{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:42:07Z","timestamp":1785156127312,"version":"3.55.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0229597","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T14:08:05Z","timestamp":1583244485000},"page":"e0229597","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Preoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of Vater cancer"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1391-048X","authenticated-orcid":true,"given":"Young Jin","family":"Yoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Moo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munseok","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Yoon","family":"Rho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Kyung","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Jung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1692-6126","authenticated-orcid":true,"given":"Eun Wha","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4280-8131","authenticated-orcid":true,"given":"Jin Ae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"issue":"7","key":"pone.0229597.ref001","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/jso.21374","article-title":"Cancers of the ampulla of vater: demographics, morphology, and survival based on 5,625 cases from the SEER program","volume":"100","author":"J Albores-Saavedra","year":"2009","journal-title":"J Surg Oncol"},{"key":"pone.0229597.ref002","first-page":"A128","article-title":"Staging of ampullary carcinoma by endoscopic ultrasonography","volume":"301","author":"L. Palazzo","year":"1998","journal-title":"Endoscopy"},{"issue":"5","key":"pone.0229597.ref003","first-page":"526","article-title":"Tumor of the Ampulla of Vater: Experience With Local or Radical Resection in 171 Consecutively Treated Patients","volume":"134","author":"HG Beger","year":"1999","journal-title":"JAMA Surgery"},{"issue":"2","key":"pone.0229597.ref004","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1177\/145749691110000205","article-title":"Surgical outcomes and prognostic factors for ampulla of Vater cancer","volume":"100","author":"SB Choi","year":"2011","journal-title":"Scand J Surg"},{"issue":"1","key":"pone.0229597.ref005","first-page":"225","article-title":"Prognostic Factors and Survival of Patients with Carcinoma of the Ampulla of Vater after Pancreaticoduodenectomy","volume":"18","author":"S Junrungsee","year":"2017","journal-title":"Asian Pac J Cancer Prev"},{"issue":"3_suppl","key":"pone.0229597.ref006","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1200\/jco.2015.33.3_suppl.270","article-title":"Prognostic factor of carcinoma of the ampulla of vater after surgery","volume":"33","author":"S Tomiyasu","year":"2015","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"pone.0229597.ref007","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.pan.2017.01.007","article-title":"The histopathologic type predicts survival of patients with ampullary carcinoma after resection: A meta-analysis","volume":"17","author":"Y Zhou","year":"2017","journal-title":"Pancreatology"},{"issue":"1","key":"pone.0229597.ref008","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/MPA.0000000000001194","article-title":"Perineural Invasion is a Strong Prognostic Moderator in Ampulla of Vater Carcinoma: A Meta-analysis","volume":"48","author":"C Luchini","year":"2019","journal-title":"Pancreas"},{"issue":"10","key":"pone.0229597.ref009","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1097\/PAS.0b013e3181f0b05a","article-title":"Tumor budding as a strong prognostic indicator in invasive ampullary adenocarcinomas","volume":"34","author":"N Ohike","year":"2010","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"pone.0229597.ref010","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/MEG.0000000000000520","article-title":"Extranodal extension in N1-adenocarcinoma of the pancreas and papilla of Vater: a systematic review and meta-analysis of its prognostic significance","volume":"28","author":"C Luchini","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"9","key":"pone.0229597.ref011","first-page":"1001","article-title":"[Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients]","volume":"85","author":"T Onodera","year":"1984","journal-title":"Nihon Geka Gakkai zasshi"},{"issue":"9","key":"pone.0229597.ref012","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1007\/s00432-014-1714-3","article-title":"The prognostic significance of the prognostic nutritional index in cancer: a systematic review and meta-analysis","volume":"140","author":"K Sun","year":"2014","journal-title":"J Cancer Res Clin Oncol"},{"issue":"8","key":"pone.0229597.ref013","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1245\/s10434-013-2926-5","article-title":"The prognostic nutritional index predicts long-term outcomes of gastric cancer patients independent of tumor stage","volume":"20","author":"K Migita","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"5","key":"pone.0229597.ref014","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1007\/s13277-014-2973-y","article-title":"The prognostic nutritional index (PNI) predicts overall survival of small-cell lung cancer patients","volume":"36","author":"S Hong","year":"2015","journal-title":"Tumour Biol"},{"issue":"9","key":"pone.0229597.ref015","doi-asserted-by":"crossref","first-page":"e0136897","DOI":"10.1371\/journal.pone.0136897","article-title":"The Significance of the Prognostic Nutritional Index in Patients with Completely Resected Non-Small Cell Lung Cancer","volume":"10","author":"S Mori","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"pone.0229597.ref016","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/bjs.7305","article-title":"Nutritional predictors of postoperative outcome in pancreatic cancer","volume":"98","author":"M Kanda","year":"2011","journal-title":"Br J Surg"},{"issue":"11","key":"pone.0229597.ref017","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.ejso.2015.07.022","article-title":"Prognostic nutritional index predicts survival and correlates with systemic inflammatory response in advanced pancreatic cancer","volume":"41","author":"Y Geng","year":"2015","journal-title":"Eur J Surg Oncol"},{"issue":"11","key":"pone.0229597.ref018","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1007\/s00268-013-2156-9","article-title":"Prognostic nutritional index predicts postoperative outcome in colorectal cancer","volume":"37","author":"Y Mohri","year":"2013","journal-title":"World J Surg"},{"issue":"8","key":"pone.0229597.ref019","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/bjc.2012.92","article-title":"A novel, externally validated inflammation-based prognostic algorithm in hepatocellular carcinoma: the prognostic nutritional index (PNI)","volume":"106","author":"DJ Pinato","year":"2012","journal-title":"Br J Cancer"},{"issue":"6","key":"pone.0229597.ref020","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s00268-015-2982-z","article-title":"Preoperative neutrophil to lymphocyte ratio and prognostic nutritional index predict overall survival after hepatectomy for hepatocellular carcinoma","volume":"39","author":"Y Okamura","year":"2015","journal-title":"World J Surg"},{"issue":"13","key":"pone.0229597.ref021","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1245\/s10434-015-4516-1","article-title":"Prognostic Nutritional Index (PNI) Predicts Tumor Recurrence of Very Early\/Early Stage Hepatocellular Carcinoma After Surgical Resection","volume":"22","author":"AW Chan","year":"2015","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"pone.0229597.ref022","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/ejso.2002.1257","article-title":"Correlation of pre-operative nutritional condition with post-operative complications in surgical treatment for oesophageal carcinoma","volume":"28","author":"T Nozoe","year":"2002","journal-title":"Eur J Surg Oncol"},{"issue":"2","key":"pone.0229597.ref023","doi-asserted-by":"crossref","first-page":"68 e1","DOI":"10.1016\/j.urolonc.2014.08.005","article-title":"The preoperative prognostic nutritional index is an independent predictor of survival in patients with renal cell carcinoma","volume":"33","author":"SL Hofbauer","year":"2015","journal-title":"Urol Oncol"},{"issue":"5","key":"pone.0229597.ref024","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s11605-012-1859-9","article-title":"Serum CA19-9 is a Significant Predictor among Preoperative Parameters for Early Recurrence after Resection of Pancreatic Adenocarcinoma","volume":"16","author":"T Sugiura","year":"2012","journal-title":"Journal of Gastrointestinal Surgery"},{"issue":"3","key":"pone.0229597.ref025","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.amjsurg.2008.12.031","article-title":"CA19-9 serum levels in obstructive jaundice: clinical value in benign and malignant conditions","volume":"198","author":"D Marrelli","year":"2009","journal-title":"The American Journal of Surgery"},{"issue":"1","key":"pone.0229597.ref026","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jss.2006.10.007","article-title":"The Use of Adjusted Preoperative CA 19\u20139 to Predict the Recurrence of Resectable Pancreatic Cancer","volume":"140","author":"CM Kang","year":"2007","journal-title":"Journal of Surgical Research"},{"issue":"2","key":"pone.0229597.ref027","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/00000658-199908000-00002","article-title":"Preoperative biliary drainage and surgical outcome","volume":"230","author":"KD Lillemoe","year":"1999","journal-title":"Annals of surgery"},{"key":"pone.0229597.ref028","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12893-015-0019-z","article-title":"Long-term prognosis of surgical treatment for early ampullary cancers and implications for local ampullectomy","volume":"15","author":"J Song","year":"2015","journal-title":"BMC surgery"},{"issue":"2","key":"pone.0229597.ref029","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"D Dindo","year":"2004","journal-title":"Ann Surg"},{"issue":"1","key":"pone.0229597.ref030","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.surg.2005.05.001","article-title":"Postoperative pancreatic fistula: An international study group (ISGPF) definition","volume":"138","author":"C Bassi","year":"2005","journal-title":"Surgery"},{"issue":"6","key":"pone.0229597.ref031","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.rec.2011.01.017","article-title":"Regression Modeling Strategies","volume":"64","author":"E N\u00fa\u00f1ez","year":"2011","journal-title":"Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"},{"issue":"6","key":"pone.0229597.ref032","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/bjc.1994.192","article-title":"Statistical aspects of prognostic factor studies in oncology","volume":"69","author":"R