{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:04:03Z","timestamp":1790291043309,"version":"4.1.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0228158","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T13:36:05Z","timestamp":1579786565000},"page":"e0228158","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Mutual interaction between motor cortex activation and pain in fibromyalgia: EEG-fNIRS study"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1556-8518","authenticated-orcid":true,"given":"Eleonora","family":"Gentile","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1934-0983","authenticated-orcid":true,"given":"Antonio","family":"Brunetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Delussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-0788","authenticated-orcid":true,"given":"Vitoantonio","family":"Bevilacqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"de Tommaso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"issue":"5","key":"pone.0228158.ref001","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/acr.20140","article-title":"The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity","volume":"62","author":"F Wolfe","year":"2010","journal-title":"Arthritis Care and Research"},{"issue":"Suppl 116","key":"pone.0228158.ref002","first-page":"3","article-title":"One year review 2019: fibromyalgia","volume":"37","author":"F Atzeni","year":"2019","journal-title":"Clin exp Rheumatol"},{"key":"pone.0228158.ref003","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/art.23826","article-title":"Identifying the clinical domains of fibromyalgia: contributions from clinician and patient delphi exercises","volume":"59","author":"PJ Mease","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"3","key":"pone.0228158.ref004","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/papr.12276","article-title":"Repetitive transcranial magnetic stimulation for fibromyalgia: systematic review and meta-analysis","volume":"16","author":"LM Knijnik","year":"2015","journal-title":"Pain Pract"},{"key":"pone.0228158.ref005","first-page":"CD008208","article-title":"Non-invasive brain stimulation techniques for chronic pain","volume":"9","author":"NE O\u2019Connell","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"pone.0228158.ref006","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.pain.0000000000000006","article-title":"Transcranial direct current stimulation as a treatment for patients with fibromyalgia","volume":"156","author":"AJ Fagerlund","year":"2015","journal-title":"Pain"},{"key":"pone.0228158.ref007","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1002\/art.22195","article-title":"A randomized, sham-controlled, proof of principle study of transcranial direct current stimulation for the treatment of pain in fibromyalgia","volume":"54","author":"F Fregni","year":"2006","journal-title":"Arthritis Rheum"},{"key":"pone.0228158.ref008","first-page":"353","article-title":"Efficacy of anodal transcranial direct current stimulation (tDCS) for the treatment of fibromyalgia: results of a randomized, sham-controlled longitudinal clinical trial","volume":"2","author":"A Valle","year":"2009","journal-title":"J Pain Manag"},{"key":"pone.0228158.ref009","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1002\/hbm.21380","article-title":"Modulating cortico-striatal and thalamo-cortical functional connectivity with transcranial direct current stimulation","volume":"33","author":"R Polan\u00eda","year":"2012","journal-title":"Hum Brain Mapp"},{"issue":"11","key":"pone.0228158.ref010","doi-asserted-by":"crossref","first-page":"e008540","DOI":"10.1136\/bmjopen-2015-008540","article-title":"Organisation and function of the primary motor cortex in chronic pain: protocol for a systematic review and meta-analysis","volume":"5","author":"WJ Chang","year":"2015","journal-title":"BMJ Open"},{"issue":"5","key":"pone.0228158.ref011","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s11916-011-0214-2","article-title":"Exercise therapy for fibromyalgia","volume":"15","author":"AJ Busch","year":"2011","journal-title":"Curr. Pain Headache Rep"},{"issue":"16","key":"pone.0228158.ref012","first-page":"S219","article-title":"Motor cortex tRNS ameliorates pain, anxiety, depression, quality of life and cognitive impairment in patients with fibromyalgia: preliminary results of a randomized sham-controlled trial","volume":"88","author":"G La Bianca","year":"2017","journal-title":"Neurology"},{"issue":"2","key":"pone.0228158.ref013","first-page":"158","article-title":"Handgrip Strength in Fibromyalgia, Archives of Rheumatology","volume":"31","author":"K K\u00f6kl\u00fc","year":"2016"},{"issue":"9","key":"pone.0228158.ref014","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s00393-018-0558-7","article-title":"Assessment of hand function and disability in fibromyalgia","volume":"78","author":"G Devrimsel","year":"2019","journal-title":"Z Rheumatol"},{"issue":"4","key":"pone.0228158.ref015","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/ptj\/83.4.340","article-title":"Effects