{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:04:53Z","timestamp":1788998693917,"version":"build-2803163510"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013420","name":"Tsumura and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013420","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0230156","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T18:33:35Z","timestamp":1583433215000},"page":"e0230156","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Starvation-induced autophagy via calcium-dependent TFEB dephosphorylation is suppressed by Shigyakusan"],"prefix":"10.1371","volume":"15","author":[{"given":"Sumiko","family":"Ikari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiou-Ling","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feike","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo-hei","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Yuan","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobukazu","family":"Shitan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamotsu","family":"Yoshimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanobu","family":"Otomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"pone.0230156.ref001","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41556-018-0092-5","article-title":"A brief history of autophagy from cell biology to physiology and disease","volume":"20","author":"N. Mizushima","year":"2018","journal-title":"Nat Cell Biol"},{"key":"pone.0230156.ref002","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ceb.2019.08.003","article-title":"Core autophagy genes and human diseases","volume":"61","author":"YG Zhao","year":"2019","journal-title":"Curr Opin Cell Biol"},{"key":"pone.0230156.ref003","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1080\/15548627.2015.1034405","article-title":"PSMD10\/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression","volume":"12","author":"T Luo","year":"2016","journal-title":"Autophagy"},{"key":"pone.0230156.ref004","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1111\/cas.13746","article-title":"Cytoplasmic liver kinase B1 promotes the growth of human lung adenocarcinoma by enhancing autophagy","volume":"109","author":"M Liu","year":"2018","journal-title":"Cancer Sci"},{"key":"pone.0230156.ref005","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41591-019-0367-9","article-title":"Protective autophagy elicited by RAF\u2192MEK\u2192ERK inhibition suggests a treatment strategy for RAS-driven cancers","volume":"25","author":"CG Kinsey","year":"2019","journal-title":"Nat Med"},{"key":"pone.0230156.ref006","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/eye.2016.298","article-title":"Hydroxychloroquine retinopathy","volume":"31","author":"IH Yusuf","year":"2017","journal-title":"Eye"},{"key":"pone.0230156.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI78652","article-title":"Autophagy: a druggable process th a t is deregulated in aging and hum an disease","volume":"125","author":"Guido Kroemer","year":"2015","journal-title":"J Clin Invest"},{"key":"pone.0230156.ref008","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrd3802","article-title":"Autophagy modulation as a potential therapeutic target for diverse diseases","volume":"11","author":"DC Rubinsztein","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"pone.0230156.ref009","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jep.2016.10.069","article-title":"Autophagy modulators from traditional Chinese medicine: Mechanisms and therapeutic potentials for cancer and neurodegenerative diseases","volume":"194","author":"SF Wang","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"pone.0230156.ref010","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/147323000603400301","article-title":"Traditional Chinese medicine and kampo: A review from the distant past for the future","volume":"34","author":"F Yu","year":"2006","journal-title":"J Int Med Res"},{"key":"pone.0230156.ref011","first-page":"2017","article-title":"The Preventive Effect of the Traditional Japanese Herbal Medicine, Hochuekkito, against Influenza A Virus via Autophagy in vitro","volume":"99","author":"K Takanashi","year":"2019","journal-title":"Phamacology"},{"issue":"2","key":"pone.0230156.ref012","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/medicines6020063","article-title":"Screening of Crude Drugs Used in Japanese Kampo Formulas for Autophagy-Mediated Cell Survival of the Human Hepatocellular Carcinoma Cell Line","volume":"6","author":"S Okubo","year":"2019","journal-title":"Medicines"},{"key":"pone.0230156.ref013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0076-6879(08)03601-X","article-title":"Monitoring Autophagy in Mammalian Cultured Cells through the Dynamics of LC3","volume":"452","author":"S Kimura","year":"2009","journal-title":"Method in Enzymology"},{"key":"pone.0230156.ref014","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.molcel.2018.10.035","article-title":"Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics","volume":"73","author":"C Chang","year":"2019","journal-title":"Mol Cell"},{"key":"pone.0230156.ref015","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1091\/mbc.e10-11-0893","article-title":"The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella","volume":"22","author":"S