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Burns","year":"2005","journal-title":"Neurology"},{"key":"pone.0227631.ref081","first-page":"1038","article-title":"Effect of aging on tryptophan hydroxylase in rat brain: implications on serotonin level.","volume":"28","author":"AM Hussain","year":"2000","journal-title":"Drug Metab Dispos"},{"key":"pone.0227631.ref082","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0047-6374(01)00349-9","article-title":"Ageing and apoptosis.","volume":"123","author":"Y Zhang","year":"2002","journal-title":"Mech Ageing Dev"},{"key":"pone.0227631.ref083","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/jnr.20845","article-title":"Chronic systemic D\u2010galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R\u2010\u03b1\u2010lipoic acid.","volume":"83","author":"XU Cui","year":"2006","journal-title":"J Neurosci Res"},{"key":"pone.0227631.ref084","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.neuro.2005.11.007","article-title":"Aluminum in hippocampal neurons from humans with Alzheimer's disease","volume":"27","author":"JR Walton","year":"2006","journal-title":"Neurotoxicol"},{"key":"pone.0227631.ref085","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1152\/ajpcell.00430.2010","article-title":"Van Ypersele de Strihou C. Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets","volume":"300","author":"T Miyata","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"pone.0227631.ref086","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s11011-014-9643-z","article-title":"Blueberry treatment decreased D-galactose-induced oxidative stress and brain damage in rats","volume":"30","author":"J \u00c7oban","year":"2015","journal-title":"Metab Brain Dis"},{"key":"pone.0227631.ref087","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3109\/01480545.2014.900068","article-title":"Protective effect of L-theanine against aluminium induced neurotoxicity in cerebral cortex, hippocampus and cerebellum of rat brain\u2013histopathological, and biochemical approach","volume":"38","author":"T Sumathi","year":"2015","journal-title":"Drug Chem Toxicol"},{"key":"pone.0227631.ref088","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/s41598-018-19732-0","article-title":"Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose","volume":"8","author":"P Chen","year":"2018","journal-title":"Sci Rep"},{"key":"pone.0227631.ref089","doi-asserted-by":"crossref","first-page":"e0183565","DOI":"10.1371\/journal.pone.0183565","article-title":"Involvement of insulin resistance in D-galactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin","volume":"12","author":"S Kenawy","year":"2017","journal-title":"PloS one"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T18:52:46Z","timestamp":1665514366000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227631"}},"subtitle":[],"editor":[{"given":"Israel","family":"Silman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1,16]]},"references-count":89,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0227631","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,16]]}}}