{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:21:43Z","timestamp":1779394903459,"version":"3.53.1"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0231398","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T22:04:58Z","timestamp":1586556298000},"page":"e0231398","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Drug induced liver injury is associated with high mortality\u2014A study from a tertiary care hospital in Pakistan"],"prefix":"10.1371","volume":"15","author":[{"given":"Adeel","family":"Abid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faryal","family":"Subhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhana","family":"Kayani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safia","family":"Awan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-0378","authenticated-orcid":true,"given":"Shahab","family":"Abid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,4,10]]},"reference":[{"issue":"6","key":"pone.0231398.ref001","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1053\/j.gastro.2008.09.011","article-title":"Drug Induced Liver Injury N. Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States","volume":"135","author":"N Chalasani","year":"2008","journal-title":"Gastroenterology"},{"issue":"4","key":"pone.0231398.ref002","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1159\/000374089","article-title":"Drug-induced liver injury is a major risk for new drugs","volume":"33","author":"LB Seeff","year":"2015","journal-title":"J Dig Dis"},{"issue":"2","key":"pone.0231398.ref003","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4103\/0974-7788.64405","article-title":"Tinosporacordifolia (Willd.)Hook.f. and Thoms.(Guduchi)-validation of the Ayurvedic pharmacology through experimental and clinical studies","volume":"1","author":"AK Upadhyay","year":"2010","journal-title":"Int J Ayurveda Res"},{"issue":"2","key":"pone.0231398.ref004","first-page":"332","article-title":"Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria","volume":"129","author":"M Porceddu","year":"2012","journal-title":"ToxicolSci"},{"issue":"5","key":"pone.0231398.ref005","first-page":"233","article-title":"Drug-induced hepatotoxicity: a review","volume":"2","author":"A Pandit","year":"2012","journal-title":"J Appl Pharm Sci"},{"issue":"12","key":"pone.0231398.ref006","doi-asserted-by":"crossref","first-page":"947","DOI":"10.7326\/0003-4819-137-12-200212170-00007","article-title":"Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States","volume":"137","author":"G Ostapowicz","year":"2002","journal-title":"Ann Intern Med"},{"issue":"1","key":"pone.0231398.ref007","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cld.2016.08.004","article-title":"Epidemiology and genetic risk factors of drug hepatotoxicity","volume":"21","author":"J Ahmad","year":"2017","journal-title":"Clinics in liver disease"},{"issue":"5","key":"pone.0231398.ref008","first-page":"463","article-title":"Important elements for the diagnosis of drug-induced liver injury","volume":"8","author":"Network DILI","year":"2010","journal-title":"ClinGastroenterolHepatol"},{"issue":"11","key":"pone.0231398.ref009","first-page":"1323","article-title":"Causality assessment of adverse reactions to drugs\u00e2\u20ac\u201dI. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries","volume":"46","author":"G Danan","year":"1993","journal-title":"ClinEpidemiol"},{"issue":"7","key":"pone.0231398.ref010","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1053\/j.gastro.2013.02.006","article-title":"Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland","volume":"144","author":"ES Bjornsson","year":"2013","journal-title":"Gastroenterology"},{"issue":"2","key":"pone.0231398.ref011","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1053\/jhep.2002.34857","article-title":"Incidence of drug-induced hepatic injuries: a French population-based study","volume":"36","author":"C Sgro","year":"2002","journal-title":"Hepatol"},{"issue":"10","key":"pone.0231398.ref012","first-page":"1227","article-title":"Ascertainment of acute liver injury in two European primary care databases","volume":"70","author":"A Ruigomez","year":"2014","journal-title":"ClinPharmacol"},{"issue":"7","key":"pone.0231398.ref013","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1053\/j.gastro.2015.03.006","article-title":"Features and outcomes of 899 patients with drug-induced liver injury: the DILIN prospective study","volume":"148","author":"N Chalasani","year":"2015","journal-title":"Gastroenterology"},{"issue":"2","key":"pone.0231398.ref014","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.gastro.2005.05.006","article-title":"Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period","volume":"129","author":"RlJ Andrade","year":"2005","journal-title":"Gastroenterology"},{"issue":"4","key":"pone.0231398.ref015","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/hep.27317","article-title":"Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network","volume":"60","author":"V. J. Navarro","year":"2014","journal-title":"Hepatology"},{"issue":"2","key":"pone.0231398.ref016","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jhep.2011.07.023","article-title":"Hepatotoxicity associated with statins: reports of idiosyncratic liver injury post-marketing","volume":"56","author":"E Bjornsson","year":"2012","journal-title":"J Hepatol"},{"issue":"6","key":"pone.0231398.ref017","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.amjmed.2005.02.008","article-title":"Evaluation of cases of severe statin-related transaminitis within a large health maintenance organization","volume":"118","author":"EC Charles","year":"2005","journal-title":"Am J Med"},{"issue":"6","key":"pone.0231398.ref018","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1136\/gutjnl-2016-313369","article-title":"Drug-induced liver injury: recent advances in diagnosis and risk assessment","volume":"66","author":"GA Kullak-Ublick","year":"2017","journal-title":"Gut"},{"issue":"1","key":"pone.0231398.ref019","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.lungcan.2015.01.026","article-title":"Pooled safety analysis of EGFR-TKI treatment for EGFR mutation-positive non-small cell lung cancer","volume":"88","author":"M Takeda","year":"2015","journal-title":"Lung Cancer"},{"issue":"1","key":"pone.0231398.ref020","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.clinre.2017.08.003","article-title":"Features and outcomes from a retrospective study of 570 hospitalized Chinese patients with drug-induced liver injury","volume":"42","author":"L Pang","year":"2018","journal-title":"Clinics and research in hepatology and gastroenterology"},{"issue":"3","key":"pone.0231398.ref021","first-page":"221","article-title":"guidelines for the diagnosis and treatment of drug-induced liver injury","volume":"11","author":"Y-c Yu","year":"2017","journal-title":"HepatolInt"},{"issue":"3","key":"pone.0231398.ref022","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1056\/NEJMra1816149","article-title":"Drug-Induced Liver Injury\u2014Types and Phenotypes","volume":"381","author":"Jay H. Hoofnagle","year":"2019","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"pone.0231398.ref023","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/hep.1840130407","article-title":"Incidence of parenchymal liver diseases in Denmark, 1981 to 1985: analysis of hospitalization registry data","volume":"13","author":"TP Almdal","year":"1991","journal-title":"Hepatol"},{"issue":"1","key":"pone.0231398.ref024","first-page":"57","article-title":"Traditional Chinese medicine and herb-induced liver injury: comparison with drug-induced liver injury","volume":"6","author":"J Jing","year":"2018","journal-title":"J ClinTranslHepatol"},{"issue":"6","key":"pone.0231398.ref025","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2165\/11535340-000000000-00000","article-title":"Drugs associated with hepatotoxicity and their reporting frequency of liver adverse events in VigiBase:unified list based on international collaborative work","volume":"33","author":"A Suzuki","year":"2010","journal-title":"Drug safety"},{"issue":"7","key":"pone.0231398.ref026","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ajg.2014.131","article-title":"ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury","volume":"109","author":"NP Chalasani","year":"2014","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"pone.0231398.ref027","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/hep.20800","article-title":"Outcome and prognostic markers in severe drug-induced liver disease","volume":"42","author":"E Bjornsson","year":"2005","journal-title":"Hepatol"},{"issue":"11","key":"pone.0231398.ref028","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1038\/ajg.2010.287","article-title":"Single-center experience with drug-induced liver injury from India: causes, outcome, prognosis, and predictors of mortality","volume":"105","author":"H Devarbhavi","year":"2010","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"pone.0231398.ref029","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3748\/wjg.v13.i4.628","article-title":"Evaluation of prognostic markers in severe drug-induced liver disease","volume":"13","author":"B Li","year":"2007","journal-title":"World J. Gastroenterol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0231398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T22:05:13Z","timestamp":1586556313000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0231398"}},"subtitle":[],"editor":[{"given":"Chiara","family":"Lazzeri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,10]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0231398","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,10]]}}}