{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:15:35Z","timestamp":1771658135980,"version":"3.50.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001862","name":"Formas","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0226815","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T18:40:41Z","timestamp":1577731241000},"page":"e0226815","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Hold your breath \u2013 Differential behavioral and sensory acuity of mosquitoes to acetone and carbon dioxide"],"prefix":"10.1371","volume":"14","author":[{"given":"Majid","family":"Ghaninia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahid","family":"Majeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teun","family":"Dekker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6474-0214","authenticated-orcid":true,"given":"Sharon R.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-5986","authenticated-orcid":true,"given":"Rickard","family":"Ignell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,12,30]]},"reference":[{"key":"pone.0226815.ref001","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev-ento-120811-153618","article-title":"Host preferences of blood-feeding mosquitoes","volume":"58","author":"W Takken","year":"2013","journal-title":"Annual Review of Entomology"},{"issue":"5","key":"pone.0226815.ref002","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.cell.2014.02.003","article-title":"Stop the biting: targeting a mosquito\u2019s sense of smell","volume":"156","author":"CJ Potter","year":"2014","journal-title":"Cell"},{"issue":"18","key":"pone.0226815.ref003","doi-asserted-by":"crossref","first-page":"R793","DOI":"10.1016\/j.cub.2015.07.057","article-title":"Multi-cue integration: how female mosquitoes locate a human host","volume":"25","author":"RT Card\u00e9","year":"2015","journal-title":"Current Biology"},{"issue":"11","key":"pone.0226815.ref004","doi-asserted-by":"crossref","first-page":"160467","DOI":"10.1098\/rsos.160467","article-title":"Detection and perception of generic host volatiles by mosquitoes modulate host preference: context dependence of (R)-1-octen-3-ol","volume":"3","author":"S Majeed","year":"2016","journal-title":"Royal Society Open Science"},{"issue":"5","key":"pone.0226815.ref005","doi-asserted-by":"crossref","first-page":"170189","DOI":"10.1098\/rsos.170189","article-title":"Detection and perception of generic host volatiles by mosquitoes: responses to CO2 constrains host-seeking behaviour","volume":"4","author":"S Majeed","year":"2017","journal-title":"Royal Society Open Science"},{"issue":"1","key":"pone.0226815.ref006","doi-asserted-by":"crossref","first-page":"e8951","DOI":"10.1371\/journal.pone.0008951","article-title":"Development and field evaluation of a synthetic mosquito lure that is more attractive than humans","volume":"5","author":"FO Okumu","year":"2010","journal-title":"PloS One"},{"issue":"13","key":"pone.0226815.ref007","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.phytochem.2011.04.011","article-title":"Perception of plant volatile blends by herbivorous insects\u2013finding the right mix","volume":"72","author":"TJ Bruce","year":"2011","journal-title":"Phytochemistry"},{"issue":"18","key":"pone.0226815.ref008","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.cub.2007.07.062","article-title":"Odor coding in the maxillary palp of the malaria vector mosquito Anopheles gambiae","volume":"17","author":"T Lu","year":"2007","journal-title":"Current Biology"},{"issue":"8","key":"pone.0226815.ref009","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/chemse\/bjm040","article-title":"Maxillary palps are broad spectrum odorant detectors in Culex quinquefasciatus","volume":"32","author":"Z Syed","year":"2007","journal-title":"Chemical Senses"},{"issue":"4","key":"pone.0226815.ref010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/01652176.1996.9694638","article-title":"Detection of ketosis in dairy cows by analysis of exhaled breath","volume":"18","author":"P Dobbelaar","year":"1996","journal-title":"Veterinary Quarterly"},{"issue":"4","key":"pone.0226815.ref011","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1006\/jaer.1997.0168","article-title":"Preliminary investigation of breath sampling as a monitor of health in dairy cattle","volume":"67","author":"R Elliott-Martin","year":"1997","journal-title":"Journal