{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:37:28Z","timestamp":1785908248069,"version":"3.56.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0227410","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T18:51:40Z","timestamp":1578509500000},"page":"e0227410","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of effects and safety in providing controlled hypotension during surgery between dexmedetomidine and magnesium sulphate: A meta-analysis of randomized controlled trials"],"prefix":"10.1371","volume":"15","author":[{"given":"Bingchen","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1407-8098","authenticated-orcid":true,"given":"Lingli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-shan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"pone.0227410.ref001","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1056\/NEJM199902113400606","article-title":"Transfusion medicine: First of two parts-Blood transfusion","volume":"340","author":"LT Goodnough","year":"1999","journal-title":"N Engl J Med"},{"key":"pone.0227410.ref002","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1054\/bjom.2000.0593","article-title":"Hypotensive anaesthesia and blood loss in orthognathic surgery: a clinical study","volume":"39","author":"K Praveen","year":"2001","journal-title":"Br J Oral Maxillofac Surg"},{"key":"pone.0227410.ref003","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1007\/s00405-012-2311-1","article-title":"Effects of three different types of anaesthesia on perioperative bleeding control in functional endoscopic sinus surgery","volume":"270","author":"J Milonski","year":"2013","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"pone.0227410.ref004","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2165\/00003495-200767070-00007","article-title":"Controlled hypotension: a guide to drug choice","volume":"67","author":"CS Degoute","year":"2007","journal-title":"Drugs"},{"issue":"4","key":"pone.0227410.ref005","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/ACO.0b013e328305e3ef","article-title":"Dexmedetomidine: a review of clinical applications","volume":"21","author":"DS Carollo","year":"2008","journal-title":"Curr Opin Anaesthesiol"},{"key":"pone.0227410.ref006","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1213\/ane.0b013e3181804298","article-title":"The effect of Dexmedetomidine on perioperative hemodynamicsin patients undergoing craniotomy","volume":"107","author":"A Bekker","year":"2008","journal-title":"Anaesth Analg"},{"key":"pone.0227410.ref007","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jclinane.2008.04.008","article-title":"Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations","volume":"20","author":"H Ayoglu","year":"2008","journal-title":"J Clin Anesth"},{"key":"pone.0227410.ref008","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/bja\/ael085","article-title":"Magnesium sulphate as a technique of hypotensive anaesthesia","volume":"96","author":"NM Elsharnouby","year":"2006","journal-title":"Br J Anaesth"},{"key":"pone.0227410.ref009","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1161\/01.HYP.0000146536.68208.84","article-title":"Magnesium inhibits norepinephrine release by blocking N-type calcium channels at peripheral sympathetic nerve endings","volume":"44","author":"T Shimosawa","year":"2004","journal-title":"Hypertension"},{"key":"pone.0227410.ref010","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses. The PRISMA statement","volume":"339","author":"PRISMA Group","year":"2009","journal-title":"BMJ"},{"key":"pone.0227410.ref011","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1213\/00000539-198606000-00021","article-title":"Controlled hypotension for orthognathic surgery","volume":"65","author":"GA Fromme","year":"1986","journal-title":"Anesth Analg"},{"key":"pone.0227410.ref012","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0952-8180(94)00001-K","article-title":"The post-anesthesia recovery score revisited","volume":"7","author":"JA Aldrete","year":"1995","journal-title":"J Clinical Anesth"},{"key":"pone.0227410.ref013","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/9780470712184.ch8","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"JP Higgins","year":"2008"},{"key":"pone.0227410.ref014","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.egja.2011.07.008","article-title":"A comparative study between magnesium sulphate and dexmedetomidine for deliberate hypotension during middle ear surgery","volume":"27","author":"OH Aboushanab","year":"2011","journal-title":"Egypt J Anaesth"},{"key":"pone.0227410.ref015","first-page":"406","article-title":"Comparison of the effects of magnesium sulphate and dexmedetomidine on surgical vision quality in endoscopic sinus surgery: randomized clinical study","volume":"64","author":"A Akkaya","year":"2014","journal-title":"Rev Bras Anestesiol"},{"key":"pone.0227410.ref016","first-page":"61","article-title":"Comparison between magnesium sulfate and dexmedetomidine in controlled hypotension during functional endoscopic sinus surgery","volume":"65","author":"A Bayram","year":"2015","journal-title":"Rev Bras Anestesiol"},{"key":"pone.0227410.ref017","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4103\/2045-9912.235124","article-title":"Comparing