{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:11:45Z","timestamp":1779207105714,"version":"3.51.4"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Rsearch Foundation of Korea","award":["NRF-2017R1D1A1B03029589"],"award-info":[{"award-number":["NRF-2017R1D1A1B03029589"]}]},{"name":"Inha University Research Grant","award":["61529-01"],"award-info":[{"award-number":["61529-01"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0231174","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T17:31:20Z","timestamp":1586367080000},"page":"e0231174","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Vibrational stress affects extracellular signal-regulated kinases activation and cytoskeleton structure in human keratinocytes"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3698-9346","authenticated-orcid":true,"given":"Dongjoo","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5324-2711","authenticated-orcid":true,"given":"Soonjo","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"pone.0231174.ref001","volume-title":"The structure and function of skin","author":"W Montagna","year":"1974"},{"key":"pone.0231174.ref002","first-page":"19","volume-title":"Structure and function of the skin: overview of the epidermis and dermis","author":"A Haake","year":"2001"},{"key":"pone.0231174.ref003","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1600-0625.2008.00786.x","article-title":"The skin: an indispensable barrier","volume":"17","author":"E Proksch","year":"2008","journal-title":"Exp Dermatol"},{"key":"pone.0231174.ref004","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0039-6109(05)70566-1","article-title":"General principles of wound healing.","volume":"77","author":"MB Witte","year":"1997","journal-title":"Surg Clin North Am"},{"key":"pone.0231174.ref005","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature07039","article-title":"Wound repair and regeneration","volume":"453","author":"GC Gurtner","year":"2008","journal-title":"Nature"},{"key":"pone.0231174.ref006","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0022034509359125","article-title":"Factors affecting wound healing","volume":"89","author":"S Guo","year":"2010","journal-title":"J Dent Res"},{"key":"pone.0231174.ref007","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1445-2197.1994.tb02196.x","article-title":"Epidemiology of chronic leg ulcers in Australia","volume":"64","author":"SR Baker","year":"1994","journal-title":"Aust N Z J Surg"},{"key":"pone.0231174.ref008","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1472-6963-13-86","article-title":"Health service pathways for patients with chronic leg ulcers: identifying effective pathways for facilitation of evidence based wound care.","volume":"13","author":"H Edwards","year":"2013","journal-title":"BMC Health Serv Res"},{"key":"pone.0231174.ref009","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/bmj.324.7330.160","article-title":"Healing chronic wounds","volume":"324","author":"KG Harding","year":"2002","journal-title":"BMJ"},{"key":"pone.0231174.ref010","doi-asserted-by":"crossref","unstructured":"Frykberg RG, Banks J. Challenges in the treatment of chronic wounds. Advances in Wound Care. 140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA; 2015. pp. 560\u2013582. doi: 10.1089\/wound.2015.0635","DOI":"10.1089\/wound.2015.0635"},{"key":"pone.0231174.ref011","doi-asserted-by":"crossref","unstructured":"Kloth LC. Electrical Stimulation Technologies for Wound Healing. Advances in Wound Care. 140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA; 2014. pp. 81\u201390. doi: 10.1089\/wound.2013.0459","DOI":"10.1089\/wound.2013.0459"},{"key":"pone.0231174.ref012","article-title":"Electrical stimulation to accelerate wound healing.","author":"G Thakral","year":"2013","journal-title":"Diabetic Foot & Ankle."},{"key":"pone.0231174.ref013","doi-asserted-by":"crossref","first-page":"79","DOI":"10.12968\/jowc.1999.8.2.25844","article-title":"Topical negative pressure therapy in wound care.","volume":"8","author":"PE Banwell","year":"1999","journal-title":"J Wound Care"},{"key":"pone.0231174.ref014","doi-asserted-by":"crossref","first-page":"402e","DOI":"10.1097\/PRS.0000000000000467","article-title":"Noncontact, low-frequency ultrasound therapy enhances neovascularization and wound healing in diabetic mice","author":"ZN Maan","year":"2014","journal-title":"Plastic and Reconstructive Surgery"},{"key":"pone.0231174.ref015","doi-asserted-by":"crossref","first-page":"e91355","DOI":"10.1371\/journal.pone.0091355","article-title":"Low-intensity vibration improves angiogenesis and wound healing in diabetic mice.","volume":"9","author":"EM Weinheimer-Haus","year":"2014","journal-title":"PLoS