{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:46:46Z","timestamp":1774007206513,"version":"3.50.1"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0228429","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T15:02:47Z","timestamp":1595948567000},"page":"e0228429","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pterostilbene protects cochlea from ototoxicity in streptozotocin-induced diabetic rats by inhibiting\u00a0apoptosis"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4610-2785","authenticated-orcid":true,"given":"Sibel","family":"\u00d6zda\u015f","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bora","family":"Ta\u015ftekin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seren G.","family":"G\u00fcrgen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talih","family":"\u00d6zda\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aykut","family":"Pelit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanem O.","family":"Erkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birg\u00fcl","family":"Tuhanio\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birg\u00fcl","family":"G\u00fclnar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orhan","family":"G\u00f6rg\u00fcl\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"key":"pone.0228429.ref001","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF02867866","article-title":"Regulation of metabolic pathways in liver and kidney during experimental diabetes: effects of antidiabetic compounds","volume":"13","author":"NZ Baquer","year":"1998","journal-title":"Indian J Clin Biochem"},{"key":"pone.0228429.ref002","doi-asserted-by":"crossref","first-page":"269","DOI":"10.5001\/omj.2012.68","article-title":"Type 2 diabetes mellitus: a review of current trends","volume":"27","author":"AB Olokoba","year":"2012","journal-title":"Oman Med J"},{"key":"pone.0228429.ref003","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2337\/diab.43.8.1066","article-title":"Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes","volume":"43","author":"CR Kahn","year":"1994","journal-title":"Diabetes"},{"key":"pone.0228429.ref004","unstructured":"International Diabetes Federation. IDF Diabetes Atlas, 8th Edition. Available at: http:\/\/www.diabetesatlas.org\/. Accessed July 29, 2019."},{"key":"pone.0228429.ref005","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.nutres.2012.06.003","article-title":"Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus","volume":"32","author":"JK Bhatt","year":"2012","journal-title":"Nutr Res"},{"key":"pone.0228429.ref006","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000231636","article-title":"Diabetes, cardiovascular risk factors and idiopathic sudden sensorineural hearing loss: A case-control study","volume":"15","author":"C Aimoni","year":"2010","journal-title":"Audiol Neurotol"},{"key":"pone.0228429.ref007","first-page":"1","article-title":"Hearing in diabetics","volume":"356","author":"A Axelsson","year":"1978","journal-title":"Acta Otolaryngol Suppl"},{"key":"pone.0228429.ref008","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ecl.2010.05.011","article-title":"Epidemiology of type 1 diabetes","volume":"39","author":"DM Maahs","year":"2010","journal-title":"Endocrinol Metab Clin North Am"},{"key":"pone.0228429.ref009","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1001\/jama.295.4.416","article-title":"Does this patient have hearing impairment?","volume":"295","author":"A Bagai","year":"2006","journal-title":"JAMA"},{"key":"pone.0228429.ref010","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/MAO.0000000000000293","article-title":"Histopathologic changes in the cochlea associated with diabetes mellitus-a review","volume":"35","author":"OV Akinpelu","year":"2014","journal-title":"Otol Neurotol"},{"key":"pone.0228429.ref011","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1017\/S0022215100122571","article-title":"Hearing loss in diabetics","volume":"107","author":"JR Cullen","year":"1993","journal-title":"J Laryngol Otol"},{"key":"pone.0228429.ref012","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1121\/1.382104","article-title":"Stimulated acoustic emissions from within the human auditory system","volume":"64","author":"DT Kemp","year":"1978","journal-title":"J Acoust Soc Am"},{"key":"pone.0228429.ref013","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3109\/14992027.2013.879341","article-title":"Increased prevalence of early cochlear damage in young patients with type 1 diabetes detected by distortion product otoacoustic emissions","volume":"53","author":"CT Botelho","year":"2014","journal-title":"Int J Audiol"},{"key":"pone.0228429.ref014","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2337\/diacare.20.2.194","article-title":"Total radical-trapping antioxidant parameter in NIDDM patients","volume":"20","author":"A Ceriello","year":"1997","journal-title":"Diabetes