{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:30:51Z","timestamp":1790047851565,"version":"4.0.1"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Municipal Science & Technology Commission","award":["No. Z181100001718044)"],"award-info":[{"award-number":["No. Z181100001718044)"]}]},{"name":"the priming scientific research foundation for the junior researcher in Beijing Tongren Hospital, Capital Medical University","award":["No.2018-YJJ-ZZL-028"],"award-info":[{"award-number":["No.2018-YJJ-ZZL-028"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0227602","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T16:17:45Z","timestamp":1580228265000},"page":"e0227602","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Disease-related and age-related changes of anterior chamber angle structures in patients with primary congenital glaucoma: An in vivo high-frequency ultrasound biomicroscopy-based study"],"prefix":"10.1371","volume":"15","author":[{"given":"Yan","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Oatts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaizhou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8933-4482","authenticated-orcid":true,"given":"Ningli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"issue":"12","key":"pone.0227602.ref001","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1172\/JCI95545","article-title":"Angiopoietin-1 is required for Schlemm's canal development in mice and humans","volume":"127","author":"BR Thomson","year":"2017","journal-title":"J Clin Invest"},{"issue":"4","key":"pone.0227602.ref002","first-page":"302","article-title":"Scanning electron microscopy of the trabecular meshwork in normal and glucomatous eyes","volume":"16","author":"R Sampaolesi","year":"1977","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"pone.0227602.ref003","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1136\/bjo.84.12.1354","article-title":"Morphological variability of the trabecular meshwork in glaucoma patients: implications for non-perforating glaucoma surgery","volume":"84","author":"TS Dietlein","year":"2000","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"pone.0227602.ref004","doi-asserted-by":"crossref","first-page":"e0176386","DOI":"10.1371\/journal.pone.0176386","article-title":"Goniodysgenesis variability and activity of CYP1B1 genotypes in primary congenital glaucoma","volume":"12","author":"MT Garcia-Anton","year":"2017","journal-title":"PLoS One"},{"key":"pone.0227602.ref005","first-page":"1725","article-title":"Ultrasound biomicroscopy as a diagnostic tool in infants with primary congenital glaucoma","author":"T Hussain","year":"2014","journal-title":"Clin Ophthalmol"},{"issue":"6","key":"pone.0227602.ref006","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.jaapos.2007.06.014","article-title":"Ultrasound biomicroscopic characteristics of the anterior segment in primary congenital glaucoma","volume":"11","author":"V Gupta","year":"2007","journal-title":"J AAPOS"},{"issue":"6","key":"pone.0227602.ref007","first-page":"338","article-title":"Ultrasound biomicroscopy diagnosis of congenital glaucoma","volume":"215","author":"BF Engels","year":"1999","journal-title":"Klin Monbl Augenheilkd"},{"issue":"7","key":"pone.0227602.ref008","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S0161-6420(97)30175-4","article-title":"Ultrasound biomicroscopy in infantile glaucoma","volume":"104","author":"A Azuara-Blanco","year":"1997","journal-title":"Ophthalmology"},{"issue":"5","key":"pone.0227602.ref009","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/bjo.83.5.559","article-title":"Ultrasound biomicroscopic measurement of development of anterior chamber angle","volume":"83","author":"H Kobayashi","year":"1999","journal-title":"Br J Ophthalmol"},{"issue":"10","key":"pone.0227602.ref010","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1080\/02713683.2017.1324631","article-title":"The Relationship between the 24-hour Fluctuations in Schlemm's Canal and Intraocular Pressure: An observational study using high-frequency ultrasound biomicroscopy","volume":"42","author":"M Li","year":"2017","journal-title":"Curr Eye Res"},{"issue":"11","key":"pone.0227602.ref011","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.1167\/iovs.16-19475","article-title":"Influence of exercise on intraocular pressure, Schlemm's canal, and the trabecular meshwork","volume":"57","author":"X Yan","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"pone.0227602.ref012","doi-asserted-by":"crossref","first-page":"e0145824","DOI":"10.1371\/journal.pone.0145824","article-title":"Schlemm's canal and trabecular meshwork in eyes with primary open angle glaucoma: A comparative study using high-frequency ultrasound biomicroscopy","volume":"11","author":"X Yan","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"pone.0227602.ref013","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jaapos.2017.03.011","article-title":"Ultrasound