{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:53:36Z","timestamp":1792760016187,"version":"4.5.0"},"reference-count":87,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BR1551\/7-1"],"award-info":[{"award-number":["BR1551\/7-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0227926","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T18:32:58Z","timestamp":1579285978000},"page":"e0227926","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction"],"prefix":"10.1371","volume":"15","author":[{"given":"Elif","family":"Aplak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2130-0363","authenticated-orcid":true,"given":"Claudia","family":"von Montfort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Haasler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Stucki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodo","family":"Steckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-3113","authenticated-orcid":true,"given":"Andreas S.","family":"Reichert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3405-0287","authenticated-orcid":true,"given":"Peter","family":"Brenneisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,1,17]]},"reference":[{"issue":"2","key":"pone.0227926.ref001","article-title":"Nanotherapy and Reactive Oxygen Species (ROS) in Cancer: A Novel Perspective","volume":"7","author":"P Brenneisen","year":"2018","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"pone.0227926.ref002","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrc3180","article-title":"Treating metastatic cancer with nanotechnology","volume":"12","author":"A Schroeder","year":"2011","journal-title":"Nat Rev Cancer"},{"issue":"10","key":"pone.0227926.ref003","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1039\/b615134e","article-title":"Superoxide dismutase mimetic properties exhibited by vacancy engineered ceria nanoparticles","author":"C Korsvik","year":"2007","journal-title":"Chem Commun (Camb)"},{"issue":"3","key":"pone.0227926.ref004","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11837-008-0029-8","article-title":"Nanoceria as Antioxidant: Synthesis and Biomedical Applications","volume":"60","author":"AS Karakoti","year":"2008","journal-title":"Jom (1989)"},{"issue":"8","key":"pone.0227926.ref005","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1089\/ars.2012.4831","article-title":"Downregulation of tumor growth and invasion by redox-active nanoparticles","volume":"19","author":"L Alili","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"pone.0227926.ref006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.redox.2014.11.007","article-title":"Redox-active cerium oxide nanoparticles protect human dermal fibroblasts from PQ-induced damage","volume":"4","author":"C von Montfort","year":"2015","journal-title":"Redox Biol"},{"issue":"4","key":"pone.0227926.ref007","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2217\/nnm-2016-0342","article-title":"Cerium oxide nanoparticles: the regenerative redox machine in bioenergetic imbalance","volume":"12","author":"I Pezzini","year":"2017","journal-title":"Nanomedicine (Lond)"},{"issue":"27","key":"pone.0227926.ref008","first-page":"4510","volume":"2015","author":"J Gagnon","year":"2015","journal-title":"Toxicity and Protective Effects of Cerium Oxide Nanoparticles (Nanoceria) Depending on Their Preparation Method, Particle Size, Cell Type, and Exposure Route"},{"issue":"12","key":"pone.0227926.ref009","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1166\/jbn.2017.2452","article-title":"Efficacy of Different Compositions of Cerium Oxide Nanoparticles in Tumor-Stroma Interaction","volume":"13","author":"M Sack-Zschauer","year":"2017","journal-title":"J Biomed Nanotechnol"},{"issue":"11","key":"pone.0227926.ref010","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1016\/j.biomaterials.2010.12.056","article-title":"Combined cytotoxic and anti-invasive properties of redox-active nanoparticles in tumor-stroma interactions","volume":"32","author":"L Alili","year":"2011","journal-title":"Biomaterials"},{"issue":"1","key":"pone.0227926.ref011","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20130091","article-title":"Fibroblast-to-myofibroblast switch is mediated by NAD(P)H oxidase generated reactive oxygen species","volume":"34","author":"L