{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:43:35Z","timestamp":1790505815072,"version":"4.1.0"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2019R1A2C1002375"],"award-info":[{"award-number":["2019R1A2C1002375"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"crossref","award":["6-2017-0170"],"award-info":[{"award-number":["6-2017-0170"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0228968","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T13:31:31Z","timestamp":1581600691000},"page":"e0228968","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Radiomics in predicting mutation status for thyroid cancer: A preliminary study using radiomics features for predicting BRAFV600E mutations in papillary thyroid carcinoma"],"prefix":"10.1371","volume":"15","author":[{"given":"Jung Hyun","family":"Yoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyunghwa","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jandee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jung","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian Youngjean","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Hyun","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6212-1495","authenticated-orcid":true,"given":"Jin Young","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"pone.0228968.ref001","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1002\/cncr.24416","article-title":"Increasing incidence of differentiated thyroid cancer in the United States, 1988\u20132005","volume":"115","author":"AY Chen","year":"2009","journal-title":"Cancer"},{"key":"pone.0228968.ref002","unstructured":"George JR, Henderson YC, Williams MD, Roberts DB, Hei H, Lai SY, et al. Association of TERT Promoter Mutation, But Not BRAF Mutation, With Increased Mortality in PTC."},{"key":"pone.0228968.ref003","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1001\/jamaoto.2014.3740","article-title":"The effects of race and ethnicity on thyroid cancer incidence","volume":"141","author":"A Magreni","year":"2015","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"pone.0228968.ref004","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1001\/jama.295.18.2164","article-title":"Increasing incidence of thyroid cancer in the United States, 1973\u20132002","volume":"295","author":"L Davies","year":"2006","journal-title":"JAMA"},{"key":"pone.0228968.ref005","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1158\/1055-9965.EPI-08-0960","article-title":"Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980\u20132005","volume":"18","author":"L Enewold","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"pone.0228968.ref006","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/cen.13017","article-title":"Clinicopathological significance of TERT promoter mutation in papillary thyroid carcinomas: a systematic review and meta-analysis","volume":"85","author":"DT Yin","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"key":"pone.0228968.ref007","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1158\/1055-9965.EPI-16-0520","article-title":"Cancer Incidence and Survival Trends by Subtype Using Data from the Surveillance Epidemiology and End Results Program, 1992\u20132013","volume":"26","author":"AM Noone","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"pone.0228968.ref008","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1001\/jama.2013.3190","article-title":"Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer","volume":"309","author":"M Xing","year":"2013","journal-title":"JAMA"},{"key":"pone.0228968.ref009","doi-asserted-by":"crossref","first-page":"193","DOI":"10.7150\/jca.2.193","article-title":"Thyroid cancer: burden of illness and management of disease","volume":"2","author":"RL Brown","year":"2011","journal-title":"J Cancer"},{"key":"pone.0228968.ref010","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0002-9343(94)90321-2","article-title":"Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer","volume":"97","author":"EL Mazzaferri","year":"1994","journal-title":"Am J Med"},{"key":"pone.0228968.ref011","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1200\/JCO.2014.55.5094","article-title":"BRAF V600E and TERT Promoter Mutations Cooperatively Identify the Most Aggressive Papillary Thyroid Cancer With Highest Recurrence","volume":"32","author":"MZ Xing","year":"2014","journal-title":"Journal of Clinical Oncology"},{"key":"pone.0228968.ref012","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1210\/jcem.82.11.4373","article-title":"Pathological tumor-node-metastasis (pTNM) staging for papillary and follicular thyroid carcinomas: a retrospective analysis of 700 patients","volume":"82","author":"KC Loh","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"pone.0228968.ref013","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000456576","article-title":"Molecular Markers Involved in Tumorigenesis of Thyroid Carcinoma: Focus on Aggressive Histotypes","volume":"150","author":"GC Penna","year":"2016","journal-title":"Cytogenet Genome Res"},{"key":"pone.0228968.ref014","unstructured":"Melo M, Gaspar da Rocha A, Batista R, Vinagre J, Martins MJ, Costa G, et al. TERT, BRAF, and NRAS in Primary Thyroid Cancer and Metastatic Disease."},{"key":"pone.0228968.ref015","article-title":"The association of the BRAF(V600E) mutation with prognostic factors and poor clinical outcome in papillary thyroid cancer: A Meta-Analysis","author":"TH Kim","year":"2011","journal-title":"Cancer"},{"key":"pone.0228968.ref016","author":"R Liu","journal-title":"Mortality Risk Stratification by Combining BRAF V600E and TERT Promoter Mutations in Papillary Thyroid Cancer: Genetic Duet of BRAF and TERT Promoter Mutations in Thyroid Cancer Mortality"},{"key":"pone.0228968.ref017","unstructured":"Gevaert O, Echegaray S, Khuong A, Hoang CD, Shrager JB, Jensen KC, et al. Predictive radiogenomics modeling of EGFR mutation status in lung cancer."},{"key":"pone.0228968.ref018","unstructured":"Braman NM, Etesami M, Prasanna P, Dubchuk C, Gilmore H, Tiwari P, et al. Intratumoral and peritumoral radiomics for the pretreatment prediction of pathological complete response to neoadjuvant chemotherapy based on breast DCE-MRI."},{"key":"pone.0228968.ref019","author":"B Zhang","journal-title":"Radiomics Features of Multiparametric MRI as Novel Prognostic Factors in Advanced Nasopharyngeal Carcinoma"},{"key":"pone.0228968.ref020","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1007\/s00330-017-5146-8","article-title":"Can CT-based radiomics signature predict KRAS\/NRAS\/BRAF mutations in colorectal cancer?","volume":"28","author":"L Yang","year":"2018","journal-title":"Eur Radiol"},{"key":"pone.0228968.ref021","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1210\/jc.2012-2104","article-title":"BRAF V600E mutation and its association with clinicopathological features of papillary thyroid cancer: a meta-analysis","volume":"97","author":"C Li","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"pone.0228968.ref022","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1038\/ncomms5006","article-title":"Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach","volume":"5","author":"HJ Aerts","year":"2014","journal-title":"Nat Commun"},{"key":"pone.0228968.ref023","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-19425-7","volume-title":"Regression Modeling Strategies With Applicators to Linear Models, Logistic regression, and Survival Analysis","author":"F Harell","year":"2015"},{"key":"pone.0228968.ref024","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1038\/s41598-018-37748-4","article-title":"Association Between Radiomics Signature and Disease-Free Survival in Conventional Papillary Thyroid Carcinoma","volume":"9","author":"VY Park","year":"2019","journal-title":"Sci Rep"},{"key":"pone.0228968.ref025","first-page":"1533033819831713","article-title":"Prediction of Lymph Node Metastasis in Patients With Papillary Thyroid Carcinoma: A Radiomics Method Based on Preoperative Ultrasound Images","volume":"18","author":"T Liu","year":"2019","journal-title":"Technol Cancer Res Treat"},{"key":"pone.0228968.ref026","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3349\/ymj.2004.45.5.818","article-title":"Mutations of the BRAF gene in papillary thyroid carcinoma in a Korean population","volume":"45","author":"KH Kim","year":"2004","journal-title":"Yonsei Med J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0228968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T13:31:42Z","timestamp":1581600702000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0228968"}},"subtitle":[],"editor":[{"given":"Jeeun","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,2,13]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0228968","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,13]]}}}