biomicroscopy measurement of Schlemm's canal in pediatric patients with and without glaucoma","volume":"21","author":"A Tandon","year":"2017","journal-title":"J AAPOS"},{"issue":"4","key":"pone.0227602.ref014","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1001\/archopht.1982.01030030576003","article-title":"Ocular echometry in the diagnosis of congenital glaucoma","volume":"100","author":"R Sampaolesi","year":"1982","journal-title":"Arch Ophthalmol"},{"key":"pone.0227602.ref015","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ajo.2018.08.022","article-title":"Correlation between trabeculodysgenesis assessed by ultrasound biomicroscopy and surgical outcomes in primary congenital glaucoma","volume":"196","author":"Y Shi","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"pone.0227602.ref016","first-page":"e52611","article-title":"Trabecular meshwork response to pressure elevation in the living human eye","volume":"100","author":"L Kagemann","year":"2015","journal-title":"J Vis Exp"},{"issue":"2","key":"pone.0227602.ref017","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/bjophthalmol-2012-302147","article-title":"Spectral domain optical coherence tomography imaging of the aqueous outflow structures in normal participants of the EPIC-Norfolk Eye Study","volume":"97","author":"AC Day","year":"2013","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"pone.0227602.ref018","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1167\/iovs.14-15593","article-title":"Shorter scleral spur in eyes with primary open-angle glaucoma","volume":"56","author":"DL Swain","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"pone.0227602.ref019","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/s41433-018-0148-6","article-title":"Effect of age on the morphologies of the human Schlemm\u2019s canal and trabecular meshwork measured with swept-source optical coherence tomography","volume":"32","author":"Z Chen","year":"2018","journal-title":"Eye"},{"key":"pone.0227602.ref020","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3389\/fphys.2018.00630","article-title":"Age-related changes in human Schlemm's canal: An in vivo optical coherence tomography-based study","volume":"9","author":"Y Zhao","year":"2018","journal-title":"Front Physiol"},{"issue":"13","key":"pone.0227602.ref021","doi-asserted-by":"crossref","first-page":"6000","DOI":"10.1167\/iovs.17-22695","article-title":"In Vivo Analysis of Angle Dysgenesis in Primary Congenital, Juvenile, and Adult-Onset Open Angle Glaucoma","volume":"58","author":"V Gupta","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"pone.0227602.ref022","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/0002-9394(81)90644-9","article-title":"Developmental immaturity of the trabecular meshwork in congenital glaucoma","volume":"92","author":"A Tawara","year":"1981","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"pone.0227602.ref023","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jaapos.2012.06.012","article-title":"Newborn primary congenital glaucoma: Histopathologic features of the anterior chamber filtration angle","volume":"16","author":"LP Perry","year":"2012","journal-title":"J AAPOS"},{"issue":"3","key":"pone.0227602.ref024","first-page":"297","article-title":"Pathogenesis of congenital glaucoma; gonioscopic and microscopic anatomy","volume":"59","author":"RN Shaffer","year":"1955","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"issue":"2","key":"pone.0227602.ref025","first-page":"65","article-title":"Structural changes of the anterior chamber angle in primary congenital glaucoma with respect to normal development","volume":"81","author":"B Rojas","year":"2006","journal-title":"Arch Soc Esp Oftalmol"},{"issue":"6","key":"pone.0227602.ref026","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.ajo.2006.07.054","article-title":"Genotype and Phenotype Correlations in Congenital Glaucoma: CYP1B1 Mutations, Goniodysgenesis, and Clinical Characteristics","volume":"142","author":"DA Hollander","year":"2006","journal-title":"Am J Ophthalmol"},{"issue":"8","key":"pone.0227602.ref027","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1167\/iovs.10-6948","article-title":"Segmental versican expression in the trabecular meshwork and involvement in outflow facility","volume":"52","author":"KE Keller","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"pone.0227602.ref028","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1167\/iovs.12-10930","article-title":"Effects of Y27632 on Aqueous Humor Outflow Facility With Changes in Hydrodynamic Pattern and Morphology in Human Eyes","volume":"54","author":"CY Yang","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"pone.0227602.ref029","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1167\/iovs.08-2375","article-title":"Preferential Fluid Flow in the Human Trabecular