{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:15:22Z","timestamp":1790374522598,"version":"4.1.0"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T00:00:00Z","timestamp":1585785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grant-in-Aid for Young Scientists B","award":["18K16930"],"award-info":[{"award-number":["18K16930"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0231074","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T13:42:30Z","timestamp":1585834950000},"page":"e0231074","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Anterior and posterior ratio of corneal surface areas: A novel index for detecting early stage keratoconus"],"prefix":"10.1371","volume":"15","author":[{"given":"Motohiro","family":"Itoi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-5776","authenticated-orcid":true,"given":"Koji","family":"Kitazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Wakimasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Hieda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Teramukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Sotozono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,4,2]]},"reference":[{"key":"pone.0231074.ref001","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00003226-199603000-00006","volume":"15","author":"K Zadnik","year":"1996","journal-title":"Study Group. Cornea"},{"key":"pone.0231074.ref002","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/ICO.0000000000000408","article-title":"Global consensus on keratoconus and ectatic diseases","volume":"34","author":"JA Gomes","year":"2015","journal-title":"Cornea"},{"key":"pone.0231074.ref003","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0002-9394(86)90817-2","article-title":"A 48-year clinical and epidemiologic study of keratoconus","volume":"101","author":"RH Kennedy","year":"1986","journal-title":"Am J Ophthalmol"},{"key":"pone.0231074.ref004","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/01.icu.0000233963.26628.f0","article-title":"Post-laser in-situ keratomileusis ectasia: current understanding and future directions","volume":"4","author":"JB Randleman","year":"2006","journal-title":"Curr Opin Ophthalmol"},{"key":"pone.0231074.ref005","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/01.ico.0000222479.68242.77","article-title":"Corneal ectasia after laser in situ keratomileusis in patients without apparent preoperative risk factors","volume":"25","author":"SR Klein","year":"2006","journal-title":"Cornea"},{"key":"pone.0231074.ref006","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jcrs.2007.12.039","article-title":"Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results","volume":"34","author":"F Raiskup-Wolf","year":"2008","journal-title":"J Cataract Refract Surg"},{"key":"pone.0231074.ref007","doi-asserted-by":"crossref","first-page":"5546","DOI":"10.1167\/iovs.10-5369","article-title":"Topographic and tomographic properties of forme fruste keratoconus corneas","volume":"51","author":"A Saad","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"pone.0231074.ref008","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.ophtha.2003.06.020","article-title":"Longitudinal study of the normal eyes in unilateral keratoconus patients","volume":"111","author":"X Li","year":"2004","journal-title":"Ophthalmology"},{"key":"pone.0231074.ref009","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.jcrs.2013.03.023","article-title":"Posterior corneal elevation and back difference corneal elevation in diagnosing forme fruste keratoconus in the fellow eyes of unilateral keratoconus patients","volume":"39","author":"O Muftuoglu","year":"2013","journal-title":"J Cataract Refract Surg"},{"key":"pone.0231074.ref010","doi-asserted-by":"crossref","first-page":"e110249","DOI":"10.1371\/journal.pone.0110249","article-title":"Geometrical custom modeling of human cornea in vivo and its use for the diagnosis of cornealectasia","volume":"9","author":"F Cavas-Mart\u00ednez","year":"2014","journal-title":"PLoS One"},{"key":"pone.0231074.ref011","doi-asserted-by":"crossref","first-page":"e0184569","DOI":"10.1371\/journal.pone.0184569","article-title":"A new approach to keratoconus detection based on corneal morphogeometric analysis","volume":"12","author":"F Cavas-Mart\u00ednez","year":"2017","journal-title":"PLoS One"},{"key":"pone.0231074.ref012","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12886-017-0584-2","article-title":"Objective and subjective diagnostic parameters in the fellow eye of unilateral keratoconus","volume":"17","author":"EA Awad","year":"2017","journal-title":"BMC Ophthalmol"},{"key":"pone.0231074.ref013","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.ophtha.2008.02.020","article-title":"Sensitivity and specificity of posterior corneal elevation measured by Pentacam in discriminating keratoconus\/subclinical keratoconus","volume":"115","author":"U de