{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:57:46Z","timestamp":1790873866715,"version":"4.1.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["22590267"],"award-info":[{"award-number":["22590267"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Japan Agency for Medical Research and Develoment","award":["17im0210612h0001 and 18im020612h0002"],"award-info":[{"award-number":["17im0210612h0001 and 18im020612h0002"]}]},{"name":"TheJapan Foundation for Aging and Health"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0231265","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T17:34:41Z","timestamp":1586367281000},"page":"e0231265","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characterization of a novel compound that promotes myogenesis via\u00a0Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells"],"prefix":"10.1371","volume":"15","author":[{"given":"Manami","family":"Kodaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengju","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-8801","authenticated-orcid":true,"given":"Kyoko","family":"Arimoto-Matsuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Akazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Oyaizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Ishigami-Yuasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomi","family":"Tsuemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kagechika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nishina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1304-5286","authenticated-orcid":true,"given":"Yutaka","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"issue":"1","key":"pone.0231265.ref001","first-page":"77","article-title":"YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human disease","volume":"87","author":"K Wang","year":"2009","journal-title":"Biochem Cell Biol"},{"key":"pone.0231265.ref002","article-title":"YAP and TAZ: a nexus for Hippo signaling and beyond","author":"CG Hansen","year":"2015","journal-title":"Trends Cell Biol"},{"issue":"7","key":"pone.0231265.ref003","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1128\/MCB.01874-07","article-title":"TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway","volume":"28","author":"QY Lei","year":"2008","journal-title":"Mol Cell Biol"},{"issue":"7","key":"pone.0231265.ref004","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1158\/0008-5472.CAN-10-2711","article-title":"Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF","volume":"71","author":"D Lai","year":"2011","journal-title":"Cancer Res"},{"issue":"4","key":"pone.0231265.ref005","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cell.2011.09.048","article-title":"The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells","volume":"147","author":"M Cordenonsi","year":"2011","journal-title":"Cell"},{"issue":"5737","key":"pone.0231265.ref006","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1110955","article-title":"TAZ, a transcriptional modulator of mesenchymal stem cell differentiation","volume":"309","author":"JH Hong","year":"2005","journal-title":"Science"},{"issue":"17","key":"pone.0231265.ref007","doi-asserted-by":"crossref","first-page":"17384","DOI":"10.1074\/jbc.M312569200","article-title":"TAZ interacts with TTF-1 and regulates expression of surfactant protein-C","volume":"279","author":"KS Park","year":"2004","journal-title":"J Biol Chem"},{"key":"pone.0231265.ref008","article-title":"TAZ is required for lung alveolar epithelial cell differentiation after injury","volume":"5","author":"T Sun","year":"2019","journal-title":"JCI Insight"},{"issue":"50","key":"pone.0231265.ref009","doi-asserted-by":"crossref","first-page":"18034","DOI":"10.1073\/pnas.0509109102","article-title":"A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome","volume":"102","author":"M Murakami","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"29","key":"pone.0231265.ref010","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1038\/onc.2017.58","article-title":"MOB1-YAP1\/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation","volume":"36","author":"K Otsubo","year":"2017","journal-title":"Oncogene"},{"issue":"4","key":"pone.0231265.ref011","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1164\/rccm.200812-1827OC","article-title":"Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice","volume":"180","author":"A Mitani","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"pone.0231265.ref012","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1128\/MCB.23.3.1004-1013.2003","article-title":"Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ","volume":"23","author":"CB Cui","year":"2003","journal-title":"Mol Cell Biol"},{"issue":"9","key":"pone.0231265.ref013","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/ncb3394","article-title":"Snail\/Slug binding interactions with YAP\/TAZ control skeletal stem cell self-renewal and differentiation","volume":"18","author":"Y Tang","year":"2016","journal-title":"Nat Cell Biol"},{"issue":"2","key":"pone.0231265.ref014","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.stem.2018.06.009","article-title":"PGC-1\u03b1 Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ","volume":"23","author":"B Yu","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"6","key":"pone.0231265.ref015","volume":"145","author":"H Goto","year":"2018","journal-title":"Loss of. Development"},{"issue":"5","key":"pone.0231265.ref016","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/acel.12631","article-title":"Transcriptional coactivator with PDZ-binding motif is required to