Meshwork Near Collector Channels","volume":"50","author":"CR Hann","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"pone.0227602.ref030","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1080\/02713683.2017.1324631","article-title":"The Relationship between the 24-hour Fluctuations in Schlemm\u2019s Canal and Intraocular Pressure: An Observational Study using High-Frequency Ultrasound Biomicroscopy","volume":"42","author":"L Mu","year":"2017","journal-title":"Curr Eye Res"},{"issue":"Suppl 2","key":"pone.0227602.ref031","doi-asserted-by":"crossref","first-page":"ii10","DOI":"10.1136\/bjophthalmol-2013-304629","article-title":"Characterisation of Schlemm's canal cross-sectional area","volume":"98","author":"L Kagemann","year":"2014","journal-title":"Br J Ophthalmol"},{"issue":"8","key":"pone.0227602.ref032","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1167\/iovs.09-4559","article-title":"Identification and assessment of Schlemm's canal by spectral-domain optical coherence tomography","volume":"51","author":"L Kagemann","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"pone.0227602.ref033","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ophtha.2012.10.008","article-title":"Spectral-domain optical coherence tomographic assessment of Schlemm's canal in Chinese subjects with primary open-angle glaucoma","volume":"120","author":"J Hong","year":"2013","journal-title":"Ophthalmology"},{"issue":"1","key":"pone.0227602.ref034","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/exer.1996.0012","article-title":"Schlemm\u2019s canal and primary open angle glaucoma correlation between Schlemm\u2019s canal dimensions and outflow facility","volume":"62","author":"RR Allingham","year":"1996","journal-title":"Exp Eye Res"},{"key":"pone.0227602.ref035","first-page":"431","article-title":"New studies on the functional morphology of the trabecular meshwork and the outflow channels","volume":"89","author":"JW Rohen","year":"1970","journal-title":"Trans Ophthalmol Soc U K"},{"issue":"1","key":"pone.0227602.ref036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00430625","article-title":"Histometrische Untersuchungen \u00fcber die Kammerwinkelregion des menschlichen Auges bei verschiedenen Altersstufen und Glaukomformen","volume":"176","author":"E L\u00fctjen","year":"1968","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"pone.0227602.ref037","first-page":"458","article-title":"The development of the trabecular meshwork and its abnormality in primary infantile glaucoma","volume":"79","author":"DR Anderson","year":"1981","journal-title":"Trans Am Ophthalmol Soc"},{"issue":"2","key":"pone.0227602.ref038","first-page":"83","article-title":"The real-time observation of anterior segment of primary congenital glaucoma","volume":"14","author":"N Wang","year":"1998","journal-title":"Yan Ke Xue Bao"},{"issue":"2","key":"pone.0227602.ref039","first-page":"112","article-title":"Central corneal thickness in pediatric glaucoma","volume":"44","author":"JE Lopes","year":"2007","journal-title":"J AAPOS"},{"issue":"3","key":"pone.0227602.ref040","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00061198-200406000-00002","article-title":"Corneal thickness in congenital glaucoma","volume":"13","author":"MJ Henriques","year":"2004","journal-title":"J Glaucoma"},{"issue":"6","key":"pone.0227602.ref041","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/01.ijg.0000212293.93292.c9","article-title":"Central corneal thickness and corneal diameter in patients with childhood glaucoma","volume":"15","author":"TY Tai","year":"2006","journal-title":"J Glaucoma"},{"issue":"3","key":"pone.0227602.ref042","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00417-007-0690-6","article-title":"Evolution of central corneal thickness in children with congenital glaucoma requiring glaucoma surgery","volume":"246","author":"I Oberacher-Velten","year":"2008","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"2","key":"pone.0227602.ref043","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/0974-9233.95248","article-title":"Central Corneal Thickness in Iranian Congenital Glaucoma Patients","volume":"19","author":"H Amini","year":"2012","journal-title":"Middle East Afr J Ophthalmol"},{"issue":"1","key":"pone.0227602.ref044","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5005\/jp-journals-10008-1217","article-title":"Fellow Eye in Unilateral Primary Congenital Glaucoma","volume":"11","author":"NH Bayoumi","year":"2017","journal-title":"J Curr Glaucoma Pract"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T16:18:22Z","timestamp":1580228302000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227602"}},"subtitle":[],"editor":[{"given":"Michele","family":"Madigan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1,28]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0227602","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,28]]}}}