One"},{"key":"pone.0231174.ref016","doi-asserted-by":"crossref","first-page":"11631","DOI":"10.1038\/s41598-017-11934-2","article-title":"Low-Magnitude High-Frequency Vibration Accelerated the Foot Wound Healing of n5-streptozotocin-induced Diabetic Rats by Enhancing Glucose Transporter 4 and Blood Microcirculation","volume":"7","author":"CO-L Yu","year":"2017","journal-title":"Sci Rep"},{"key":"pone.0231174.ref017","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.ygyno.2008.07.054","article-title":"Push-pull theory: using mechanotransduction to achieve tissue perfusion and wound healing in complex cases","volume":"111","author":"WJ Ennis","year":"2008","journal-title":"Gynecol Oncol"},{"key":"pone.0231174.ref018","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1177\/1534734611424648","article-title":"Low-frequency ultrasound (20\u201340 kHz) as an adjunctive therapy for chronic wound healing: a systematic review of the literature and meta-analysis of eight randomized controlled trials.","volume":"10","author":"J Voigt","year":"2011","journal-title":"Int J Low Extrem Wounds"},{"key":"pone.0231174.ref019","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/archsurg.2007.54","article-title":"Negative pressure wound therapy: a vacuum of evidence?","volume":"143","author":"S Gregor","year":"2008","journal-title":"Arch Surg"},{"key":"pone.0231174.ref020","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bone.2014.09.026","article-title":"Whole body vibration improves osseointegration by up-regulating osteoblastic activity but down-regulating osteoblast-mediated osteoclastogenesis via ERK1\/2 pathway","volume":"71","author":"Y Zhou","year":"2015","journal-title":"Bone"},{"key":"pone.0231174.ref021","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1089\/ten.tea.2013.0496","article-title":"Dynamic vibration cooperates with connective tissue growth factor to modulate stem cell behaviors","volume":"20","author":"Z Tong","year":"2014","journal-title":"Tissue Eng Part A"},{"key":"pone.0231174.ref022","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.cr.7290105","article-title":"MAPK signal pathways in the regulation of cell proliferation in mammalian cells","volume":"12","author":"W Zhang","year":"2002","journal-title":"Cell Res"},{"key":"pone.0231174.ref023","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases","volume":"298","author":"GL Johnson","year":"2002","journal-title":"Science"},{"key":"pone.0231174.ref024","first-page":"355","article-title":"Crosstalk and signaling switches in mitogen-activated protein kinase cascades.","volume":"3","author":"D Fey","year":"2012","journal-title":"Front Physiol."},{"key":"pone.0231174.ref025","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"pone.0231174.ref026","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/dth.12051","article-title":"Evidence-based management of common chronic lower extremity ulcers.","volume":"26","author":"NA Richmond","year":"2013","journal-title":"Dermatol Ther"},{"key":"pone.0231174.ref027","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM199909023411006","article-title":"Cutaneous wound healing","volume":"341","author":"AJ Singer","year":"1999","journal-title":"N Engl J Med"},{"key":"pone.0231174.ref028","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2119\/2006-00054.Brem","article-title":"Molecular markers in patients with chronic wounds to guide surgical debridement","author":"H Brem","year":"2007","journal-title":"Molecular Medicine"},{"key":"pone.0231174.ref029","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1001\/archderm.135.8.920","article-title":"Risk factors associated with the failure of a venous leg ulcer to heal","volume":"135","author":"DJ Margolis","year":"1999","journal-title":"Arch Dermatol"},{"key":"pone.0231174.ref030","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/jor.21334","article-title":"Effect of low-magnitude, high-frequency vibration on osteogenic differentiation of rat mesenchymal stromal cells","volume":"29","author":"E Lau","year":"2011","journal-title":"J Orthop Res"},{"key":"pone.0231174.ref031","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1007\/s10439-016-1587-5","article-title":"Development of Vibrational Culture Model Mimicking Vocal Fold Tissues","volume":"44","author":"D Kim","year":"2016","journal-title":"Ann Biomed Eng"},{"key":"pone.0231174.ref032","doi-asserted-by":"crossref","first-page":"E258","DOI":"10.1002\/lary.27113","article-title":"Characteristics and Responses of Human Vocal Fold Cells in a Vibrational Culture Model","volume":"128","author":"D Kim","year":"2018","journal-title":"Laryngoscope"},{"key":"pone.0231174.ref033","doi-asserted-by":"crossref","first-page":"638","DOI":"10.5114\/aoms.2015.52370","article-title":"Influence of different intensities of vibration on proliferation and differentiation of human periodontal ligament stem cells","author":"C Zhang","year":"2015","journal-title":"Archives of Medical Science: AMS"},{"key":"pone.0231174.ref034","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000454919","article-title":"Skin Wound Healing: An Update on the Current Knowledge and Concepts.","volume":"58","author":"H Sorg","year":"2017","journal-title":"Eur Surg Res."