of short versus long bouts of aerobic exercise in sedentary women with fibromyalgia: a randomized controlled trial","volume":"83","author":"CL Schachter","year":"2003","journal-title":"Phys. Ther"},{"issue":"7","key":"pone.0228158.ref016","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/j.1526-4637.2009.00707.x","article-title":"Barriers and facilitators to chronic pain self-management: a qualitative study of primary care patients with comorbid musculoskeletal pain and depression","volume":"10","author":"MJ Bair","year":"2009","journal-title":"Pain Med"},{"key":"pone.0228158.ref017","doi-asserted-by":"crossref","first-page":"180003","DOI":"10.1038\/sdata.2018.3","article-title":"Simultaneous acquisition of EEG and NIRS during cognitive tasks for an open access dataset","volume":"5","author":"J Shin","year":"2018","journal-title":"Sci Data"},{"issue":"2","key":"pone.0228158.ref018","first-page":"107","article-title":"Motor cortex function in fibromyalgia: a pilot study by near-infrared spectroscopy and laser evoked potentials co-recording","volume":"34","author":"E Gentile","year":"2019","journal-title":"Functional Neurology"},{"key":"pone.0228158.ref019","doi-asserted-by":"crossref","first-page":"16438","DOI":"10.1038\/srep16438","article-title":"Simultaneous measurement of electroencephalography and near-infrared spectroscopy during voluntary motor preparation","volume":"5","author":"T Zama","year":"2015","journal-title":"Scientific reports"},{"key":"pone.0228158.ref020","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3389\/fnhum.2017.00503","article-title":"Multi-Modal Integration of EEG-fNIRS for Brain-Computer Interfaces\u2014Current Limitations and Future Directions","volume":"11","author":"S Ahn","year":"2017","journal-title":"Front Hum Neurosci"},{"key":"pone.0228158.ref021","article-title":"Motor Cortex Function in Fibromyalgia: A Study by Functional Near-Infrared Spectroscopy","author":"E Gentile","year":"2019","journal-title":"Pain Research and Treatment"},{"key":"pone.0228158.ref022","first-page":"97","article-title":"The assessment and analysis of handedness: The Edinburgh inventory, Neuropsychologia","volume":"9","author":"RC Oldfield","year":"1971"},{"issue":"4","key":"pone.0228158.ref023","first-page":"459","article-title":"Validation of an Italian version of the Fibromyalgia Impact Questionnaire (FIQ-I)","volume":"21","author":"P Sarzi-Puttini","year":"2003","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"pone.0228158.ref024","first-page":"210","article-title":"New diagnostic criteria for fibromyalgia: Here to stay?","volume":"11","author":"S Moyano","year":"2015","journal-title":"Reumatol Clin"},{"key":"pone.0228158.ref025","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0033-3182(71)71479-0","article-title":"A rating instrument for anxiety disorders","volume":"12","author":"WW Zung","year":"1971","journal-title":"Psychosomatics"},{"key":"pone.0228158.ref026","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/archpsyc.1965.01720310065008","article-title":"A self-rating depression scale","volume":"12","author":"WW Zung","year":"1965","journal-title":"Archives of General Psychiatry"},{"issue":"1","key":"pone.0228158.ref027","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1891\/1061-3749.26.1.36","article-title":"A Systematic Review of Studies Using the Multidimensional Assessment of Fatigue Scale","volume":"26","author":"B Belza","year":"2018","journal-title":"J Nurs Meas"},{"key":"pone.0228158.ref028","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2114\/jpa.23.105","article-title":"The effect of maximal finger tapping on cerebral activation","volume":"23","author":"N Kuboyama","year":"2004","journal-title":"Journal of physiological anthropology and applied human science"},{"issue":"6","key":"pone.0228158.ref029","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neucli.2003.10.009","article-title":"Clinical usefulness of laser-evoked potentials","volume":"33","author":"RD Treede","year":"2003","journal-title":"Neurophysiol Clin"},{"key":"pone.0228158.ref030","article-title":"Pain Processing and Vegetative Dysfunction in Fibromyalgia: A Study by Sympathetic Skin Response and Laser Evoked Potentials","volume":"28","author":"M de Tommaso","year":"2017","journal-title":"Pain Res Treat"},{"key":"pone.0228158.ref031","unstructured":"Xu Y, Graber H, Barbour R. Nirlab user manual. Available from: https:\/\/www.nitrc.org\/frs\/shownotes.php?release_id=2663."