sustain testicular function on aging","volume":"16","author":"MG Jeong","year":"2017","journal-title":"Aging Cell"},{"issue":"1","key":"pone.0231265.ref017","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1172\/JCI88486","article-title":"Hippo signaling interactions with Wnt\/\u03b2-catenin and Notch signaling repress liver tumorigenesis","volume":"127","author":"W Kim","year":"2017","journal-title":"J Clin Invest"},{"key":"pone.0231265.ref018","doi-asserted-by":"crossref","first-page":"31931","DOI":"10.1038\/srep31931","article-title":"The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis","volume":"6","author":"E Seo","year":"2016","journal-title":"Sci Rep"},{"key":"pone.0231265.ref019","article-title":"Dysregulated YAP1\/TAZ and TGF-\u03b2 signaling mediate hepatocarcinogenesis in Mob1a\/1b-deficient mice","author":"M Nishio","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"pone.0231265.ref020","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1101\/gad.192856.112","article-title":"Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP","volume":"26","author":"Y Liu-Chittenden","year":"2012","journal-title":"Genes Dev"},{"issue":"1","key":"pone.0231265.ref021","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.bone.2011.10.035","article-title":"TAZ is required for the osteogenic and anti-adipogenic activities of kaempferol","volume":"50","author":"MR Byun","year":"2012","journal-title":"Bone"},{"issue":"5","key":"pone.0231265.ref022","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1111\/j.1476-5381.2011.01664.x","article-title":"TM-25659 enhances osteogenic differentiation and suppresses adipogenic differentiation by modulating the transcriptional co-activator TAZ","volume":"165","author":"EJ Jang","year":"2012","journal-title":"Br J Pharmacol"},{"issue":"5","key":"pone.0231265.ref023","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/jb\/mvv051","article-title":"A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1\/2 cells","volume":"158","author":"S Kawano","year":"2015","journal-title":"J Biochem"},{"issue":"2","key":"pone.0231265.ref024","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1089\/thy.2016.0264","article-title":"TAZ Induction Directs Differentiation of Thyroid Follicular Cells from Human Embryonic Stem Cells","volume":"27","author":"R Ma","year":"2017","journal-title":"Thyroid"},{"key":"pone.0231265.ref025","article-title":"Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in the muscle injury model","author":"Z Yang","year":"2014","journal-title":"Mol Cell Biol"},{"issue":"4","key":"pone.0231265.ref026","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2012.06.037","article-title":"Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling","volume":"150","author":"FX Yu","year":"2012","journal-title":"Cell"},{"issue":"2","key":"pone.0231265.ref027","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00018-014-1742-9","article-title":"The mammalian Hippo pathway: regulation and function of YAP1 and TAZ","volume":"72","author":"M Kodaka","year":"2015","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"pone.0231265.ref028","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"KC Fearon","year":"2012","journal-title":"Cell Metab"},{"issue":"2","key":"pone.0231265.ref029","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00424-014-1527-x","article-title":"Current understanding of sarcopenia: possible candidates modulating muscle mass","volume":"467","author":"K Sakuma","year":"2015","journal-title":"Pflugers Arch"},{"issue":"3","key":"pone.0231265.ref030","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00424-010-0919-9","article-title":"The role and regulation of MAFbx\/atrogin-1 and MuRF1 in skeletal muscle atrophy","volume":"461","author":"VC Foletta","year":"2011","journal-title":"Pflugers Arch"},{"key":"pone.0231265.ref031","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1038\/ncomms7670","article-title":"Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy","volume":"6","author":"G Milan","year":"2015","journal-title":"Nat Commun"},{"issue":"5","key":"pone.0231265.ref032","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2010.10.007","article-title":"FOXO\/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging","volume":"143","author":"F Demontis","year":"2010","journal-title":"Cell"},{"key":"pone.0231265.ref033","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.biocel.2016.06.012","article-title":"High mTORC1 signaling is maintained, while protein degradation pathways are perturbed in old murine skeletal muscles in the fasted state","volume":"78","author":"Z White","year":"2016","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"pone.0231265.ref034","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/jcsm.12045","article-title":"p62\/SQSTM1 but not LC3 is accumulated in sarcopenic muscle of mice","volume":"7","author":"K Sakuma","year":"2016","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"pone.0231265.ref035","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrc2070","article-title":"The Salvador-Warts-Hippo pathway\u2014an emerging tumour-suppressor network","volume":"7","author":"K Harvey","year":"2007","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"pone.0231265.ref036","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nrc3458","article-title":"The Hippo pathway and human cancer","volume":"13","author":"KF Harvey","year":"2013","journal-title":"Nat Rev Cancer"},{"issue":"7","key":"pone.0231265.ref037","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.tcb.2012.04.006","article-title":"The