{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:03:13Z","timestamp":1740146593811,"version":"3.37.3"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education","award":["2018R1D1A3B07043344"],"award-info":[{"award-number":["2018R1D1A3B07043344"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0231428","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T17:31:55Z","timestamp":1586367115000},"page":"e0231428","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Homocysteine is not a risk factor for subclinical coronary atherosclerosis in asymptomatic individuals"],"prefix":"10.1371","volume":"15","author":[{"given":"Sangwoo","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-0606","authenticated-orcid":true,"given":"Gyung-Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhee","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Rak","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Hyung","family":"Roh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Ji","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-Bum","family":"Won","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soe Hee","family":"Ann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Giun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Jae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Gon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hyun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon-Won","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Hwan","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Kyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaewon","family":"Choe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Whan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Hak","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"pone.0231428.ref001","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMra1112570","article-title":"A tale of coronary artery disease and myocardial infarction","volume":"366","author":"EG Nabel","year":"2012","journal-title":"N Engl J Med"},{"key":"pone.0231428.ref002","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.atherosclerosis.2010.06.021","article-title":"Predicting the risk of coronary heart disease. II: the role of novel molecular biomarkers and genetics in estimating risk, and the future of risk prediction","volume":"213","author":"TH Dent","year":"2010","journal-title":"Atherosclerosis"},{"key":"pone.0231428.ref003","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jacc.2011.05.028","article-title":"Homocysteine and reclassification of cardiovascular disease risk","volume":"58","author":"V Veeranna","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"pone.0231428.ref004","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","article-title":"Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis","volume":"288","author":"Homocysteine Studies C","year":"2002","journal-title":"JAMA"},{"key":"pone.0231428.ref005","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1056\/NEJM199104253241701","article-title":"Hyperhomocysteinemia: an independent risk factor for vascular disease","volume":"324","author":"R Clarke","year":"1991","journal-title":"N Engl J Med"},{"key":"pone.0231428.ref006","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.1995.03530130055028","article-title":"A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes","volume":"274","author":"CJ Boushey","year":"1995","journal-title":"JAMA"},{"key":"pone.0231428.ref007","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","volume":"354","author":"E Lonn","year":"2006","journal-title":"N Engl J Med"},{"key":"pone.0231428.ref008","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/jama.2015.2274","article-title":"Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial","volume":"313","author":"Y Huo","year":"2015","journal-title":"JAMA"},{"key":"pone.0231428.ref009","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/jama.291.5.565","article-title":"Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial","volume":"291","author":"JF Toole","year":"2004","journal-title":"JAMA"},{"key":"pone.0231428.ref010","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S1474-4422(10)70187-3","article-title":"B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial","volume":"9","author":"VTS Group","year":"2010","journal-title":"Lancet Neurol"},{"key":"pone.0231428.ref011","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.2010.840","article-title":"Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial","volume":"303","author":"Study of the Effectiveness of Additional Reductions in C","year":"2010","journal-title":"JAMA"},{"key":"pone.0231428.ref012","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJMoa055227","article-title":"Homocysteine lowering and cardiovascular events after acute myocardial infarction","volume":"354","author":"KH Bonaa","year":"2006","journal-title":"N Engl J Med"},{"key":"pone.0231428.ref013","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/S0735-1097(03)00485-6","article-title":"Secondary prevention with folic acid: effects on clinical outcomes","volume":"41","author":"A Liem","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"pone.0231428.ref014","first-page":"CD006612","article-title":"Homocysteine-lowering interventions for preventing cardiovascular events","volume":"8","author":"AJ Marti-Carvajal","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"pone.0231428.ref015","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ijcard.2017.05.073","article-title":"Prediabetes is not a risk factor for subclinical coronary atherosclerosis","volume":"243","author":"GM Park","year":"2017","journal-title":"Int J Cardiol"},{"key":"pone.0231428.ref016","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.atherosclerosis.2019.07.017","article-title":"Serum uric acid level and subclinical coronary atherosclerosis in asymptomatic individuals: An observational cohort study","volume":"288","author":"DH Lim","year":"2019","journal-title":"Atherosclerosis"},{"key":"pone.0231428.ref017","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jhep.2017.12.012","article-title":"Association between non-alcoholic fatty liver disease and subclinical coronary atherosclerosis: An observational cohort study","volume":"68","author":"SB Lee","year":"2018","journal-title":"J Hepatol"},{"key":"pone.0231428.ref018","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1161\/CIRCOUTCOMES.114.001305","article-title":"Model for assessing cardiovascular risk in a Korean population","volume":"7","author":"GM Park","year":"2014","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"pone.0231428.ref019","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.amjcard.2015.04.046","article-title":"Comparison of Coronary Computed Tomographic Angiographic Findings in Asymptomatic Subjects With Versus Without Diabetes Mellitus","volume":"116","author":"GM Park","year":"2015","journal-title":"Am J Cardiol"},{"key":"pone.0231428.ref020","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jcct.2009.01.001","article-title":"SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography","volume":"3","author":"GL Raff","year":"2009","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"pone.0231428.ref021","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"AS Agatston","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"pone.0231428.ref022","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jacc.2005.10.058","article-title":"Accuracy of 64-slice computed tomography to classify and quantify plaque volumes in the proximal coronary system: a comparative study using intravascular ultrasound","volume":"47","author":"AW Leber","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"pone.0231428.ref023","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jacc.2007.03.067","article-title":"Prognostic value of multidetector coronary computed tomographic angiography for prediction of all-cause mortality","volume":"50","author":"JK Min","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"pone.0231428.ref024","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1097\/HJH.0000000000000647","article-title":"Effects of 2-year vitamin B12 and folic acid supplementation in hyperhomocysteinemic elderly on arterial stiffness and cardiovascular outcomes within the B-PROOF trial","volume":"33","author":"SC van Dijk","year":"2015","journal-title":"J Hypertens"},{"key":"pone.0231428.ref025","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/STROKEAHA.108.526798","article-title":"High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial","volume":"40","author":"HN Hodis","year":"2009","journal-title":"Stroke"},{"key":"pone.0231428.ref026","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s11064-014-1338-7","article-title":"Toxic effects of mildly elevated homocysteine concentrations in neuronal-like cells","volume":"39","author":"M Curro","year":"2014","journal-title":"Neurochem Res"},{"key":"pone.0231428.ref027","doi-asserted-by":"crossref","first-page":"6920","DOI":"10.1523\/JNEUROSCI.20-18-06920.2000","article-title":"Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity","volume":"20","author":"II Kruman","year":"2000","journal-title":"J Neurosci"},{"key":"pone.0231428.ref028","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2288-8-37","article-title":"Challenges of self-reported medical conditions and electronic medical records among members of a large military cohort","volume":"8","author":"B Smith","year":"2008","journal-title":"BMC Med Res Methodol"},{"key":"pone.0231428.ref029","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/eurheartj\/ehu053","article-title":"Coronary computed tomography angiography with model-based iterative reconstruction using a radiation exposure similar to chest X-ray examination","volume":"35","author":"TA Fuchs","year":"2014","journal-title":"Eur Heart J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0231428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T17:32:09Z","timestamp":1586367129000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0231428"}},"subtitle":[],"editor":[{"given":"Timir","family":"Paul","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,8]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0231428","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2020,4,8]]}}}