{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T11:46:11Z","timestamp":1777203971651,"version":"3.51.4"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Uniwersytet Medyczny w Bialymstoku","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0229462","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T18:25:42Z","timestamp":1583173542000},"page":"e0229462","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ageing-related changes in the levels of \u03b2-catenin, CacyBP\/SIP, galectin-3 and immunoproteasome subunit LMP7 in the heart of men"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3980-5183","authenticated-orcid":true,"given":"Irena","family":"Kasacka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u017baneta","family":"Piotrowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Niezgoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicja","family":"Lewandowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"\u0141ebkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"pone.0229462.ref001","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3389\/fphys.2017.00341","article-title":"Cardiac Remodeling from Middle Age to Senescence","volume":"8","author":"MJ M\u00f6tt\u00f6nen","year":"2017","journal-title":"Front Physiol"},{"key":"pone.0229462.ref002","doi-asserted-by":"crossref","first-page":"32","DOI":"10.21037\/cdt.2017.03.06","article-title":"Global progress in prevention of cardiovascular disease","volume":"7","author":"S Mendis","year":"2017","journal-title":"Cardiovasc Diagn Ther"},{"key":"pone.0229462.ref003","doi-asserted-by":"crossref","first-page":"30979","DOI":"10.1074\/jbc.M603916200","article-title":"Beta-catenin overexpression reduces myocardial infarct size through differential effects on cardiomyocytes and cardiac fibroblasts","volume":"281","author":"JY Hahn","year":"2006","journal-title":"J Biol Chem"},{"key":"pone.0229462.ref004","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.devcel.2007.06.006","article-title":"Wnt\/beta-catenin signaling and cardiogenesis: timing does matter","volume":"13","author":"E Tzahor","year":"2007","journal-title":"Dev Cell"},{"key":"pone.0229462.ref005","doi-asserted-by":"crossref","first-page":"195","DOI":"10.5603\/CJ.a2016.0087","article-title":"Enhancement of beta-catenin in cardiomyocytes suppresses survival protein expression but promotes apoptosis and fibrosis","volume":"24","author":"JC Lin","year":"2017","journal-title":"Cardiol J"},{"key":"pone.0229462.ref006","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1172\/JCI7798","article-title":"Wnt-1 regulation of connexin43 in cardiac myocytes","volume":"105","author":"Z Ai","year":"2000","journal-title":"J Clin Invest"},{"key":"pone.0229462.ref007","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/nature09249","article-title":"Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel","volume":"466","author":"D Pan\u00e1kov\u00e1","year":"2010","journal-title":"Nature"},{"key":"pone.0229462.ref008","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1152\/ajpheart.00653.2013","article-title":"Rapid electrical stimulation causes alterations in cardiac intercellular junction proteins of cardiomyocytes","volume":"306","author":"T Nakashima","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"pone.0229462.ref009","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1113\/jphysiol.2014.285551","article-title":"Wnt signalling suppresses voltage-dependent Na\u207a channel expression in postnatal rat cardiomyocytes","volume":"593","author":"W Liang","year":"2015","journal-title":"J Physiol"},{"key":"pone.0229462.ref010","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1073\/pnas.0835895100","article-title":"Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth","volume":"100","author":"S Haq","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"pone.0229462.ref011","doi-asserted-by":"crossref","first-page":"19762","DOI":"10.1073\/pnas.0808393105","article-title":"Beta-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation","volume":"105","author":"LC Zelaray\u00e1n","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"pone.0229462.ref012","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1016\/j.bbadis.2018.07.035","article-title":"A novel porcupine inhibitor blocks WNT pathways and attenuates cardiac hypertrophy","volume":"1864","author":"J Jiang","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"pone.0229462.ref013","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1177\/0267659118787143","article-title":"GSK-3\u03b2 inhibition confers cardioprotection associated with the restoration of mitochondrial function and suppression of endoplasmic reticulum stress in sevoflurane preconditioned rats following ischemia\/reperfusion injury","volume":"33","author":"Y Wang","year":"2018","journal-title":"Perfusion"},{"key":"pone.0229462.ref014","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0092-8674(02)00685-2","article-title":"Control of beta-catenin phosphorylation\/degradation by a dual-kinase mechanism","volume":"108","author":"C