{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:35:36Z","timestamp":1761060936174,"version":"3.37.3"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0226986","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T13:29:38Z","timestamp":1576848578000},"page":"e0226986","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cell sources of inflammatory mediators present in bone marrow areas inside the meniscus"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4370-3294","authenticated-orcid":true,"given":"Francisco Airton Castro","family":"Rocha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virg\u00ednia Claudia Carneiro","family":"Gir\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo de Melo","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina Matias Dinelly","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Eurico","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"pone.0226986.ref001","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrrheum.2012.69","article-title":"Meniscus pathology, osteoarthritis and the treatment controversy","volume":"8","author":"M Englund","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"pone.0226986.ref002","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.joca.2015.08.005","article-title":"Evidence that meniscus damage may be a component of osteoarthritis: the Framingham study","volume":"24","author":"M Englund","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"pone.0226986.ref003","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1002\/art.39176","article-title":"What comes first? Multitissue involvement leading to radiographic osteoarthritis: magnetic resonance imaging-based trajectory analysis over four years in the osteoarthritis initiative","volume":"67","author":"FW Roemer","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"pone.0226986.ref004","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/art.39177","article-title":"Toward a new paradigm of knee osteoarthritis","volume":"67","author":"TE McAlindon","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"pone.0226986.ref005","doi-asserted-by":"crossref","first-page":"7411","DOI":"10.1016\/j.biomaterials.2011.06.037","article-title":"The knee meniscus: structure-function, pathophysiology, current repair techniques, and prospects for regeneration","volume":"32","author":"EA Makris","year":"2011","journal-title":"Biomaterials"},{"key":"pone.0226986.ref006","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.joca.2005.01.010","article-title":"Characterisation of human knee meniscus cell phenotype","volume":"13","author":"PC Verdonk","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"pone.0226986.ref007","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.acthis.2014.12.009","article-title":"Comparative immunohistochemical evaluation of the zonal distribution of extracellular matrix and inflammation markers in human meniscus in osteoarthritis and rheumatoid arthritis","volume":"117","author":"IK Fuhrmann","year":"2015","journal-title":"Acta Histochem"},{"key":"pone.0226986.ref008","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.joca.2013.11.002","article-title":"Pro-inflammatory stimulation of meniscus cells increases production of matrix metalloproteinases and additional catabolic factors involved in osteoarthritis pathogenesis","volume":"22","author":"AV Stone","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"pone.0226986.ref009","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.joca.2008.02.019","article-title":"IL-1 and iNOS gene expression and NO synthesis in the superior region of meniscal explants are dependent on the magnitude of compressive strains","volume":"16","author":"T Gupta","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"pone.0226986.ref010","article-title":"Formation and maturation of the murine meniscus","author":"LW Gamer","year":"2016","journal-title":"J Orthop Res"},{"key":"pone.0226986.ref011","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1016\/j.joca.2014.07.019","article-title":"Meniscal transection rather than excision increases pain behavior and structural damage in experimental osteoarthritis in mice","volume":"22","author":"AC de Melo Leite","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"pone.0226986.ref012","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1053\/joca.1999.0312","article-title":"Meniscal ossification in spontaneous osteoarthritis in the guinea-pig","volume":"8","author":"RD Kapadia","year":"2000","journal-title":"Osteoarthritis Cartilage"},{"key":"pone.0226986.ref013","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00776-007-1140-3","article-title":"Meniscal ossicles","volume":"12","author":"Y Kato","year":"2007","journal-title":"J Orthop Sci"},{"key":"pone.0226986.ref014","article-title":"Bone Marrow-Derived Macrophages (BMM): Isolation and Applications","author":"J Weischenfeldt","year":"2008","journal-title":"B. CSH Protoc"},{"key":"pone.0226986.ref015","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joca.2012.11.012","article-title":"Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)","volume":"21","author":"F Berenbaum","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"issue":"Suppl 2","key":"pone.0226986.ref016","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/S1063-4584(08)60008-4","article-title":"Osteoarthritis and nitric oxide","volume":"16","author":"SB Abramson","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"pone.0226986.ref017","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11926-008-0007-8","article-title":"Cell death in osteoarthritis","volume":"10","author":"M Del Carlo","year":"2008","journal-title":"Curr Rheumatol Rep"},{"key":"pone.0226986.ref018","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1359\/jbmr.2002.17.3.434","article-title":"Evidence that peroxynitrite affects human osteoblast proliferation and differentiation","volume":"17","author":"FA da Rocha","year":"2002","journal-title":"J Bone Miner Res"},{"key":"pone.0226986.ref019","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13075-017-1229-9","article-title":"Synovitis in osteoarthritis: current understanding with therapeutic implications","volume":"19","author":"A Mathiessen","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"pone.0226986.ref020","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/S0140-6736(17)31472-1","article-title":"Pathogenetic insights from the treatment of rheumatoid arthritis","volume":"389","author":"IB McInnes","year":"2017","journal-title":"Lancet"},{"key":"pone.0226986.ref021","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.joca.2010.05.027","article-title":"Recommendations for the use of preclinical models in the study and treatment of osteoarthritis","volume":"18","author":"R Poole","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"pone.0226986.ref022","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-642-02450-4_1","volume-title":"The Meniscus","author":"B Lebel","year":"2010"},{"key":"pone.0226986.ref023","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.joca.2012.01.017","article-title":"What constitutes an \"animal model of osteoarthritis\"\u2014the need for consensus?","volume":"20","author":"CB Little","year":"2012","journal-title":"Osteoarthritis Cartilage"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0226986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T13:29:52Z","timestamp":1576848592000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0226986"}},"subtitle":[],"editor":[{"given":"Oreste","family":"Gualillo","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,12,20]]},"references-count":23,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0226986","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2019,12,20]]}}}