Hippo signaling pathway and stem cell biology","volume":"22","author":"A Ramos","year":"2012","journal-title":"Trends Cell Biol"},{"key":"pone.0231265.ref038","doi-asserted-by":"crossref","first-page":"12133","DOI":"10.1038\/ncomms12133","article-title":"\u03b1E-catenin inhibits YAP\/TAZ activity to regulate signalling centre formation during tooth development","volume":"7","author":"CY Li","year":"2016","journal-title":"Nat Commun"},{"issue":"1","key":"pone.0231265.ref039","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrd4161","article-title":"The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment","volume":"13","author":"R Johnson","year":"2014","journal-title":"Nat Rev Drug Discov"},{"issue":"7350","key":"pone.0231265.ref040","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"S Dupont","year":"2011","journal-title":"Nature"},{"issue":"4","key":"pone.0231265.ref041","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ncb3111","article-title":"Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway","volume":"17","author":"JS Mo","year":"2015","journal-title":"Nat Cell Biol"},{"issue":"4","key":"pone.0231265.ref042","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/ncb3113","article-title":"AMPK modulates Hippo pathway activity to regulate energy homeostasis","volume":"17","author":"W Wang","year":"2015","journal-title":"Nat Cell Biol"},{"issue":"1","key":"pone.0231265.ref043","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ncb3073","article-title":"Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase","volume":"17","author":"B Ma","year":"2015","journal-title":"Nat Cell Biol"},{"issue":"8","key":"pone.0231265.ref044","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/ncb3581","article-title":"Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation","volume":"19","author":"KC Lin","year":"2017","journal-title":"Nat Cell Biol"},{"issue":"2","key":"pone.0231265.ref045","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/s41388-019-0988-y","article-title":"A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis","volume":"39","author":"T Azad","year":"2019","journal-title":"Oncogene"},{"issue":"3","key":"pone.0231265.ref046","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1172\/JCI95802","article-title":"Hippo-mediated suppression of IRS2\/AKT signaling prevents hepatic steatosis and liver cancer","volume":"128","author":"SH Jeong","year":"2018","journal-title":"J Clin Invest"},{"key":"pone.0231265.ref047","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.biocel.2015.07.002","article-title":"Photoactivation of TAZ via Akt\/GSK3\u03b2 signaling pathway promotes osteogenic differentiation","volume":"66","author":"J Feng","year":"2015","journal-title":"Int J Biochem Cell Biol"},{"key":"pone.0231265.ref048","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejphar.2019.01.064","article-title":"IRS-1 targets TAZ to inhibit adipogenesis of rat bone marrow mesenchymal stem cells through PI3K-Akt and MEK-ERK pathways","volume":"849","author":"N Wang","year":"2019","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"pone.0231265.ref049","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1158\/1541-7786.MCR-17-0023","article-title":"Insulin Receptor and GPCR Crosstalk Stimulates YAP via PI3K and PKD in Pancreatic Cancer Cells","volume":"15","author":"F Hao","year":"2017","journal-title":"Mol Cancer Res"},{"issue":"10","key":"pone.0231265.ref050","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1158\/0008-5472.CAN-17-4052","article-title":"YAP1-Mediated Suppression of USP31 Enhances NF\u03baB Activity to Promote Sarcomagenesis","volume":"78","author":"S Ye","year":"2018","journal-title":"Cancer Res"},{"issue":"2","key":"pone.0231265.ref051","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bbrc.2005.10.214","article-title":"Transcriptional activity of Pax3 is co-activated by TAZ","volume":"339","author":"M Murakami","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"24","key":"pone.0231265.ref052","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1242\/dev.027151","article-title":"Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling","volume":"135","author":"M Ota","year":"2008","journal-title":"Development"},{"issue":"3","key":"pone.0231265.ref053","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2443.2007.01052.x","article-title":"c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases","volume":"12","author":"N Kobayashi","year":"2007","journal-title":"Genes Cells"},{"issue":"2","key":"pone.0231265.ref054","doi-asserted-by":"crossref","first-page":"e88347","DOI":"10.1371\/journal.pone.0088347","article-title":"NF-\u03baB inducing kinase, a central signaling component of the non-canonical pathway of NF-\u03baB, contributes to ovarian cancer progression","volume":"9","author":"M Uno","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"pone.0231265.ref055","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.yexcr.2007.02.013","article-title":"Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways","volume":"313","author":"M Ikeda","year":"2007","journal-title":"Exp Cell Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0231265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T17:35:28Z","timestamp":1586367328000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0231265"}},"subtitle":[],"editor":[{"given":"Arun","family":"Rishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,8]]},"references-count":55,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0231265","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,8]]}}}