{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:30:11Z","timestamp":1775147411050,"version":"3.50.1"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK110871"],"award-info":[{"award-number":["DK110871"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DK110429"],"award-info":[{"award-number":["DK110429"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX001471"],"award-info":[{"award-number":["I01BX001471"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX003025"],"award-info":[{"award-number":["I01BX003025"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0230379","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T17:30:45Z","timestamp":1584984645000},"page":"e0230379","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["N-acetylcysteine (NAC), an anti-oxidant, does not improve bone mechanical properties in a rat model of progressive chronic kidney disease-mineral bone disorder"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1174-9004","authenticated-orcid":true,"given":"Matthew R.","family":"Allen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"McNerney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffry","family":"Nyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Avin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Moe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,3,23]]},"reference":[{"key":"pone.0230379.ref001","first-page":"6","volume":"04","author":"MS Molinuevo","year":"2013","journal-title":"Ages and Bone Ageing in Diabetes Mellitus. J Diabetes Metab"},{"key":"pone.0230379.ref002","unstructured":"US Department of Health and Prevention C for DC and PH. Centers for Disease Control and Prevention. National Chronic Kidney Disease Fact Sheet, 2017. 2017; 1\u20134. Available: https:\/\/www.cdc.gov\/diabetes\/pubs\/pdf\/kidney_factsheet.pdf"},{"key":"pone.0230379.ref003","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1097\/01.ASN.0000067413.32377.CF","article-title":"Plasma pentosidine is associated with inflammation and malnutrition in end-stage renal disease patients starting on dialysis therapy","volume":"14","author":"ME Suliman","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"pone.0230379.ref004","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrneph.2013.198","article-title":"Evaluating bone quality in patients with chronic kidney disease","volume":"9","author":"HH Malluche","year":"2013","journal-title":"Nat Rev Nephrol"},{"key":"pone.0230379.ref005","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11914-017-0366-z","article-title":"Bone Quality in Chronic Kidney Disease: Definitions and Diagnostics","volume":"15","author":"EMB McNerny","year":"2017","journal-title":"Curr Osteoporos Rep"},{"key":"pone.0230379.ref006","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.redox.2013.12.016","article-title":"Role of advanced glycation end products in cellular signaling","volume":"2","author":"C Ott","year":"2014","journal-title":"Redox Biol"},{"key":"pone.0230379.ref007","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s00223-015-9985-5","article-title":"Effects of Collagen Crosslinking on Bone Material Properties in Health and Disease","volume":"97","author":"M Saito","year":"2015","journal-title":"Calcif Tissue Int"},{"key":"pone.0230379.ref008","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.bone.2012.11.014","article-title":"In vitro non-enzymatic ribation reduces post-yield strain accommodation in cortical bone","volume":"52","author":"TL Willett","year":"2013","journal-title":"Bone"},{"key":"pone.0230379.ref009","article-title":"Effects of non-enzymatic glycation on cancellous bone fragility","author":"SY Tang","year":"2007","journal-title":"Bone"},{"key":"pone.0230379.ref010","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S8756-3282(00)00434-8","article-title":"Influence of nonenzymatic glycation on biomechanical properties of cortical bone","volume":"28","author":"D Vashishth","year":"2001","journal-title":"Bone"},{"key":"pone.0230379.ref011","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00198-008-0754-4","article-title":"Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate","volume":"20","author":"SY Tang","year":"2009","journal-title":"Osteoporos Int"},{"key":"pone.0230379.ref012","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s00198-014-2978-9","article-title":"Changes in skeletal collagen cross-links and matrix hydration in high- and low-turnover chronic kidney disease","volume":"26","author":"MR Allen","year":"2015","journal-title":"Osteoporos Int"},{"key":"pone.0230379.ref013","article-title":"Altered Tissue Composition, Microarchitecture, and Mechanical Performance in Cancellous