{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:48:19Z","timestamp":1790646499126,"version":"4.1.0"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T00:00:00Z","timestamp":1585785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS107797"],"award-info":[{"award-number":["R21NS107797"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0227464","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T13:41:25Z","timestamp":1585834885000},"page":"e0227464","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["PolyQ-independent toxicity associated with novel translational products from CAG repeat expansions"],"prefix":"10.1371","volume":"15","author":[{"given":"Paige","family":"Rudich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7332-9075","authenticated-orcid":true,"given":"Todd","family":"Lamitina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,4,2]]},"reference":[{"key":"pone.0227464.ref001","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/B978-0-444-63233-3.00009-9","article-title":"Repeat expansion diseases","volume":"147","author":"H Paulson","year":"2018","journal-title":"Handbook of clinical neurology"},{"issue":"5","key":"pone.0227464.ref002","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/hmg\/8.5.731","article-title":"Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone","volume":"8","author":"DL Stenoien","year":"1999","journal-title":"Human molecular genetics"},{"issue":"9","key":"pone.0227464.ref003","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1073\/pnas.0400243101","article-title":"Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease","volume":"101","author":"WC Lee","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"pone.0227464.ref004","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cell.2013.06.003","article-title":"PolyQ proteins interfere with nuclear degradation of cytosolic proteins by sequestering the Sis1p chaperone","volume":"154","author":"SH Park","year":"2013","journal-title":"Cell"},{"issue":"12","key":"pone.0227464.ref005","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S0166-2236(98)01276-4","article-title":"Ubiquitin, cellular inclusions and their role in neurodegeneration","volume":"21","author":"A Alves-Rodrigues","year":"1998","journal-title":"Trends in neurosciences"},{"issue":"1","key":"pone.0227464.ref006","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0092-8674(00)81782-1","article-title":"Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions","volume":"95","author":"F Saudou","year":"1998","journal-title":"Cell"},{"issue":"7652","key":"pone.0227464.ref007","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature22078","article-title":"Polyglutamine tracts regulate beclin 1-dependent autophagy","volume":"545","author":"A Ashkenazi","year":"2017","journal-title":"Nature"},{"issue":"6","key":"pone.0227464.ref008","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2016.08.042","article-title":"Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis","volume":"166","author":"KM Berendzen","year":"2016","journal-title":"Cell"},{"issue":"17","key":"pone.0227464.ref009","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1073\/pnas.0307697101","article-title":"Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation","volume":"101","author":"EA Nollen","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"pone.0227464.ref010","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.neuron.2015.10.038","article-title":"RAN Translation in Huntington Disease","volume":"88","author":"M Banez-Coronel","year":"2015","journal-title":"Neuron"},{"issue":"4","key":"pone.0227464.ref011","article-title":"Electronic address ghmhe, Genetic Modifiers of Huntington's Disease C. CAG Repeat Not Polyglutamine Length Determines Timing of Huntington's Disease Onset","volume":"178","author":"Genetic Modifiers of Huntington's Disease Consortium","year":"2019","journal-title":"Cell"},{"issue":"6","key":"pone.0227464.ref012","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.ajhg.2019.04.007","article-title":"Length of Uninterrupted CAG, Independent of Polyglutamine Size, Results in Increased Somatic Instability, Hastening Onset of Huntington Disease","volume":"104","author":"GEB Wright","year":"2019","journal-title":"American journal of human genetics"},{"issue":"7","key":"pone.0227464.ref013","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/s41374-019-0241-x","article-title":"Repeat-associated non-AUG (RAN) translation: insights from pathology","volume":"99","author":"M Banez-Coronel","year":"2019","journal-title":"Lab Invest"},{"issue":"2","key":"pone.0227464.ref014","doi-asserted-by":"crossref","first-page":"e9423","DOI":"10.15252\/emmm.201809423","article-title":"Repeat-associated non-AUG translation in C9orf72-ALS\/FTD is driven by neuronal excitation and stress","volume":"11","author":"T Westergard","year":"2019","journal-title":"EMBO Molecular Medicine"},{"issue":"1","key":"pone.0227464.ref015","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41467-017-02643-5","article-title":"CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS\/FTD C9ORF72 transcripts","volume":"9","author":"R Tabet","year":"2018","journal-title":"Nature communications"},{"issue":"1","key":"pone.0227464.ref016","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41467-017-02495-z","article-title":"C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2\u03b1 