remifentanil, magnesium sulfate, and dexmedetomidine for intraoperative hypotension and bleeding and postoperative recovery in endoscopic sinus surgery and tympanomastoidectomy","volume":"8","author":"H Modir","year":"2018","journal-title":"Med Gas Res"},{"key":"pone.0227410.ref018","first-page":"e64032","article-title":"Controlled Hypotension During Rhinoplasty: A Comparison of Dexmedetomidine with Magnesium Sulfate","volume":"7","author":"F Rokhtabnak","year":"2017","journal-title":"Anesth Pain Med"},{"key":"pone.0227410.ref019","first-page":"8","article-title":"Effect of magnesium sulphate and dexmedetomidine on blood loss during lumbar spinal fusion surgeries","volume":"12","author":"TG Oommen","year":"2018","journal-title":"J Clin Diagn Res"},{"key":"pone.0227410.ref020","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.egja.2017.08.004","article-title":"Comparative study between dexmedetomidine, magnesium sulphate and fentanyl as sedatives throughout awake fiberoptic intubation for patients undergoing cervical spine surgeries","volume":"33","author":"T Radwan","year":"2017","journal-title":"Egypt J Anaesth"},{"key":"pone.0227410.ref021","doi-asserted-by":"crossref","first-page":"75","DOI":"10.15171\/apb.2016.012","article-title":"Comparative evaluation of dexmedetomidine and magnesium sulphate on propofol consumption, haemodynamics and postoperative recovery in spine surgery: A prospective, randomized, placebo controlled, double-blind study","volume":"6","author":"VK Srivastava","year":"2016","journal-title":"Adv Pharm Bull"},{"key":"pone.0227410.ref022","doi-asserted-by":"crossref","first-page":"410","DOI":"10.4103\/ija.IJA_581_16","article-title":"The effects of dexmedetomidine and magnesium sulphate in adult patients undergoing endoscopic transnasal transsphenoidal resection of pituitary adenoma: A double-blind randomised study","volume":"61","author":"R Soliman","year":"2017","journal-title":"Indian J Anaesth"},{"key":"pone.0227410.ref023","first-page":"7172920","article-title":"Dexmedetomidine versus magnesium sulfate as adjunct during anesthesia for laparoscopic colectomy","author":"P Zarif","year":"2016","journal-title":"Anesthesiol Res Pract"},{"issue":"2","key":"pone.0227410.ref024","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","article-title":"Trim and fill: a simple funnel-plot\u2013based method of testing and adjusting for publication bias in meta-analysis","volume":"56","author":"S Duval","year":"2000","journal-title":"Biometrics"},{"key":"pone.0227410.ref025","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1177\/000348941112000906","article-title":"Evaluation of outcomesin patients given dexmedetomidine in functional endoscopicsinus surgery","volume":"120","author":"DG Guven","year":"2011","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"3","key":"pone.0227410.ref026","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4103\/0970-9185.83675","article-title":"Comparison of total intravenous anesthesia using propofol and inhalational anesthesia using isoflurane for controlled hypotension in functional endoscopic sinus surgery","volume":"27","author":"SP Ankichetty","year":"2011","journal-title":"J Anaesthesiol Clin Pharmacol"},{"issue":"3","key":"pone.0227410.ref027","first-page":"137","article-title":"Total intravenous anaesthesia in endoscopic sinus-nasal surgery","volume":"24","author":"G Tirelli","year":"2004","journal-title":"Acta Otorhinolaryngol Ital"},{"issue":"4","key":"pone.0227410.ref028","first-page":"225","article-title":"The assessment of correlation between mean arterial pressure and intraoperative bleeding during endoscopic sinus surgery in patients with low heart rate","volume":"64","author":"A Sieskiewicz","year":"2010","journal-title":"Otolaryngol Polska Polish Otolaryngol"},{"key":"pone.0227410.ref029","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1517\/17425255.4.5.619","article-title":"Dexmedetomidine: sedation, analgesia and beyond","volume":"4","author":"C Chrysostomou","year":"2008","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"1","key":"pone.0227410.ref030","first-page":"111","article-title":"A simplified scoring system for the post-operative recovery room. Canadian Anaesthetists\u2019","volume":"22","author":"DJ Steward","year":"1975","journal-title":"Society Journal"},{"key":"pone.0227410.ref031","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1213\/00000539-197011000-00020","article-title":"A post anesthetic recovery score","volume":"49","author":"JA Aldrete","year":"1970","journal-title":"Anesth Analg"},{"issue":"5","key":"pone.0227410.ref032","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1016\/j.jamcollsurg.2007.07.034","article-title":"Post-anesthetic recovery score","volume":"205","author":"JA Aldrete","year":"2007","journal-title":"Journal of the American College of Surgeons"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T18:52:02Z","timestamp":1578509522000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227410"}},"subtitle":[],"editor":[{"given":"Ehab","family":"Farag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1,8]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0227410","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,8]]}}}