{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:00:56Z","timestamp":1787022056706,"version":"build-2736575974"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0226735","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T13:31:32Z","timestamp":1578576692000},"page":"e0226735","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction"],"prefix":"10.1371","volume":"15","author":[{"given":"Malcolm","family":"Eaton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair H.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Devine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00edn","family":"Mar\u00edusd\u00f3ttir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R. C.","family":"Natale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Matyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Bering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Workentine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7192-9103","authenticated-orcid":true,"given":"Benedikt","family":"Hallgrimsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-9378","authenticated-orcid":true,"given":"James C.","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"issue":"SUPPL 2","key":"pone.0226735.ref001","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/j.placenta.2012.05.002","article-title":"Maternal-fetal resource allocation: Co-operation and conflict","volume":"33","author":"AL Fowden","year":"2012","journal-title":"Placenta"},{"issue":"1\u20132","key":"pone.0226735.ref002","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1071\/RD15342","article-title":"Adaptability and potential for treatment of placental functions to improve embryonic development and postnatal health","volume":"28","author":"JC Cross","year":"2016","journal-title":"Reprod Fertil Dev"},{"issue":"3","key":"pone.0226735.ref003","first-page":"332","article-title":"Intrauterine growth retardation (IUGR): epidemiology and etiology","volume":"6","author":"A Romo","year":"2009","journal-title":"Pediatr Endocrinol Rev"},{"issue":"2","key":"pone.0226735.ref004","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1017\/S2040174412000529","article-title":"Placental transport in response to altered maternal nutrition","volume":"4","author":"F Gaccioli","year":"2013","journal-title":"J Dev Orig Health Dis"},{"issue":"Suppl 1","key":"pone.0226735.ref005","first-page":"S21","article-title":"Biological mechanisms of environmentally induced causes of IUGR","volume":"52","author":"J Prada","year":"1998","journal-title":"Eur J Clin Nutr"},{"key":"pone.0226735.ref006","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/ije\/31.6.1235","article-title":"Fetal origins of adult disease: strength of effects and biological basis","volume":"31","author":"D Barker","year":"2002","journal-title":"Int J Epidemiol"},{"issue":"7","key":"pone.0226735.ref007","first-page":"33","article-title":"The programming power of the placenta","volume":"7","author":"AN Sferruzzi-Perri","year":"2016","journal-title":"Front Physiol"},{"issue":"Pt 14","key":"pone.0226735.ref008","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1113\/jphysiol.2009.173013","article-title":"Placental efficiency and adaptation: endocrine regulation","volume":"587","author":"AL Fowden","year":"2009","journal-title":"J Physiol"},{"issue":"7","key":"pone.0226735.ref009","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1440-1681.2008.04975.x","article-title":"Sheep models of intrauterine growth restriction: Fetal adaptations and consequences","volume":"35","author":"JL Morrison","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"12","key":"pone.0226735.ref010","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1002\/dvdy.20981","article-title":"Origin and characteristics of glycogen cells in the developing murine placenta","volume":"235","author":"PM Coan","year":"2006","journal-title":"Dev Dyn"},{"issue":"6","key":"pone.0226735.ref011","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1095\/biolreprod.103.024166","article-title":"Developmental Dynamics of the Definitive Mouse Placenta Assessed by Stereology","volume":"70","author":"PM Coan","year":"2004","journal-title":"Biol Reprod"},{"issue":"2","key":"pone.0226735.ref012","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ydbio.2007.01.009","article-title":"Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta","volume":"304","author":"DG Simmons","year":"2007","journal-title":"Dev