{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:00:57Z","timestamp":1787022057301,"version":"build-2736575974"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BioFire Biomeri\u00e9ux"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0228596","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T13:32:07Z","timestamp":1580995927000},"page":"e0228596","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["Impact of the BioFire FilmArray gastrointestinal panel on patient care and infection control"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2606-8276","authenticated-orcid":true,"given":"Julian D.","family":"Machiels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelieke J. H.","family":"Cremers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muri\u00ebl C. G. T.","family":"van Bergen-Verkuyten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra J. M.","family":"Paardekoper-Strijbosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly C. J.","family":"Frijns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiman F. L.","family":"Wertheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janette","family":"Rahamat-Langendoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem J. G.","family":"Melchers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,2,6]]},"reference":[{"issue":"7","key":"pone.0228596.ref001","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/aje\/154.7.666","article-title":"Sensor, a population-based cohort study on gastroenteritis in the Netherlands: incidence and etiology","volume":"154","author":"M.A. de Wit","year":"2001","journal-title":"Am J Epidemiol"},{"issue":"8","key":"pone.0228596.ref002","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1007\/s10096-011-1518-1","article-title":"Costs of gastroenteritis in the Netherlands, with special attention for severe cases","volume":"31","author":"I.H. Friesema","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"pone.0228596.ref003","article-title":"Swab guideline antimicrobial therapy in acute infectious diarrhea","author":"J. Bos","year":"2014"},{"issue":"4","key":"pone.0228596.ref004","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/clinids\/19.4.728","article-title":"Clinical features and duration of traveler's diarrhea in relation to its etiology","volume":"19","author":"L. Mattila","year":"1994","journal-title":"Clin Infect Dis"},{"issue":"5","key":"pone.0228596.ref005","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ajg.2016.126","article-title":"ACG Clinical Guideline: Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults","volume":"111","author":"M.S. Riddle","year":"2016","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"pone.0228596.ref006","doi-asserted-by":"crossref","first-page":"179.e9","DOI":"10.1016\/j.cmi.2014.07.011","article-title":"How well does physician selection of microbiologic tests identify Clostridium difficile and other pathogens in paediatric diarrhoea? Insights using multiplex PCR-based detection","volume":"21","author":"C. Stockmann","year":"2015","journal-title":"Clin Microbiol Infect"},{"issue":"9","key":"pone.0228596.ref007","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1128\/JCM.00908-12","article-title":"Unrecognized norovirus infections in health care institutions and their clinical impact","volume":"50","author":"M.F. Beersma","year":"2012","journal-title":"J Clin Microbiol"},{"issue":"1","key":"pone.0228596.ref008","article-title":"A Gastrointestinal PCR Panel Improves Clinical Management and Lowers Health Care Costs","volume":"56","author":"S.G. Beal","year":"2018","journal-title":"J Clin Microbiol"},{"key":"pone.0228596.ref009","unstructured":"FilmArray\u00ae Panels, Gastrointestinal Panel. 26-07-2018]; Available from: https:\/\/www.biofiredx.com\/products\/the-filmarray-panels\/#gastrointestinal."},{"issue":"5","key":"pone.0228596.ref010","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1128\/JCM.42.5.2031-2035.2004","article-title":"Detection of Shigella by a PCR assay targeting the ipaH gene suggests increased prevalence of shigellosis in Nha Trang, Vietnam","volume":"42","author":"D.T. Vu","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"12","key":"pone.0228596.ref011","doi-asserted-by":"crossref","first-page":"7046","DOI":"10.1128\/AEM.70.12.7046-7052.2004","article-title":"Diagnostic real-time PCR for detection of Salmonella in food","volume":"70","author":"B. Malorny","year":"2004","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"pone.0228596.ref012","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1128\/JCM.01716-12","article-title":"Detection of Campylobacter species and Arcobacter butzleri in stool samples by use of real-time multiplex PCR","volume":"51","author":"R.F. de Boer","year":"2013","journal-title":"J Clin Microbiol"},{"issue":"3","key":"pone.0228596.ref013","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jcv.2010.07.019","article-title":"Diagnosis of viral gastroenteritis by simultaneous detection of Adenovirus group F, Astrovirus, Rotavirus group A, Norovirus genogroups I and II, and Sapovirus in two internally controlled multiplex real-time PCR assays","volume":"49","author":"N.M. van Maarseveen","year":"2010","journal-title":"J Clin Virol"},{"issue":"7","key":"pone.0228596.ref014","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1089\/fpd.2009.0457","article-title":"Development of a multiplex real-time polymerase chain reaction for simultaneous detection of enterohemorrhagic Escherichia coli and enteropathogenic Escherichia coli strains","volume":"7","author":"M. Pavlovic","year":"2010","journal-title":"Foodborne Pathog