{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:31:26Z","timestamp":1782840686496,"version":"3.54.5"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0227059","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T13:47:47Z","timestamp":1578664067000},"page":"e0227059","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pancreatic secretory trypsin inhibitor reduces multi-organ injury caused by gut ischemia\/reperfusion in mice"],"prefix":"10.1371","volume":"15","author":[{"given":"Raymond J.","family":"Playford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2076-9098","authenticated-orcid":true,"given":"Tania","family":"Marchbank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"pone.0227059.ref001","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1053\/j.semperi.2008.01.003","article-title":"The neonatal intestinal vasculature: contributing factors to necrotizing enterocolitis","volume":"32","author":"CA Nankervis","year":"2008","journal-title":"Semin Perinatol"},{"key":"pone.0227059.ref002","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.bpg.2013.08.006","article-title":"Gastro-intestinal vascular emergencies","volume":"27","author":"O Corcos","year":"2013","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"pone.0227059.ref003","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/icvts\/ivu139","article-title":"Mesenteric ischaemia following cardiac surgery: the influence of intraoperative perfusion parameters","volume":"19","author":"P Sastry","year":"2014","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"pone.0227059.ref004","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1097\/SLA.0000000000000631","article-title":"Intraluminal nonbacterial intestinal components control gut and lung injury after trauma hemorrhagic shock","volume":"260","author":"JE Fishman","year":"2014","journal-title":"Ann Surg"},{"key":"pone.0227059.ref005","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1097\/00005373-199412000-00002","article-title":"The postischemic gut serves as a priming bed for circulating neutrophils that provoke multiple organ failure","volume":"37","author":"EE Moore","year":"1994","journal-title":"J Trauma"},{"key":"pone.0227059.ref006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00024382-200115010-00001","article-title":"Post-injury multiple organ failure: the role of the gut","volume":"15","author":"HT Hassoun","year":"2001","journal-title":"Shock"},{"key":"pone.0227059.ref007","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nrd4422","article-title":"Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases","volume":"13","author":"HK Eltzschig","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"pone.0227059.ref008","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ccc.2015.11.004","article-title":"The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness","volume":"32","author":"NJ Klingensmith","year":"2016","journal-title":"Crit Care Clin"},{"key":"pone.0227059.ref009","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1021\/ja01189a060","article-title":"Isolation of a crystalline trypsin inhibitor-anticoagulant protein from the pancreas","volume":"70","author":"LA Kazal","year":"1948","journal-title":"J Am Chem Soc"},{"key":"pone.0227059.ref010","first-page":"715","article-title":"Distribution and expression of pancreatic secretory trypsin inhibitor and its possible role in epithelial restitution","volume":"148","author":"T Marchbank","year":"1996","journal-title":"Am J Pathol"},{"key":"pone.0227059.ref011","first-page":"310","article-title":"Influence of inflammatory bowel disease on the distribution and concentration of pancreatic secretory trypsin inhibitor within the colon","volume":"146","author":"RJ Playford","year":"1995","journal-title":"Am J Pathol"},{"key":"pone.0227059.ref012","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2353\/ajpath.2007.070192","article-title":"Human pancreatic secretory trypsin inhibitor stabilizes intestinal mucosa against noxious agents","volume":"171","author":"T Marchbank","year":"2007","journal-title":"Am J Pathol"},{"key":"pone.0227059.ref013","doi-asserted-by":"crossref","first-page":"F382","DOI":"10.1152\/ajprenal.00357.2012","article-title":"Pancreatic secretory trypsin inhibitor causes autocrine-mediated migration and invasion in bladder cancer and phosphorylates the EGF receptor, Akt2 and Akt3, and ERK1 and ERK2","volume":"305","author":"T Marchbank","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"pone.0227059.ref014","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/jnci\/59.1.221","article-title":"One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice","volume":"59","author":"J Fogh","year":"1977","journal-title":"J Natl Cancer Inst"},{"key":"pone.0227059.ref015","first-page":"1703","article-title":"Establishment and characterization of an in vitro model system for human adenocarcinoma of the stomach","volume":"43","author":"SC Barranco","year":"1983","journal-title":"Cancer Res"},{"key":"pone.0227059.ref016","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0309-1651(84)90054-7","article-title":"Characterization of an epithelioid cell line derived from rat small intestine: demonstration of cytokeratin filaments","volume":"8","author":"J Blay","year":"1984","journal-title":"Cell Biol Int Rep"},{"key":"pone.0227059.ref017","first-page":"69","article-title":"A critical assessment of the use of microculture tetrazolium assays to measure cell growth and function","volume":"5","author":"NJ Marshall","year":"1995","journal-title":"Growth Regul"},{"key":"pone.0227059.ref018","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3945\/ajcn.116.134403","article-title":"Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers","volume":"104","author":"G Davison","year":"2016","journal-title":"Am