Alili","year":"2014","journal-title":"Biosci Rep"},{"issue":"3","key":"pone.0227926.ref012","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.tiv.2013.02.005","article-title":"Cerium oxide nanoparticles induce cytotoxicity in human hepatoma SMMC-7721 cells via oxidative stress and the activation of MAPK signaling pathways","volume":"27","author":"G Cheng","year":"2013","journal-title":"Toxicology in vitro: an international journal published in association with BIBRA"},{"key":"pone.0227926.ref013","doi-asserted-by":"crossref","first-page":"891934","DOI":"10.1155\/2014\/891934","article-title":"Cerium oxide nanoparticles induced toxicity in human lung cells: role of ROS mediated DNA damage and apoptosis","volume":"2014","author":"S Mittal","year":"2014","journal-title":"Biomed Res Int"},{"issue":"1","key":"pone.0227926.ref014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"MP Murphy","year":"2009","journal-title":"Biochem J"},{"key":"pone.0227926.ref015","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.redox.2016.01.010","article-title":"Redox homeostasis: The Golden Mean of healthy living","volume":"8","author":"F Ursini","year":"2016","journal-title":"Redox Biol"},{"issue":"10","key":"pone.0227926.ref016","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1039\/c0mb00014k","article-title":"Unveiling the mechanism of uptake and sub-cellular distribution of cerium oxide nanoparticles","volume":"6","author":"S Singh","year":"2010","journal-title":"Mol Biosyst"},{"issue":"6","key":"pone.0227926.ref017","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"J Nunnari","year":"2012","journal-title":"Cell"},{"issue":"14","key":"pone.0227926.ref018","doi-asserted-by":"crossref","first-page":"R551","DOI":"10.1016\/j.cub.2006.06.054","article-title":"Mitochondria: more than just a powerhouse","volume":"16","author":"HM McBride","year":"2006","journal-title":"Current biology: CB"},{"key":"pone.0227926.ref019","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1146\/annurev-biochem-060815-014352","article-title":"Mitochondrial Machineries for Protein Import and Assembly","volume":"86","author":"N Wiedemann","year":"2017","journal-title":"Annual review of biochemistry"},{"issue":"11","key":"pone.0227926.ref020","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nrm2275","article-title":"Functions and dysfunctions of mitochondrial dynamics","volume":"8","author":"SA Detmer","year":"2007","journal-title":"Nature reviews Molecular cell biology"},{"issue":"3","key":"pone.0227926.ref021","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2016.07.002","article-title":"Mitochondria and Cancer","volume":"166","author":"S Vyas","year":"2016","journal-title":"Cell"},{"issue":"10","key":"pone.0227926.ref022","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrc3365","article-title":"Mitochondria and cancer","volume":"12","author":"DC Wallace","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"pone.0227926.ref023","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1042\/bse0470115","article-title":"Roles of mitochondria in human disease","volume":"47","author":"MR Duchen","year":"2010","journal-title":"Essays Biochem"},{"issue":"7\u20138","key":"pone.0227926.ref024","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.exger.2010.03.018","article-title":"Impaired quality control of mitochondria: aging from a new perspective","volume":"45","author":"TA Weber","year":"2010","journal-title":"Exp Gerontol"},{"issue":"11","key":"pone.0227926.ref025","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.tig.2004.08.012","article-title":"Mitochondriomics or what makes us breathe","volume":"20","author":"AS Reichert","year":"2004","journal-title":"Trends Genet"},{"issue":"7\u20138","key":"pone.0227926.ref026","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.exger.2010.01.016","article-title":"Oxidative stress causes reversible changes in mitochondrial permeability and structure","volume":"45","author":"NB Cole","year":"2010","journal-title":"Exp Gerontol"},{"issue":"1","key":"pone.0227926.ref027","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1096\/fj.14-268904","article-title":"Nrf2 protects mitochondrial decay by oxidative stress","volume":"30","author":"J Strom","year":"2016","journal-title":"FASEB J"},{"issue":"1","key":"pone.0227926.ref028","article-title":"Reactive