\/000358645","article-title":"Experimental Heart Failure Induces Alterations of the Lung Proteome\u2014Insight into Molecular Mechanisms","volume":"33","author":"C Birner","year":"2014","journal-title":"Cell Physiol Biochem"},{"key":"pone.0225937.ref029","doi-asserted-by":"crossref","first-page":"D331","DOI":"10.1093\/nar\/gkw1108","article-title":"Expansion of the Gene Ontology knowledgebase and resources","volume":"45","author":"The Gene Ontology Consortium","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"pone.0225937.ref030","doi-asserted-by":"crossref","first-page":"D158","DOI":"10.1093\/nar\/gkw1099","article-title":"UniProt: the universal protein knowledgebase","volume":"45","author":"A Bateman","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"pone.0225937.ref031","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1471-2105-13-84","article-title":"Augmented annotation and orthologue analysis for Oryctolagus cuniculus: Better Bunny","volume":"13","author":"DB Craig","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"pone.0225937.ref032","doi-asserted-by":"crossref","first-page":"D183","DOI":"10.1093\/nar\/gkw1138","article-title":"PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements","volume":"45","author":"H Mi","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"pone.0225937.ref033","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ab.2012.10.010","article-title":"Stain-Free technology as a normalization tool in Western blot analysis","volume":"433","author":"A G\u00fcrtler","year":"2013","journal-title":"Anal Biochem"},{"key":"pone.0225937.ref034","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1373\/clinchem.2005.050146","article-title":"Automated spectrophotometric analysis of mitochondrial respiratory chain complex enzyme activities in cultured skin fibroblasts","volume":"51","author":"KA Kramer","year":"2005","journal-title":"Clin Chem"},{"key":"pone.0225937.ref035","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nprot.2012.058","article-title":"Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells","volume":"7","author":"M Spinazzi","year":"2012","journal-title":"Nat Protoc"},{"key":"pone.0225937.ref036","first-page":"3","volume-title":"Methods in enzymology, citric acid cycle","author":"P Srere","year":"1973"},{"key":"pone.0225937.ref037","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1373\/clinchem.2004.044594","article-title":"Quality Specifications for B-Type Natriuretic Peptide Assays","volume":"51","author":"FS Apple","year":"2005","journal-title":"Clin Chem"},{"key":"pone.0225937.ref038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/2983630","article-title":"The Biological Standardization of Insulin","volume":"7","author":"EC Fieller","year":"1940","journal-title":"Suppl to J R Stat Soc"},{"key":"pone.0225937.ref039","unstructured":"GraphPad QuickCalcs: error propagation calculator [Internet]. [cited 15 Oct 2019]. https:\/\/www.graphpad.com\/quickcalcs\/errorProp1\/"},{"key":"pone.0225937.ref040","first-page":"389","volume-title":"Methods in molecular biology","author":"SM Smith","year":"2017"},{"key":"pone.0225937.ref041","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jacc.2014.04.083","article-title":"Metabolic impairment in heart failure: the myocardial and systemic perspective","volume":"64","author":"W Doehner","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"pone.0225937.ref042","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1161\/CIRCULATIONAHA.109.882068","article-title":"Genetic Deletion of Myostatin From the Heart Prevents Skeletal Muscle Atrophy in Heart Failure","volume":"121","author":"J Heineke","year":"2010","journal-title":"Circulation"},{"key":"pone.0225937.ref043","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1365-2613.2012.00812.x","article-title":"Muscle wasting in animal models of severe illness","volume":"93","author":"M Holecek","year":"2012","journal-title":"Int J Exp Pathol"},{"key":"pone.0225937.ref044","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jcsm.12034","article-title":"Skeletal muscle alterations in chronic heart failure: differential effects on quadriceps and diaphragm","volume":"6","author":"N Mangner","year":"2015","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"pone.0225937.ref045","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0735-1097(96)00592-X","article-title":"Tachycardia-induced cardiomyopathy: A review of animal models and clinical studies","author":"JS Shinbane","year":"1997","journal-title":"Journal of the American College of Cardiology. Elsevier USA"},{"key":"pone.0225937.ref046","first-page":"335","article-title":"Arrhythmia-induced cardiomyopathy","volume":"115","author":"S Sossalla","year":"2018","journal-title":"Dtsch Aerzteblatt Online"},{"key":"pone.0225937.ref047","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2459\/JCM.0000000000000631","article-title":"Long-term outcomes and predictors of recurrence after pulmonary vein isolation with multielectrode ablation catheter in patients with atrial fibrillation","volume":"19","author":"S Fredersdorf","year":"2018","journal-title":"J Cardiovasc Med"},{"key":"pone.0225937.ref048","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMoa1707855","article-title":"Catheter Ablation for Atrial Fibrillation with Heart Failure","volume":"378","author":"NF Marrouche","year":"2018","journal-title":"N Engl J Med"},{"key":"pone.0225937.ref049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchf.2012.10.002","article-title":"Heart Failure","volume":"1","author":"E Braunwald","year":"2013","journal-title":"JACC Hear Fail"},{"key":"pone.0225937.ref050","doi-asserted-by":"crossref","first-page":"e59225","DOI":"10.1371\/journal.pone.0059225","article-title":"Prevalence of Symptomatic Heart Failure with Reduced and with Normal Ejection Fraction in an Elderly General Population\u2013The CARLA Study","volume":"8","author":"D Tiller","year":"2013","journal-title":"PLoS One"},{"key":"pone.0225937.ref051","doi-asserted-by":"crossref","DOI":"10.1001\/jama.289.2.194","article-title":"Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic","volume":"289","author":"MM Redfield","year":"2003","journal-title":"JAMA"},{"key":"pone.0225937.ref052","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"JJV McMurray","year":"2014","journal-title":"N Engl J Med"},{"key":"pone.0225937.ref053","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00210-012-0791-6","article-title":"Antihypertrophic effects of combined inhibition of the renin-angiotensin system (RAS) and neutral endopeptidase (NEP) in progressive, tachycardia-induced experimental heart failure","volume":"385","author":"C Birner","year":"2012","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"pone.0225937.ref054","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cyto.2007.08.009","article-title":"Head-to-head comparison of BNP and IL-6 as markers of clinical and experimental heart failure: Superiority of BNP","volume":"40","author":"CM Birner","year":"2007","journal-title":"Cytokine"},{"key":"pone.0225937.ref055","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/1071-9164(95)90029-2","article-title":"Experimental heart failure produced by rapid ventricular pacing in the dog","volume":"1","author":"D Elsner","year":"1995","journal-title":"J Card Fail"},{"key":"pone.0225937.ref056","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1161\/01.CIR.80.5.1338","article-title":"Contribution of intrinsic skeletal muscle changes to 31P NMR skeletal muscle metabolic abnormalities in patients with chronic heart failure","volume":"80","author":"DM Mancini","year":"1989","journal-title":"Circulation"},{"key":"pone.0225937.ref057","doi-asserted-by":"crossref","first-page":"e004800","DOI":"10.1161\/CIRCHEARTFAILURE.117.004800","article-title":"Skeletal Muscle Abnormalities and Iron Deficiency in Chronic Heart Failure","volume":"11","author":"V Melenovsky","year":"2018","journal-title":"Circ Hear Fail"},{"key":"pone.0225937.ref058","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1183\/09031936.00170111","article-title":"Quadriceps wasting and physical inactivity in patients with COPD","volume":"40","author":"D Shrikrishna","year":"2012","journal-title":"Eur Respir J"},{"key":"pone.0225937.ref059","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1152\/physiolgenomics.00043.2018","article-title":"A mini review: Proteomics approaches to understand disused vs. exercised human skeletal muscle","volume":"50","author":"Y Cho","year":"2018","journal-title":"Physiol Genomics"},{"key":"pone.0225937.ref060","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1002\/pmic.200900817","article-title":"Long term bed rest with and without vibration exercise countermeasures: Effects on human muscle protein dysregulation","volume":"10","author":"M