Care"},{"key":"pone.0228429.ref015","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1210\/endo.138.11.5521","article-title":"Vanadate, but not insulin, inhibits insulin receptor gene expression in rat hepatoma cells","volume":"138","author":"S Bortoli","year":"1997","journal-title":"Endocrinology"},{"key":"pone.0228429.ref016","first-page":"381","volume-title":"Indian Medicinal Plants","author":"PK Warrier","year":"1995"},{"key":"pone.0228429.ref017","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1211\/jpp.58.11.0009","article-title":"The antioxidant role of pterostilbene in streptozotocin nicotinamide-induced type 2 diabetes mellitus in Wistar rats","volume":"58","author":"A Satheesh","year":"2006","journal-title":"JPP"},{"key":"pone.0228429.ref018","first-page":"609","article-title":"Antihyperglycemic activity of phenolics from Pterocarpus marsupium","volume":"60","author":"M Manickam","year":"1997","journal-title":"J Nat"},{"issue":"1","key":"pone.0228429.ref019","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1002\/lary.27253","article-title":"The effect of resveratrol on the histologic characteristics of the cochlea in diabetic rats","volume":"129","author":"SO Erkan","year":"2019","journal-title":"Laryngoscope"},{"key":"pone.0228429.ref020","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"A flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"F Faul","year":"2007","journal-title":"Behav Res Methods"},{"key":"pone.0228429.ref021","volume-title":"High-Dose Streptozotocin Induction Protocol (Mouse); Animal Models of Diabetic Complications Consortium","author":"F Brosius"},{"key":"pone.0228429.ref022","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0378-8741(01)00207-0","article-title":"Hypoglycemic effect of Suaeda fruticosa in streptozotocin induced diabetic rats","volume":"76","author":"M Benwahhoud","year":"2001","journal-title":"J Rethnopharmacol"},{"key":"pone.0228429.ref023","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1017\/S0007114516001069","article-title":"Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozocin-induced diabetic rats","volume":"115","author":"HE Pyhu","year":"2016","journal-title":"Br J Nutr"},{"key":"pone.0228429.ref024","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/00016489.2016.1223344","article-title":"Early detection of hearing impairment in patients with diabetes mellitus with otoacoustic emission. A systematic review and meta-analysis","volume":"137","author":"J Hao","year":"2017","journal-title":"Acta Oto-laryngologica"},{"key":"pone.0228429.ref025","first-page":"115","article-title":"Search for extra pancreatic effects of new oral hypoglycemic agent A-1466: 1. Oral glucose tolerance tests in normal and hereditary insulin resistant rats","volume":"32","author":"I Klimes","year":"1998","journal-title":"Endocrinology Regulations"},{"key":"pone.0228429.ref026","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/08941939.2016.1178358","article-title":"Effects of Aloe Vera on Spinal Cord Ischemia-Reperfusion Injury of Rats","volume":"29","author":"Y Yuksel","year":"2016","journal-title":"J Invest Surg"},{"key":"pone.0228429.ref027","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/nu8010017","article-title":"Polyphenols and Glycemic Control","volume":"8","author":"Y Kim","year":"2016","journal-title":"Nutrients"},{"key":"pone.0228429.ref028","doi-asserted-by":"crossref","first-page":"283","DOI":"10.5808\/GI.2014.12.4.283","article-title":"Elucidation of the inhibitory effect of phytochemicals with Kir6.2 wild-type and mutant models associated in type-1 diabetes through molecular docking approach","volume":"12","author":"M Jagadeb","year":"2014","journal-title":"Genomics Inform"},{"key":"pone.0228429.ref029","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1021\/jf0116855","article-title":"Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol","volume":"50","author":"AM Rimando","year":"2002","journal-title":"J Agric Food Chem"},{"key":"pone.0228429.ref030","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1111\/bph.12577","article-title":"Therapeutic potential of pterostilbene against pancreatic beta-cell apoptosis mediated through Nrf2","volume":"171","author":"E Bhakkiyalakshmi","year":"2014","journal-title":"Br J Pharmacol"},{"key":"pone.0228429.ref031","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cyto.2015.11.006","article-title":"Pterostilbene exerts an anti-inflammatory effect via regulating endoplasmic reticulum stress in endothelial cells","volume":"77","author":"J Liu","year":"2016","journal-title":"Cytokine"},{"issue":"15\u201316","key":"pone.0228429.ref032","first-page":"575482","article-title":"A review of pterostilbene antioxidant activity and disease modification","author":"D McCormack","year":"2013","journal-title":"Oxid Med Cell Longev"},{"key":"pone.0228429.ref033","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.tiv.2010.02.007","article-title":"In