Bone From Men With Type 2 Diabetes Mellitus","author":"HB Hunt","year":"2019","journal-title":"J Bone Miner Res"},{"key":"pone.0230379.ref014","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00467-001-0815-9","article-title":"Advanced glycation end products in children with chronic renal failure and type 1 diabetes","volume":"17","author":"J Misselwitz","year":"2002","journal-title":"Pediatr Nephrol"},{"key":"pone.0230379.ref015","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1525-139X.2009.00589.x","article-title":"Highlights and hotspots of protein glycation in end-stage renal disease","volume":"22","author":"PJ Thornalley","year":"2009","journal-title":"Semin Dial"},{"key":"pone.0230379.ref016","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/labinvest.2013.105","article-title":"Advanced glycation end products suppress lysyl oxidase and induce bone collagen degradation in a rat model of renal osteodystrophy","volume":"93","author":"C Aoki","year":"2013","journal-title":"Lab Investig"},{"key":"pone.0230379.ref017","first-page":"539","article-title":"Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy","volume":"30","author":"SM Moe","year":"2015","journal-title":"J Bone Miner Res"},{"key":"pone.0230379.ref018","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/jbmr.2089","article-title":"A comparison of calcium to zoledronic acid for improvement of cortical bone in an animal model of CKD","volume":"29","author":"SM Moe","year":"2014","journal-title":"J Bone Miner Res"},{"key":"pone.0230379.ref019","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bone.2015.04.021","article-title":"Compromised vertebral structural and mechanical properties associated with progressive kidney disease and the effects of traditional pharmacological interventions","volume":"77","author":"CL Newman","year":"2015","journal-title":"Bone"},{"key":"pone.0230379.ref020","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1681\/ASN.2009121208","article-title":"Bone Mass and Microarchitecture in CKD Patients with Fracture","volume":"21","author":"TL Nickolas","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"pone.0230379.ref021","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1681\/ASN.2010121275","article-title":"Discriminants of prevalent fractures in chronic kidney disease","volume":"22","author":"TL Nickolas","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"pone.0230379.ref022","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/jbmr.1916","article-title":"Rapid cortical bone loss in patients with chronic kidney disease","volume":"28","author":"TL Nickolas","year":"2013","journal-title":"J Bone Miner Res"},{"key":"pone.0230379.ref023","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/ki.2009.558","article-title":"High-resolution computed tomography imaging: A virtual bone biopsy","volume":"77","author":"TL Nickolas","year":"2010","journal-title":"Kidney Int"},{"key":"pone.0230379.ref024","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.lfs.2014.11.024","article-title":"N-acetylcysteine as a potential strategy to attenuate the oxidative stress induced by uremic serum in the vascular system","volume":"121","author":"SD Rodrigues","year":"2015","journal-title":"Life Sci"},{"key":"pone.0230379.ref025","article-title":"Mechanisms of oxidative modification of low density lipoproteins under conditions of oxidative and carbonyl stress","author":"VZ Lankin","year":"2007","journal-title":"Biochem"},{"key":"pone.0230379.ref026","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1681\/ASN.2005060601","article-title":"Missense Mutation in Sterile Motif of Novel Protein SamCystin is Associated with Polycystic Kidney Disease in (cy\/+) Rat","volume":"16","author":"JH Brown","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"pone.0230379.ref027","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/ar.a.20022","article-title":"Development of Multiorgan Pathology in the wpk Rat Model of Polycystic Kidney Disease","volume":"277","author":"VH Gattone","year":"2004","journal-title":"Anat Rec\u2014Part A Discov Mol Cell Evol Biol"},{"key":"pone.0230379.ref028","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/ki.2008.456","article-title":"A rat model of chronic kidney disease-mineral bone disorder","volume":"75","author":"SM Moe","year":"2009","journal-title":"Kidney Int"},{"key":"pone.0230379.ref029","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/jbmr.485","article-title":"The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat","volume":"26","author":"SM Moe","year":"2011","journal-title":"J Bone Miner Res"},{"key":"pone.0230379.ref030","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s00198-012-2103-x","article-title":"Skeletal