Moriggi","year":"2010","journal-title":"Proteomics"},{"key":"pone.0225937.ref061","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s11897-012-0090-z","article-title":"Skeletal Muscle Abnormalities in Chronic Heart Failure","volume":"9","author":"P Georgiadou","year":"2012","journal-title":"Curr Heart Fail Rep"},{"key":"pone.0225937.ref062","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/jcsm.12256","article-title":"Casting the net broader to confirm our imaginations: the long road to treating wasting disorders","volume":"8","author":"S von Haehling","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"pone.0225937.ref063","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s13539-013-0109-7","article-title":"Relation of respiratory muscle strength, cachexia and survival in severe chronic heart failure","volume":"4","author":"D Habedank","year":"2013","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"pone.0225937.ref064","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/resp.13432","article-title":"Respiratory muscle weakness increases dead-space ventilation ratio aggravating ventilation-perfusion mismatch during exercise in patients with chronic heart failure","volume":"24","author":"N Hamazaki","year":"2019","journal-title":"Respirology"},{"key":"pone.0225937.ref065","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1161\/01.CIR.96.2.526","article-title":"Hormonal changes and catabolic\/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia","volume":"96","author":"SD Anker","year":"1997","journal-title":"Circulation"},{"key":"pone.0225937.ref066","first-page":"366","article-title":"Lactate oxidation at the mitochondria: a lactate-malate-aspartate shuttle at work","volume":"8","author":"DA Kane","year":"2014","journal-title":"Front Neurosci"},{"key":"pone.0225937.ref067","doi-asserted-by":"crossref","first-page":"R502","DOI":"10.1152\/ajpregu.00114.2004","article-title":"Biochemistry of exercise-induced metabolic acidosis","volume":"287","author":"RA Robergs","year":"2004","journal-title":"Am J Physiol Integr Comp Physiol"},{"key":"pone.0225937.ref068","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1113\/JP274134","article-title":"The impact of age and frailty on ventricular structure and function in C57BL\/6J mice","volume":"595","author":"HA Feridooni","year":"2017","journal-title":"J Physiol"},{"key":"pone.0225937.ref069","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/01.CIR.76.5.1009","article-title":"Skeletal muscle metabolism in patients with congestive heart failure: relation to clinical severity and blood flow","volume":"76","author":"B Massie","year":"1987","journal-title":"Circulation"},{"key":"pone.0225937.ref070","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1172\/JCI103751","article-title":"The Role of Anaerobic Metabolism in the Performance of Mild Muscular Work. I. Relationship to Oxygen Consumption and Cardiac Output, and the Effect of Congestive Heart Failure1","volume":"37","author":"WE Huckabee","year":"1958","journal-title":"J Clin Invest"},{"key":"pone.0225937.ref071","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s11897-017-0347-7","article-title":"Targeting Mitochondrial Calcium Handling and Reactive Oxygen Species in Heart Failure","volume":"14","author":"A Dietl","year":"2017","journal-title":"Curr Heart Fail Rep"},{"key":"pone.0225937.ref072","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1039\/c3mb70227h","article-title":"Metabolomic identification of diagnostic plasma biomarkers in humans with chronic heart failure","volume":"9","author":"J Wang","year":"2013","journal-title":"Mol Biosyst"},{"key":"pone.0225937.ref073","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/ejhf.1156","article-title":"Increased blood lactate is prevalent and identifies poor prognosis in patients with acute heart failure without overt peripheral hypoperfusion","volume":"20","author":"R Zymli\u0144ski","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"pone.0225937.ref074","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s13539-012-0087-1","article-title":"Cancer cachexia: impact, mechanisms and emerging treatments","volume":"4","author":"VC Vaughan","year":"2013","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"pone.0225937.ref075","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1152\/physrev.00016.2008","article-title":"Mechanisms of cancer cachexia","volume":"89","author":"MJ Tisdale","year":"2009","journal-title":"Physiol Rev"},{"key":"pone.0225937.ref076","first-page":"5910","article-title":"Glucose metabolism in cachectic patients with colorectal cancer","volume":"44","author":"CP Holroyde","year":"1984","journal-title":"Cancer Res"},{"key":"pone.0225937.ref077","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1038\/oncsis.2016.3","article-title":"Understanding cachexia as a cancer metabolism syndrome","volume":"5","author":"PE Porporato","year":"2016","journal-title":"Oncogenesis"},{"key":"pone.0225937.ref078","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.metabol.2014.01.006","article-title":"The many roles of PGC-1\u03b1 in muscle\u2014recent developments","volume":"63","author":"MC Chan","year":"2014","journal-title":"Metabolism"},{"key":"pone.0225937.ref079","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nature00904","article-title":"Transcriptional co-activator PGC-1\u03b1 drives the formation of slow-twitch muscle fibres","volume":"418","author":"J Lin","year":"2002","journal-title":"Nature"},{"key":"pone.0225937.ref080","doi-asserted-by":"crossref","first-page":"30014","DOI":"10.1074\/jbc.M704817200","article-title":"Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1\u03b1 Muscle-specific Knock-out Animals","volume":"282","author":"C Handschin","year":"2007","journal-title":"J Biol Chem"},{"key":"pone.0225937.ref081","doi-asserted-by":"crossref","first-page":"36642","DOI":"10.1074\/jbc.M707006200","article-title":"A Role for the Transcriptional Coactivator PGC-1\u03b1 in Muscle Refueling","volume":"282","author":"AR Wende","year":"2007","journal-title":"J Biol Chem"},{"key":"pone.0225937.ref082","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1","volume":"98","author":"Z Wu","year":"1999","journal-title":"Cell"},{"key":"pone.0225937.ref083","doi-asserted-by":"crossref","first-page":"e0164060","DOI":"10.1371\/journal.pone.0164060","article-title":"NT-proBNP predicts cardiovascular death in the general population independent of left ventricular mass and function: Insights from a large population-based study with long-term follow-up","volume":"11","author":"A Dietl","year":"2016","journal-title":"PLoS One"},{"key":"pone.0225937.ref084","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/eurjhf\/hfn037","article-title":"The cyclic guanosine monophosphate\/B-type natriuretic peptide ratio and mortality in advanced heart failure","volume":"11","author":"P Louren\u00e7o","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"pone.0225937.ref085","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1016\/S0735-1097(02)01881-8","article-title":"Vasopeptidase inhibition with omapatrilat in chronic heart failure: acute and long-term hemodynamic and neurohumoral effects","volume":"39","author":"DR McClean","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"pone.0225937.ref086","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/1755-5922.12183","article-title":"Pharmacodynamic and Pharmacokinetic Profiles of Sacubitril\/Valsartan (LCZ696) in Patients with Heart Failure and Reduced Ejection Fraction","volume":"34","author":"Z Kobalava","year":"2016","journal-title":"Cardiovasc Ther"},{"key":"pone.0225937.ref087","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.ejheart.2005.12.005","article-title":"Intact acute cardiorenal and humoral responsiveness following chronic subcutaneous administration of the cardiac peptide BNP in experimental heart failure","volume":"8","author":"HH Chen","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"pone.0225937.ref088","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/01.RES.0000232322.06633.d3","article-title":"Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure","volume":"99","author":"G Singh","year":"2006","journal-title":"Circ Res"},{"key":"pone.0225937.ref089","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1210\/en.2006-0092","article-title":"Homologous and lysophosphatidic acid-induced desensitization of the atrial natriuretic peptide receptor, guanylyl cyclase-A, in MA-10 leydig cells","volume":"147","author":"D M\u00fcller","year":"2006","journal-title":"Endocrinology"},{"key":"pone.0225937.ref090","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1111\/j.1742-4658.2010.07658.x","article-title":"Homologous desensitization of guanylyl cyclase A, the receptor for atrial natriuretic peptide, is associated with a complex phosphorylation