phosphorylation","volume":"9","author":"W Cheng","year":"2018","journal-title":"Nature Communications"},{"issue":"51","key":"pone.0227464.ref017","doi-asserted-by":"crossref","first-page":"E4968","DOI":"10.1073\/pnas.1315438110","article-title":"RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia","volume":"110","author":"T Zu","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"10","key":"pone.0227464.ref018","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1093\/hmg\/9.10.1543","article-title":"The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1)","volume":"9","author":"JP Nemes","year":"2000","journal-title":"Human molecular genetics"},{"issue":"1","key":"pone.0227464.ref019","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1073\/pnas.1013343108","article-title":"Non-ATG-initiated translation directed by microsatellite expansions","volume":"108","author":"T Zu","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"24","key":"pone.0227464.ref020","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1093\/hmg\/ddx372","article-title":"Nuclear localized C9orf72-associated arginine-containing dipeptides exhibit age-dependent toxicity in C. elegans","volume":"26","author":"P Rudich","year":"2017","journal-title":"Human molecular genetics"},{"issue":"2","key":"pone.0227464.ref021","article-title":"The Hairpin Form of r(G4C2)(exp) in c9ALS\/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules","volume":"26","author":"ZF Wang","year":"2019","journal-title":"Cell Chem Biol"},{"key":"pone.0227464.ref022","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.neuron.2015.10.038","article-title":"RAN Translation in Huntington Disease","volume":"88","author":"M Ba\u00f1ez-Coronel","year":"2015","journal-title":"Neuron"},{"issue":"3","key":"pone.0227464.ref023","doi-asserted-by":"crossref","first-page":"e0173644","DOI":"10.1371\/journal.pone.0173644","article-title":"A new Caenorhabditis elegans model of human huntingtin 513 aggregation and toxicity in body wall muscles","volume":"12","author":"AL Lee","year":"2017","journal-title":"PloS one"},{"issue":"16","key":"pone.0227464.ref024","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.152161099","article-title":"The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans","volume":"99","author":"JF Morley","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"11","key":"pone.0227464.ref025","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.1073\/pnas.100107297","article-title":"Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans","volume":"97","author":"SH Satyal","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"26","key":"pone.0227464.ref026","doi-asserted-by":"crossref","first-page":"17131","DOI":"10.1073\/pnas.262544899","article-title":"Glutamine\/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity","volume":"99","author":"PW Faber","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"pone.0227464.ref027","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1073\/pnas.96.1.179","article-title":"Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron","volume":"96","author":"PW Faber","year":"1999","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4688","key":"pone.0227464.ref028","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.3155875","article-title":"Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington&#039;s disease","volume":"227","author":"GA Graveland","year":"1985","journal-title":"Science"},{"issue":"7","key":"pone.0227464.ref029","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.tins.2004.05.005","article-title":"The GABA nervous system in C. elegans","volume":"27","author":"K Schuske","year":"2004","journal-title":"Trends in Neurosciences"},{"key":"pone.0227464.ref030","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1101\/gad.1575307","article-title":"Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells","volume":"21","author":"SM Garcia","year":"2007","journal-title":"Genes & Development"},{"issue":"32","key":"pone.0227464.ref031","doi-asserted-by":"crossref","first-page":"14460","DOI":"10.1073\/pnas.0910630107","article-title":"Coenzyme Q protects Caenorhabditis elegans GABA neurons from calcium-dependent degeneration","volume":"107","author":"LR Earls","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0227464.ref032","article-title":"Nuclear localized C9orf72-associated arginine-containing dipeptides exhibit age-dependent toxicity in C. elegans","author":"P Rudich","year":"2017","journal-title":"Human Molecular Genetics"},{"issue":"2","key":"pone.0227464.ref033","doi-asserted-by":"crossref","first-page":"e31321","DOI":"10.1371\/journal.pone.0031321","article-title":"Mutant TDP-43 and FUS Cause Age-Dependent Paralysis and Neurodegeneration in C. elegans","volume":"7","author":"A Vaccaro","year":"2012","journal-title":"PLOS ONE"},{"issue":"17","key":"pone.0227464.ref034","doi-asserted-by":"crossref","first-page":"9980","DOI":"10.1073\/pnas.1533448100","article-title":"Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy","volume":"100","author":"BC Kraemer","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pone.0227464.ref035","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1523\/JNEUROSCI.3859-13.2014","article-title":"Axon Regeneration Genes Identified