Biol"},{"key":"pone.0226735.ref013","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1152\/physiol.00001.2005","article-title":"Development of Structures and Transport Functions in the Mouse Placenta","volume":"20","author":"E Watson","year":"2005","journal-title":"Physiology"},{"issue":"1","key":"pone.0226735.ref014","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1128\/MCB.00662-09","article-title":"The Imprinted Phlda2 Gene Regulates Extraembryonic Energy Stores","volume":"30","author":"S. J Tunster","year":"2010","journal-title":"Mol Cell Biol"},{"key":"pone.0226735.ref015","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1186\/1471-2164-9-352","article-title":"Spatial and temporal expression of the 23 murine Prolactin\/Placental Lactogen-related genes is not associated with their position in the locus","volume":"9","author":"DG Simmons","year":"2008","journal-title":"BMC Genomics"},{"issue":"3","key":"pone.0226735.ref016","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.tem.2007.02.005","article-title":"The prolactin family: effectors of pregnancy-dependent adaptations","volume":"18","author":"MJ Soares","year":"2007","journal-title":"Trends Endocrinol Metab"},{"key":"pone.0226735.ref017","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.placenta.2018.01.005","article-title":"Regulating needs: Exploring the role of insulin-like growth factor-2 signalling in materno-fetal resource allocation","volume":"33","author":"AN Sferruzzi-Perri","year":"2018","journal-title":"Placenta"},{"issue":"5","key":"pone.0226735.ref018","doi-asserted-by":"crossref","first-page":"e1004330","DOI":"10.1371\/journal.pgen.1004330","article-title":"More of a Good Thing or Less of a Bad Thing: Gene Copy Number Variation in Polyploid Cells of the Placenta","volume":"10","author":"JC Cross","year":"2014","journal-title":"PLoS Genet"},{"issue":"5","key":"pone.0226735.ref019","doi-asserted-by":"crossref","first-page":"1004290","DOI":"10.1371\/journal.pgen.1004290","article-title":"Copy Number Variation Is a Fundamental Aspect of the Placental Genome","volume":"10","author":"RL Hannibal","year":"2014","journal-title":"PLoS Genet"},{"issue":"2","key":"pone.0226735.ref020","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.cub.2015.11.060","article-title":"Selective Amplification of the Genome Surrounding Key Placental Genes in Trophoblast Giant Cells","volume":"26","author":"RL Hannibal","year":"2016","journal-title":"Curr Biol"},{"issue":"589","key":"pone.0226735.ref021","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1113\/jphysiol.2011.208629","article-title":"Dietary composition programmes placental phenotype in mice","volume":"58914","author":"PM Coan","year":"2011","journal-title":"J Physiol"},{"issue":"Pt 3","key":"pone.0226735.ref022","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1113\/jphysiol.2009.181214","article-title":"Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice","volume":"588","author":"PM Coan","year":"2010","journal-title":"J Physiol"},{"issue":"04","key":"pone.0226735.ref023","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1079\/BJN2003967","article-title":"The maternal endocrine environment in the low-protein model of intra-uterine growth restriction","volume":"90","author":"DS Fernandez-Twinn","year":"2003","journal-title":"Br J Nutr"},{"issue":"6","key":"pone.0226735.ref024","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s10735-013-9522-7","article-title":"Gestational protein restriction induces alterations in placental morphology and mitochondrial function in rats during late pregnancy","volume":"44","author":"HJ Rebelato","year":"2013","journal-title":"J Mol Histol"},{"issue":"5","key":"pone.0226735.ref025","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1095\/biolreprod.112.103218","article-title":"Leptin and the Placental Response to Maternal Food Restriction During Early Pregnancy in Mice","volume":"87","author":"LC Schulz","year":"2012","journal-title":"Biol Reprod"},{"issue":"12","key":"pone.0226735.ref026","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.3945\/jn.110.127803","article-title":"A low-protein diet during gestation in rats activates the placental mammalian amino acid response pathway and programs the growth capacity of offspring","volume":"140","author":"RS Strakovsky","year":"2010","journal-title":"J Nutr"},{"key":"pone.0226735.ref027","article-title":"Fetal Exposure to Low Protein Diet Alters the