Simon","year":"1994","journal-title":"Br J Cancer"},{"issue":"1","key":"pone.0229597.ref033","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/0272989X0102100106","article-title":"Prognostic modeling with logistic regression analysis: in search of a sensible strategy in small data sets","volume":"21","author":"EW Steyerberg","year":"2001","journal-title":"Medical decision making: an international journal of the Society for Medical Decision Making"},{"issue":"10","key":"pone.0229597.ref034","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1002\/sim.6428","article-title":"Tests of calibration and goodness-of-fit in the survival setting","volume":"34","author":"OV Demler","year":"2015","journal-title":"Statistics in medicine"},{"key":"pone.0229597.ref035","unstructured":"Meyers J, Mandrekar J, editors. Cutpoint Determination Methods in Survival Analysis using SAS\u00ae: Updated% FINDCUT macro. Proc SAS Glob Forum; 2015."},{"key":"pone.0229597.ref036","unstructured":"Mandrekar J, Mandrekar S, Cha S, editors. Cutpoint determination methods in survival analysis using SAS\u00ae. Proceedings of the 28th SAS Users Group International Conference (SUGI); 2003."},{"key":"pone.0229597.ref037","first-page":"27","article-title":"Discretizing a continuous covariate in survival studies","volume":"23","author":"JP Klein","year":"2003"},{"issue":"2","key":"pone.0229597.ref038","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.cmpb.2014.11.009","article-title":"PSHREG: A SAS macro for proportional and nonproportional subdistribution hazards regression","volume":"118","author":"M Kohl","year":"2015","journal-title":"Computer Methods and Programs in Biomedicine"},{"issue":"7","key":"pone.0229597.ref039","first-page":"825","article-title":"Inflammation\u2013nutrition score predicts prognosis of patients with resectable hepatocellular carcinoma","volume":"24","author":"X-C Ni","year":"2019"},{"issue":"15","key":"pone.0229597.ref040","doi-asserted-by":"crossref","first-page":"e6610","DOI":"10.1097\/MD.0000000000006610","article-title":"Baseline serum albumin and other common clinical markers are prognostic factors in colorectal carcinoma: A retrospective cohort study","volume":"96","author":"S Gonz\u00e1lez-Trejo","year":"2017","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"pone.0229597.ref041","first-page":"799","article-title":"The value of the systematic inflammation-based Glasgow Prognostic Score in patients with gastric cancer: A literature review","volume":"10","author":"Y Gao","year":"2014"},{"issue":"9","key":"pone.0229597.ref042","first-page":"5473","article-title":"Prognostic significance of basic laboratory methods in non-small-cell-lung cancer","volume":"14","author":"V Kaya","year":"2013","journal-title":"Yalcin AYJAPJCP."},{"issue":"3","key":"pone.0229597.ref043","first-page":"384","article-title":"Prognostic importance of serum CRP, prealbumin, and transferrin levels in patients with advanced stage esophageal cancer","volume":"19","author":"Y Ayd\u0131n","year":"2011"},{"issue":"1","key":"pone.0229597.ref044","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1475-2891-9-69","article-title":"Pretreatment serum albumin as a predictor of cancer survival: A systematic review of the epidemiological literature","volume":"9","author":"D Gupta","year":"2010","journal-title":"Nutrition Journal"},{"issue":"10","key":"pone.0229597.ref045","first-page":"2393","article-title":"Is Hypoalbuminemia an Independent Prognostic Factor in Patients with Gastric Cancer?","volume":"34","author":"ABC Crumley","year":"2010"},{"issue":"3","key":"pone.0229597.ref046","first-page":"687","article-title":"Serum Prealbumin, Retinol-Binding Protein, Transferrin, and Albumin Levels in Patients With Large Bowel Cancer2","volume":"61","author":"G Milano","year":"1978","journal-title":"JNCI: Journal of the National Cancer Institute"},{"issue":"11","key":"pone.0229597.ref047","first-page":"2688","volume":"37","author":"Y Mohri","year":"2013","journal-title":"Prognostic Nutritional Index Predicts Postoperative Outcome in Colorectal Cancer"},{"issue":"2","key":"pone.0229597.ref048","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cgh.2011.08.016","article-title":"Prevalence and Mechanisms of Malnutrition in Patients With Advanced Liver Disease, and Nutrition Management Strategies","volume":"10","author":"K Cheung","year":"2012","journal-title":"Clinical Gastroenterology and Hepatology"},{"issue":"1","key":"pone.0229597.ref049","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12957-016-0920-7","article-title":"Impact of prognostic nutritional index on long-term outcomes in patients with breast cancer","volume":"14","author":"T Mohri","year":"2016","journal-title":"World Journal of Surgical Oncology"},{"key":"pone.0229597.ref050","first-page":"1","article-title":"Significance of the prognostic nutritional index in patients with esophageal squamous cell carcinoma","volume":"10","author":"J-F Feng","year":"2014","journal-title":"Ther Clin Risk Manag"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0229597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T14:08:31Z","timestamp":1583244511000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0229597"}},"subtitle":[],"editor":[{"given":"Sevtap","family":"Savas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,3,3]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0229597","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,3]]}}}