Sanctis","year":"2008","journal-title":"Ophthalmology"},{"key":"pone.0231074.ref014","first-page":"2749","article-title":"Automated keratoconus screening with corneal topography analysis","volume":"35","author":"N Maeda","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"pone.0231074.ref015","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1001\/archopht.1995.01100070044023","article-title":"Comparison of methods for detecting keratoconus using videokeratography","volume":"113","author":"N Maeda","year":"1995","journal-title":"Arch Ophthalmol"},{"key":"pone.0231074.ref016","doi-asserted-by":"crossref","first-page":"14993","DOI":"10.1038\/s41598-018-33490-z","article-title":"Involvement of anterior and posterior cornea surface area imbalance in the pathological change of keratoconus","volume":"8","author":"K Kitazawa","year":"2018","journal-title":"Sci Rep"},{"key":"pone.0231074.ref017","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1097\/ICO.0000000000000963","article-title":"Measurement of Corneal Endothelial Surface Area Using Anterior Segment Optical Coherence Tomography in Normal Subjects","volume":"35","author":"K Kitazawa","year":"2016","journal-title":"Cornea"},{"key":"pone.0231074.ref018","doi-asserted-by":"crossref","first-page":"e0205998","DOI":"10.1371\/journal.pone.0205998","article-title":"Keratoconus severity identification using unsupervised machine learning","volume":"13","author":"S Yousefi","year":"2018","journal-title":"PLoS One"},{"issue":"3","key":"pone.0231074.ref019","doi-asserted-by":"crossref","first-page":"297","DOI":"10.11613\/BM.2016.034","article-title":"On determining the most appropriate test cut-off value: the case of tests with continuous results","volume":"26","author":"F Habibzadeh","year":"2016","journal-title":"Biochem Med (Zagreb)"},{"key":"pone.0231074.ref020","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s10792-017-0620-5","article-title":"Ocular, corneal, and internal aberrations in eyes with keratoconus, forme fruste keratoconus, and healthy eyes","volume":"38","author":"M Naderan","year":"2018","journal-title":"Int Ophthalmol"},{"key":"pone.0231074.ref021","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00134-003-1761-8","article-title":"A readers\u2019 guide to the interpretation of diagnostic test properties: clinical example of sepsis","volume":"29","author":"JE Fischer","year":"2003","journal-title":"Intensive Care Med"},{"key":"pone.0231074.ref022","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.jcrs.2006.02.060","article-title":"Corneal elevation indices in normal and keratoconic eyes","volume":"32","author":"H. B. Fam","year":"2006","journal-title":"J Cataract Refract Surg"},{"key":"pone.0231074.ref023","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/S0161-6420(02)01121-1","article-title":"Role of Orbscan II in screening keratoconus suspects before refractive corneal surgery","volume":"109","author":"SN Rao","year":"2002","journal-title":"Ophthalmology"},{"key":"pone.0231074.ref024","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s40135-012-0003-z","article-title":"Enhanced Screening for Ectasia Susceptibility Among Refractive Candidates: The Role of Corneal Tomography and Biomechanics","volume":"1","author":"R Ambr\u00f3sio","year":"2013","journal-title":"Curr Ophthalmol Rep"},{"key":"pone.0231074.ref025","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.ophtha.2012.06.005","article-title":"Use of a support vector machine for keratoconus and subclinical keratoconus detection by topographic and tomographic data","volume":"119","author":"MC Arbelaez","year":"2012","journal-title":"Ophthalmology"},{"key":"pone.0231074.ref026","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3928\/1081597X-20170621-09","article-title":"Comparison of Corneal Dynamic and Tomographic Analysis in Normal, Forme Fruste Keratoconic, and Keratoconic Eyes","volume":"33","author":"YM Wang","year":"2017","journal-title":"J Refract Surg"},{"key":"pone.0231074.ref027","doi-asserted-by":"crossref","first-page":"920","DOI":"10.5301\/ejo.5000184","article-title":"Corneal biomechanical properties and anterior segment parameters in forme fruste keratoconus","volume":"22","author":"V Kozobolis","year":"2012","journal-title":"Eur J Ophthalmol"},{"key":"pone.0231074.ref028","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1167\/iovs.09-3689","article-title":"Screening of forme fruste keratoconus with the ocular response analyzer","volume":"51","author":"C Schweitzer","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0231074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T13:42:51Z","timestamp":1585834971000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0231074"}},"subtitle":[],"editor":[{"given":"Yu-Chi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,2]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0231074","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,2]]}}}