by RNAi Screening in C. elegans","volume":"34","author":"P Nix","year":"2014","journal-title":"The Journal of Neuroscience"},{"issue":"12","key":"pone.0227464.ref036","doi-asserted-by":"crossref","first-page":"e114459","DOI":"10.1371\/journal.pone.0114459","article-title":"Exposure to Mitochondrial Genotoxins and Dopaminergic Neurodegeneration in Caenorhabditis elegans","volume":"9","author":"CP Gonz\u00e1lez-Hunt","year":"2014","journal-title":"PLOS ONE"},{"issue":"6975","key":"pone.0227464.ref037","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nature02302","article-title":"A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans","volume":"427","author":"S Kennedy","year":"2004","journal-title":"Nature"},{"key":"pone.0227464.ref038","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.152161099","article-title":"The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans","volume":"99","author":"JF Morley","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt 3","key":"pone.0227464.ref039","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1042\/bj3600645","article-title":"Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells","volume":"360","author":"RK Jain","year":"2001","journal-title":"The Biochemical Journal"},{"issue":"14","key":"pone.0227464.ref040","doi-asserted-by":"crossref","first-page":"9251","DOI":"10.1016\/S0021-9258(18)31577-1","article-title":"Systematic analysis of stop-transfer sequence for microsomal membrane","volume":"266","author":"T Kuroiwa","year":"1991","journal-title":"The Journal of Biological Chemistry"},{"issue":"23","key":"pone.0227464.ref041","first-page":"14115","article-title":"Artificial Transmembrane Segments.","volume":"270","author":"H Chen","year":"1995","journal-title":"Requirements for Stop Transfer and Polypeptide Orientation The Journal of Biological Chemistry"},{"key":"pone.0227464.ref042","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nbt1172","article-title":"Engineering and characterization of a superfolder green fluorescent protein","volume":"24","author":"J-D P\u00e9delacq","year":"2005","journal-title":"Nature Biotechnology"},{"issue":"5","key":"pone.0227464.ref043","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1600-0854.2011.01168.x","article-title":"Superfolder GFP is fluorescent in oxidizing environments when targeted via the Sec translocon","volume":"12","author":"DE Aronson","year":"2011","journal-title":"Traffic (Copenhagen, Denmark)"},{"key":"pone.0227464.ref044","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.1073\/pnas.100107297","article-title":"Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans","volume":"97","author":"SH Satyal","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0227464.ref045","first-page":"256","volume-title":"Methods in Enzymology","author":"HR Brignull","year":"2006"},{"issue":"1","key":"pone.0227464.ref046","doi-asserted-by":"crossref","first-page":"e16417","DOI":"10.1371\/journal.pone.0016417","article-title":"Long Tract of Untranslated CAG Repeats Is Deleterious in Transgenic Mice","volume":"6","author":"R-J Hsu","year":"2011","journal-title":"PLOS ONE"},{"issue":"6","key":"pone.0227464.ref047","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.devcel.2006.10.003","article-title":"Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion","volume":"11","author":"R Takada","year":"2006","journal-title":"Developmental Cell"},{"issue":"5716","key":"pone.0227464.ref048","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1126\/science.1105654","article-title":"An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms","volume":"307","author":"O Rocks","year":"2005","journal-title":"Science"},{"issue":"1","key":"pone.0227464.ref049","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41598-017-00036-8","article-title":"A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis","volume":"7","author":"C Diez-Ardanuy","year":"2017","journal-title":"Scientific reports"},{"issue":"19","key":"pone.0227464.ref050","doi-asserted-by":"crossref","first-page":"e99023","DOI":"10.15252\/embj.201899023","article-title":"SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F","volume":"37","author":"F Ayhan","year":"2018","journal-title":"The EMBO Journal"},{"key":"pone.0227464.ref051","doi-asserted-by":"crossref","first-page":"E4968","DOI":"10.1073\/pnas.1315438110","article-title":"RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia","volume":"110","author":"T Zu","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"20","key":"pone.0227464.ref052","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1093\/hmg\/ddh277","article-title":"A molecular pathogenesis for transcription factor associated poly-alanine tract expansions","volume":"13","author":"AN Albrecht","year":"2004","journal-title":"Human Molecular Genetics"},{"issue":"10","key":"pone.0227464.ref053","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1110\/ps.072955307","article-title":"Interactions between homopolymeric amino acids (HPAAs)","volume":"16","author":"Y Oma","year":"2007","journal-title":"Protein Sci"},{"issue":"11","key":"pone.0227464.ref054","doi-asserted-by":"crossref","first-page":"e0166854","DOI":"10.1371\/journal.pone.0166854","article-title":"Single Amino Acid Repeats in the Proteome World: Structural, Functional, and Evolutionary Insights","volume":"11","author":"AS