},{"issue":"3","key":"pone.0228158.ref032","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF02447083","article-title":"System for long-term measurement of cerebral blood and tissue oxygenation on newborn infants by near infra-red transillumination","volume":"26","author":"M Cope","year":"1988","journal-title":"Medical & Biological Engineering & Computing"},{"issue":"11","key":"pone.0228158.ref033","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1364\/BOE.5.004053","article-title":"Modified Beer-Lambert law for blood flow","volume":"5","author":"WB Baker","year":"2014","journal-title":"Biomedical optics express"},{"issue":"4","key":"pone.0228158.ref034","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0168-5597(96)95625-7","article-title":"Scalp topography and dipolar source modelling of potentials evoked by CO2 laser stimulation of the hand","volume":"100","author":"M Valeriani","year":"1996","journal-title":"Electroencephalography and Clinical Neurophysiology"},{"issue":"2","key":"pone.0228158.ref035","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.neuroimage.2008.08.036","article-title":"NIRS-SPM: statistical parametric mapping for near-infrared spectroscopy","volume":"44","author":"JC Ye","year":"2009","journal-title":"Neuroimage"},{"issue":"2","key":"pone.0228158.ref036","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/1971400917739083","article-title":"Functional near-infrared spectroscopy is in moderate accordance with functional MRI in determining lateralisation of frontal language areas","volume":"31","author":"KM Arun","year":"2018","journal-title":"The neuroradiology journal"},{"issue":"5","key":"pone.0228158.ref037","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.mri.2007.10.010","article-title":"Laterality index in functional MRI: methodological issues","volume":"26","author":"ML Seghier","year":"2008","journal-title":"Magnetic resonance imaging"},{"issue":"2","key":"pone.0228158.ref038","first-page":"369","article-title":"Pain extent and diagnosis: development and validation of the regional pain scale in 12,799 patients with rheumatic disease","volume":"30","author":"F Wolfe","year":"2003","journal-title":"J Rheumatol"},{"issue":"1","key":"pone.0228158.ref039","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.neuroimage.2008.04.025","article-title":"Functional neuroimaging correlates of finger-tapping task variations: an ALE meta-analysis","volume":"42","author":"ST Witt","year":"2008","journal-title":"NeuroImage"},{"key":"pone.0228158.ref040","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnhum.2017.00014","article-title":"Altered Functional Performance in Patients with Fibromyalgia","volume":"11","author":"ID Costa","year":"2017","journal-title":"Frontiers in human neuroscience"},{"issue":"4","key":"pone.0228158.ref041","doi-asserted-by":"crossref","first-page":"506","DOI":"10.5014\/ajot.63.4.506","article-title":"Reliability of the box and block test of manual dexterity for use with patients with fibromyalgia","volume":"63","author":"ML Canny","year":"2009","journal-title":"American Journal of Occupational Therapy"},{"issue":"8","key":"pone.0228158.ref042","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s10067-013-2277-4","article-title":"Fear of movement and avoidance behaviour toward physical activity in chronic-fatigue syndrome and fibromyalgia: state of the art and implications for clinical practice","volume":"32","author":"J Nijs","year":"2013","journal-title":"Clin Rheumatol"},{"issue":"3","key":"pone.0228158.ref043","doi-asserted-by":"crossref","first-page":"828","DOI":"10.2466\/04.15.PR0.115c32z1","article-title":"Cognitive dysfunction in fibromyalgia: slow access to the mental lexicon","volume":"115","author":"F Leavitt","year":"2014","journal-title":"Psychol Rep"},{"issue":"1","key":"pone.0228158.ref044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jnp.12030","article-title":"Attention network test: assessment of cognitive function in chronic fatigue syndrome","volume":"9","author":"F Togo","year":"2015","journal-title":"J Neuropsychol"},{"key":"pone.0228158.ref045","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2147\/JPR.S127038","article-title":"Gross and fine motor function in fibromyalgia and chronic fatigue syndrome","volume":"10","author":"O Rasouli","year":"2017","journal-title":"Journal of pain research"},{"issue":"15","key":"pone.0228158.ref046","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1001\/jama.2014.3266","article-title":"Fibromyalgia: a clinical review","volume":"311","author":"DJ Clauw","year":"2014","journal-title":"Jama"},{"issue":"4","key":"pone.0228158.ref047","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jpain.2017.10.007","article-title":",Altered Primary Motor Cortex Structure, Organization, and Function in Chronic Pain: A Systematic Review and Meta-Analysis","volume":"19","author":"WJ Chang","year":"2018","journal-title":"The Journal of Pain"},{"issue":"3","key":"pone.0228158.ref048","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3138\/ptc.2010-08p","article-title":"Interactions between pain and the motor cortex: insights from research on phantom limb pain and complex regional pain syndrome. Physiotherapy Canada","volume":"63","author":"C Mercier","year":"2011","journal-title":"Physiotherapie Canada"},{"issue":"9","key":"pone.0228158.ref049","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1212\/01.wnl.0000242731.10074.3c","article-title":"Motor cortex rTMS restores defective intracortical inhibition in chronic neuropathic pain","volume":"67","author":"JP