{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:30:54Z","timestamp":1788582654824,"version":"build-2803163510"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0229710","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T13:29:15Z","timestamp":1582723755000},"page":"e0229710","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Improved health care utilization and costs in transplanted versus non-transplanted adults with sickle cell disease"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-4194","authenticated-orcid":true,"given":"Santosh L.","family":"Saraf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Ghimire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritesh","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Sweiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Gowhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3623-7395","authenticated-orcid":true,"given":"Robert E.","family":"Molokie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor R.","family":"Gordeuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiano","family":"Rondelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"issue":"4 Suppl","key":"pone.0229710.ref001","doi-asserted-by":"crossref","first-page":"S512","DOI":"10.1016\/j.amepre.2009.12.022","article-title":"Population estimates of sickle cell disease in the U.S","volume":"38","author":"KL Hassell","year":"2010","journal-title":"Am J Prev Med"},{"issue":"6","key":"pone.0229710.ref002","doi-asserted-by":"crossref","first-page":"480","DOI":"10.2471\/BLT.06.036673","article-title":"Global epidemiology of haemoglobin disorders and derived service indicators","volume":"86","author":"B Modell","year":"2008","journal-title":"Bulletin of the World Health Organization"},{"key":"pone.0229710.ref003","unstructured":"CDC. Sickle Cell Disease Health Disparities."},{"issue":"1","key":"pone.0229710.ref004","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/pbc.22979","article-title":"Sickle cell disease in California: sociodemographic predictors of emergency department utilization","volume":"58","author":"JA Wolfson","year":"2012","journal-title":"Pediatric blood & cancer"},{"issue":"6","key":"pone.0229710.ref005","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ajh.21408","article-title":"The cost of health care for children and adults with sickle cell disease","volume":"84","author":"TL Kauf","year":"2009","journal-title":"American journal of hematology"},{"issue":"6","key":"pone.0229710.ref006","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/ajh.21443","article-title":"The cost of health care for patients with sickle cell disease","volume":"84","author":"SK Ballas","year":"2009","journal-title":"American journal of hematology"},{"issue":"20","key":"pone.0229710.ref007","first-page":"1317","article-title":"Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia","volume":"332","author":"S Charache","year":"1995","journal-title":"Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. The New England journal of medicine"},{"issue":"1","key":"pone.0229710.ref008","first-page":"26","article-title":"Cost-effectiveness of hydroxyurea in sickle cell anemia","volume":"64","author":"RD Moore","year":"2000","journal-title":"Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. American journal of hematology"},{"issue":"4","key":"pone.0229710.ref009","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1542\/peds.2013-0333","article-title":"Hydroxyurea is associated with lower costs of care of young children with sickle cell anemia","volume":"132","author":"WC Wang","year":"2013","journal-title":"Pediatrics"},{"issue":"10","key":"pone.0229710.ref010","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/ajh.21772","article-title":"Cost-effectiveness of hydroxyurea in reducing the frequency of pain episodes and hospitalization in pediatric sickle cell disease","volume":"85","author":"JR Stallworth","year":"2010","journal-title":"American journal of hematology"},{"issue":"12","key":"pone.0229710.ref011","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/ajh.20703","article-title":"Hospitalization rates and costs of care of patients with sickle-cell anemia in the state of Maryland in the era of hydroxyurea","volume":"81","author":"S Lanzkron","year":"2006","journal-title":"American journal of hematology"},{"issue":"6","key":"pone.0229710.ref012","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1056\/NEJMoa1903212","article-title":"A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease","volume":"381","author":"E Vichinsky","year":"2019","journal-title":"The New England journal of medicine"},{"key":"pone.0229710.ref013","article-title":"Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation","author":"E Gluckman","year":"2016","journal-title":"Blood"},{"key":"pone.0229710.ref014","article-title":"Allogeneic Hematopoietic Cell Transplantation for Children with Sickle Cell Disease Is Beneficial and Cost-Effective: A Single-Center Analysis","author":"SD Arnold","year":"2015","journal-title":"Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation"},{"issue":"11","key":"pone.0229710.ref015","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.3324\/haematol.2017.169581","article-title":"Clinical risks and healthcare utilization of hematopoietic cell transplantation for sickle cell disease in the USA