vitro evaluation of the cytotoxic, anti-proliferative and anti-oxidant properties of pterostilbene isolated from Pterocarpus marsupium","volume":"24","author":"A Chakraborty","year":"2010","journal-title":"Toxicol In Vitro"},{"issue":"2","key":"pone.0228429.ref034","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/toxsci\/kfh263","article-title":"Resveratrol-associated renal toxicity","volume":"82","author":"JA Crowell","year":"2004","journal-title":"Toxicol Sci"},{"issue":"6","key":"pone.0228429.ref035","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jnutbio.2008.05.003","article-title":"Resveratrol, a unique phytoalexin present in red wine, delivers either survival signal or death signal to the ischemic myocardium depending on dose","volume":"20","author":"J Dudley","year":"2009","journal-title":"J Nutr Biochem"},{"key":"pone.0228429.ref036","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.lfs.2006.02.036","article-title":"Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin-and nicotinamide-induced diabetic rats","volume":"79","author":"L Pari","year":"2006","journal-title":"Life Sci"},{"key":"pone.0228429.ref037","first-page":"176","article-title":"Diabetes mellitus and hearing loss: clinical and histopathological relationships","volume":"7","author":"PA Wackym","year":"1986","journal-title":"Am J Otol"},{"key":"pone.0228429.ref038","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1288\/00005537-199503000-00002","article-title":"Insulin-dependent diabetic microangiopathy in the inner ear","volume":"105","author":"TL Smith","year":"1995","journal-title":"Laryngoscope"},{"key":"pone.0228429.ref039","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/archotol.132.9.934","article-title":"Effects of type 2 diabetes mellitus on cochlear structure in humans","volume":"132","author":"H Fukushima","year":"2006","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"pone.0228429.ref040","first-page":"313","article-title":"The cochlea of the spontaneously diabetic mouse. II. Electron microscopic observations of non-obese diabetic mice","volume":"243","author":"S Nakae","year":"1986","journal-title":"Arch Otorhinolaryngol"},{"key":"pone.0228429.ref041","first-page":"63","article-title":"Cochlear histopathologic analysis in diabetic rats","volume":"19","author":"B Nageris","year":"1998","journal-title":"Am J Otol"},{"key":"pone.0228429.ref042","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/BF00464437","article-title":"The cochlea of the spontaneously diabetic mouse. I. Electron microscopic observation of KK mice","volume":"243","author":"M Tachibana","year":"1986","journal-title":"Arch Otorhinolaryngol"},{"key":"pone.0228429.ref043","first-page":"1342","article-title":"Reperfusion cellular injury in an animal model of transient ischemia","volume":"25","author":"SK Lee","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"pone.0228429.ref044","doi-asserted-by":"crossref","first-page":"F21","DOI":"10.1084\/jem.192.8.F21","article-title":"Cross-talk in cell death signaling","volume":"192","author":"S Roy","year":"2000","journal-title":"J Exp Med"},{"key":"pone.0228429.ref045","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/annonc\/mdi077","article-title":"Expression of survivin and bax\/bcl-2 in peroxisome proliferator activated receptor-\u03b3 ligands induces apoptosis on human myeloid leukemia cells in vitro","volume":"16","author":"J Liu","year":"2005","journal-title":"Ann Oncol"},{"key":"pone.0228429.ref046","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s00405-002-0519-1","article-title":"Exploration of the early auditory effects of hyperlipoproteinemia and diabetes mellitus using otoacoustic emissions","volume":"260","author":"T Erdem","year":"2003","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"pone.0228429.ref047","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12906-016-1032-1","article-title":"Allium hookeri root protects oxidative stress induced inflammatory responses and -cell damage in pancreas of streptozotocin-induced diabetic rats","volume":"16","author":"S Roh","year":"2016","journal-title":"BMC Complement Altern Med"},{"issue":"1","key":"pone.0228429.ref048","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-8741(02)00059-4","article-title":"Medicinal plants of India with anti-diabetic potential","volume":"81","author":"JK Grover","year":"2002","journal-title":"J Ethnopharmacol"},{"key":"pone.0228429.ref049","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.lfs.2017.06.015","article-title":"Pterostilbene ameliorates insulin sensitivity, glycemic control and oxidative stress in fructose-fed diabetic rats","volume":"182","author":"R Kosuru","year":"2017","journal-title":"Life Sci"},{"key":"pone.0228429.ref050","doi-asserted-by":"crossref","first-page":"172526","DOI":"10.1016\/j.ejphar.2019.172526","article-title":"Antidiabetic effects