pattern","volume":"277","author":"J Schr\u00f6ter","year":"2010","journal-title":"FEBS J"},{"key":"pone.0225937.ref091","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.jacc.2006.08.066","article-title":"Acute phosphodiesterase 5 inhibition mimics hemodynamic effects of B-type natriuretic peptide and potentiates B-type natriuretic peptide effects in failing but not normal canine heart","volume":"49","author":"PR Forfia","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"pone.0225937.ref092","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/01.CIR.0000029801.86489.50","article-title":"Comparison of omapatrilat and enalapril in patients with chronic heart failure: the Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE)","volume":"106","author":"M Packer","year":"2002","journal-title":"Circulation"},{"key":"pone.0225937.ref093","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/eurheartj\/eht466","article-title":"Natriuretic peptides in cardiovascular diseases: current use and perspectives","volume":"35","author":"M Volpe","year":"2014","journal-title":"Eur Heart J"},{"key":"pone.0225937.ref094","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1096\/fj.04-2173com","article-title":"Coordinated changes in mitochondrial function and biogenesis in healthy and diseased human skeletal muscle","volume":"19","author":"A Garnier","year":"2005","journal-title":"FASEB J"},{"key":"pone.0225937.ref095","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1096\/fj.02-0367com","article-title":"Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1","volume":"16","author":"K Baar","year":"2002","journal-title":"FASEB J"},{"key":"pone.0225937.ref096","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1161\/CIRCULATIONAHA.117.028002","article-title":"Physical Activity and Prognosis in the TOPCAT Trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist)","volume":"136","author":"SM Hegde","year":"2017","journal-title":"Circulation"},{"key":"pone.0225937.ref097","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11897-018-0382-z","article-title":"The Evolving Role of Cardiorespiratory Fitness and Exercise in Prevention and Management of Heart Failure","volume":"15","author":"W Omar","year":"2018","journal-title":"Curr Heart Fail Rep"},{"key":"pone.0225937.ref098","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/clinchem\/37.2.186","article-title":"Release of cyclic guanosine monophosphate evaluated as a diagnostic tool in cardiac diseases","volume":"37","author":"KP Vorderwinkler","year":"1991","journal-title":"Clin Chem"},{"key":"pone.0225937.ref099","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature14332","article-title":"Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease","volume":"519","author":"DI Lee","year":"2015","journal-title":"Nature"},{"key":"pone.0225937.ref100","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/FJC.0b013e318210fc7e","article-title":"Concomitant Angiotensin AT1 Receptor Antagonism and Neprilysin Inhibition Produces Omapatrilat-like Antihypertensive Effects Without Promoting Tracheal Plasma Extravasation in the Rat","volume":"57","author":"LG Hegde","year":"2011","journal-title":"J Cardiovasc Pharmacol"},{"key":"pone.0225937.ref101","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1172\/JCI115477","article-title":"Angiotensin inhibition potentiates the renal responses to neutral endopeptidase inhibition in dogs with congestive heart failure","volume":"88","author":"KB Margulies","year":"1991","journal-title":"J Clin Invest"},{"key":"pone.0225937.ref102","doi-asserted-by":"crossref","first-page":"40","DOI":"10.15420\/cfr.2016:1:1","article-title":"The Mechanism of Action of LCZ696","volume":"2","author":"JT Menendez","year":"2016","journal-title":"Card Fail Rev"},{"key":"pone.0225937.ref103","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1136\/heartjnl-2017-311295","article-title":"Sacubitril\/valsartan: beyond natriuretic peptides","volume":"103","author":"JSS Singh","year":"2017","journal-title":"Heart"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T18:00:57Z","timestamp":1665165657000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225937"}},"subtitle":[],"editor":[{"given":"Xiongwen","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,12,4]]},"references-count":103,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0225937","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,4]]}}}