using merged databases","volume":"102","author":"SD Arnold","year":"2017","journal-title":"Haematologica"},{"issue":"1","key":"pone.0229710.ref016","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1001\/jama.2014.7192","article-title":"Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype","volume":"312","author":"MM Hsieh","year":"2014","journal-title":"Jama"},{"issue":"3","key":"pone.0229710.ref017","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.bbmt.2015.08.036","article-title":"Nonmyeloablative Stem Cell Transplantation with Alemtuzumab\/Low-Dose Irradiation to Cure and Improve the Quality of Life of Adults with Sickle Cell Disease","volume":"22","author":"SL Saraf","year":"2016","journal-title":"Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation"},{"key":"pone.0229710.ref018","first-page":"370","article-title":"Allogeneic transplantation strategies including haploidentical transplantation in sickle cell disease","volume":"2013","author":"E Gluckman","year":"2013","journal-title":"Hematology \/ the Education Program of the American Society of Hematology American Society of Hematology Education Program"},{"issue":"5","key":"pone.0229710.ref019","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3324\/haematol.2013.099747","article-title":"Hematopoietic stem cell transplantation in thalassemia major and sickle cell disease: indications and management recommendations from an international expert panel","volume":"99","author":"E Angelucci","year":"2014","journal-title":"Haematologica"},{"issue":"5","key":"pone.0229710.ref020","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/pbc.24459","article-title":"Age-related treatment patterns in sickle cell disease patients and the associated sickle cell complications and healthcare costs","volume":"60","author":"MA Blinder","year":"2013","journal-title":"Pediatr Blood Cancer"},{"issue":"5","key":"pone.0229710.ref021","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/jhm.850","article-title":"Prediction of onset and course of high hospital utilization in sickle cell disease","volume":"6","author":"CP Carroll","year":"2011","journal-title":"J Hosp Med"},{"issue":"13","key":"pone.0229710.ref022","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1001\/jama.2010.378","article-title":"Acute care utilization and rehospitalizations for sickle cell disease","volume":"303","author":"DC Brousseau","year":"2010","journal-title":"JAMA"},{"issue":"18","key":"pone.0229710.ref023","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1182\/bloodadvances.2018018382","article-title":"Increased acute care utilization in a prospective cohort of adults with sickle cell disease","volume":"2","author":"S Lanzkron","year":"2018","journal-title":"Blood Adv"},{"issue":"1","key":"pone.0229710.ref024","article-title":"An analysis of inpatient pediatric sickle cell disease: Incidence, costs, and outcomes","volume":"65","author":"LM Bou-Maroun","year":"2018","journal-title":"Pediatr Blood Cancer"},{"issue":"3","key":"pone.0229710.ref025","doi-asserted-by":"crossref","first-page":"765","DOI":"10.11124\/JBISRIR-2016-002983","article-title":"Factors influencing utilization of hospital services by adult sickle cell disease patients: a systematic review","volume":"15","author":"I Benenson","year":"2017","journal-title":"JBI Database System Rev Implement Rep"},{"issue":"3","key":"pone.0229710.ref026","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/pubmed\/fdu026","article-title":"A retrospective analysis of the cost of hospitalizations for sickle cell disease with crisis in England, 2010\/11","volume":"37","author":"E Pizzo","year":"2015","journal-title":"J Public Health (Oxf)"},{"issue":"17","key":"pone.0229710.ref027","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1182\/blood-2014-06-583351","article-title":"Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use","volume":"125","author":"MJ Telen","year":"2015","journal-title":"Blood"},{"issue":"5","key":"pone.0229710.ref028","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1056\/NEJMoa1611770","article-title":"Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease","volume":"376","author":"KI Ataga","year":"2017","journal-title":"The New England journal of medicine"},{"issue":"9","key":"pone.0229710.ref029","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1056\/NEJMoa1609677","article-title":"Gene Therapy in a Patient with Sickle Cell Disease","volume":"376","author":"JA Ribeil","year":"2017","journal-title":"The New England journal of medicine"},{"issue":"11","key":"pone.0229710.ref030","doi-asserted-by":"crossref","first-page":"e1915374","DOI":"10.1001\/jamanetworkopen.2019.15374","article-title":"Estimated Life Expectancy and Income of Patients With Sickle Cell Disease Compared With Those Without Sickle Cell Disease","volume":"2","author":"D Lubeck","year":"2019","journal-title":"JAMA Netw Open"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0229710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T13:29:30Z","timestamp":1582723770000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0229710"}},"subtitle":[],"editor":[{"given":"Senthilnathan","family":"Palaniyandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,2,26]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0229710","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,26]]}}}