},{"key":"pone.0231174.ref035","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0092-8674(03)00108-9","article-title":"Sticky business: Orchestrating cellular signals at adherens junctions","volume":"112","author":"M Perez-Moreno","year":"2003","journal-title":"Cell"},{"key":"pone.0231174.ref036","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm2593","article-title":"Environmental sensing through focal adhesions","volume":"10","author":"B Geiger","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"pone.0231174.ref037","first-page":"245","article-title":"Roles of the cytoskeleton, cell adhesion and rho signalling in mechanosensing and mechanotransduction","volume":"161","author":"K Ohashi","year":"2017","journal-title":"J Biochem"},{"key":"pone.0231174.ref038","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.0906-6705.2004.00117.x","article-title":"ERK activation by mechanical strain is regulated by the small G proteins rac-1 and rhoA","volume":"13","author":"J Laboureau","year":"2004","journal-title":"Exp Dermatol"},{"key":"pone.0231174.ref039","doi-asserted-by":"crossref","first-page":"L883","DOI":"10.1152\/ajplung.00203.2001","article-title":"Cyclic stretch activates ERK1\/2 via G proteins and EGFR in alveolar epithelial cells","volume":"282","author":"E Correa-Meyer","year":"2002","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"pone.0231174.ref040","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"S Barrientos","year":"2008","journal-title":"Wound Repair Regen"},{"key":"pone.0231174.ref041","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1346-8138.1992.tb03755.x","article-title":"The effects of basic fibroblast growth factor and doxorubicin on cultured human skin fibroblasts: relevance to wound healing","volume":"19","author":"T. Sasaki","year":"1992","journal-title":"J Dermatol"},{"key":"pone.0231174.ref042","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1743-6109.2006.00143.x","article-title":"Basic fibroblast growth factor stimulates human keratinocyte motility by Rac activation.","volume":"14","author":"Y Sogabe","year":"2006","journal-title":"Wound Repair Regen"},{"key":"pone.0231174.ref043","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1152\/physrev.1999.79.4.1283","article-title":"Mechanism of action and in vivo role of platelet-derived growth factor","volume":"79","author":"CH Heldin","year":"1999","journal-title":"Physiol Rev"},{"key":"pone.0231174.ref044","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00129334-200401000-00012","article-title":"Growth factors and chronic wound healing: past, present, and future","volume":"17","author":"R. Goldman","year":"2004","journal-title":"Adv Skin Wound Care."},{"key":"pone.0231174.ref045","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1242\/jcs.02346","article-title":"Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing","volume":"118","author":"Y Shirakata","year":"2005","journal-title":"J Cell Sci"},{"key":"pone.0231174.ref046","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1126\/science.3487831","article-title":"Transforming growth factor factor-\u03b2: Biological function and chemical structure","volume":"233","author":"MB Sporn","year":"1986","journal-title":"Science"},{"key":"pone.0231174.ref047","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.det.2007.06.017","article-title":"Keratinocyte growth factor receptors.","volume":"25","author":"V de Giorgi","year":"2007","journal-title":"Dermatol Clin"},{"key":"pone.0231174.ref048","doi-asserted-by":"crossref","DOI":"10.1177\/2325967115585783","article-title":"Low-Magnitude, High-Frequency Vibration Fails to Accelerate Ligament Healing but Stimulates Collagen Synthesis in the Achilles Tendon.","volume":"3","author":"WR Thompson","year":"2015","journal-title":"Orthop J Sport Med."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0231174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T17:31:44Z","timestamp":1586367104000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0231174"}},"subtitle":[],"editor":[{"given":"Vivek K.","family":"Bajpai","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,8]]},"references-count":48,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0231174","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,8]]}}}