Susceptibility of Young Adult Rats to Sulfur Dioxide-Induced Lung Injury","volume":"127","author":"SC Langley-Evans","year":"1997","journal-title":"J. Nutr"},{"issue":"3","key":"pone.0226735.ref028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0152227","article-title":"Chronic protein restriction in mice impacts placental function and maternal body weight before fetal growth","volume":"11","author":"PN Gonzalez","year":"2016","journal-title":"PLoS One"},{"issue":"11","key":"pone.0226735.ref029","doi-asserted-by":"crossref","first-page":"e47986","DOI":"10.1371\/journal.pone.0047986","article-title":"Maternal Diets Trigger Sex-Specific Divergent Trajectories of Gene Expression and Epigenetic Systems in Mouse Placenta","volume":"7","author":"A Gabory","year":"2012","journal-title":"PLoS One"},{"key":"pone.0226735.ref030","first-page":"3127","article-title":"Mid-to late term hypoxia in the mouse alters placental morphology, glucocorticoid regulatory pathways and nutrient transporters in a sex-specific manner","volume":"592","author":"JSM Cuffe","year":"2014","journal-title":"Authors J Physiol C"},{"key":"pone.0226735.ref031","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1095\/biolreprod.102.012641","article-title":"Effects of Sex Chromosome Dosage on Placental Size in Mice 1","volume":"69","author":"H Ishikawa","year":"2003","journal-title":"Biol Reprod"},{"issue":"18","key":"pone.0226735.ref032","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1113\/jphysiol.2008.156133","article-title":"Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice","volume":"586","author":"PM Coan","year":"2008","journal-title":"J Physiol"},{"issue":"12","key":"pone.0226735.ref033","doi-asserted-by":"crossref","first-page":"e14398","DOI":"10.1371\/journal.pone.0014398","article-title":"Sex-and Diet-Specific Changes of Imprinted Gene Expression and DNA Methylation in Mouse Placenta under a High-Fat Diet","volume":"5","author":"C Gallou-Kabani","year":"2010","journal-title":"PLoS One"},{"issue":"12","key":"pone.0226735.ref034","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1073\/pnas.1000440107","article-title":"Contrasting effects of different maternal diets on sexually dimorphic gene expression in the murine placenta","volume":"107","author":"J Mao","year":"2010","journal-title":"Proc Natl Acad Sci"},{"issue":"14","key":"pone.0226735.ref035","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1152\/physiolgenomics.00034.2013","article-title":"Intrauterine calorie restriction affects placental DNA methylation and gene expression","volume":"45","author":"P-Y Chen","year":"2013","journal-title":"Physiol Genomics"},{"issue":"Pt 1","key":"pone.0226735.ref036","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1113\/jphysiol.2005.100313","article-title":"A low maternal protein diet during pregnancy and lactation has sex- and window of exposure-specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the rat","volume":"571","author":"E Zambrano","year":"2006","journal-title":"J Physiol"},{"key":"pone.0226735.ref037","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.2741\/e472","article-title":"Maternal protein restriction regulates IGF2 system in placental labyrinth","volume":"4","author":"H Gao","year":"2012","journal-title":"Front Biosci (Elite Ed)"},{"key":"pone.0226735.ref038","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2818.1987.tb02837.x","article-title":"The efficiency of systematic sampling in stereology and its prediction*","volume":"147","author":"HJG Gundersen","year":"1986","journal-title":"J Microsc"},{"issue":"1","key":"pone.0226735.ref039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2013.08.005","article-title":"The transcriptional co-repressor TLE3 regulates development of trophoblast giant cells lining maternal blood spaces in the mouse placenta","volume":"382","author":"M Gasperowicz","year":"2013","journal-title":"Dev Biol"},{"key":"pone.0226735.ref040","doi-asserted-by":"crossref","DOI":"10.1007\/BF00174416","article-title":"Expression of alkaline phosphatase in the mature mouse placenta visualized by in situ hybridization and enzyme histochemistry","volume":"187","author":"S Johansson","year":"1993","journal-title":"Anat Embryol"},{"issue":"7","key":"pone.0226735.ref041","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nmeth.4324","article-title":"Differential analysis of rna-seq incorporating quantification uncertainty","volume":"14","author":"H