{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T09:13:59Z","timestamp":1773738839165,"version":"3.50.1"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["110886"],"award-info":[{"award-number":["110886"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner Fresenius Stiftung","doi-asserted-by":"crossref","award":["2013_A284"],"award-info":[{"award-number":["2013_A284"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["EXC 1003"],"award-info":[{"award-number":["EXC 1003"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0229271","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T18:30:54Z","timestamp":1582309854000},"page":"e0229271","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Radiation synergizes with antitumor activity of CD13-targeted tissue factor in a HT1080 xenograft model of human soft tissue sarcoma"],"prefix":"10.1371","volume":"15","author":[{"given":"Caroline","family":"Brand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkhard","family":"Greve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"B\u00f6lling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans T.","family":"Eich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Normann","family":"Willich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saliha","family":"Harrach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Hintelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Lenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf M.","family":"Mesters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schliemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3030-6567","authenticated-orcid":true,"given":"Wolfgang E.","family":"Berdel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schw\u00f6ppe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,2,21]]},"reference":[{"key":"pone.0229271.ref001","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"D Hanahan","year":"2011","journal-title":"Cell"},{"key":"pone.0229271.ref002","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/bjc.1982.16","article-title":"Endothelial cell proliferation as a novel approach to targeting tumour therapy","volume":"45","author":"J Denekamp","year":"1982","journal-title":"Br J Cancer"},{"key":"pone.0229271.ref003","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1126\/science.275.5299.547","article-title":"Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature","volume":"275","author":"X Huang","year":"1997","journal-title":"Science"},{"key":"pone.0229271.ref004","first-page":"722","article-title":"Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis","volume":"60","author":"R Pasqualini","year":"2000","journal-title":"Cancer Res"},{"key":"pone.0229271.ref005","first-page":"867","article-title":"Differential binding of drugs containing the NGR motif to CD13 isoforms in tumor vessels, epithelia, and myeloid cells","volume":"62","author":"F Curnis","year":"2002","journal-title":"Cancer Res"},{"key":"pone.0229271.ref006","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1349-7006.2010.01826.x","article-title":"Aminopeptidase N (CD13) as a target for cancer chemotherapy","volume":"102","author":"M Wickstr\u00f6m","year":"2011","journal-title":"Cancer Science"},{"key":"pone.0229271.ref007","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1073\/pnas.1120790109","article-title":"Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment","volume":"109","author":"L Guzman-Rojas","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"pone.0229271.ref008","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1158\/1078-0432.CCR-06-0338","article-title":"Clinical significance of aminopeptidase N in non-small cell lung cancer","volume":"12","author":"T Tokuhara","year":"2006","journal-title":"Clin Cancer Res"},{"key":"pone.0229271.ref009","first-page":"1503","article-title":"Clinical significance of aminopeptidase N\/CD13 expression in human pancreatic carcinoma","volume":"9","author":"N Ikeda","year":"2003","journal-title":"Clin Cancer Res"},{"key":"pone.0229271.ref010","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1053\/gast.2002.31095","article-title":"Aminopeptidase N is involved in cell motility and angiogenesis: its clinical significance in human colon cancer","volume":"122","author":"H Hashida","year":"2002","journal-title":"Gastroenterology"},{"key":"pone.0229271.ref011","doi-asserted-by":"crossref","first-page":"e0177146","DOI":"10.1371\/journal.pone.0177146","article-title":"Potential therapeutic impact of CD13 expression in non-small cell lung cancer","volume":"12","author":"LH Schmidt","year":"2017","journal-title":"PLoS One"},{"key":"pone.0229271.ref012","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1111\/j.1525-1438.2006.00657.x","article-title":"Expression of aminopeptidase N\/CD13 in human ovarian cancers","volume":"16","author":"P Surowiak","year":"2006","journal-title":"Int J Gynecol Cancer"},{"key":"pone.0229271.ref013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/157016308783769487","article-title":"Generation of fusion proteins for selective occlusion of tumor vessels","volume":"5","author":"T Kessler","year":"2008","journal-title":"Current Drug Discovery Technologies"},{"key":"pone.0229271.ref014","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.1182\/blood-2008-04-150318","article-title":"Infarction of tumor vessels by NGR-peptide-directed targeting of tissue factor: experimental results and first-in man experience","volume":"113","author":"R Bieker","year":"2009","journal-title":"Blood"},{"issue":"Suppl 2","key":"pone.0229271.ref015","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1016\/S0049-3848(10)70033-5","article-title":"Tissue-factor fusion proteins induce occlusion of tumor vessels","volume":"125","author":"C Schw\u00f6ppe","year":"2010","journal-title":"Thrombosis Research"},{"key":"pone.0229271.ref016","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1021\/jm301669z","article-title":"Anticancer therapy by tumor vessel infarction with polyethylene glycol conjugated retargeted tissue factor","volume":"56","author":"C Schw\u00f6ppe","year":"2013","journal-title":"J Med Chem"},{"key":"pone.0229271.ref017","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10456-013-9391-4","article-title":"Non-invasive monitoring of tumor-vessel infarction by retargeted truncated tissue factor tTF-NGR using multi-modal imaging","volume":"17","author":"T Persigehl","year":"2014","journal-title":"Angiogenesis"},{"key":"pone.0229271.ref018","doi-asserted-by":"crossref","first-page":"82458","DOI":"10.18632\/oncotarget.12559","article-title":"Combinatorial effects of doxorubicin and retargeted tissue factor by intratumoral entrapment of doxorubicin and proapoptotic