{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T08:23:02Z","timestamp":1746346982351},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T00:00:00Z","timestamp":1577750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0226871","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T13:31:30Z","timestamp":1577799090000},"page":"e0226871","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypofibrinolysis induced by tranexamic acid does not influence inflammation and mortality in a polymicrobial sepsis model"],"prefix":"10.1371","volume":"14","author":[{"given":"Yzabella Alves","family":"Campos Nogueira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana Nilkenes","family":"Gomes da Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Emilio","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Andrade","family":"Orsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franciele","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce M.","family":"Annichinno-Bizzacchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich Vinicius","family":"De Paula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,12,31]]},"reference":[{"key":"pone.0226871.ref001","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","article-title":"Coagulation and sepsis","volume":"149","author":"M Levi","year":"2017","journal-title":"Thromb Res"},{"key":"pone.0226871.ref002","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"B Engelmann","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"pone.0226871.ref003","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12916-015-0327-2","article-title":"Causes and consequences of coagulation activation in sepsis: an evolutionary medicine perspective","volume":"13","author":"MML Fiusa","year":"2015","journal-title":"BMC Med"},{"key":"pone.0226871.ref004","doi-asserted-by":"crossref","first-page":"16037","DOI":"10.1038\/nrdp.2016.37","article-title":"Disseminated intravascular coagulation","volume":"2","author":"S Gando","year":"2016","journal-title":"Nat Rev Dis Prim"},{"key":"pone.0226871.ref005","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1160\/TH07-02-0117","article-title":"Fibrinolysis and host response in bacterial infections","volume":"98","author":"S Bergmann","year":"2007","journal-title":"Thromb Haemost"},{"key":"pone.0226871.ref006","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1055\/s-0033-1334140","article-title":"Role of fibrinolysis in sepsis","volume":"39","author":"S. Gando","year":"2013","journal-title":"Semin Thromb Hemost"},{"key":"pone.0226871.ref007","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1055\/s-0037-1616084","article-title":"Early inhibition of activated fibrinolysis predicts microbial infection, shock and mortality in febrile medical patients","volume":"86","author":"J Raaphorst","year":"2001","journal-title":"Thromb Haemost"},{"key":"pone.0226871.ref008","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.3389\/fimmu.2018.01218","article-title":"Plasminogen Activator Inhibitor 1 for Predicting Sepsis Severity and Mortality Outcomes: A Systematic Review and Meta-Analysis","volume":"9","author":"TL Tipoe","year":"2018","journal-title":"Front Immunol"},{"key":"pone.0226871.ref009","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1126\/science.1439793","article-title":"A surface protease and the invasive character of plague","volume":"258","author":"OA Sodeinde","year":"1992","journal-title":"Science"},{"key":"pone.0226871.ref010","first-page":"128","article-title":"The role of coagulation\/fibrinolysis during Streptococcus pyogenes infection","volume":"4","author":"TG Loof","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"key":"pone.0226871.ref011","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2165\/11209070-000000000-00000","article-title":"Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis","volume":"72","author":"PL McCormack","year":"2012","journal-title":"Drugs"},{"key":"pone.0226871.ref012","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.thromres.2014.11.012","article-title":"Tranexamic acid\u2013an old drug still going strong and making a revival","volume":"135","author":"L Tengborn","year":"2015","journal-title":"Thromb Res"},{"key":"pone.0226871.ref013","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0140-6736(10)60835-5","article-title":"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial","volume":"376","author":"CRASH-2 trial collaborators","year":"2010","journal-title":"Lancet (London, England)"},{"key":"pone.0226871.ref014","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/S0140-6736(17)30638-4","article-title":"Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial","volume":"389","author":"WOMAN Trial Collaborators H","year":"2017","journal-title":"Lancet (London, England)"},{"key":"pone.0226871.ref015","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"D Rittirsch","year":"2009","journal-title":"Nat Protoc"},{"key":"pone.0226871.ref016","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1161\/ATVBAHA.109.202259","article-title":"Enhanced abdominal aortic aneurysm formation in thrombin-activatable procarboxypeptidase B-deficient mice","volume":"30","author":"G Schultz","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"pone.0226871.ref017","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3109\/00365540903510690","article-title":"Tranexamic acid, an inhibitor of plasminogen activation, aggravates staphylococcal septic arthritis and sepsis","volume":"42","author":"M K\u0142ak","year":"2010","journal-title":"Scand J Infect Dis"},{"key":"pone.0226871.ref018","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1124\/jpet.113.210880","article-title":"The antifibrinolytic drug tranexamic Acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury","volume":"349","author":"N Joshi","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"pone.0226871.ref019","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/SHK.0b013e3182939831","article-title":"Ensuring animal welfare while meeting scientific aims using a murine pneumonia model of septic shock","volume":"39","author":"O Huet","year":"2013","journal-title":"Shock"},{"key":"pone.0226871.ref020","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1055\/s-0038-1653821","article-title":"Haemostasis factors in angina pectoris; relation to gender, age and acute-phase