of pterostilbene through PI3K\/Akt signal pathway in high fat diet and STZ-induced diabetic rats","volume":"859","author":"H Sun","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"pone.0228429.ref051","first-page":"712092","article-title":"Traditional Indian medicines used for the management of diabetes mellitus","volume":"2013","author":"SI Rizvi","year":"2013","journal-title":"J Diabetes Res"},{"issue":"6","key":"pone.0228429.ref052","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1039\/C5FO00151J","article-title":"Pterostilbene improves glycaemic control in rats fed an obesogenic diet: involvement of skeletal muscle and liver","volume":"6","author":"S G\u00f3mez-Zorita","year":"2015","journal-title":"Food Funct"},{"issue":"1","key":"pone.0228429.ref053","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jfda.2016.07.004","article-title":"Biological actions and molecular effects of resveratrol, pterostilbene, and 3'-hydroxypterostilbene","volume":"25","author":"HY Tsai","year":"2017","journal-title":"J Food Drug Anal"},{"key":"pone.0228429.ref054","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2016.02.054","article-title":"Anti-hyperlipidemic and anti-peroxidative role of pterostilbene via Nrf2 signaling in experimental diabetes","volume":"777","author":"E Bhakkiyalakshmi","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"pone.0228429.ref055","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1021\/acs.chemrestox.5b00378","article-title":"Pterostilbene Ameliorates Streptozotocin-Induced Diabetes through Enhancing Antioxidant Signaling Pathways Mediated by Nrf2","volume":"29","author":"B Elango","year":"2016","journal-title":"Chem Res Toxicol"},{"key":"pone.0228429.ref056","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.sjbs.2016.11.007","article-title":"Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats: an in vivo approach","volume":"25","author":"W Li","year":"2018","journal-title":"Saudi J Biol Sci"},{"key":"pone.0228429.ref057","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.pharep.2017.04.005","article-title":"Diosmin ameliorates the effects of oxidative stress in lenses of streptozotocin-induced type 1 diabetic rats","volume":"69","author":"W Wojnar","year":"2017","journal-title":"Pharmacol Rep"},{"issue":"15","key":"pone.0228429.ref058","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1021\/jf040095e","article-title":"Resveratrol, pterostilbene, and piceatannol in vaccinium berries","volume":"52","author":"AM Rimando","year":"2004","journal-title":"J Agric Food Chem"},{"issue":"15\u201316","key":"pone.0228429.ref059","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jchromb.2011.03.025","article-title":"Development of a reversed phase high performance liquid chromatography method based on the use of cyclodextrins as mobile phase additives to determine pterostilbene in blueberries","volume":"879","author":"P Rodr\u00edguez-Bonilla","year":"2011","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"2","key":"pone.0228429.ref060","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jss.2011.09.054","article-title":"Pterostilbene and cancer: current review","volume":"173","author":"D. McCormack","year":"2012","journal-title":"J Surg Res"},{"key":"pone.0228429.ref061","first-page":"24","article-title":"Flexible dose open trial of Vijayasar in cases of newly-diagnosed non-insulin-dependent diabetes mellitus","volume":"108","author":"S Philip","year":"1998","journal-title":"Indian J Med Res"},{"issue":"6","key":"pone.0228429.ref062","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.18203\/2319-2003.ijbcp20151356","article-title":"Hypoglycemic activity of Pterocarpus marsupium in patients with Type 2 diabetes mellitus","volume":"4","author":"A Patidar","year":"2015","journal-title":"Int J Basic Clin Pharmacol"},{"issue":"5","key":"pone.0228429.ref063","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1055\/s-2005-864130","article-title":"Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers","volume":"71","author":"S Hougee","year":"2005","journal-title":"Planta Med"},{"key":"pone.0228429.ref064","doi-asserted-by":"crossref","first-page":"463595","DOI":"10.1155\/2013\/463595","article-title":"Analysis of Safety from a Human Clinical Trial with Pterostilbene","volume":"2013","author":"DM Riche","year":"2013","journal-title":"J Toxicol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0228429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T15:03:21Z","timestamp":1595948601000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0228429"}},"subtitle":[],"editor":[{"given":"Michael","family":"Bader","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,7,28]]},"references-count":64,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0228429","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.01.16.908798","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,28]]}}}