{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:10:58Z","timestamp":1790104258311,"version":"4.0.1"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ZUK63"],"award-info":[{"award-number":["ZUK63"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009397","name":"Medizinischen Fakult\u00e4t, Eberhard Karls Universit\u00e4t T\u00fcbingen","doi-asserted-by":"publisher","award":["IZKF (2510-0-0)"],"award-info":[{"award-number":["IZKF (2510-0-0)"]}],"id":[{"id":"10.13039\/501100009397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003542","name":"Ministerium f\u00fcr Wissenschaft, Forschung und Kunst Baden-W\u00fcrttemberg","doi-asserted-by":"crossref","award":["Margarete von Wrangell-Habilitationsprogramm f\u00fcr Frauen (31-7635.41\/118\/3)"],"award-info":[{"award-number":["Margarete von Wrangell-Habilitationsprogramm f\u00fcr Frauen (31-7635.41\/118\/3)"]}],"id":[{"id":"10.13039\/501100003542","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002345","name":"Eberhard Karls Universit\u00e4t T\u00fcbingen","doi-asserted-by":"publisher","award":["Open access funds"],"award-info":[{"award-number":["Open access funds"]}],"id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0230044","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T17:33:15Z","timestamp":1585762395000},"page":"e0230044","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["LEFTY2\/endometrial\u00a0bleeding-associated factor up-regulates Na+\u00a0Coupled Glucose Transporter SGLT1 expression and Glycogen Accumulation in Endometrial Cancer Cells"],"prefix":"10.1371","volume":"15","author":[{"given":"Ni","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md","family":"Alauddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Khozooei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Rajaxavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaqiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Y.","family":"Brucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diethelm","family":"Wallwiener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-289X","authenticated-orcid":true,"given":"Madhuri S.","family":"Salker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"issue":"6","key":"pone.0230044.ref001","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"B Gellersen","year":"2014","journal-title":"Endocrine reviews"},{"key":"pone.0230044.ref002","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1749-6632.2010.05944.x","article-title":"Isolation characterization, and function of EBAF\/LEFTY B: role in infertility","volume":"1221","author":"S. Tabibzadeh","year":"2011","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"9","key":"pone.0230044.ref003","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1177\/153537020222700905","article-title":"Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium","volume":"227","author":"C Welt","year":"2002","journal-title":"Experimental biology and medicine"},{"issue":"6","key":"pone.0230044.ref004","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(00)81696-7","article-title":"Smads: transcriptional activators of TGF-beta responses","volume":"95","author":"R Derynck","year":"1998","journal-title":"Cell"},{"issue":"1","key":"pone.0230044.ref005","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1517\/13543780903382609","article-title":"Targeting the transforming growth factor-beta signaling pathway in human cancer","volume":"19","author":"NS Nagaraj","year":"2010","journal-title":"Expert Opin Investig Drugs"},{"issue":"36","key":"pone.0230044.ref006","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.2174\/092986711798347252","article-title":"Left-right asymmetry in embryonic development and breast cancer: common molecular determinants?","volume":"18","author":"J Wilting","year":"2011","journal-title":"Current medicinal chemistry"},{"issue":"1","key":"pone.0230044.ref007","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ydbio.2014.06.014","article-title":"Symmetry breakage in the vertebrate embryo: when does it happen and how does it work?","volume":"393","author":"M Blum","year":"2014","journal-title":"Developmental biology"},{"issue":"1","key":"pone.0230044.ref008","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ydbio.2013.11.020","article-title":"FGF signaling is required for brain left-right asymmetry and brain midline formation","volume":"386","author":"JM Neugebauer","year":"2014","journal-title":"Developmental