of Agricultural Engineering Research"},{"issue":"5","key":"pone.0226815.ref012","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1080\/10473289.1999.10463831","article-title":"Human breath emissions of VOCs","volume":"49","author":"JD Fenske","year":"1999","journal-title":"Journal of the Air & Waste Management Association"},{"issue":"1\u20132","key":"pone.0226815.ref013","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0021-9673(99)00017-5","article-title":"Analysis of volatile organic compounds in human urine by headspace gas chromatography\u2013mass spectrometry with a multipurpose sampler","volume":"847","author":"HG Wahl","year":"1999","journal-title":"Journal of Chromatography A"},{"issue":"10","key":"pone.0226815.ref014","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3168\/jds.S0022-0302(42)95346-3","article-title":"Studies on ketosis in dairy cattle. I. Effect of stall and pasture feeding upon the concentration of blood and urinary acetone bodies of dairy cattle1","volume":"25","author":"C Knodt","year":"1942","journal-title":"Journal of Dairy Science"},{"issue":"2","key":"pone.0226815.ref015","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1017\/S0007485300014292","article-title":"The role of 1-octen-3-ol, acetone and carbon dioxide in the attraction of tsetse flies, Glossina spp. (Diptera: Glossinidae), to ox odour","volume":"75","author":"G Vale","year":"1985","journal-title":"Bulletin of Entomological Research"},{"issue":"1","key":"pone.0226815.ref016","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1017\/S000748530005210X","article-title":"Responses of tsetse flies (Diptera: Glossinidae) to natural and synthetic ox odours","volume":"85","author":"S Torr","year":"1995","journal-title":"Bulletin of Entomological Research"},{"issue":"3","key":"pone.0226815.ref017","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2915.2010.00924.x","article-title":"Behavioural responses of Anopheles gambiae sensu stricto to components of human breath, sweat and urine depend on mixture composition and concentration","volume":"25","author":"Y Qiu","year":"2011","journal-title":"Medical and Veterinary Entomology"},{"issue":"3","key":"pone.0226815.ref018","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2915.1995.tb00143.x","article-title":"Activation of Anopheles gambiae mosquitoes by carbon dioxide and human breath","volume":"9","author":"T Healy","year":"1995","journal-title":"Medical and Veterinary Entomology"},{"issue":"3","key":"pone.0226815.ref019","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/BF02765606","article-title":"Odor-mediated flight behavior of Anopheles gambiae giles Sensu Stricto and An. stephensi liston in response to CO 2, acetone, and 1-octen-3-ol (Diptera: Culicidae)","volume":"10","author":"W Takken","year":"1997","journal-title":"Journal of Insect Behavior"},{"issue":"4","key":"pone.0226815.ref020","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2987\/16-6599.1","article-title":"Laboratory evaluation of synthetic blends of l-(+)-lactic acid, ammonia, and ketones as potential attractants for Aedes aegypti","volume":"33","author":"P Venkatesh","year":"2017","journal-title":"Journal of the American Mosquito Control Association"},{"issue":"5","key":"pone.0226815.ref021","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1603\/0022-2585-40.5.653","article-title":"Synergistic attraction of Aedes aegypti (L.) to binary blends of L-lactic acid and acetone, dichloromethane, or dimethyl disulfide","volume":"40","author":"UR Bernier","year":"2003","journal-title":"Journal of Medical Entomology"},{"issue":"3","key":"pone.0226815.ref022","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2987\/8756-971X(2007)23[288:LCOAAA]2.0.CO;2","article-title":"Laboratory comparison of Aedes aegypti attraction to human odors and to synthetic human odor compounds and blends","volume":"23","author":"UR Bernier","year":"2007","journal-title":"Journal of the American Mosquito Control Association"},{"issue":"4","key":"pone.0226815.ref023","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF00187475","article-title":"Electrophysiological responses of receptor neurons in mosquito maxillary palp sensilla to carbon dioxide","volume":"177","author":"A Grant","year":"1995","journal-title":"Journal of Comparative Physiology