Liu","year":"2002","journal-title":"Cell"},{"issue":"9","key":"pone.0229462.ref015","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1101\/gad.230302","article-title":"Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway","volume":"16","author":"S Amit","year":"2002","journal-title":"Genes Dev"},{"key":"pone.0229462.ref016","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bbagen.2015.10.012","article-title":"CacyBP\/SIP-Structure and variety of functions","volume":"1860","author":"AM Topolska-Wo\u015b","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"pone.0229462.ref017","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/jcb.20710","article-title":"Calcyclin binding protein promotes DNA synthesis and differentiation in rat neonatal cardiomyocytes","volume":"98","author":"KW Au","year":"2006","journal-title":"J Cell Biochem"},{"key":"pone.0229462.ref018","article-title":"Comparative evaluation of CacyBP\/SIP protein, \u03b2-catenin, and immunoproteasome subunit LMP7 in the heart of rats with hypertension of different etiology","volume":"24","author":"I Kasacka","year":"2018","journal-title":"Exp Biol Med (Maywood)"},{"key":"pone.0229462.ref019","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bbagen.2005.12.020","article-title":"Galectin-3: an open-ended story. Galectin-3: an open-ended story","volume":"1760","author":"J Dumic","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"pone.0229462.ref020","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1158\/0008-5472.CAN-05-0104","article-title":"Implication of galectin-3 in Wnt signaling","volume":"65","author":"T Shimura","year":"2005","journal-title":"Cancer Res"},{"key":"pone.0229462.ref021","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1158\/0008-5472.CAN-08-4153","article-title":"Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity","volume":"69","author":"S Song","year":"2009","journal-title":"Cancer Res"},{"key":"pone.0229462.ref022","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/1440-1681.13048","article-title":"The role of galectin-3 in heart failure and cardiovascular disease","volume":"46","author":"X Zhong","year":"2019","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"pone.0229462.ref023","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/AC.70.3.3080637","article-title":"Galectin-3 in heart failure pathology-\"another brick in the wall\"?","volume":"70","author":"RI Lala","year":"2015","journal-title":"Acta Cardiol"},{"key":"pone.0229462.ref024","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3909\/ricm0624","article-title":"Galectin-3: a novel blood test for the evaluation and management of patients with heart failure","volume":"12","author":"PA McCullough","year":"2011","journal-title":"Rev Cardiovasc Med"},{"key":"pone.0229462.ref025","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jacc.2012.04.053","article-title":"Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community","volume":"60","author":"JE Ho","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"pone.0229462.ref026","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1042\/CS20171389","article-title":"Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage","volume":"132","author":"J Ibarrola","year":"2018","journal-title":"Clin Sci (Lond.)"},{"key":"pone.0229462.ref027","first-page":"4106","article-title":"Therapeutic inhibition of galectin-3 improves cardiomyocyte apoptosis and survival during heart failure","volume":"17","author":"X Li","year":"2018","journal-title":"Mol Med Rep"},{"key":"pone.0229462.ref028","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S1568-1637(03)00030-8","article-title":"Immunoproteasomes and immunosenescence","volume":"2","author":"M Mishto","year":"2003","journal-title":"Ageing Res Rev"},{"key":"pone.0229462.ref029","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.mad.2008.04.007","article-title":"Aging and dietary restriction effects on ubiquitination, sumoylation, and the proteasome in the heart","volume":"129","author":"F Li","year":"2008","journal-title":"Mech Ageing Dev"},{"key":"pone.0229462.ref030","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000113503","article-title":"The aging cardiomyocyte: a mini-review","volume":"54","author":"D Bernhard","year":"2008","journal-title":"Gerontology"},{"key":"pone.0229462.ref031","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.abb.2003.10.010","article-title":"Altered proteasome function and subunit composition in aged muscle","volume":"421","author":"AD Husom","year":"2004","journal-title":"Arch Biochem Biophys"},{"key":"pone.0229462.ref032","doi-asserted-by":"crossref","first-page":"E106","DOI":"10.3390\/ijms19010106","article-title":"Proteasome and Organs Ischemia-Reperfusion Injury","volume":"19","author":"J Oliva","year":"2017","journal-title":"Int J Mol Sci"},{"key":"pone.0229462.ref033","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1006\/abbi.2001.2663","article-title":"Age-dependent declines in proteasome activity in the heart","volume":"397","author":"AL Bulteau","year":"2002","journal-title":"Arch