Oxygen Species and Mitochondrial Dynamics: The Yin and Yang of Mitochondrial Dysfunction and Cancer Progression","volume":"7","author":"J Jezek","year":"2018","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"pone.0227926.ref029","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1712","article-title":"Targeting mitochondria metabolism for cancer therapy","volume":"11","author":"SE Weinberg","year":"2015","journal-title":"Nat Chem Biol"},{"issue":"13","key":"pone.0227926.ref030","doi-asserted-by":"crossref","first-page":"8735","DOI":"10.1074\/jbc.R113.544635","article-title":"Role of metabolic H2O2 generation: redox signaling and oxidative stress","volume":"289","author":"H. Sies","year":"2014","journal-title":"J Biol Chem"},{"key":"pone.0227926.ref031","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: a concept in redox biology and medicine","volume":"4","author":"H. Sies","year":"2015","journal-title":"Redox Biol"},{"issue":"13","key":"pone.0227926.ref032","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1089\/ars.2012.4655","article-title":"Principles in redox signaling: from chemistry to functional significance","volume":"18","author":"A Bindoli","year":"2013","journal-title":"Antioxid Redox Signal"},{"issue":"Pt 4","key":"pone.0227926.ref033","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1242\/jcs.098475","article-title":"Mitochondrial redox signalling at a glance","volume":"125","author":"Y Collins","year":"2012","journal-title":"J Cell Sci"},{"issue":"11","key":"pone.0227926.ref034","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1089\/ars.2012.4532","article-title":"Reactive oxygen species: the achilles' heel of cancer cells","volume":"16","author":"X. Cui","year":"2012","journal-title":"Antioxid Redox Signal"},{"issue":"38","key":"pone.0227926.ref035","doi-asserted-by":"crossref","first-page":"16163","DOI":"10.1073\/pnas.0903015106","article-title":"Profiling protein thiol oxidation in tumor cells using sulfenic acid-specific antibodies","volume":"106","author":"YH Seo","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"pone.0227926.ref036","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"T. Mosmann","year":"1983","journal-title":"Journal of immunological methods"},{"issue":"8","key":"pone.0227926.ref037","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3109\/00498254.2012.754112","article-title":"Chemical reactivity and biological activity of chalcones and other alpha,beta-unsaturated carbonyl compounds","volume":"43","author":"D Maydt","year":"2013","journal-title":"Xenobiotica"},{"issue":"5259","key":"pone.0227926.ref038","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"UK Laemmli","year":"1970","journal-title":"Nature"},{"issue":"9","key":"pone.0227926.ref039","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1039\/C4AY00288A","article-title":"Measurement of DCF fluorescence as a measure of reactive oxygen species in murine islets of Langerhans","volume":"6","author":"X Wang","year":"2014","journal-title":"Anal Methods"},{"issue":"2","key":"pone.0227926.ref040","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.vascn.2013.01.195","article-title":"Troubleshooting the dichlorofluorescein assay to avoid artifacts in measurement of toxicant-stimulated cellular production of reactive oxidant species","volume":"67","author":"LM Tetz","year":"2013","journal-title":"J Pharmacol Toxicol Methods"},{"key":"pone.0227926.ref041","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/B978-0-12-801415-8.00013-8","article-title":"Use of potentiometric fluorophores in the measurement of mitochondrial reactive oxygen species","volume":"547","author":"BM Polster","year":"2014","journal-title":"Methods Enzymol"},{"issue":"1","key":"pone.0227926.ref042","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1002\/cpcb.45","article-title":"Monitoring the Effects of Pharmacological Reagents on Mitochondrial Morphology","volume":"79","author":"D Fu","year":"2018","journal-title":"Curr Protoc Cell Biol"},{"issue":"11","key":"pone.0227926.ref043","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1038\/nprot.2009.151","article-title":"Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells","volume":"4","author":"MR Wieckowski","year":"2009","journal-title":"Nat