Kageyama","year":"2011","journal-title":"Mol Biol Cell"},{"key":"pone.0230156.ref016","doi-asserted-by":"crossref","first-page":"jcs208017","DOI":"10.1242\/jcs.208017","article-title":"Rheb localized on the Golgi membrane activates lysosome- localized mTORC1 at the Golgi\u2013lysosome contact site","volume":"131","author":"F Hao","year":"2018","journal-title":"J Cell Sci"},{"key":"pone.0230156.ref017","doi-asserted-by":"crossref","first-page":"36005","DOI":"10.1074\/jbc.M304266200","article-title":"TWEAK induces NF-\u03baB2 p100 processing and long lasting NF-\u03baB activation","volume":"278","author":"T Saitoh","year":"2003","journal-title":"J Biol Chem"},{"key":"pone.0230156.ref018","doi-asserted-by":"crossref","first-page":"6970","DOI":"10.1073\/pnas.0908536107","article-title":"Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus","volume":"107","author":"S Bloor","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0230156.ref019","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A Gene Network Regulating Lysosomal Biognesis and Function","volume":"325","author":"Marco Sardiello","year":"2009","journal-title":"Science"},{"key":"pone.0230156.ref020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/84397","article-title":"A high signal-to-noise Ca2+ probe composed of a single green fluorescent protein","volume":"19","author":"J Nakai","year":"2001","journal-title":"Nat Biotechnol"},{"key":"pone.0230156.ref021","doi-asserted-by":"crossref","first-page":"452","DOI":"10.4161\/auto.4451","article-title":"Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3","volume":"3","author":"S Kimura","year":"2007","journal-title":"Autophagy"},{"key":"pone.0230156.ref022","doi-asserted-by":"crossref","first-page":"8023","DOI":"10.1074\/jbc.M900301200","article-title":"An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1","volume":"284","author":"CC Thoreen","year":"2009","journal-title":"J Biol Chem"},{"key":"pone.0230156.ref023","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1247\/csf.23.33","article-title":"Bafilomycin Ai Prevents Maturation of Autophagic Vacuoles by Inhibiting Fusion between Autophagosomesand Lysosomesin Rat Hepatoma Cell Line","volume":"23","author":"A Yamamoto","year":"1998","journal-title":"Cell Struct Funct"},{"key":"pone.0230156.ref024","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/736905","article-title":"Aggrephagy: Selective disposal of protein aggregates by macroautophagy","volume":"2012","author":"T Lamark","year":"2012","journal-title":"Int J Cell Biol"},{"key":"pone.0230156.ref025","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/832704","article-title":"The role of the selective adaptor p62 and ubiquitin-like proteins in autophagy","volume":"2014","author":"M Lippai","year":"2014","journal-title":"Biomed Res Int"},{"key":"pone.0230156.ref026","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4161\/auto.1.2.1697","article-title":"Lysosomal Turnover, but Not a Cellular Level, of Endogenous LC3 is a Marker for Autophagy","volume":"1","author":"I Tanida","year":"2005","journal-title":"Autophagy"},{"key":"pone.0230156.ref027","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1083\/jcb.152.4.657","article-title":"Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells","volume":"152","author":"N Mizushima","year":"2001","journal-title":"J Cell Biol"},{"key":"pone.0230156.ref028","first-page":"497","article-title":"FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells","volume":"9","author":"T Hara","year":"2007","journal-title":"J Cell Biol"},{"key":"pone.0230156.ref029","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1242\/jcs.146258","article-title":"WIPI proteins: Essential PtdIns3P effectors at the nascent autophagosome","volume":"128","author":"T Proikas-Cezanne","year":"2015","journal-title":"J Cell Sci"},{"key":"pone.0230156.ref030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom7030052","article-title":"Regulation of autophagy through TORC1 and mTORC1","volume":"7","author":"T. Noda","year":"2017","journal-title":"Biomolecules"},{"key":"pone.0230156.ref031","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB Links Autophagy to Lysosomal Biogenesis","volume":"332","author":"C Settembre","year":"2011","journal-title":"Science"},{"key":"pone.0230156.ref032","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ceb.2009.12.004","article-title":"The role of the Atg1\/ULK1 complex in autophagy regulation","volume":"22","author":"N. Mizushima","year":"2010","journal-title":"Curr Opin Cell Biol"},{"key":"pone.0230156.ref033","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1128\/MCB.24.1.200-216.2004","article-title":"mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1\/Eukaryotic Translation Initiation Factor 4E","volume":"24","author":"DC Fingar","year":"2004","journal-title":"Mol Cell Biol"},{"key":"pone.0230156.ref034","doi-asserted-by":"crossref","first-page":"e96690","DOI":"10.1371\/journal.pone.0096690","article-title":"Sensitivity and Specificity of In situ Proximity Ligation for Protein Interaction Analysis in a Model of Steatohepatitis with Mallory-Denk