{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:47:46Z","timestamp":1791726466519,"version":"4.3.4"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18PRE33960397"],"award-info":[{"award-number":["18PRE33960397"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1R01NS072248-06A1"],"award-info":[{"award-number":["1R01NS072248-06A1"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1R01NS075764-01A1"],"award-info":[{"award-number":["1R01NS075764-01A1"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21HD093021"],"award-info":[{"award-number":["R21HD093021"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0230566","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T17:27:17Z","timestamp":1585070837000},"page":"e0230566","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":70,"title":["Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5153-8068","authenticated-orcid":true,"given":"Elena","family":"Buglo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Sarmiento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole Belliard","family":"Martuscelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7372-9896","authenticated-orcid":true,"given":"David W.","family":"Sant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1568-5965","authenticated-orcid":true,"given":"Matt C.","family":"Danzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7543-6464","authenticated-orcid":true,"given":"Alexander J.","family":"Abrams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5839-807X","authenticated-orcid":true,"given":"Julia E.","family":"Dallman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Z\u00fcchner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,3,24]]},"reference":[{"issue":"998","key":"pone.0230566.ref001","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/207785a0","article-title":"Synthesis of ribonucleic acid by the X-chromosomes of Drosophila melanogaster and the problem of dosage compensation","volume":"207","author":"AS Mukherjee","year":"1965","journal-title":"Nature"},{"issue":"1","key":"pone.0230566.ref002","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1097-2765(00)80193-8","article-title":"The rox1 and rox2 RNAs are essential components of the compensasome, which mediates dosage compensation in Drosophila","volume":"4","author":"A Franke","year":"1999","journal-title":"Mol Cell"},{"issue":"11\u201312","key":"pone.0230566.ref003","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0168-9525(91)90254-F","article-title":"Drosophila abl and genetic redundancy in signal transduction","volume":"7","author":"FM Hoffmann","year":"1991","journal-title":"Trends Genet"},{"issue":"18","key":"pone.0230566.ref004","doi-asserted-by":"crossref","first-page":"8567","DOI":"10.1073\/pnas.91.18.8567","article-title":"Redundant functions of the genes knirps and knirps-related for the establishment of anterior Drosophila head structures","volume":"91","author":"M Gonzalez-Gaitan","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"14","key":"pone.0230566.ref005","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1073\/pnas.91.14.6324","article-title":"Functional redundancy: the respective roles of the two sloppy paired genes in Drosophila segmentation","volume":"91","author":"KM Cadigan","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pone.0230566.ref006","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1369-5266(00)00145-X","article-title":"Arabidopsis gene knockout: phenotypes wanted","volume":"4","author":"N Bouche","year":"2001","journal-title":"Curr Opin Plant Biol"},{"issue":"7","key":"pone.0230566.ref007","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1073\/pnas.1500365112","article-title":"Auxin binding protein 1 (ABP1) is not required for either auxin signaling or Arabidopsis development","volume":"112","author":"Y Gao","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"pone.0230566.ref008","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1101\/gr.205955.116","article-title":"The nonessentiality of essential genes in yeast provides therapeutic insights into a human disease","volume":"26","author":"P Chen","year":"2016","journal-title":"Genome Res"},{"issue":"7751","key":"pone.0230566.ref009","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41586-019-1064-z","article-title":"Genetic compensation triggered by mutant mRNA degradation","volume":"568","author":"MA El-Brolosy","year":"2019","journal-title":"Nature"},{"issue":"2","key":"pone.0230566.ref010","doi-asserted-by":"crossref","first-page":"e1007212","DOI":"10.1371\/journal.pgen.1007212","article-title":"Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein","volume":"14","author":"TE Sztal","year":"2018","journal-title":"PLoS Genet"},{"issue":"7751","key":"pone.0230566.ref011","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41586-019-1057-y","article-title":"PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components","volume":"568","author":"Z Ma","year":"2019","journal-title":"Nature"},{"issue":"7564","key":"pone.0230566.ref012","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature14580","article-title":"Genetic