Lefaucheur","year":"2006","journal-title":"Neurology"},{"issue":"10","key":"pone.0228158.ref050","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1093\/brain\/awm131","article-title":"The motor system shows adaptive changes in complex regional pain syndrome","volume":"130","author":"C Maih\u04e7fner","year":"2007","journal-title":"Brain"},{"issue":"4","key":"pone.0228158.ref051","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.brs.2016.03.020","article-title":"Is Motor Cortical Excitability Altered in People with Chronic Pain?","volume":"9","author":"RS Parker","year":"2016","journal-title":"A Systematic Review and Meta-Analysis, Brain Stimulation"},{"issue":"1","key":"pone.0228158.ref052","doi-asserted-by":"crossref","first-page":"7986","DOI":"10.1038\/s41598-017-08208-2","article-title":"Repetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain","volume":"7","author":"M Cha","year":"2017","journal-title":"Scientific Reports"},{"issue":"2","key":"pone.0228158.ref053","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1179\/016164103101201283","article-title":"Pain-related modulation of the human motor cortex","volume":"25","author":"S Farina","year":"2003","journal-title":"Neurological Research"},{"key":"pone.0228158.ref054","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.nicl.2016.11.006","article-title":"Neurochemical changes in patients with chronic low back pain detected by proton magnetic resonance spectroscopy: a systematic review","volume":"13","author":"X Zhao","year":"2016","journal-title":"Neuroimage Clin"},{"issue":"3","key":"pone.0228158.ref055","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00415-013-7211-9","article-title":"Update on laser evoked potential findings in fibromyalgia patients in light of clinical and skin biopsy features","volume":"261","author":"M de Tommaso","year":"2014","journal-title":"J Neurol"},{"issue":"12","key":"pone.0228158.ref056","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1007\/s10067-018-4300-2","article-title":"Fibromyalgia and small fiber neuropathy: the plot thickens!","volume":"37","author":"M Mart\u00ecnez-Lavin","year":"2018","journal-title":"Clin Rheumatol"},{"issue":"6","key":"pone.0228158.ref057","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neucli.2003.10.008","article-title":"Brain generators of laser-evoked potentials: from dipole to finctional significance","volume":"33","author":"L Garcia-Larrea","year":"2003","journal-title":"Neurophysiol Clin"},{"issue":"6","key":"pone.0228158.ref058","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1111\/j.1460-9568.2007.05389.x","article-title":"Inhibitory effect of voluntary movement preparation on cutaneous heat pain and laser-evoked potentials","volume":"25","author":"D Le Pera","year":"2007","journal-title":"Eur J Neurosci"},{"issue":"3","key":"pone.0228158.ref059","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.neuroimage.2010.09.084","article-title":"A multisensory investigation of the functional significance of the \u201cpain matrix\u201d","volume":"54","author":"A Mouraux","year":"2011","journal-title":"Neuorimage"},{"issue":"Suppl 1","key":"pone.0228158.ref060","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/j.neuroimage.2007.05.062","article-title":"Motor cortex stimulation for neuropathic pain: From phenomenology to mechanisms","volume":"37","author":"L Garcia-Larrea","year":"2007","journal-title":"Neuroimage"},{"issue":"10","key":"pone.0228158.ref061","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1093\/brain\/awm189","article-title":"Effects of unilateral repetitive transcranial magnetic stimulation of the motor cortex on chronic widespread pain in fibromyalgia","volume":"130","author":"A Passard","year":"2007","journal-title":"Brain"},{"key":"pone.0228158.ref062","first-page":"14","article-title":"Brain modulation by electric currents in fibromyalgia: a structured review on non-invasive approach with transcranial electrical stimulation","volume":"11","author":"F Brighina","year":"2019","journal-title":"Front Hum Neurosci"},{"key":"pone.0228158.ref063","first-page":"CD008208","article-title":"Non-invasive brain stimulation techniques for chronic pain","volume":"3","author":"NE O\u2019Connell","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"6","key":"pone.0228158.ref064","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10194-010-0247-7","article-title":"Effects of high-frequency repetitive trasncranial magnetic stimulation of primary motor cortex on laser-evoked potentials in migraine","volume":"11","author":"M de Tommaso","year":"2010","journal-title":"J Headache Pain"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0228158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T13:36:55Z","timestamp":1579786615000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0228158"}},"subtitle":[],"editor":[{"given":"Domenico Paolo Emanuele","family":"Margiotta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1,23]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0228158","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,23]]}}}