effects of zoledronic acid in an animal model of chronic kidney disease","volume":"24","author":"MR Allen","year":"2013","journal-title":"Osteoporos Int"},{"key":"pone.0230379.ref031","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3109\/0886022X.2011.560987","article-title":"Evaluation of efficacy of vitamin e and N-Acetyl cysteine in gentamicin-induced nephrotoxicity in rats","volume":"33","author":"B Patel Manali","year":"2011","journal-title":"Ren Fail"},{"key":"pone.0230379.ref032","article-title":"The Protective Effect of N-Acetylcysteine on Oxidative Stress in the Brain Caused by the Long-Term Intake of Aspartame by Rats","author":"IA Finamor","year":"2014","journal-title":"Neurochem Res"},{"key":"pone.0230379.ref033","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bone.2019.05.002","article-title":"Time course of rapid bone loss and cortical porosity formation observed by longitudinal \u03bcCT in a rat model of CKD","volume":"125","author":"EMB McNerny","year":"2019","journal-title":"Bone"},{"key":"pone.0230379.ref034","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","author":"ML Bouxsein","year":"2010","journal-title":"Journal of Bone and Mineral Research"},{"key":"pone.0230379.ref035","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000444423","article-title":"Calcitriol Suppression of Parathyroid Hormone Fails to Improve Skeletal Properties in an Animal Model of Chronic Kidney Disease","volume":"46202","author":"CL Newman","year":"2016","journal-title":"Am J Nephrol"},{"key":"pone.0230379.ref036","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/8756-3282(93)90081-K","article-title":"Basic biomechanical measurements of bone: A tutorial","volume":"14","author":"CH Turner","year":"1993","journal-title":"Bone"},{"key":"pone.0230379.ref037","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ki.2015.315","article-title":"Raloxifene improves skeletal properties in an animal model of cystic chronic kidney disease","volume":"89","author":"CL Newman","year":"2016","journal-title":"Kidney Int"},{"key":"pone.0230379.ref038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0099262","article-title":"Cortical bone mechanical properties are altered in an animal model of progressive chronic kidney disease","volume":"9","author":"CL Newman","year":"2014","journal-title":"PLoS One"},{"key":"pone.0230379.ref039","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00198-008-0754-4","article-title":"Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate","volume":"20","author":"SY Tang","year":"2009","journal-title":"Osteoporos Int"},{"key":"pone.0230379.ref040","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s00467-018-4005-4","article-title":"Oxidative stress in chronic kidney disease","volume":"34","author":"K Daenen","year":"2019","journal-title":"Pediatr Nephrol"},{"key":"pone.0230379.ref041","first-page":"1","article-title":"Skeletal muscle regeneration and oxidative stress are altered in chronic kidney disease","volume":"11","author":"KG Avin","year":"2016","journal-title":"PLoS One"},{"key":"pone.0230379.ref042","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.mrgentox.2015.09.004","article-title":"Ameliorative effects of N-acetylcysteine on fluoride-induced oxidative stress and DNA damage in male rats\u2019 testis","volume":"792","author":"D Feng","year":"2015","journal-title":"Mutat Res\u2014Genet Toxicol Environ Mutagen"},{"key":"pone.0230379.ref043","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00223-015-9996-2","article-title":"The Role of Collagen Organization on the Properties of Bone","volume":"97","author":"P Garnero","year":"2015","journal-title":"Calcif Tissue Int"},{"key":"pone.0230379.ref044","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/nep.13024","article-title":"Overview of bone microstructure, and treatment of bone fragility in chronic kidney disease","volume":"22","author":"E Seeman","year":"2017","journal-title":"Nephrology"},{"key":"pone.0230379.ref045","first-page":"270","article-title":"Why bones bend but don\u2019t break","volume":"11","year":"2011","journal-title":"J Musculoskelet Neuronal Interact"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0230379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T17:31:16Z","timestamp":1584984676000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0230379"}},"subtitle":[],"editor":[{"given":"Jaap A.","family":"Joles","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,3,23]]},"references-count":45,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0230379","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,23]]}}}