compensation induced by deleterious mutations but not gene knockdowns","volume":"524","author":"A Rossi","year":"2015","journal-title":"Nature"},{"issue":"2","key":"pone.0230566.ref013","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.cell.2013.06.022","article-title":"Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes","volume":"154","author":"JK White","year":"2013","journal-title":"Cell"},{"issue":"52","key":"pone.0230566.ref014","doi-asserted-by":"crossref","first-page":"18081","DOI":"10.1073\/pnas.0407378102","article-title":"RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy","volume":"101","author":"S Nedvetzki","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"pone.0230566.ref015","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1074\/jbc.275.5.3479","article-title":"Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40","volume":"275","author":"EW Lam","year":"2000","journal-title":"J Biol Chem"},{"issue":"5","key":"pone.0230566.ref016","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/ng.3243","article-title":"Identification of a large set of rare complete human knockouts","volume":"47","author":"P Sulem","year":"2015","journal-title":"Nat Genet"},{"issue":"10","key":"pone.0230566.ref017","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s00439-013-1331-2","article-title":"Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease","volume":"132","author":"DN Cooper","year":"2013","journal-title":"Hum Genet"},{"issue":"3","key":"pone.0230566.ref018","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/35056009","article-title":"Modifier genes in mice and humans","volume":"2","author":"JH Nadeau","year":"2001","journal-title":"Nat Rev Genet"},{"issue":"7","key":"pone.0230566.ref019","doi-asserted-by":"crossref","first-page":"e1006780","DOI":"10.1371\/journal.pgen.1006780","article-title":"Genetic compensation: A phenomenon in search of mechanisms","volume":"13","author":"MA El-Brolosy","year":"2017","journal-title":"PLoS Genet"},{"issue":"1","key":"pone.0230566.ref020","doi-asserted-by":"crossref","first-page":"e0210217","DOI":"10.1371\/journal.pone.0210217","article-title":"The ezh2(sa1199) mutant zebrafish display no distinct phenotype","volume":"14","author":"B San","year":"2019","journal-title":"PLoS One"},{"issue":"10","key":"pone.0230566.ref021","doi-asserted-by":"crossref","first-page":"e0141611","DOI":"10.1371\/journal.pone.0141611","article-title":"klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes","volume":"10","author":"P Novodvorsky","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"pone.0230566.ref022","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1371\/journal.pgen.0030078","article-title":"p53 activation by knockdown technologies","volume":"3","author":"ME Robu","year":"2007","journal-title":"PLoS Genet"},{"issue":"7","key":"pone.0230566.ref023","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.4161\/cbt.6.7.4202","article-title":"P21 gene knock down does not identify genetic effectors seen with gene knock out","volume":"6","author":"B Karakas","year":"2007","journal-title":"Cancer Biol Ther"},{"issue":"6","key":"pone.0230566.ref024","doi-asserted-by":"crossref","first-page":"e100268","DOI":"10.1371\/journal.pone.0100268","article-title":"The serine-threonine protein kinase PAK4 is dispensable in zebrafish: identification of a morpholino-generated pseudophenotype","volume":"9","author":"SH Law","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"pone.0230566.ref025","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.devcel.2014.11.018","article-title":"Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish","volume":"32","author":"FO Kok","year":"2015","journal-title":"Dev Cell"},{"key":"pone.0230566.ref026","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fnmol.2016.00055","article-title":"Function Over Form: Modeling Groups of Inherited Neurological Conditions in Zebrafish","volume":"9","author":"RA Kozol","year":"2016","journal-title":"Front Mol Neurosci"},{"issue":"8","key":"pone.0230566.ref027","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/mds.26716","article-title":"SLC25A46 mutations underlie progressive myoclonic ataxia with optic atrophy and neuropathy","volume":"31","author":"G Charlesworth","year":"2016","journal-title":"Mov Disord"},{"issue":"4\u20135","key":"pone.0230566.ref028","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000464445","article-title":"SLC25A46 Mutations Associated with Autosomal Recessive Cerebellar Ataxia in North African Families","volume":"17","author":"MB Hammer","year":"2017","journal-title":"Neurodegener Dis"},{"issue":"1","key":"pone.0230566.ref029","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/cge.12774","article-title":"Novel pathogenic SLC25A46 splice-site mutation causes an optic atrophy spectrum disorder","volume":"91","author":"M Nguyen","year":"2017","journal-title":"Clin