{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:33:17Z","timestamp":1767771197568,"version":"3.37.3"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000351","name":"British Lung Foundation","doi-asserted-by":"publisher","award":["RG14-9"],"award-info":[{"award-number":["RG14-9"]}],"id":[{"id":"10.13039\/501100000351","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0227175","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T18:51:10Z","timestamp":1578682270000},"page":"e0227175","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Simple non-mydriatic retinal photography is feasible and demonstrates retinal microvascular dilation in Chronic Obstructive Pulmonary Disease (COPD)"],"prefix":"10.1371","volume":"15","author":[{"given":"G. J.","family":"McKay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. V.","family":"McCarter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Hogg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4176-5408","authenticated-orcid":true,"given":"D. H.","family":"Higbee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M-P. K.","family":"Bajaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6128-9202","authenticated-orcid":true,"given":"D. R.","family":"Burrage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ruickbie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. H.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. W.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4805-5759","authenticated-orcid":true,"given":"J. W.","family":"Dodd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"pone.0227175.ref001","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1164\/rccm.200703-456SO","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"176","author":"KF Rabe","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"pone.0227175.ref002","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1183\/09031936.03.00405703","article-title":"Systemic effects of chronic obstructive pulmonary disease","volume":"21","author":"AG Agusti","year":"2003","journal-title":"Eur Respir J"},{"key":"pone.0227175.ref003","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1440-1843.2007.01136.x","article-title":"Cardiovascular risk in chronic obstructive pulmonary disease","volume":"12","author":"JD Maclay","year":"2007","journal-title":"Respirology"},{"key":"pone.0227175.ref004","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1136\/thx.2009.128082","article-title":"Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care","volume":"65","author":"JR Feary","year":"2010","journal-title":"Thorax"},{"key":"pone.0227175.ref005","doi-asserted-by":"crossref","first-page":"233","DOI":"10.7326\/0003-4819-142-4-200502150-00005","article-title":"The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial","volume":"142","author":"NR Anthonisen","year":"2005","journal-title":"Ann Intern Med"},{"issue":"6","key":"pone.0227175.ref006","first-page":"L908","article-title":"Endothelial dysfunction in pulmonary arteries of patients with mild COPD","volume":"274","author":"VI Peinado","year":"1998","journal-title":"Am J Physiol"},{"key":"pone.0227175.ref007","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1183\/09031936.00128008","article-title":"Systemic manifestations and comorbidities of COPD","volume":"33","author":"PJ Barnes","year":"2009","journal-title":"Eur Respir J"},{"key":"pone.0227175.ref008","unstructured":"McKay GJ, McCarter RV, Hogg RE, Bajaj MPK, Burrage D, Ruickbie S, et al. Retinal Microvascular Changes In People With COPD Compared To Age-Matched Smokers Without COPD. American Thoracic Society 2017 International Conference; Washington DC: Am J Respir Crit Care Med. 2017. p. A1012."},{"key":"pone.0227175.ref009","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1152\/japplphysiol.90549.2008","article-title":"Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage","volume":"105","author":"GF Mitchell","year":"2008","journal-title":"J Appl Physiol"},{"key":"pone.0227175.ref010","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1161\/STROKEAHA.111.642264","article-title":"Arterial stiffness and cerebral small vessel disease: The Rotterdam Scan Study","volume":"43","author":"MM Poels","year":"2012","journal-title":"Stroke"},{"key":"pone.0227175.ref011","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1164\/rccm.200707-1080OC","article-title":"Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease","volume":"176","author":"DA McAllister","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"pone.0227175.ref012","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1161\/01.STR.0000195134.04355.e5","article-title":"Retinal Microvascular abnormalities and MRI-defined subclinical cerebral infarction: The Atherosclerosis Risk in Communities study","volume":"37","author":"LS Cooper","year":"2006","journal-title":"Stroke"},{"key":"pone.0227175.ref013","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1161\/STROKEAHA.112.673335","article-title":"Retinal microvascular signs and risk of stroke. The Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"43","author":"R Kawasaki","year":"2012","journal-title":"Stroke"},{"key":"pone.0227175.ref014","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1212\/WNL.0b013e31820e7baa","article-title":"Retinal vascular caliber and risk of dementia: The Rotterdam Study","volume":"76","author":"FJ de Jong","year":"2011","journal-title":"Neurology"},{"key":"pone.0227175.ref015","doi-asserted-by":"crossref","first-page":"e50224","DOI":"10.1371\/journal.pone.0050224","article-title":"The association of systemic microvascular changes with lung function and lung density: a cross-sectional study","volume":"7","author":"B Harris","year":"2012","journal-title":"PloS One"},{"key":"pone.0227175.ref016","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000368544","article-title":"Hypertensive\/microvascular disease and COPD: a case control study","volume":"41","author":"SK Chew","year":"2016","journal-title":"Kidney Blood Press Res"},{"key":"pone.0227175.ref017","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1167\/iovs.05-1539","article-title":"Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA)","volume":"47","author":"TY Wong","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"pone.0227175.ref018","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0140-6736(07)61377-4","article-title":"International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study","volume":"370","author":"AS