biology"},{"issue":"1","key":"pone.0230044.ref009","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ydbio.2014.03.020","article-title":"miR-373 is regulated by TGFbeta signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells","volume":"391","author":"A Rosa","year":"2014","journal-title":"Developmental biology"},{"issue":"5","key":"pone.0230044.ref010","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1158\/1535-7163.MCT-16-0215","article-title":"Nodal Signaling as a Developmental Therapeutics Target in Oncology","volume":"16","author":"A Kalyan","year":"2017","journal-title":"Mol Cancer Ther"},{"issue":"5","key":"pone.0230044.ref011","doi-asserted-by":"crossref","first-page":"e1600200","DOI":"10.1126\/sciadv.1600200","article-title":"Fundamentals of cancer metabolism","volume":"2","author":"RJ DeBerardinis","year":"2016","journal-title":"Sci Adv"},{"issue":"5","key":"pone.0230044.ref012","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"D Hanahan","year":"2011","journal-title":"Cell"},{"issue":"1","key":"pone.0230044.ref013","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2015.12.006","article-title":"The Emerging Hallmarks of Cancer Metabolism","volume":"23","author":"NN Pavlova","year":"2016","journal-title":"Cell Metab"},{"issue":"3","key":"pone.0230044.ref014","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The Warburg Effect: How Does it Benefit Cancer Cells?","volume":"41","author":"MV Liberti","year":"2016","journal-title":"Trends Biochem Sci"},{"issue":"9","key":"pone.0230044.ref015","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrc3579","article-title":"Disrupting proton dynamics and energy metabolism for cancer therapy","volume":"13","author":"SK Parks","year":"2013","journal-title":"Nature reviews Cancer"},{"issue":"1638","key":"pone.0230044.ref016","doi-asserted-by":"crossref","first-page":"20130100","DOI":"10.1098\/rstb.2013.0100","article-title":"Role of pHi, and proton transporters in oncogene-driven neoplastic transformation","volume":"369","author":"SJ Reshkin","year":"2014","journal-title":"Philosophical transactions of the Royal Society of London Series B, Biological sciences"},{"issue":"1","key":"pone.0230044.ref017","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pharmthera.2008.09.005","article-title":"Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond","volume":"121","author":"V Ganapathy","year":"2009","journal-title":"Pharmacology & therapeutics"},{"issue":"9","key":"pone.0230044.ref018","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1096\/fj.03-1001fje","article-title":"Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand","volume":"18","author":"DE Bauer","year":"2004","journal-title":"Faseb Journal"},{"issue":"6","key":"pone.0230044.ref019","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.4049\/jimmunol.1001250","article-title":"Oxidative Phosphorylation Induces De Novo Expression of the MHC Class I in Tumor Cells through the ERK5 Pathway","volume":"185","author":"S Charni","year":"2010","journal-title":"J Immunol"},{"issue":"11","key":"pone.0230044.ref020","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1158\/0008-5472.CAN-03-2904","article-title":"Akt stimulates aerobic glycolysis in cancer cells","volume":"64","author":"RL Elstrom","year":"2004","journal-title":"Cancer Res"},{"issue":"20","key":"pone.0230044.ref021","doi-asserted-by":"crossref","first-page":"14898","DOI":"10.1074\/jbc.M110.104232","article-title":"Interleukin-7 Compartmentalizes Its Receptor Signaling Complex to Initiate CD4 T Lymphocyte Response","volume":"285","author":"T Rose","year":"2010","journal-title":"J Biol Chem"},{"issue":"1","key":"pone.0230044.ref022","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.pharmthera.2012.07.005","article-title":"Hypoxia-inducible factor as a therapeutic target for cardioprotection","volume":"136","author":"SG Ong","year":"2012","journal-title":"Pharmacology & therapeutics"},{"issue":"7","key":"pone.0230044.ref023","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/onc.2012.114","article-title":"Role of Lefty in the anti tumor activity of human adult liver stem cells","volume":"32","author":"C Cavallari","year":"2013","journal-title":"Oncogene"},{"issue":"5","key":"pone.0230044.ref024","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/MPA.0b013e31823b66d3","article-title":"Transforming growth factor beta and Ras\/MEK\/ERK signaling regulate the expression level of a novel tumor suppressor Lefty","volume":"41","author":"N