{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:56:58Z","timestamp":1790888218719,"version":"4.1.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"the Ministry of Education, Culture, Sports, Science and Technology, Japan","doi-asserted-by":"crossref","award":["17K10768"],"award-info":[{"award-number":["17K10768"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0228954","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T13:31:26Z","timestamp":1580995886000},"page":"e0228954","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Factors related to white blood cell elevation in acute type A aortic dissection"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2108-3509","authenticated-orcid":true,"given":"Keito","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Mieno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daijiro","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Sezai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,2,6]]},"reference":[{"key":"pone.0228954.ref001","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/ncpcardio1417","article-title":"Observational study of mortality risk stratification by ischemic presentation in patients with acute type A aortic dissection: the Penn classification","volume":"6","author":"JG Augoustides","year":"2009","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"pone.0228954.ref002","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.amjcard.2013.11.017","article-title":"Utility of the Penn classification in predicting outcomes of surgery for acute type a aortic dissection","volume":"113","author":"N Kimura","year":"2014","journal-title":"Am J Cardiol"},{"key":"pone.0228954.ref003","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s11748-019-01072-z","article-title":"Malperfusion in type A aortic dissection: results of emergency central aortic repair","volume":"67","author":"K Kawahito","year":"2019","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"pone.0228954.ref004","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1016\/j.jacc.2015.04.030","article-title":"The Impact of pre-operative malperfusion on outcome in acute type A aortic dissection: results from the GERAADA registry","volume":"65","author":"M Czerny","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"pone.0228954.ref005","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.carpath.2005.08.006","article-title":"Takayasu aortitis with acute dissection and hemopericardium","volume":"14","author":"F Tavora","year":"2005","journal-title":"Cardiovasc Pathol"},{"key":"pone.0228954.ref006","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/RHU.0000000000000381","article-title":"Predictors of dissection in aortic aneurysms from giant cell arteritis","volume":"22","author":"TA Kermani","year":"2016","journal-title":"J Clin Rheumatol"},{"key":"pone.0228954.ref007","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/ejcts\/ezx095","article-title":"Gene expression profiling of acute type A aortic dissection combined with in vitro assessment","volume":"52","author":"N Kimura","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"pone.0228954.ref008","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1161\/CIRCRESAHA.116.304918","article-title":"Adventitial CXCL1\/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture","volume":"116","author":"A Anzai","year":"2015","journal-title":"Circ Res"},{"key":"pone.0228954.ref009","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3400\/avd.oa.19-00007","article-title":"STAT3 activation correlates with adventitial neutrophil infiltration in human aortic dissection","volume":"12","author":"S Yoshida","year":"2019","journal-title":"Ann Vasc Dis"},{"key":"pone.0228954.ref010","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijcard.2004.03.076","article-title":"Serum C-reactive protein elevation predicts poor clinical outcome in patients with distal type acute aortic dissection: association with the occurrence of oxygenation impairment","volume":"102","author":"Y Sugano","year":"2005","journal-title":"Inter J Cardiol"},{"key":"pone.0228954.ref011","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1161\/HYPERTENSIONAHA.109.143131","article-title":"Peak C-reactive protein level predicts long-term outcomes in type B acute aortic dissection","volume":"55","author":"K Sakakura","year":"2010","journal-title":"Hypertension"},{"key":"pone.0228954.ref012","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1536\/ihj.15-484","article-title":"Biomarkers Investigation for in-hospital death in patients with Stanford type A acute aortic dissection","volume":"57","author":"R Zhang","year":"2016","journal-title":"Int Heart J"},{"key":"pone.0228954.ref013","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/0267659115590625","article-title":"Neutrophil to lymphocyte ratio: a novel marker for predicting hospital mortality of patients with acute type A aortic dissection","volume":"32","author":"ME Kalkan","year":"2015","journal-title":"Perfusion"},{"key":"pone.0228954.ref014","doi-asserted-by":"crossref","first-page":"e1761","DOI":"10.1097\/MD.0000000000001761","article-title":"Impact of admission white blood cell count on short- and long-term mortality in patients with type A acute aortic dissection: an observational study","volume":"94","author":"X Fan","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"pone.0228954.ref015","doi-asserted-by":"crossref","first-page":"E119","DOI":"10.1532\/hsf.1736","article-title":"Prognostic value of neutrophil to lymphocyte ratio and risk factors for mortality in patients with Stanford type A aortic dissection","volume":"20","author":"K Oz","year":"2017","journal-title":"Heart Surg Forum"},{"key":"pone.0228954.ref016","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.7754\/Clin.Lab.2015.150216","article-title":"Increased neutrophil to lymphocyte ratio is associated