Kumar","year":"2016","journal-title":"PLOS ONE"},{"issue":"345","key":"pone.0227464.ref055","article-title":"Differential Occurrence of Interactions and Interaction Domains in Proteins Containing Homopolymeric Amino Acid Repeats","volume":"6","author":"I Pelassa","year":"2015","journal-title":"Frontiers in Genetics"},{"issue":"1","key":"pone.0227464.ref056","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1038\/s41467-017-02200-0","article-title":"RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response","volume":"8","author":"KM Green","year":"2017","journal-title":"Nature Communications"},{"issue":"3","key":"pone.0227464.ref057","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.neurobiolaging.2012.06.020","article-title":"ApoE \u03b54 is associated with eIF2\u03b1 phosphorylation and impaired learning in young mice","volume":"34","author":"Y Segev","year":"2013","journal-title":"Neurobiology of Aging"},{"key":"pone.0227464.ref058","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/hmg\/11.13.1487","article-title":"Strong aggregation and increased toxicity of polyleucine over polyglutamine stretches in mammalian cells","volume":"11","author":"JC Dorsman","year":"2002","journal-title":"Human Molecular Genetics"},{"issue":"2","key":"pone.0227464.ref059","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbapap.2004.12.017","article-title":"Comparative analysis of the cytotoxicity of homopolymeric amino acids","volume":"1748","author":"Y Oma","year":"2005","journal-title":"Biochimica et Biophysica Acta (BBA)\u2014Proteins and Proteomics"},{"issue":"3","key":"pone.0227464.ref060","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/hmg\/ddr487","article-title":"Comparative toxicity of polyglutamine, polyalanine and polyleucine tracts in Drosophila models of expanded repeat disease","volume":"21","author":"CL van Eyk","year":"2011","journal-title":"Human Molecular Genetics"},{"issue":"14","key":"pone.0227464.ref061","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1074\/jbc.274.14.9265","article-title":"A Heptad Motif of Leucine Residues Found in Membrane Proteins Can Drive Self-assembly of Artificial Transmembrane Segments","volume":"274","author":"R Gurezka","year":"1999","journal-title":"The Journal of Biological Chemistry"},{"issue":"13","key":"pone.0227464.ref062","doi-asserted-by":"crossref","first-page":"7583","DOI":"10.1074\/jbc.271.13.7583","article-title":"A 12-Residue-long Polyleucine Tail Is Sufficient to Anchor Synaptobrevin to the Endoplasmic Reticulum Membrane","volume":"271","author":"P Whitley","year":"1996","journal-title":"The Journal of Biological Chemistry"},{"issue":"9","key":"pone.0227464.ref063","doi-asserted-by":"crossref","first-page":"e1006256","DOI":"10.1371\/journal.pcbi.1006256","article-title":"Proteome-scale relationships between local amino acid composition and protein fates and functions","volume":"14","author":"SM Cascarina","year":"2018","journal-title":"PLoS computational biology"},{"issue":"5","key":"pone.0227464.ref064","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1091\/mbc.01-10-0514","article-title":"Targeting of Rough Endoplasmic Reticulum Membrane Proteins and Ribosomes in Invertebrate Neurons","volume":"13","author":"MM Rolls","year":"2002","journal-title":"Molecular Biology of the Cell"},{"key":"pone.0227464.ref065","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1472-6750-11-87","article-title":"Directed PCR-free engineering of highly repetitive DNA sequences","volume":"11","author":"A Scior","year":"2011","journal-title":"BMC biotechnology"},{"issue":"7019","key":"pone.0227464.ref066","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/432822a","article-title":"Neurosurgery: functional regeneration after laser axotomy","volume":"432","author":"MF Yanik","year":"2004","journal-title":"Nature"},{"issue":"7","key":"pone.0227464.ref067","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"J Schindelin","year":"2012","journal-title":"Nature methods"},{"issue":"86","key":"pone.0227464.ref068","doi-asserted-by":"crossref","DOI":"10.3791\/51086","article-title":"Sample drift correction following 4D confocal time-lapse imaging","author":"A Parslow","year":"2014","journal-title":"Journal of visualized experiments: JoVE"},{"issue":"8","key":"pone.0227464.ref069","doi-asserted-by":"crossref","first-page":"e23525","DOI":"10.1371\/journal.pone.0023525","article-title":"OASIS: online application for the survival analysis of lifespan assays performed in aging research","volume":"6","author":"JS Yang","year":"2011","journal-title":"PloS one"},{"issue":"13","key":"pone.0227464.ref070","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1093\/nar\/gkg595","article-title":"Mfold web server for nucleic acid folding and hybridization prediction","volume":"31","author":"M Zuker","year":"2003","journal-title":"Nucleic acids research"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T23:27:11Z","timestamp":1615073231000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227464"}},"subtitle":[],"editor":[{"given":"David R","family":"Borchelt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,2]]},"references-count":70,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0227464","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2019.12.20.884254","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,2]]}}}