Genet"},{"issue":"11","key":"pone.0230566.ref030","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1093\/brain\/aww212","article-title":"Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia","volume":"139","author":"J Wan","year":"2016","journal-title":"Brain"},{"issue":"8","key":"pone.0230566.ref031","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/ng.3354","article-title":"Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder","volume":"47","author":"AJ Abrams","year":"2015","journal-title":"Nat Genet"},{"issue":"2","key":"pone.0230566.ref032","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/cge.12963","article-title":"A novel mutation in SLC25A46 causes optic atrophy and progressive limb spasticity, with no cerebellar atrophy or axonal neuropathy","volume":"92","author":"RA Sulaiman","year":"2017","journal-title":"Clin Genet"},{"issue":"19","key":"pone.0230566.ref033","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1093\/hmg\/ddx262","article-title":"Loss of SLC25A46 causes neurodegeneration by affecting mitochondrial dynamics and energy production in mice","volume":"26","author":"Z Li","year":"2017","journal-title":"Hum Mol Genet"},{"issue":"4","key":"pone.0230566.ref034","doi-asserted-by":"crossref","first-page":"e1006656","DOI":"10.1371\/journal.pgen.1006656","article-title":"Novel insights into SLC25A46-related pathologies in a genetic mouse model","volume":"13","author":"ME Terzenidou","year":"2017","journal-title":"PLoS Genet"},{"issue":"4","key":"pone.0230566.ref035","doi-asserted-by":"crossref","first-page":"e1006597","DOI":"10.1371\/journal.pgen.1006597","article-title":"Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health","volume":"13","author":"A Duchesne","year":"2017","journal-title":"PLoS Genet"},{"issue":"2\u20133","key":"pone.0230566.ref036","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.mam.2012.05.005","article-title":"The mitochondrial transporter family SLC25: identification, properties and physiopathology","volume":"34","author":"F Palmieri","year":"2013","journal-title":"Mol Aspects Med"},{"issue":"3","key":"pone.0230566.ref037","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1042\/BJ20121753","article-title":"Physiological and pathological roles of mitochondrial SLC25 carriers","volume":"454","author":"M Gutierrez-Aguilar","year":"2013","journal-title":"Biochem J"},{"issue":"9","key":"pone.0230566.ref038","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.15252\/emmm.201506159","article-title":"SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome","volume":"8","author":"A Janer","year":"2016","journal-title":"EMBO Mol Med"},{"issue":"5","key":"pone.0230566.ref039","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1091\/mbc.e16-07-0545","article-title":"Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1\/2-mediated hyperfusion of mitochondria","volume":"28","author":"J Steffen","year":"2017","journal-title":"Mol Biol Cell"},{"issue":"3","key":"pone.0230566.ref040","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nbt.2501","article-title":"Efficient genome editing in zebrafish using a CRISPR-Cas system","volume":"31","author":"WY Hwang","year":"2013","journal-title":"Nat Biotechnol"},{"issue":"34","key":"pone.0230566.ref041","doi-asserted-by":"crossref","first-page":"13904","DOI":"10.1073\/pnas.1308335110","article-title":"Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system","volume":"110","author":"LE Jao","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"pone.0230566.ref042","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nmeth.3360","article-title":"Rapid reverse genetic screening using CRISPR in zebrafish","volume":"12","author":"AN Shah","year":"2015","journal-title":"Nat Methods"},{"issue":"7","key":"pone.0230566.ref043","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1101\/gr.186379.114","article-title":"High-throughput gene targeting and phenotyping in zebrafish using CRISPR\/Cas9","volume":"25","author":"GK Varshney","year":"2015","journal-title":"Genome Res"},{"issue":"12","key":"pone.0230566.ref044","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1002\/humu.23639","article-title":"Insights into the genotype-phenotype correlation and molecular function of SLC25A46","volume":"39","author":"AJ Abrams","year":"2018","journal-title":"Hum Mutat"},{"issue":"9\u201310","key":"pone.0230566.ref045","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.bbabio.2006.03.021","article-title":"The conserved substrate binding site of mitochondrial carriers","volume":"1757","author":"ER Kunji","year":"2006","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"pone.0230566.ref046","doi-asserted-by":"crossref","first-page":"e1007105","DOI":"10.1371\/journal.pgen.1007105","article-title":"mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay","volume":"13","author":"JL Anderson","year":"2017","journal-title":"PLoS Genet"},{"issue":"22","key":"pone.0230566.ref047","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.1093\/nar\/gkv802","article-title":"CRISPR-STAT: an easy and reliable PCR-based method to evaluate target-specific sgRNA