reaction. Results of the ECAT Angina Pectoris Study Group","volume":"73","author":"F Haverkate","year":"1995","journal-title":"Thromb Haemost"},{"key":"pone.0226871.ref021","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/MBC.0000000000000444","article-title":"Laboratory evaluation of patients with undiagnosed bleeding disorders","volume":"27","author":"GSA Alves","year":"2016","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"Suppl 1","key":"pone.0226871.ref022","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1538-7836.2007.02519.x","article-title":"Fibrin and fibrinolysis in infection and host defense","volume":"5","author":"JL Degen","year":"2007","journal-title":"J Thromb Haemost"},{"key":"pone.0226871.ref023","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4161\/viru.25436","article-title":"Host innate immune responses to sepsis","volume":"5","author":"WJ Wiersinga","year":"2014","journal-title":"Virulence. Landes Bioscience"},{"key":"pone.0226871.ref024","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1097\/00003246-200009001-00017","article-title":"Phylogenetic and functional relationships between coagulation and the innate immune response","volume":"28","author":"SM Opal","year":"2000","journal-title":"Crit Care Med"},{"key":"pone.0226871.ref025","first-page":"41","article-title":"Fibrin in peritonitis. I. Beneficial and adverse effects of fibrin in experimental E. coli peritonitis","volume":"88","author":"DH Ahrenholz","year":"1980","journal-title":"Surgery"},{"key":"pone.0226871.ref026","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/00000658-198009000-00010","article-title":"Radical peritoneal debridement for established peritonitis. The results of a prospective randomized clinical trial","volume":"192","author":"HC Polk","year":"1980","journal-title":"Ann Surg"},{"key":"pone.0226871.ref027","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/01.shk.0000246897.27574.1b","article-title":"Effects of intra-abdominal administration of recombinant tissue plasminogen activator on coagulation, fibrinolysis and inflammatory responses in experimental polymicrobial peritonitis","volume":"27","author":"SQ van Veen","year":"2007","journal-title":"Shock"},{"key":"pone.0226871.ref028","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1182\/blood.V76.12.2520.2520","article-title":"Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways","volume":"76","author":"SJ van Deventer","year":"1990","journal-title":"Blood"},{"key":"pone.0226871.ref029","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.4049\/jimmunol.177.2.1189","article-title":"Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice","volume":"177","author":"R Renckens","year":"2006","journal-title":"J Immunol"},{"key":"pone.0226871.ref030","doi-asserted-by":"crossref","first-page":"e24774","DOI":"10.1371\/journal.pone.0024774","article-title":"Beneficial and Detrimental Effects of Plasmin(ogen) during Infection and Sepsis in Mice","volume":"6","author":"Y Guo","year":"2011","journal-title":"PLoS One"},{"key":"pone.0226871.ref031","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1111\/j.1538-7836.2011.04473.x","article-title":"Plasminogen activator inhibitor type I contributes to protective immunity during experimental Gram-negative sepsis (melioidosis)","volume":"9","author":"LM Kager","year":"2011","journal-title":"J Thromb Haemost"},{"key":"pone.0226871.ref032","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1097\/CCM.0b013e31824ea05e","article-title":"Endogenous tissue-type plasminogen activator impairs host defense during severe experimental gram-negative sepsis (melioidosis)*","volume":"40","author":"LM Kager","year":"2012","journal-title":"Crit Care Med"},{"key":"pone.0226871.ref033","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbrc.2011.09.023","article-title":"Critical role of type 1 plasminogen activator inhibitor (PAI-1) in early host defense against nontypeable Haemophilus influenzae (NTHi) infection","volume":"414","author":"JH Lim","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"pone.0226871.ref034","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1182\/blood-2006-05-025197","article-title":"Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia","volume":"109","author":"R Renckens","year":"2007","journal-title":"Blood"},{"key":"pone.0226871.ref035","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1111\/jth.12956","article-title":"Carboxypeptidase B2 deficiency reveals opposite effects of complement C3a and C5a in a murine polymicrobial sepsis model","volume":"13","author":"Z Shao","year":"2015","journal-title":"J Thromb Haemost"},{"key":"pone.0226871.ref036","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1213\/ANE.0b013e3181e2914d","article-title":"Tranexamic acid: how much is enough?","volume":"111","author":"MA Fox","year":"2010","journal-title":"Anesth Analg"},{"key":"pone.0226871.ref037","doi-asserted-by":"crossref","first-page":"21","DOI":"10.12688\/wellcomeopenres.14977.1","article-title":"No effect of tranexamic acid on platelet function and thrombin generation (ETAPlaT) in postpartum haemorrhage: a randomised placebo-controlled trial","volume":"4","author":"K Dallaku","year":"2019","journal-title":"Wellcome open Res"},{"key":"pone.0226871.ref038","first-page":"279","article-title":"[The effect of aprotinin and tranexamic acid on fibrinolysis and thrombin generation during cardiopulmonary bypass]","volume":"49","author":"A Risch","year":"2000","journal-title":"Anaesthesist"},{"key":"pone.0226871.ref039","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1007\/s00134-004-2349-7","article-title":"Beneficial effect of low-molecular-weight heparin against lipopolysaccharide-induced disseminated intravascular coagulation in rats is abolished by coadministration of tranexamic acid","volume":"30","author":"H Asakura","year":"2004","journal-title":"Intensive Care Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0226871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T13:31:48Z","timestamp":1577799108000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0226871"}},"subtitle":[],"editor":[{"given":"Pablo","family":"Garcia de Frutos","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,12,31]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0226871","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,31]]}}}