Pimentel","year":"2017","journal-title":"Nat Methods"},{"issue":"53","key":"pone.0226735.ref042","article-title":"Gene-level differential analysis at transcript-level resolution","volume":"19","author":"L Yi","year":"2018","journal-title":"Genome Biol"},{"key":"pone.0226735.ref043","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1039\/C5MB00663E","article-title":"ReactomePA: an R\/Bioconductor package for reactome pathway analysis and visualization","volume":"12","author":"G Yu","year":"2016","journal-title":"Mol BioSyst"},{"issue":"5","key":"pone.0226735.ref044","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters","volume":"16","author":"G Yu","year":"2012","journal-title":"Omi A J Integr Biol"},{"key":"pone.0226735.ref045","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"D Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"pone.0226735.ref046","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1469-7580.2008.00994.x","article-title":"A stereological perspective on placental morphology in normal and complicated pregnancies","volume":"215","author":"TM Mayhew","year":"2009","journal-title":"J Anat"},{"issue":"2","key":"pone.0226735.ref047","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/excr.2000.4888","article-title":"The Ki-67 Protein: Fascinating Forms and an Unknown Function","volume":"257","author":"E Endl","year":"2000","journal-title":"Exp Cell Res"},{"key":"pone.0226735.ref048","doi-asserted-by":"crossref","DOI":"10.1007\/s004120050256","article-title":"Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation","volume":"106","author":"MJ Hendzel","year":"1997","journal-title":"Chromosoma"},{"key":"pone.0226735.ref049","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1242\/dev.02843","article-title":"The Mrj co-chaperone mediates keratin turnover and prevents the formation of toxic inclusion bodies in trophoblast cells of the placenta","volume":"134","author":"ED Watson","year":"2007","journal-title":"Development"},{"key":"pone.0226735.ref050","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1469-7580.2005.00488.x","article-title":"Ultrastructural changes in the interhaemal membrane and junctional zone of the murine chorioallantoic placenta across gestation","volume":"207","author":"PM Coan","year":"2005","journal-title":"J Anat"},{"key":"pone.0226735.ref051","first-page":"222","article-title":"Region-specific changes in brain size and cell composition under chronic nutrient restriction","author":"J Barbeito-Andr\u00e9s","year":"2019","journal-title":"J Exp Biol"},{"issue":"8\u20139","key":"pone.0226735.ref052","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.placenta.2007.05.002","article-title":"Regulation of Placental Nutrient Transport\u2014A Review","volume":"28","author":"HN Jones","year":"2007","journal-title":"Placenta"},{"key":"pone.0226735.ref053","first-page":"417","article-title":"Placental-specific IGF-II is a major modulator of placental and fetal growth","author":"M Const\u00e2ncia","year":"2002","journal-title":"Nat Lett"},{"issue":"21","key":"pone.0226735.ref054","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1073\/pnas.0402508101","article-title":"Placental-specific insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta","volume":"101","author":"CP Sibley","year":"2004","journal-title":"PNAS"},{"key":"pone.0226735.ref055","first-page":"152","article-title":"Placental-Specific Igf2 Deficiency Alters Developmental Adaptations to Undernutrition in Mice","author":"AN Sferruzzi-Perri","year":"2011","journal-title":"Endocrinology"},{"key":"pone.0226735.ref056","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1053\/plac.2001.0700","article-title":"Villous Trophoblast: Morphometric Perspectives on Growth, Differentiation, Turnover and Deposition of Fibrin-type Fibrinoid During Gestation","volume":"22","author":"TM Mayhew","year":"2001","journal-title":"Placenta"},{"key":"pone.0226735.ref057","doi-asserted-by":"crossref","DOI":"10.1177\/002215549704500711","article-title":"Spatiotemporal Expression of C-CAM in the Rat Placenta","volume":"45","author":"H Sawa","year":"1997","journal-title":"The Journal of Histochemistry & Cytochemistry"},{"issue":"2","key":"pone.0226735.ref058","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1006\/dbio.2002.0773","article-title":"Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta","volume":"250","author":"SL Adamson","year":"2002","journal-title":"Dev