J Clin Nutr"},{"key":"pone.0227059.ref019","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/archsurg.1970.01340280030009","article-title":"Intestinal mucosal lesion in low-flow states. A morphological, hemodynamic, and metabolic reappraisal","volume":"101","author":"CJ Chiu","year":"1970","journal-title":"Arch Surg"},{"key":"pone.0227059.ref020","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.phrs.2004.11.007","article-title":"Inhibition of poly (ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia reperfusion in rats","volume":"51","author":"O Koksel","year":"2005","journal-title":"Pharmacol Res"},{"key":"pone.0227059.ref021","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.peptides.2003.12.022","article-title":"Synergistic effects of systemic trefoil factor family 1 (TFF1) peptide and epidermal growth factor in a rat model of colitis","volume":"25","author":"AJ FitzGerald","year":"2004","journal-title":"Peptides"},{"key":"pone.0227059.ref022","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0009-8981(78)90081-5","article-title":"Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method","volume":"90","author":"K Satoh","year":"1978","journal-title":"Clin Chim Acta"},{"key":"pone.0227059.ref023","doi-asserted-by":"crossref","first-page":"G63","DOI":"10.1152\/ajpgi.00112.2013","article-title":"Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research","volume":"308","author":"LM Gonzalez","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"pone.0227059.ref024","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0002-9440(10)64192-2","article-title":"Prophylactic use of epidermal growth factor reduces ischemia\/reperfusion intestinal damage","volume":"161","author":"J Berlanga","year":"2002","journal-title":"Am J Pathol"},{"key":"pone.0227059.ref025","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.amjsurg.2010.05.010","article-title":"Splanchnic hypoperfusion provokes acute lung injury via a 5-lipoxygenase-dependent mechanism","volume":"200","author":"EE Moore","year":"2010","journal-title":"Am J Surg"},{"key":"pone.0227059.ref026","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1097\/TA.0b013e31816c5ca6","article-title":"Gut ischemia\/reperfusion induced acute lung injury is an alveolar macrophage dependent event","volume":"64","author":"LB Moraes","year":"2008","journal-title":"J Trauma"},{"key":"pone.0227059.ref027","doi-asserted-by":"crossref","first-page":"D12","DOI":"10.1046\/j.1440-1746.2000.02144.x","article-title":"Role of heat shock proteins in gastric mucosal protection","volume":"15","author":"K Rokutan","year":"2000","journal-title":"J Gastroenterol Hepatol"},{"key":"pone.0227059.ref028","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1172\/JCI200421086","article-title":"Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis","volume":"114","author":"J Karhausen","year":"2004","journal-title":"J Clin Invest"},{"key":"pone.0227059.ref029","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mam.2015.12.004","article-title":"The role of HIF in immunity and inflammation","volume":"47\u201348","author":"EP Cummins","year":"2016","journal-title":"Mol Aspects Med"},{"key":"pone.0227059.ref030","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1152\/japplphysiol.00159.2002","article-title":"Murine model of gastrointestinal ischemia associated with complement-dependent injury","volume":"93","author":"H Zhao","year":"1985","journal-title":"J Appl Physiol"},{"key":"pone.0227059.ref031","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1084\/jem.172.4.1133","article-title":"Identification and characterization of receptors specific for human pancreatic secretory trypsin inhibitor","volume":"172","author":"T Niinobu","year":"1990","journal-title":"J Exp Med"},{"key":"pone.0227059.ref032","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/BJ20050908","article-title":"Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway","volume":"392","author":"RJ Orton","year":"2005","journal-title":"Biochem J"},{"key":"pone.0227059.ref033","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1080\/15216540600957438","article-title":"ERK1\/2 MAP kinases in cell survival and apoptosis","volume":"58","author":"Z Lu","year":"2006","journal-title":"IUBMB Life"},{"key":"pone.0227059.ref034","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1136\/gut.52.10.1472","article-title":"Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells","volume":"52","author":"H Sheng","year":"2003","journal-title":"Gut"},{"key":"pone.0227059.ref035","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1158\/0008-5472.CAN-10-0266","article-title":"Distinct biological roles for the akt family in mammary tumor progression","volume":"70","author":"RL Dillon","year":"2010","journal-title":"Cancer Res"},{"key":"pone.0227059.ref036","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000007485","article-title":"Human pancreatic secretory trypsin inhibitor. Distribution, actions and possible role in mucosal integrity and repair","volume":"59","author":"T Marchbank","year":"1998","journal-title":"Digestion"},{"key":"pone.0227059.ref037","first-page":"579","article-title":"Responses of cytokines, acute phase proteins, and polymorphonuclear cell elastase to surgical stress in the patients with esophageal cancer","volume":"44","author":"K Kikuchi","year":"1996","journal-title":"Rinsho Byori"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T13:47:56Z","timestamp":1578664076000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227059"}},"subtitle":[],"editor":[{"given":"Partha","family":"Mukhopadhyay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1,10]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0227059","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,10]]}}}