Protoc"},{"key":"pone.0227926.ref044","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-4939-9027-6_5","article-title":"Measurement of Mitochondrial Membrane Potential with the Fluorescent Dye Tetramethylrhodamine Methyl Ester","volume":"1928","author":"S Creed","year":"2019","journal-title":"Methods Mol Biol"},{"issue":"1","key":"pone.0227926.ref045","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0006-3495(99)77214-0","article-title":"Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives","volume":"76","author":"RC Scaduto","year":"1999","journal-title":"Biophys J"},{"issue":"1","key":"pone.0227926.ref046","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF02431973","article-title":"The effect of uncouplers of oxidative phosphorylation on lipid bilayer membranes: Carbonylcyanidem-chlorophenylhydrazone","volume":"4","author":"OH Leblanc","year":"1971","journal-title":"J Membr Biol"},{"issue":"49","key":"pone.0227926.ref047","doi-asserted-by":"crossref","first-page":"37972","DOI":"10.1074\/jbc.M606059200","article-title":"Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology","volume":"281","author":"S Duvezin-Caubet","year":"2006","journal-title":"J Biol Chem"},{"key":"pone.0227926.ref048","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2210-8-8","article-title":"Comparison of four different colorimetric and fluorometric cytotoxicity assays in a zebrafish liver cell line","volume":"8","author":"SK Bopp","year":"2008","journal-title":"BMC Pharmacol"},{"issue":"2","key":"pone.0227926.ref049","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/(SICI)1520-6823(1999)7:2<77::AID-ROI3>3.0.CO;2-M","article-title":"Comparison between the clonogenic, MTT, and SRB assays for determining radiosensitivity in a panel of human bladder cancer cell lines and a ureteral cell line","volume":"7","author":"D Banasiak","year":"1999","journal-title":"Radiat Oncol Investig"},{"issue":"13","key":"pone.0227926.ref050","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","article-title":"New colorimetric cytotoxicity assay for anticancer-drug screening","volume":"82","author":"P Skehan","year":"1990","journal-title":"J Natl Cancer Inst"},{"issue":"7","key":"pone.0227926.ref051","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1158\/1535-7163.MCT-13-0950","article-title":"Combination of conventional chemotherapeutics with redox-active cerium oxide nanoparticles\u2014a novel aspect in cancer therapy","volume":"13","author":"M Sack","year":"2014","journal-title":"Mol Cancer Ther"},{"issue":"16","key":"pone.0227926.ref052","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1039\/b922024k","article-title":"Nanoceria exhibit redox state-dependent catalase mimetic activity","volume":"46","author":"T Pirmohamed","year":"2010","journal-title":"Chem Commun (Camb)"},{"issue":"18","key":"pone.0227926.ref053","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/j.biomaterials.2008.03.014","article-title":"The role of cerium redox state in the SOD mimetic activity of nanoceria","volume":"29","author":"EG Heckert","year":"2008","journal-title":"Biomaterials"},{"issue":"6","key":"pone.0227926.ref054","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.cct.2008.05.009","article-title":"Nonlinear model-based estimates of IC(50) for studies involving continuous therapeutic dose-response data","volume":"29","author":"RH Lyles","year":"2008","journal-title":"Contemp Clin Trials"},{"issue":"3","key":"pone.0227926.ref055","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tcb.2014.11.002","article-title":"Protecting the mitochondrial powerhouse","volume":"25","author":"M Scheibye-Knudsen","year":"2015","journal-title":"Trends Cell Biol"},{"issue":"9","key":"pone.0227926.ref056","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.bbabio.2008.05.001","article-title":"Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view","volume":"1777","author":"G Twig","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"pone.0227926.ref057","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.pharmtox.47.120505.105110","article-title":"Targeting antioxidants to mitochondria by conjugation to lipophilic cations","volume":"47","author":"MP Murphy","year":"2007","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"pone.0227926.ref058","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1038\/ncomms5776","article-title":"Site-specific