Biol"},{"key":"pone.0226735.ref059","article-title":"Polyploidization and Endomitosis in Giant Cells of Rabbit Trophoblast","volume":"60","author":"E V Zybina","year":"1975","journal-title":"Cell Tiss. Res"},{"key":"pone.0226735.ref060","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.micron.2007.05.006","article-title":"Modifications of nuclear envelope during differentiation and depolyploidization of rat trophoblast cells","volume":"39","author":"E V Zybina","year":"2007","journal-title":"Micron"},{"issue":"10","key":"pone.0226735.ref061","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1210\/en.2015-1227","article-title":"Sex-Specific Placental Responses in Fetal Development","volume":"156","author":"CS Rosenfeld","year":"2015","journal-title":"Endocrinology"},{"issue":"3","key":"pone.0226735.ref062","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/ajhb.20995","article-title":"Boys Live Dangerously in the Womb","volume":"22","author":"JG Eriksson","year":"2010","journal-title":"Am J Hum Biol"},{"issue":"5","key":"pone.0226735.ref063","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1113\/JP271057","article-title":"Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy","volume":"594","author":"JS Higgins","year":"2016","journal-title":"J Physiol"},{"key":"pone.0226735.ref064","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.placenta.2005.09.009","article-title":"Tracing the Glycogen Cells with Protocadherin 12 During Mouse Placenta Development","volume":"27","author":"S Bouillot","year":"2006","journal-title":"Placenta"},{"key":"pone.0226735.ref065","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod63.6.1913","article-title":"Apoptosis in Rat Placenta Is Zone-Dependent and Stimulated by Glucocorticoids","volume":"63","author":"BJ Waddell","year":"2000","journal-title":"Biology of reproduction"},{"issue":"11\u201312","key":"pone.0226735.ref066","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.placenta.2007.07.005","article-title":"Altered Trophoblast Proliferation is Insufficient to Account for Placental Dysfunction in Egfr Null Embryos","volume":"28","author":"J Dackor","year":"2007","journal-title":"Placenta"},{"issue":"1","key":"pone.0226735.ref067","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/dev.080531","article-title":"Endoreplication and polyploidy: insights into development and disease","volume":"140","author":"DT Fox","year":"2013","journal-title":"Development"},{"issue":"4","key":"pone.0226735.ref068","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1091\/mbc.9.4.795","article-title":"Reprogramming the cell cycle for endoreduplication in rodent trophoblast cells","volume":"9","author":"a MacAuley","year":"1998","journal-title":"Mol Biol Cell"},{"issue":"5811","key":"pone.0226735.ref069","article-title":"Nucleosomes of polyploid trophoblast giant cells mostly consist of histone variants and form a loose chromatin structure","volume":"8","author":"K Hayakawa","year":"2018","journal-title":"Sci Reports2"},{"issue":"1","key":"pone.0226735.ref070","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ydbio.2014.11.023","article-title":"Three-dimensional cultures of trophoblast stem cells autonomously develop vascular-like spaces lined by trophoblast giant cells","volume":"398","author":"A Rai","year":"2015","journal-title":"Dev Biol"},{"issue":"1","key":"pone.0226735.ref071","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1146\/annurev.cellbio.24.110707.175418","article-title":"The Evolution, Regulation, and Function of Placenta-Specific Genes","volume":"24","author":"SM Rawn","year":"2008","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"8","key":"pone.0226735.ref072","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.placenta.2015.05.013","article-title":"Genetic ablation of placental sinusoidal trophoblast giant cells causes fetal growth restriction and embryonic lethality","volume":"36","author":"JE Outhwaite","year":"2015","journal-title":"Placenta"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0226735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T13:32:05Z","timestamp":1578576725000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0226735"}},"subtitle":[],"editor":[{"given":"David S.","family":"Milstone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1,9]]},"references-count":72,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0226735","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,9]]}}}