A"},{"issue":"4","key":"pone.0226815.ref024","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1242\/jeb.092718","article-title":"Impact of elevated CO2 background levels on the host-seeking behaviour of Aedes aegypti","volume":"217","author":"S Majeed","year":"2014","journal-title":"Journal of Experimental Biology"},{"issue":"2","key":"pone.0226815.ref025","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1017\/S0007485300027322","article-title":"The response of Anopheles gambiae sl and A. funestus (Diptera: Culicidae) to tents baited with human odour or carbon dioxide in Tanzania","volume":"87","author":"L Mboera","year":"1997","journal-title":"Bulletin of Entomological Research"},{"issue":"6","key":"pone.0226815.ref026","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1111\/j.1460-9568.2007.05786.x","article-title":"Functional classification and central nervous projections of olfactory receptor neurons housed in antennal trichoid sensilla of female yellow fever mosquitoes, Aedes aegypti","volume":"26","author":"M Ghaninia","year":"2007","journal-title":"European Journal of Neuroscience"},{"issue":"2","key":"pone.0226815.ref027","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1017\/S0007485300031126","article-title":"Circadian flight activity in four sibling species of the Anopheles gambiae complex (Diptera, Culicidae)","volume":"64","author":"M Jones","year":"1974","journal-title":"Bulletin of Entomological Research"},{"issue":"5","key":"pone.0226815.ref028","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/jmedent\/29.5.784","article-title":"Diel sugar-feeding and host-seeking rhythms in mosquitoes (Diptera: Culicidae) under laboratory conditions","volume":"29","author":"WL Yee","year":"1992","journal-title":"Journal of Medical Entomology"},{"key":"pone.0226815.ref029","unstructured":"Ghaninia M. Olfaction in mosquitoes: Neuroanatomy and electrophysiology of the olfactory system [Doctoral dissertation]: Swedish University of Agricultural Sciences, SE.; 2007."},{"issue":"18","key":"pone.0226815.ref030","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1242\/jeb.016360","article-title":"Natural odor ligands for olfactory receptor neurons of the female mosquito Aedes aegypti: use of gas chromatography-linked single sensillum recordings","volume":"211","author":"M Ghaninia","year":"2008","journal-title":"Journal of Experimental Biology"},{"issue":"9","key":"pone.0226815.ref031","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/chemse\/bjl027","article-title":"Olfactory coding in antennal neurons of the malaria mosquito, Anopheles gambiae","volume":"31","author":"YT Qiu","year":"2006","journal-title":"Chemical Senses"},{"key":"pone.0226815.ref032","unstructured":"Suer RA. Unravelling the malaria mosquito's sense of smell: neural and behavioural responses to human-derived compounds [Doctoral dissertation]: Wageningen University, NL.; 2011."},{"issue":"1","key":"pone.0226815.ref033","first-page":"11","article-title":"Effect of human breath on mosquito attraction to man","volume":"32","author":"A Khan","year":"1972","journal-title":"Mosquito News"},{"issue":"7349","key":"pone.0226815.ref034","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nature10081","article-title":"Ultra-prolonged activation of CO 2-sensing neurons disorients mosquitoes","volume":"474","author":"SL Turner","year":"2011","journal-title":"Nature"},{"issue":"6","key":"pone.0226815.ref035","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.cell.2013.11.013","article-title":"Targeting a dual detector of skin and CO2 to modify mosquito host seeking","volume":"155","author":"GM Tauxe","year":"2013","journal-title":"Cell"},{"issue":"1","key":"pone.0226815.ref036","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1038\/s41598-019-39099-0","article-title":"Odorant ligands for the CO 2 receptor in two Anopheles vectors of malaria","volume":"9","author":"IV Coutinho-Abreu","year":"2019","journal-title":"Scientific Reports"},{"issue":"5","key":"pone.0226815.ref037","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.neuron.2018.01.028","article-title":"Signaling mode of the broad-spectrum conserved CO2 receptor is one of the important determinants of odor valence in Drosophila","volume":"97","author":"D MacWilliam","year":"2018","journal-title":"Neuron"},{"issue":"1","key":"pone.0226815.ref038","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1365-2583.2011.01120.x","article-title":"Functional