mapping and quantification of protein S-sulphenylation in cells","volume":"5","author":"J Yang","year":"2014","journal-title":"Nat Commun"},{"issue":"9","key":"pone.0227926.ref059","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1089\/ars.2015.6247","article-title":"The Redox Code","volume":"23","author":"DP Jones","year":"2015","journal-title":"Antioxid Redox Signal"},{"issue":"Pt 3","key":"pone.0227926.ref060","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1042\/BJ20050337","article-title":"Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells","volume":"389","author":"JW Baty","year":"2005","journal-title":"Biochem J"},{"issue":"14","key":"pone.0227926.ref061","doi-asserted-by":"crossref","first-page":"e14193","DOI":"10.14814\/phy2.14193","article-title":"Inhibition of ubiquitin-specific protease 2 causes accumulation of reactive oxygen species, mitochondria dysfunction, and intracellular ATP decrement in C2C12 myoblasts","volume":"7","author":"M Hashimoto","year":"2019","journal-title":"Physiol Rep"},{"key":"pone.0227926.ref062","first-page":"9817576","article-title":"Isoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells","volume":"2019","author":"XY Chen","year":"2019","journal-title":"Oxid Med Cell Longev"},{"issue":"6","key":"pone.0227926.ref063","first-page":"1582","article-title":"beta-Aescin shows potent antiproliferative activity in osteosarcoma cells by inducing autophagy, ROS generation and mitochondrial membrane potential loss","volume":"22","author":"ZR Liu","year":"2017","journal-title":"J BUON"},{"issue":"1","key":"pone.0227926.ref064","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10689-014-9757-9","article-title":"Mitochondrial membrane potential and reactive oxygen species in cancer stem cells","volume":"14","author":"BB Zhang","year":"2015","journal-title":"Fam Cancer"},{"issue":"6","key":"pone.0227926.ref065","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/sj.cdd.4401231","article-title":"Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis","volume":"10","author":"E Gottlieb","year":"2003","journal-title":"Cell Death Differ"},{"issue":"2","key":"pone.0227926.ref066","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cmet.2015.06.006","article-title":"Redox Homeostasis and Mitochondrial Dynamics","volume":"22","author":"PH Willems","year":"2015","journal-title":"Cell Metab"},{"issue":"1","key":"pone.0227926.ref067","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41598-017-01659-7","article-title":"Cryptolepine inhibits melanoma cell growth through coordinated changes in mitochondrial biogenesis, dynamics and metabolic tumor suppressor AMPKalpha1\/2-LKB1","volume":"7","author":"HC Pal","year":"2017","journal-title":"Sci Rep"},{"issue":"5\u20136","key":"pone.0227926.ref068","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.bbabio.2006.03.018","article-title":"Effect of oxidative stress on dynamics of mitochondrial reticulum","volume":"1757","author":"OY Pletjushkina","year":"2006","journal-title":"Biochim Biophys Acta"},{"issue":"46","key":"pone.0227926.ref069","doi-asserted-by":"crossref","first-page":"17807","DOI":"10.1073\/pnas.0803090105","article-title":"A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth","volume":"105","author":"M Ralser","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"pone.0227926.ref070","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.chembiol.2011.08.009","article-title":"Mitochondrial electron transport chain complex III is required for antimycin A to inhibit autophagy","volume":"18","author":"X Ma","year":"2011","journal-title":"Chem Biol"},{"issue":"1","key":"pone.0227926.ref071","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bbamcr.2008.06.013","article-title":"Cristae formation-linking ultrastructure and function of mitochondria","volume":"1793","author":"M Zick","year":"2009","journal-title":"Biochim Biophys Acta"},{"issue":"14","key":"pone.0227926.ref072","doi-asserted-by":"crossref","first-page":"6884","DOI":"10.1016\/S0021-9258(18)68727-7","article-title":"Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance","volume":"263","author":"JS Beckman","year":"1988","journal-title":"J Biol