increase of tumor vascular infarction","volume":"7","author":"J Stucke-Ring","year":"2016","journal-title":"Oncotarget"},{"key":"pone.0229271.ref019","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1016\/S0021-9258(18)52223-7","article-title":"Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function","volume":"266","author":"W Ruf","year":"1991","journal-title":"J Biol Chem"},{"key":"pone.0229271.ref020","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1055\/s-2007-999004","article-title":"Physiopathological significance of catalytic phospholipids in the generation of thrombin","volume":"22","author":"J Dachary-Prigent","year":"1996","journal-title":"Semin Thromb Hemost"},{"key":"pone.0229271.ref021","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1021\/bi00362a005","article-title":"Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine","volume":"25","author":"R Bach","year":"1986","journal-title":"Biochemistry"},{"key":"pone.0229271.ref022","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1182\/blood.V89.7.2429","article-title":"Apoptotic vascular endothelial cells become procoagulant","volume":"89","author":"T Bombeli","year":"1997","journal-title":"Blood"},{"key":"pone.0229271.ref023","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1073\/pnas.95.11.6349","article-title":"In vivo detection and imaging of phosphatidylserine expression during programmed cell death","volume":"95","author":"FG Blankenberg","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"pone.0229271.ref024","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1007\/s11307-012-0551-5","article-title":"Longitudinal PET imaging of doxorubicin-induced cell death with 18F-annexin V","volume":"14","author":"S Hu","year":"2012","journal-title":"Mol Imaging Biol"},{"key":"pone.0229271.ref025","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1538-7836.2009.03300.x","article-title":"Chemotherapeutic agents doxorubicin and epirubicin induce procoagulant phenotype on endothelial cells and blood monocytes","volume":"7","author":"LL Swystun","year":"2009","journal-title":"J Thromb Haemost"},{"key":"pone.0229271.ref026","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/MBC.0000000000000145","article-title":"Lung cancer chemotherapy agents increase procoagulant activity via protein disulfide isomerase-dependent tissue factor decryption","volume":"26","author":"Z Lysov","year":"2015","journal-title":"Blood Coagul Fibrinolysis"},{"key":"pone.0229271.ref027","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.7863\/ultra.34.7.1227","article-title":"Low-energy ultrasound treatment improves regional tumor vessel infarction by retargeted tissue factor","volume":"34","author":"C Brand","year":"2015","journal-title":"J Ultrasound Med"},{"key":"pone.0229271.ref028","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"P Carmeliet","year":"2011","journal-title":"Nature"},{"key":"pone.0229271.ref029","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1158\/1078-0432.CCR-07-0793","article-title":"Radiation-enhanced vascular targeting of human lung cancers in mice with a monoclonal antibody that binds anionic phospholipids","volume":"13","author":"J He","year":"2007","journal-title":"Clin Cancer Res"},{"key":"pone.0229271.ref030","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2307\/3575872","article-title":"Experimental chemotherapy of radiation injury with synthetic lysophospholipid analogs in mice","volume":"94","author":"WE Berdel","year":"1983","journal-title":"Radiation Res"},{"key":"pone.0229271.ref031","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1182\/blood.V97.3.652","article-title":"CD13\/APN is activated by angiogenic signals and is essential for capillary tube formation","volume":"97","author":"SV Bhagwat","year":"2001","journal-title":"Blood"},{"key":"pone.0229271.ref032","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.apradiso.2013.12.035","article-title":"Radiolabeled NGR phage display peptide sequence for tumor targeting","volume":"86","author":"BL Faintuch","year":"2014","journal-title":"Appl Radiation Isotopes"},{"key":"pone.0229271.ref033","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejps.2015.01.002","article-title":"In vivo imaging of aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer 68Ga-NOTA-c(NGR)","volume":"69","author":"G Mate","year":"2015","journal-title":"Eur J Pharm Sci"},{"key":"pone.0229271.ref034","doi-asserted-by":"crossref","first-page":"7676","DOI":"10.1158\/0008-5472.CAN-08-0689","article-title":"Quantitative molecular magnetic resonance imaging of tumor angiogenesis using cNGR-labeled paramagnetic quantum dots","volume":"68","author":"M Oostendorp","year":"2008","journal-title":"Cancer Res"},{"key":"pone.0229271.ref035","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s40259-013-0048-z","article-title":"Peptide-mediated targeting of cytokines to tumor vasculature: the NGR-hTNF example","volume":"27","author":"A Corti","year":"2013","journal-title":"BioDrugs"},{"key":"pone.0229271.ref036","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1200\/JCO.2009.27.3649","article-title":"Phase II study of asparagine-glycine-arginine-human tumor necrosis factor alpha, a selective vascular targeting agent, in previously treated patients with malignant pleural mesothelioma","volume":"28","author":"V Gregorc","year":"2010","journal-title":"J Clin Oncol"},{"key":"pone.0229271.ref037","first-page":"blood.2019000633","article-title":"R-CHOP preceded by blood-brain barrier permeabilization with engeneered tumor necrosis factor-alpha in primary CNS lymphoma","author":"AJM Ferreri","year":"2019","journal-title":"Blood"},{"key":"pone.0229271.ref038","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/med.20044","article-title":"Aminopeptidase-N\/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects","volume":"26","author":"B Bauvois","year":"2006","journal-title":"Medicinal Res Rev"},{"key":"pone.0229271.ref039","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/jnci\/95.8.605","article-title":"Randomized double-blind placebo controlled trial of bestatin in patients with resected stage I squamous-cell cancer","volume":"95","author":"Y Ichinose","year":"2003","journal-title":"J Natl Cancer Inst"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0229271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T12:04:44Z","timestamp":1614513884000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0229271"}},"subtitle":[],"editor":[{"given":"Salvatore V.","family":"Pizzo","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,2,21]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0229271","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,21]]}}}