activity","volume":"43","author":"B Carrington","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"pone.0230566.ref048","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/cne.21381","article-title":"Synaptotagmin I and II are present in distinct subsets of central synapses","volume":"503","author":"MA Fox","year":"2007","journal-title":"J Comp Neurol"},{"issue":"Database issue","key":"pone.0230566.ref049","first-page":"D377","article-title":"PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees","volume":"41","author":"H Mi","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"Pt 7","key":"pone.0230566.ref050","article-title":"Loss-of-function approaches in comparative physiology: is there a future for knockdown experiments in the era of genome editing?","volume":"222","author":"AM Zimmer","year":"2019","journal-title":"J Exp Biol"},{"issue":"1","key":"pone.0230566.ref051","doi-asserted-by":"crossref","first-page":"e53774","DOI":"10.1371\/journal.pone.0053774","article-title":"Regulation of mitochondrial morphogenesis by annexin A6","volume":"8","author":"M Chlystun","year":"2013","journal-title":"PLoS One"},{"issue":"6220","key":"pone.0230566.ref052","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"M Uhlen","year":"2015","journal-title":"Science"},{"issue":"3","key":"pone.0230566.ref053","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ymgme.2012.04.017","article-title":"Identification of a mutation in LARS as a novel cause of infantile hepatopathy","volume":"106","author":"JP Casey","year":"2012","journal-title":"Mol Genet Metab"},{"key":"pone.0230566.ref054","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1749-8104-8-18","article-title":"The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons","volume":"8","author":"MJ Schmeisser","year":"2013","journal-title":"Neural Dev"},{"issue":"23","key":"pone.0230566.ref055","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1523\/JNEUROSCI.5381-06.2007","article-title":"Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo","volume":"27","author":"S Deng","year":"2007","journal-title":"J Neurosci"},{"issue":"50","key":"pone.0230566.ref056","doi-asserted-by":"crossref","first-page":"16983","DOI":"10.1523\/JNEUROSCI.3352-10.2010","article-title":"Atypical protein kinase C regulates primary dendrite specification of cerebellar Purkinje cells by localizing Golgi apparatus","volume":"30","author":"K Tanabe","year":"2010","journal-title":"J Neurosci"},{"issue":"12","key":"pone.0230566.ref057","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1038\/nprot.2016.141","article-title":"A high-throughput functional genomics workflow based on CRISPR\/Cas9-mediated targeted mutagenesis in zebrafish","volume":"11","author":"GK Varshney","year":"2016","journal-title":"Nat Protoc"},{"issue":"1","key":"pone.0230566.ref058","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/zeb.2008.0555","article-title":"A primer for morpholino use in zebrafish","volume":"6","author":"BR Bill","year":"2009","journal-title":"Zebrafish"},{"issue":"8","key":"pone.0230566.ref059","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1523\/JNEUROSCI.06-08-02278.1986","article-title":"Development and axonal outgrowth of identified motoneurons in the zebrafish","volume":"6","author":"PZ Myers","year":"1986","journal-title":"J Neurosci"},{"issue":"1","key":"pone.0230566.ref060","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1089\/zeb.2018.1588","article-title":"Motor Neuron Abnormalities Correlate with Impaired Movement in Zebrafish that Express Mutant Superoxide Dismutase 1","volume":"16","author":"KJ Robinson","year":"2019","journal-title":"Zebrafish"},{"issue":"2","key":"pone.0230566.ref061","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1242\/dev.007559","article-title":"Position fine-tuning of caudal primary motoneurons in the zebrafish spinal cord","volume":"135","author":"M Sato-Maeda","year":"2008","journal-title":"Development"},{"issue":"17","key":"pone.0230566.ref062","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1093\/bioinformatics\/btr390","article-title":"Simple Neurite Tracer: open source software for reconstruction, visualization and analysis of neuronal processes","volume":"27","author":"MH Longair","year":"2011","journal-title":"Bioinformatics"},{"issue":"1","key":"pone.0230566.ref063","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"A Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"1","key":"pone.0230566.ref064","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"MD Robinson","year":"2010","journal-title":"Bioinformatics"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0230566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T17:28:51Z","timestamp":1585070931000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0230566"}},"subtitle":[],"editor":[{"given":"Ramani","family":"Ramchandran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,3,24]]},"references-count":64,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0230566","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,24]]}}}