Buist","year":"2007","journal-title":"Lancet"},{"key":"pone.0227175.ref019","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"ZS Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"pone.0227175.ref020","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1183\/09031936.00102509","article-title":"Development and first validation of the COPD assessment test","volume":"34","author":"PW Jones","year":"2009","journal-title":"Eur Respir J"},{"key":"pone.0227175.ref021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1183\/09031936.05.00034205","article-title":"Coming together: the ATS\/ERS consensus on clinical pulmonary function testing","volume":"26","author":"V Brusasco","year":"2005","journal-title":"Eur Respir J"},{"key":"pone.0227175.ref022","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.dadm.2015.04.001","article-title":"Retinal microvascular network attenuation in Alzheimer's disease","volume":"1","author":"MA Williams","year":"2015","journal-title":"Alzheimers Dement (Amst)"},{"key":"pone.0227175.ref023","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1076\/ceyr.27.3.143.16049","article-title":"Revised formulas for summarizing retinal vessel diameters","volume":"27","author":"MD Knudtson","year":"2003","journal-title":"Curr Eye Res"},{"key":"pone.0227175.ref024","first-page":"495","article-title":"A new method to measure peripheral retinal vascular caliber over an extended area","volume":"17","author":"CY Cheung","year":"2010","journal-title":"Microcirculation (New York, NY: 1994)"},{"key":"pone.0227175.ref025","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.ophtha.2008.05.029","article-title":"The retinal vasculature as a fractal: methodology, reliability, and relationship to blood pressure","volume":"115","author":"G Liew","year":"2008","journal-title":"Ophthalmology"},{"key":"pone.0227175.ref026","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1386-5056(98)00163-4","article-title":"Measurement and classification of retinal vascular tortuosity","volume":"53","author":"WE Hart","year":"1999","journal-title":"Int J Med Inform"},{"key":"pone.0227175.ref027","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1085\/jgp.74.4.537","article-title":"Arterial bifurcations in the human retina","volume":"74","author":"M Zamir","year":"1979","journal-title":"J Gen Physiol"},{"key":"pone.0227175.ref028","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/10739680802353868","article-title":"Determinants of retinal microvascular architecture in normal subjects","volume":"16","author":"AD Hughes","year":"2009","journal-title":"Microcirculation (New York, NY: 1994)"},{"key":"pone.0227175.ref029","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.ophtha.2007.06.036","article-title":"Arteriolar oxygen saturation, cerebral blood flow, and retinal vessel diameters. The Rotterdam Study","volume":"115","author":"FJ de Jong","year":"2008","journal-title":"Ophthalmology"},{"key":"pone.0227175.ref030","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1442-9071.2005.01130.x","article-title":"Smokers\u2019 veins: a useful clinical sign\u2013response","volume":"33","author":"ML Rosenberg","year":"2005","journal-title":"Clin Exp Ophthalmol"},{"key":"pone.0227175.ref031","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/aos.13765","article-title":"Looking into the eye of patients with chronic obstructive pulmonary disease: an opportunity for better microvascular profiling of these complex patients","volume":"96","author":"AW Vaes","year":"2018","journal-title":"Acta Ophthalmol"},{"key":"pone.0227175.ref032","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3109\/15569527.2015.1004079","article-title":"Peripapillary choroidal thickness in patients with chronic obstructive pulmonary disease","volume":"35","author":"M Ozcimen","year":"2016","journal-title":"Cutan Ocul Toxicol"},{"key":"pone.0227175.ref033","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/crj.12523","article-title":"New aspect for systemic effects of COPD: eye findings","volume":"12","author":"E Ugurlu","year":"2016","journal-title":"Clin Respir J"},{"key":"pone.0227175.ref034","first-page":"1","article-title":"The evaluation of retinal and choroidal structural changes by optical coherence tomography in patients with chronic obstructive pulmonary disease","volume":"43","author":"M Gok","year":"2017","journal-title":"Curr Eye Res"},{"key":"pone.0227175.ref035","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.survophthal.2016.02.007","article-title":"State of science: choroidal thickness and systemic health","volume":"61","author":"KA Tan","year":"2016","journal-title":"Surv Ophthalmol"},{"key":"pone.0227175.ref036","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1001\/archinte.165.9.1060","article-title":"Retinal arteriolar narrowing, hypertension, and subsequent risk of diabetes mellitus\"","volume":"165","author":"TY Wong","year":"2005","journal-title":"Arch Intern Med"},{"key":"pone.0227175.ref037","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1161\/STROKEAHA.110.598599","article-title":"Transient ischemic attack and acute ischemic stroke: associations with retinal microvascular signs","volume":"42","author":"JJ Wang","year":"2011","journal-title":"Stroke"},{"key":"pone.0227175.ref038","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1167\/iovs.05-1539","article-title":"Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA)","volume":"47","author":"TY Wong","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"pone.0227175.ref039","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s11906-012-0252-0","article-title":"Retinal arteriolar diameter and the prevalence and incidence of hypertension: a systematic review and meta-analysis of their association","volume":"14","author":"SK Chew","year":"2012","journal-title":"Curr Hypertens Rep"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T19:24:43Z","timestamp":1613935483000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227175"}},"subtitle":[],"editor":[{"given":"Giacomo","family":"Pucci","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1,10]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0227175","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2020,1,10]]}}}