Bodies","volume":"9","author":"B Zatloukal","year":"2014","journal-title":"PLoS One"},{"key":"pone.0230156.ref035","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1091\/mbc.e08-12-1248","article-title":"Nutrient-dependent mTORC1 Association with the ULK1\u2013Atg13\u2013FIP200 Complex Required for Autophagy","volume":"20","author":"N Hosokawa","year":"2009","journal-title":"Mol Biol Cell"},{"key":"pone.0230156.ref036","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1083\/jcb.201209135","article-title":"Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes","volume":"200","author":"JA Martina","year":"2013","journal-title":"J Cell Biol"},{"key":"pone.0230156.ref037","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0960-9822(02)00762-5","article-title":"Identification of a conserved motif required for mTOR signaling","volume":"12","author":"SS Schalm","year":"2002","journal-title":"Curr Biol"},{"key":"pone.0230156.ref038","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/ncb3114","article-title":"Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB","volume":"17","author":"DL Medina","year":"2015","journal-title":"Nat Cell Biol"},{"key":"pone.0230156.ref039","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0092-8674(91)90426-Y","article-title":"When worlds collide: Immunosuppressants meet protein phosphatases","volume":"66","author":"F. McKeon","year":"1991","journal-title":"Cell"},{"key":"pone.0230156.ref040","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1126\/science.285.5436.2129","article-title":"Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A","volume":"285","author":"J Aramburu","year":"1999","journal-title":"Science"},{"key":"pone.0230156.ref041","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ceca.2012.05.010","article-title":"A comparative assessment of fluo Ca2+ indicators in rat ventricular myocytes","volume":"52","author":"BM Hagen","year":"2012","journal-title":"Cell Calcium"},{"key":"pone.0230156.ref042","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molcel.2006.12.009","article-title":"Control of Macroautophagy by Calcium, Calmodulin-Dependent Kinase Kinase-\u03b2, and Bcl-2","volume":"25","author":"M H\u00f8yer-Hansen","year":"2007","journal-title":"Mol Cell"},{"key":"pone.0230156.ref043","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0014-5793(82)80319-0","article-title":"Discovery of A Ca2+and calmodulin-dependent protein phosphatase","volume":"137","author":"AA Stewart","year":"1982","journal-title":"FEBS Lett"},{"key":"pone.0230156.ref044","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1038\/sj.bjp.0704662","article-title":"Xestospongin C, a novel blocker of IP3 receptor, attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL-2H3 mast cells","volume":"135","author":"T Oka","year":"2002","journal-title":"Br J Pharmacol"},{"key":"pone.0230156.ref045","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3164\/jcbn.10.189","article-title":"Effects of TJ-35 (Shigyakusan) on Gastric Mucosal Injury Induced by Ischemia- Reperfusion and Its Oxygen-Derived Free Radical-Scavenging Activities","volume":"35","author":"T. Yoshikawa","year":"1991","journal-title":"J Clin Biochem Nutr"},{"key":"pone.0230156.ref046","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/ptr.1832","article-title":"Preventive effect of Shigyaku-san on progression of acute gastric mucosal lesions induced by compound 48\/80, a mast cell degranulator, in rats","volume":"20","author":"Y Ohta","year":"2006","journal-title":"Phyther reseatch"},{"key":"pone.0230156.ref047","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1083\/jcb.200712156","article-title":"Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells","volume":"181","author":"D Hashimoto","year":"2008","journal-title":"J Cell Biol"},{"key":"pone.0230156.ref048","first-page":"1","article-title":"MTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex","volume":"2","author":"EY Chan","year":"2009","journal-title":"Sci Signal"},{"key":"pone.0230156.ref049","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1038\/emboj.2011.257","article-title":"Regulation of TFEB and V-ATPases by mTORC1","volume":"30","author":"S Pen","year":"2011","journal-title":"EMBO J"},{"key":"pone.0230156.ref050","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ceca.2011.04.001","article-title":"A dual role for Ca2+ in autophagy regulation","volume":"50","author":"JP Decuypere","year":"2011","journal-title":"Cell Calcium"},{"key":"pone.0230156.ref051","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.4161\/auto.7.12.17909","article-title":"Ins(1,4,5)P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated.","volume":"7","author":"JP Decuypere","year":"2011","journal-title":"Autophagy"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0230156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T17:41:41Z","timestamp":1722534101000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0230156"}},"subtitle":[],"editor":[{"given":"Vladimir","family":"Trajkovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,3,5]]},"references-count":51,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0230156","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,5]]}}}