Miyata","year":"2012","journal-title":"Pancreas"},{"key":"pone.0230044.ref025","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.2741\/3221","article-title":"Lefty peptides, derived by MMP2 cleavage, act as a new class of gelatinase A inhibitor","volume":"13","author":"DG Naidu","year":"2008","journal-title":"Frontiers in bioscience: a journal and virtual library"},{"key":"pone.0230044.ref026","article-title":"Lefty inhibits glioma growth by suppressing Nodal-activated Smad and ERK1\/2 pathways","author":"G Sun","year":"2014","journal-title":"Journal of the neurological sciences"},{"issue":"2","key":"pone.0230044.ref027","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/jcp.22280","article-title":"Cancer hallmarks in induced pluripotent cells: new insights","volume":"225","author":"S Malchenko","year":"2010","journal-title":"Journal of cellular physiology"},{"key":"pone.0230044.ref028","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1477-7827-7-122","article-title":"Expression of nodal signalling components in cycling human endometrium and in endometrial cancer","volume":"7","author":"I Papageorgiou","year":"2009","journal-title":"Reproductive biology and endocrinology: RB&E"},{"issue":"11","key":"pone.0230044.ref029","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1073\/pnas.0800467105","article-title":"Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells","volume":"105","author":"LM Postovit","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"pone.0230044.ref030","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1096\/fj.12-221432","article-title":"Suppression of Lefty expression in induced pluripotent cancer cells","volume":"27","author":"A Saito","year":"2013","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"issue":"3","key":"pone.0230044.ref031","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bbrc.2015.03.120","article-title":"LeftyA sensitive cytosolic pH regulation and glycolytic flux in Ishikawa human endometrial cancer cells","volume":"460","author":"MS Salker","year":"2015","journal-title":"Biochemical and biophysical research communications"},{"issue":"1063","key":"pone.0230044.ref032","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1098\/rstb.1981.0056","article-title":"Design of glycolysis","volume":"293","author":"A Boiteux","year":"1981","journal-title":"Philosophical transactions of the Royal Society of London Series B, Biological sciences"},{"issue":"6","key":"pone.0230044.ref033","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1139\/bcb-2014-0078","article-title":"Acid-base transport in pancreatic cancer: Molecular mechanisms and clinical potential","volume":"92","author":"SC Kong","year":"2014","journal-title":"Biochemistry and cell biology = Biochimie et biologie cellulaire"},{"key":"pone.0230044.ref034","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/B978-0-12-394316-3.00009-0","article-title":"The SLC16A family of monocarboxylate transporters (MCTs)\u2014physiology and function in cellular metabolism, pH homeostasis, and fluid transport","volume":"70","author":"J Adijanto","year":"2012","journal-title":"Current topics in membranes"},{"issue":"2","key":"pone.0230044.ref035","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.metabol.2015.10.007","article-title":"Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment","volume":"65","author":"CC Barron","year":"2016","journal-title":"Metabolism: clinical and experimental"},{"issue":"2\u20133","key":"pone.0230044.ref036","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.mam.2012.07.001","article-title":"The SLC2 (GLUT) family of membrane transporters","volume":"34","author":"M Mueckler","year":"2013","journal-title":"Molecular aspects of medicine"},{"key":"pone.0230044.ref037","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pharmthera.2016.10.017","article-title":"The Na+-D-glucose cotransporters SGLT1 and SGLT2 are targets for the treatment of diabetes and cancer","volume":"170","author":"H. Koepsell","year":"2017","journal-title":"Pharmacology & therapeutics"},{"issue":"5","key":"pone.0230044.ref038","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s00424-003-1202-0","article-title":"The sodium\/glucose cotransport family SLC5","volume":"447","author":"EM Wright","year":"2004","journal-title":"Pflugers Archiv: European journal of physiology"},{"issue":"6","key":"pone.0230044.ref039","first-page":"435","article-title":"Novel and Unexpected Functions of SGLTs","volume":"32","author":"EM Wright","year":"2017","journal-title":"Physiology (Bethesda)"},{"issue":"30","key":"pone.0230044.ref040","doi-asserted-by":"crossref","first-page":"E4111","DOI":"10.1073\/pnas.1511698112","article-title":"Functional expression of sodium-glucose transporters in cancer","volume":"112","author":"C Scafoglio","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"pone.0230044.ref041","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1080\/07357900801956363","article-title":"Expression of SGLT1, Bcl-2 and p53 in primary pancreatic cancer related to survival","volume":"26","author":"VF Casneuf","year":"2008","journal-title":"Cancer investigation"},{"issue":"Suppl 1","key":"pone.0230044.ref042","doi-asserted-by":"crossref","first-page":"S197","DOI":"10.1007\/s12032-010-9696-8","article-title":"Overexpression of SGLT1 and EGFR in colorectal cancer showing a correlation with the prognosis","volume":"28","author":"GF Guo","year":"2011","journal-title":"Medical oncology"},{"issue":"13","key":"pone.0230044.ref043","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/pros.22692","article-title":"EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors","volume":"73","author":"J Ren","year":"2013","journal-title":"The Prostate"},{"issue":"1","key":"pone.0230044.ref044","doi-asserted-by":"crossref","first-page":"12612","DOI":"10.1038\/s41598-017-11674-3","article-title":"Loss of Endometrial Sodium Glucose Cotransporter SGLT1 is Detrimental to Embryo Survival and Fetal Growth in Pregnancy","volume":"7","author":"MS Salker","year":"2017","journal-title":"Sci Rep"},{"key":"pone.0230044.ref045","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1038\/srep03894","article-title":"Uterine selection of human embryos at implantation","volume":"4","author":"JJ Brosens","year":"2014","journal-title":"Scientific reports"},{"key":"pone.0230044.ref046","article-title":"Alkaline cytosolic pH and high sodium hydrogen exchanger 1 (NHE1) activity in Th9 cells","author":"Y Singh","year":"2016","journal-title":"The Journal of biological chemistry"},{"issue":"6299","key":"pone.0230044.ref047","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/348302a0","article-title":"The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle","volume":"348","author":"P Dent","year":"1990","journal-title":"Nature"},{"issue":"6","key":"pone.0230044.ref048","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1262\/jrd.2014-013","article-title":"Uterine glycogen metabolism in mink during estrus, embryonic diapause and pregnancy","volume":"60","author":"M Dean","year":"2014","journal-title":"J Reprod Dev"},{"issue":"5","key":"pone.0230044.ref049","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s00424-003-1202-0","article-title":"The sodium\/glucose cotransport family SLC5","volume":"447","author":"EM Wright","year":"2004","journal-title":"Pflug Arch Eur J Phy"},{"issue":"1","key":"pone.0230044.ref050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2015.12.006","article-title":"The Emerging Hallmarks of Cancer Metabolism","volume":"23","author":"NN Pavlova","year":"2016","journal-title":"Cell metabolism"},{"issue":"6","key":"pone.0230044.ref051","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1159\/000475655","article-title":"Negative Effect of Ellagic Acid on Cytosolic pH Regulation and Glycolytic Flux in Human Endometrial Cancer Cells","volume":"41","author":"KNM Abdelazeem","year":"2017","journal-title":"Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"issue":"2","key":"pone.0230044.ref052","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrclinonc.2016.120","article-title":"Cancer, obesity, diabetes, and antidiabetic drugs: is the fog clearing?","volume":"14","author":"AJ Klil-Drori","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"pone.0230044.ref053","doi-asserted-by":"crossref","first-page":"i3832","DOI":"10.1136\/bmj.i3832","article-title":"Cancer risk is higher in years before and shortly after type 2 diabetes diagnosis, study shows","volume":"354","author":"S. Mayor","year":"2016","journal-title":"Bmj"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0230044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T01:12:51Z","timestamp":1615079571000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0230044"}},"subtitle":[],"editor":[{"given":"Jung-Yoon","family":"Yoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,1]]},"references-count":53,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0230044","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,1]]}}}