Biochem Biophy"},{"key":"pone.0229462.ref034","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.exger.2005.10.013","article-title":"Age-associated shifts in cardiac gene transcription and transcriptional responses to ischemic stress","volume":"41","author":"KJ Ashton","year":"2006","journal-title":"Exp Gerontol"},{"key":"pone.0229462.ref035","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jjcc.2015.10.001","article-title":"Remodeling of the intercalated disc related to aging in the mouse heart","volume":"68","author":"TA Bonda","year":"2016","journal-title":"J Cardiol"},{"key":"pone.0229462.ref036","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3109\/10520299109109968","article-title":"The taming of immunohistochemistry: the new era of quality control","volume":"66","author":"GE Herman","year":"1991","journal-title":"Biotech Histochem"},{"key":"pone.0229462.ref037","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1177\/002215540004800903","article-title":"Calcyclin (S100A6) binding protein (CacyBP) is highly expressed in brain neurons","volume":"48","author":"B Jastrzebska","year":"2000","journal-title":"J Histochem Cytochem"},{"issue":"2","key":"pone.0229462.ref038","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.ijcard.2012.10.046","article-title":"Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations","volume":"168","author":"JA Finegold","year":"2013","journal-title":"Int J Cardiol"},{"key":"pone.0229462.ref039","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/0735-1097(95)00282-8","article-title":"Gender differences and aging: effects on the human heart","volume":"26","author":"G Olivetti","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"pone.0229462.ref040","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.yjmcc.2004.05.025","article-title":"Statins inhibit reoxygenation-induced cardiomyocyte apoptosis: role for glycogen synthase kinase 3beta and transcription factor beta-catenin","volume":"37","author":"MW Bergmann","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"pone.0229462.ref041","first-page":"479","article-title":"Involvement of galectin-3 in cadmium-induced cardiac toxicity","volume":"11","author":"N Yaz\u0131han","year":"2011","journal-title":"Anadolu Kardiyol Derg"},{"key":"pone.0229462.ref042","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3389\/fphar.2016.00495","article-title":"Doxazosin Stimulates Galectin-3 Expression and Collagen Synthesis in HL-1 Cardiomyocytes Independent of Protein Kinase C Pathway","volume":"7","author":"X Qian","year":"2016","journal-title":"Front Pharmacol"},{"key":"pone.0229462.ref043","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00395-010-0101-8","article-title":"Stabilised beta-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death","volume":"105","author":"A Hirschy","year":"2010","journal-title":"Basic Res Cardiol"},{"key":"pone.0229462.ref044","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1152\/ajpheart.00747.2008","article-title":"N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion\/growth-regulatory lectin","volume":"296","author":"YH Liu","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"pone.0229462.ref045","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1161\/01.CIR.0000147181.65298.4D","article-title":"Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction","volume":"110","author":"UC Sharma","year":"2004","journal-title":"Circulation"},{"key":"pone.0229462.ref046","doi-asserted-by":"crossref","first-page":"593","DOI":"10.7150\/thno.22196","article-title":"Galectin-3 Activation and Inhibition in Heart Failure and Cardiovascular Disease: An Update","volume":"8","author":"N Suthahar","year":"2018","journal-title":"Theranostics"},{"key":"pone.0229462.ref047","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1096\/fj.14-264770","article-title":"Dimerization and phosphatase activity of calcyclin-binding protein\/Siah-1 interacting protein: the influence of oxidative stress","volume":"29","author":"AM Topolska-Wo\u015b","year":"2015","journal-title":"FASEB J"},{"key":"pone.0229462.ref048","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.biocel.2018.04.012","article-title":"CacyBP\/SIP, a Hsp90 binding chaperone, in cellular stress response","volume":"99","author":"A G\u00f3ral","year":"2018","journal-title":"Int J Biochem Cell Biol"},{"key":"pone.0229462.ref049","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00062752-200105000-00001","article-title":"Aging and proinflammatory cytokines","volume":"8","author":"H Bruunsgaard","year":"2001","journal-title":"Curr Opin Hematol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0229462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T05:58:25Z","timestamp":1665986305000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0229462"}},"subtitle":[],"editor":[{"given":"Roger","family":"Chammas","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,3,2]]},"references-count":49,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0229462","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,2]]}}}