validation of the carbon dioxide receptor genes in Aedes aegypti mosquitoes using RNA interference","volume":"21","author":"C Erdelyan","year":"2012","journal-title":"Insect Molecular Biology"},{"issue":"5","key":"pone.0226815.ref039","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2013.12.044","article-title":"Multimodal integration of carbon dioxide and other sensory cues drives mosquito attraction to humans","volume":"156","author":"CJ McMeniman","year":"2014","journal-title":"Cell"},{"key":"pone.0226815.ref040","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3920\/9789086866984_009","volume-title":"Olfaction in vector-host interactions","author":"RC Smallegange","year":"2010"},{"issue":"1","key":"pone.0226815.ref041","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev.ento.44.1.131","article-title":"Odor-mediated behavior of Afrotropical malaria mosquitoes","volume":"44","author":"W Takken","year":"1999","journal-title":"Annual Review of Entomology"},{"issue":"1","key":"pone.0226815.ref042","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1475-2875-1-17","article-title":"Host-specific cues cause differential attractiveness of Kenyan men to the African malaria vector Anopheles gambiae","volume":"1","author":"WR Mukabana","year":"2002","journal-title":"Malaria Journal"},{"issue":"1","key":"pone.0226815.ref043","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1365-3032.2011.00827.x","article-title":"Identification of candidate volatiles that affect the behavioural response of the malaria mosquito Anopheles gambiae sensu stricto to an active kairomone blend: laboratory and semi\u2010field assays","volume":"37","author":"RC Smallegange","year":"2012","journal-title":"Physiological Entomology"},{"issue":"1","key":"pone.0226815.ref044","doi-asserted-by":"crossref","first-page":"9699","DOI":"10.1038\/s41598-019-46220-w","article-title":"Age-dependent regulation of host seeking in Anopheles coluzzii","volume":"9","author":"A Omondi","year":"2019","journal-title":"Scientific Reports"},{"issue":"12","key":"pone.0226815.ref045","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1242\/jeb.202.12.1639","article-title":"Influence of odour plume structure on upwind flight of mosquitoes towards hosts","volume":"202","author":"M Geier","year":"1999","journal-title":"Journal of Experimental Biology"},{"issue":"8","key":"pone.0226815.ref046","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s10886-009-9668-7","article-title":"The effect of aliphatic carboxylic acids on olfaction-based host-seeking of the malaria mosquito Anopheles gambiae sensu stricto","volume":"35","author":"RC Smallegange","year":"2009","journal-title":"Journal of Chemical Ecology"},{"issue":"2","key":"pone.0226815.ref047","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/chemse\/bji010","article-title":"Synergism between ammonia, lactic acid and carboxylic acids as kairomones in the host-seeking behaviour of the malaria mosquito Anopheles gambiae sensu stricto (Diptera: Culicidae)","volume":"30","author":"RC Smallegange","year":"2005","journal-title":"Chemical Senses"},{"issue":"2","key":"pone.0226815.ref048","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1570-7458.2011.01119.x","article-title":"Human skin microbiota and their volatiles as odour baits for the malaria mosquito Anopheles gambiae ss","volume":"139","author":"NO Verhulst","year":"2011","journal-title":"Entomologia Experimentalis et Applicata"},{"issue":"15","key":"pone.0226815.ref049","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1242\/jeb.01736","article-title":"Carbon dioxide instantly sensitizes female yellow fever mosquitoes to human skin odours","volume":"208","author":"T Dekker","year":"2005","journal-title":"Journal of Experimental Biology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0226815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T10:19:49Z","timestamp":1722248389000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0226815"}},"subtitle":[],"editor":[{"given":"Joseph Clifton","family":"Dickens","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,12,30]]},"references-count":49,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0226815","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,30]]}}}