Dis"},{"issue":"2\u20133","key":"pone.0228596.ref015","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1078\/1438-4221-00252","article-title":"Detection of Cyclospora cayetanensis in travellers returning from the tropics and subtropics using microscopy and real-time PCR","volume":"293","author":"J.J. Verweij","year":"2003","journal-title":"Int J Med Microbiol"},{"issue":"3","key":"pone.0228596.ref016","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1128\/JCM.42.3.1220-1223.2004","article-title":"Simultaneous detection of Entamoeba histolytica, Giardia lamblia, and Cryptosporidium parvum in fecal samples by using multiplex real-time PCR","volume":"42","author":"J.J. Verweij","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"19","key":"pone.0228596.ref017","doi-asserted-by":"crossref","first-page":"6060","DOI":"10.1128\/AEM.00405-08","article-title":"Real-time PCR method for detection of pathogenic Yersinia enterocolitica in food","volume":"74","author":"S.T. Lambertz","year":"2008","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"pone.0228596.ref018","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1365-2672.2005.02616.x","article-title":"Development of real-time PCR and hybridization methods for detection and identification of thermophilic Campylobacter spp. in pig faecal samples","volume":"99","author":"A.N. Jensen","year":"2005","journal-title":"J Appl Microbiol"},{"issue":"4","key":"pone.0228596.ref019","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s10096-016-2858-7","article-title":"Evaluation of the BioFire FilmArray(R) GastrointestinalPanel in a Midwestern Academic Hospital","volume":"36","author":"C.N. Murphy","year":"2017","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"pone.0228596.ref020","article-title":"Clinical impact of a Multiplex Gastrointestinal PCR Panel in Patients with Acute Gastroenteritis","author":"R.J. Cybulski","year":"2018","journal-title":"Clin Infect Dis"},{"issue":"2","key":"pone.0228596.ref021","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.diagmicrobio.2015.01.007","article-title":"Multiplex gastrointestinal pathogen panels: implications for infection control","volume":"82","author":"K.H. Rand","year":"2015","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"Suppl 4","key":"pone.0228596.ref022","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1016\/j.cmi.2016.03.010","article-title":"European Society of Clinical Microbiology and Infectious Diseases: update of the diagnostic guidance document for Clostridium difficile infection","volume":"22","author":"M.J. Crobach","year":"2016","journal-title":"Clin Microbiol Infect"},{"issue":"7","key":"pone.0228596.ref023","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/cid\/ciy149","article-title":"Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)","volume":"66","author":"L.C. McDonald","year":"2018","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"4","key":"pone.0228596.ref024","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/cid\/ciy701","article-title":"Frequency of Positive Enzyme Immunoassay for Toxin in Stool of Asymptomatic Carriers of Clostridium difficile","volume":"68","author":"Y.K.N. Wong","year":"2019","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"10","key":"pone.0228596.ref025","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1128\/JCM.00382-15","article-title":"Point-Counterpoint: Large Multiplex PCR Panels Should Be First-Line Tests for Detection of Respiratory and Intestinal Pathogens","volume":"53","author":"P.C. Schreckenberger","year":"2015","journal-title":"J Clin Microbiol"},{"issue":"23","key":"pone.0228596.ref026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta21230","article-title":"Multiplex tests to identify gastrointestinal bacteria, viruses and parasites in people with suspected infectious gastroenteritis: a systematic review and economic analysis","volume":"21","author":"K. Freeman","year":"2017","journal-title":"Health Technol Assess"},{"key":"pone.0228596.ref027","unstructured":"PHE. UK Standards for Microbiology Investigations: Gastroenteritis and Diarrhoea: SMI S7 Issue 1. 2013 [cited 2018 September 17th]; Available from: www.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/344110\/S_7i1.pdf."},{"issue":"1","key":"pone.0228596.ref028","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4161\/gmic.2.1.14755","article-title":"A review of Dientamoeba fragilis carriage in humans: several reasons why this organism should be considered in the diagnosis of gastrointestinal illness","volume":"2","author":"J.L. Barratt","year":"2011","journal-title":"Gut Microbes"},{"issue":"1","key":"pone.0228596.ref029","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/JCM.01624-16","article-title":"Clinical Microbiology Laboratories' Adoption of Culture-Independent Diagnostic Tests Is a Threat to Foodborne-Disease Surveillance in the United States","volume":"55","author":"S. Shea","year":"2017","journal-title":"J Clin Microbiol"},{"issue":"3","key":"pone.0228596.ref030","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1128\/JCM.02674-14","article-title":"Multicenter evaluation of the BioFire FilmArray gastrointestinal panel for etiologic diagnosis of infectious gastroenteritis","volume":"53","author":"S.N. Buss","year":"2015","journal-title":"J Clin Microbiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0228596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T13:32:41Z","timestamp":1580995961000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0228596"}},"subtitle":[],"editor":[{"given":"Adriana","family":"Calderaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,2,6]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0228596","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,6]]}}}