with in-hospital mortality in patients with aortic dissection","volume":"61","author":"T Onuk","year":"2015","journal-title":"Clin Lab"},{"key":"pone.0228954.ref017","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1161\/CIRCULATIONAHA.108.833004","article-title":"Diagnosis of acute aortic dissection by D-dimer: the International Registry of Acute Aortic Dissection Substudy on Biomarkers (IRAD-Bio) experience","volume":"119","author":"T Suzuki","year":"2009","journal-title":"Circulation"},{"key":"pone.0228954.ref018","doi-asserted-by":"crossref","first-page":"e009144","DOI":"10.1161\/JAHA.118.009144","article-title":"Characteristics and treatment outcomes of acute type A aortic dissection with elevated D-dimer concentration","volume":"7","author":"R Itagaki","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"pone.0228954.ref019","doi-asserted-by":"crossref","first-page":"43957","DOI":"10.1038\/srep43957","article-title":"Diagnostic implication of fibrin degradation products and D-dimer in aortic dissection","volume":"7","author":"J Dong","year":"2017","journal-title":"Sci Rep"},{"issue":"2","key":"pone.0228954.ref020","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1016\/j.jtcvs.2014.08.008","article-title":"Reoperation for enlargement of the distal aorta after initial surgery for acute type A aortic dissection","volume":"149","author":"N Kimura","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"pone.0228954.ref021","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1161\/CIRCULATIONAHA.112.097097","article-title":"Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection","volume":"126","author":"T Kurihara","year":"2012","journal-title":"Circulation"},{"key":"pone.0228954.ref022","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.21037\/jtd.2018.03.48","article-title":"Inflammation is related to preoperative hypoxemia in patients with acute Stanford type A aortic dissection","volume":"10","author":"XZ Duan","year":"2018","journal-title":"J Thorac Dis"},{"key":"pone.0228954.ref023","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1172\/JCI38308","article-title":"An adventitial IL-6\/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice","volume":"119","author":"BC Tieu","year":"2009","journal-title":"J Clin Invest"},{"key":"pone.0228954.ref024","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.2169\/internalmedicine.49.3770","article-title":"Fibrinogen\/fibrin degradation products in acute aortic dissection","volume":"49","author":"K Nagaoka","year":"2010","journal-title":"Intern Med"},{"key":"pone.0228954.ref025","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1161\/ATVBAHA.110.213405","article-title":"Leukocytes and the natural history of deep vein thrombosis: current concepts and future directions","volume":"31","author":"P Saha","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"pone.0228954.ref026","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/ATVBAHA.110.216317","article-title":"Toll-like receptor 9 signaling is critical for early experimental deep vein thrombosis resolution","volume":"31","author":"PK Henke","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"pone.0228954.ref027","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.exger.2004.01.009","article-title":"Inflammatory mediators in the elderly","volume":"39","author":"KS Krabbe","year":"2004","journal-title":"Exp Gerontol"},{"key":"pone.0228954.ref028","first-page":"501","article-title":"Effects of aging on inflammation and hemostasis through the continuum of critical illness","volume":"2","author":"SS Kale","year":"2011","journal-title":"Aging Dis"},{"key":"pone.0228954.ref029","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nri3547","article-title":"Age-dependent dysregulation of innate immunity","volume":"13","author":"AC Shaw","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"pone.0228954.ref030","doi-asserted-by":"crossref","first-page":"e13852","DOI":"10.1371\/journal.pone.0013852","article-title":"The effects of age on inflammatory and coagulation-fibrinolysis response in patients hospitalized for pneumonia","volume":"5","author":"S Kale","year":"2010","journal-title":"PLoS One"},{"key":"pone.0228954.ref031","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1161\/CIRCULATIONAHA.109.879783","article-title":"Outcomes of patients with acute type a aortic intramural hematoma","volume":"120","author":"JK Song","year":"2009","journal-title":"Circulation"},{"key":"pone.0228954.ref032","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0735-1097(02)02005-3","article-title":"Acute type A aortic dissection in the elderly: clinical characteristics, management, and outcomes in the current era","volume":"40","author":"RH Mehta","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"pone.0228954.ref033","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/SLA.0b013e3182902cca","article-title":"Acute aortic dissection type A: age-related management and outcomes reported in the German Registry for Acute Aortic Dissection Type A (GERAADA) of over 2000 patients","volume":"259","author":"B Rylski","year":"2014","journal-title":"Ann Surg"},{"key":"pone.0228954.ref034","doi-asserted-by":"crossref","first-page":"132","DOI":"10.5455\/medarh.2017.71.132-136","article-title":"Effect of cigarette smoking on haematological parameters in healthy population","volume":"71","author":"M Malenica","year":"2017","journal-title":"Med Arch"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0228954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T13:31:36Z","timestamp":1580995896000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0228954"}},"subtitle":[],"editor":[{"given":"Andrea","family":"Ballotta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,2,6]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0228954","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,6]]}}}