Chem"},{"issue":"13","key":"pone.0227926.ref073","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1089\/ars.2017.7485","article-title":"Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer","volume":"29","author":"L Chaiswing","year":"2018","journal-title":"Antioxid Redox Signal"},{"key":"pone.0227926.ref074","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.mrrev.2016.08.006","article-title":"Potentiation of hydrogen peroxide toxicity: From catalase inhibition to stable DNA-iron complexes","volume":"773","author":"T Mahaseth","year":"2017","journal-title":"Mutat Res"},{"issue":"3","key":"pone.0227926.ref075","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ccr.2006.08.015","article-title":"Reactive oxygen species in cancer cells: live by the sword, die by the sword","volume":"10","author":"PT Schumacker","year":"2006","journal-title":"Cancer Cell"},{"key":"pone.0227926.ref076","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3389\/fonc.2013.00292","article-title":"Mitochondrial dysfunction in cancer","volume":"3","author":"ML Boland","year":"2013","journal-title":"Front Oncol"},{"issue":"12","key":"pone.0227926.ref077","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nrd4002","article-title":"Modulation of oxidative stress as an anticancer strategy","volume":"12","author":"C Gorrini","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"pone.0227926.ref078","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2012.08.573","article-title":"The peroxidase activity of mitochondrial superoxide dismutase","volume":"54","author":"K Ansenberger-Fricano","year":"2013","journal-title":"Free Radic Biol Med"},{"issue":"12","key":"pone.0227926.ref079","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1182\/blood-2016-05-714816","article-title":"Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells","volume":"128","author":"JA Reisz","year":"2016","journal-title":"Blood"},{"issue":"9","key":"pone.0227926.ref080","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1172\/JCI120849","article-title":"Mitochondrial dysfunction in pathophysiology of heart failure","volume":"128","author":"B Zhou","year":"2018","journal-title":"J Clin Invest"},{"issue":"2","key":"pone.0227926.ref081","article-title":"Mitochondrial Dysfunction in Parkinson's Disease-Cause or Consequence?","volume":"8","author":"C Chen","year":"2019","journal-title":"Biology (Basel)"},{"issue":"1","key":"pone.0227926.ref082","doi-asserted-by":"crossref","DOI":"10.3390\/cells7010001","article-title":"Intra- and Intercellular Quality Control Mechanisms of Mitochondria","volume":"7","author":"Y Kiriyama","year":"2017","journal-title":"Cells"},{"issue":"6","key":"pone.0227926.ref083","first-page":"2441","volume":"16","author":"SK Jana","year":"2014","journal-title":"Redox-active nanoceria depolarize mitochondrial membrane of human colon cancer cells"},{"key":"pone.0227926.ref084","doi-asserted-by":"crossref","first-page":"6053","DOI":"10.1038\/ncomms7053","article-title":"MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer","volume":"6","author":"PC Hart","year":"2015","journal-title":"Nat Commun"},{"issue":"11","key":"pone.0227926.ref085","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.freeradbiomed.2010.08.024","article-title":"H2O2-induced mitochondrial fragmentation in C2C12 myocytes","volume":"49","author":"X Fan","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"pone.0227926.ref086","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.3389\/fphar.2018.01262","article-title":"Updates in Anthracycline-Mediated Cardiotoxicity","volume":"9","author":"CG Nebigil","year":"2018","journal-title":"Front Pharmacol"},{"issue":"1","key":"pone.0227926.ref087","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.etap.2013.08.015","article-title":"Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): a critical discussion","volume":"37","author":"DK Ingawale","year":"2014","journal-title":"Environ Toxicol Pharmacol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T21:06:53Z","timestamp":1665522413000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0227926"}},"subtitle":[],"editor":[{"given":"Partha","family":"Mukhopadhyay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1,17]]},"references-count":87,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0227926","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,17]]}}}