{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:16:20Z","timestamp":1792181780523,"version":"4.4.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 102932"],"award-info":[{"award-number":["R01 102932"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"crossref","award":["R00 018739"],"award-info":[{"award-number":["R00 018739"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R21 022422"],"award-info":[{"award-number":["R21 022422"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0227482","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T18:49:18Z","timestamp":1579114158000},"page":"e0227482","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Plasma Trimethylamine-N-oxide and impaired glucose regulation: Results from The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS)"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8887-9835","authenticated-orcid":true,"given":"Sumith","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melana","family":"Yuzefpolskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Nandakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo C.","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan T.","family":"Demmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,1,15]]},"reference":[{"key":"pone.0227482.ref001","volume-title":"National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States","year":"2014"},{"issue":"7464","key":"pone.0227482.ref002","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature12506","article-title":"Richness of human gut microbiome correlates with metabolic markers","volume":"500","author":"E Le Chatelier","year":"2013","journal-title":"Nature"},{"issue":"5","key":"pone.0227482.ref003","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis","volume":"19","author":"RA Koeth","year":"2013","journal-title":"Nature medicine"},{"issue":"7341","key":"pone.0227482.ref004","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Z Wang","year":"2011","journal-title":"Nature"},{"issue":"17","key":"pone.0227482.ref005","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJMoa1109400","article-title":"Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk","volume":"368","author":"WH Tang","year":"2013","journal-title":"The New England journal of medicine"},{"issue":"4","key":"pone.0227482.ref006","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jbiosc.2014.03.001","article-title":"Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet","volume":"118","author":"X Gao","year":"2014","journal-title":"Journal of bioscience and bioengineering"},{"key":"pone.0227482.ref007","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.1038\/ncomms7498","article-title":"Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis","volume":"6","author":"J Miao","year":"2015","journal-title":"Nature communications"},{"issue":"18","key":"pone.0227482.ref008","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/j.jacc.2014.02.617","article-title":"Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis","volume":"64","author":"WH Tang","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"pone.0227482.ref009","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3945\/ajcn.117.157107","article-title":"Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes","volume":"106","author":"Z Shan","year":"2017","journal-title":"The American journal of clinical nutrition"},{"issue":"4","key":"pone.0227482.ref010","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1055\/s-0035-1569330","article-title":"Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels","volume":"124","author":"M Dambrova","year":"2016","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"12","key":"pone.0227482.ref011","doi-asserted-by":"crossref","first-page":"e114969","DOI":"10.1371\/journal.pone.0114969","article-title":"Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study","volume":"9","author":"M Lever","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"pone.0227482.ref012","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/ajcn\/nqy058","article-title":"Plasma trimethylamine-N-oxide and related metabolites are associated with type 2 diabetes risk in the Prevencion con Dieta Mediterranea (PREDIMED) trial","volume":"108","author":"C Papandreou","year":"2018","journal-title":"The American journal of clinical nutrition"},{"issue":"9 Suppl","key":"pone.0227482.ref013","doi-asserted-by":"crossref","first-page":"201s","DOI":"10.1177\/0022034515590369","article-title":"Periodontal Bacteria and Prediabetes Prevalence in ORIGINS: The Oral Infections, Glucose Intolerance, and Insulin Resistance Study","volume":"94","author":"RT Demmer","year":"2015","journal-title":"Journal of dental research"},{"key":"pone.0227482.ref014","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ab.2014.03.016","article-title":"Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry","volume":"455","author":"Z Wang","year":"2014","journal-title":"Analytical biochemistry"},{"key":"pone.0227482.ref015","article-title":"The Subgingival Microbiome, Systemic Inflammation and Insulin Resistance: The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS)","author":"RT Demmer","year":"2016","journal-title":"J Clin Periodontol"},{"key":"pone.0227482.ref016","article-title":"Periodontal Bacteria and Prediabetes Prevalence in ORIGINS: The Oral Infections, Glucose Intolerance, and Insulin Resistance Study","author":"RT Demmer","year":"2015","journal-title":"J Dent Res"},{"issue":"7","key":"pone.0227482.ref017","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"DR Matthews","year":"1985","journal-title":"Diabetologia"},{"issue":"11","key":"pone.0227482.ref018","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.2337\/dc12-0072","article-title":"Periodontal Infection, Systemic Inflammation, and Insulin Resistance: Results from the Continuous National Health and Nutrition Examination Survey (NHANES) 1999\u20132004","volume":"35","author":"RT Demmer","year":"2012","journal-title":"Diabetes Care"},{"issue":"Suppl 1","key":"pone.0227482.ref019","first-page":"S81","article-title":"Diagnosis and classification of diabetes mellitus","volume":"37","year":"2014","journal-title":"Diabetes care"},{"issue":"1","key":"pone.0227482.ref020","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1249\/00005768-199301000-00011","article-title":"Compendium of physical activities: classification of energy costs of human physical activities","volume":"25","author":"BE Ainsworth","year":"1993","journal-title":"Medicine and science in sports and exercise"},{"issue":"3","key":"pone.0227482.ref021","doi-asserted-by":"crossref","first-page":"e92441","DOI":"10.1371\/journal.pone.0092441","article-title":"Periodontal infection and cardiorespiratory fitness in younger adults: results from continuous national health and nutrition examination survey 1999\u20132004","volume":"9","author":"A Thai","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"pone.0227482.ref022","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.3945\/jn.111.157222","article-title":"Alternative dietary indices both strongly predict risk of chronic disease","volume":"142","author":"SE Chiuve","year":"2012","journal-title":"J Nutr"},{"issue":"6","key":"pone.0227482.ref023","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1093\/ajcn\/76.6.1261","article-title":"Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance","volume":"76","author":"ML McCullough","year":"2002","journal-title":"The American journal of clinical nutrition"},{"issue":"3","key":"pone.0227482.ref024","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/CIRCRESAHA.116.305360","article-title":"Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease","volume":"116","author":"WH Tang","year":"2015","journal-title":"Circ Res"},{"issue":"10","key":"pone.0227482.ref025","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003970","article-title":"Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA)","volume":"5","author":"KA Meyer","year":"2016","journal-title":"Journal of the American Heart Association"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T04:45:49Z","timestamp":1695617149000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227482"}},"subtitle":[],"editor":[{"given":"Cheng","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1,15]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0227482","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,15]]}}}