{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:57:34Z","timestamp":1788357454101,"version":"build-2803163510"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0231701","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T17:30:53Z","timestamp":1587144653000},"page":"e0231701","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4411-7617","authenticated-orcid":true,"given":"Fabian","family":"Benz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Bogen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Praktiknjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Wree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muenevver","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Loosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihael","family":"Vucur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2195-3666","authenticated-orcid":true,"given":"Robert","family":"Schierwagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-0226","authenticated-orcid":true,"given":"Frank","family":"Tacke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonel","family":"Trebicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Roderburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,4,17]]},"reference":[{"issue":"2","key":"pone.0231701.ref001","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jhep.2018.03.024","article-title":"EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis","volume":"69","year":"2018","journal-title":"J Hepatol"},{"issue":"4","key":"pone.0231701.ref002","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jhep.2018.04.025","article-title":"The intensive care unit course and outcome in acute-on-chronic liver failure are comparable to other populations","volume":"69","author":"P. Meersseman","year":"2018","journal-title":"J Hepatol"},{"issue":"7","key":"pone.0231701.ref003","doi-asserted-by":"crossref","first-page":"e19370","DOI":"10.5812\/hepatmon.19370","article-title":"Plasma Interleukin-10: A Likely Predictive Marker for Hepatitis B Virus-Related Acute-on-Chronic Liver Failure","volume":"14","author":"K. Wang","year":"2014","journal-title":"Hepat Mon"},{"key":"pone.0231701.ref004","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cyto.2015.10.006","article-title":"Immune dysfunction in cirrhosis: Distinct cytokines phenotypes according to cirrhosis severity","volume":"77","author":"M. Dirchwolf","year":"2016","journal-title":"Cytokine"},{"key":"pone.0231701.ref005","article-title":"Biomarkers of Macrophage Activation and Immune Danger Signals Predict Clinical Outcomes in Alcoholic Hepatitis","author":"B. Saha","year":"2019","journal-title":"Hepatology"},{"issue":"2","key":"pone.0231701.ref006","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.critrevonc.2013.08.013","article-title":"Bone sialoprotein and osteopontin in bone metastasis of osteotropic cancers","volume":"89","author":"T.E. Kruger","year":"2014","journal-title":"Crit Rev Oncol Hematol"},{"issue":"1","key":"pone.0231701.ref007","doi-asserted-by":"crossref","first-page":"9750","DOI":"10.1038\/s41598-018-28201-7","article-title":"Elevated serum levels of bone sialoprotein during ICU treatment predict long-term mortality in critically ill patients","volume":"8","author":"M. Luedde","year":"2018","journal-title":"Sci Rep"},{"issue":"4","key":"pone.0231701.ref008","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.jhep.2017.06.020","article-title":"Elevated levels of circulating osteopontin are associated with a poor survival after resection of cholangiocarcinoma","volume":"67","author":"S.H. Loosen","year":"2017","journal-title":"J Hepatol"},{"issue":"1","key":"pone.0231701.ref009","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/s41598-018-38352-2","article-title":"Elevated serum levels of bone sialoprotein (BSP) predict long-term mortality in patients with pancreatic adenocarcinoma","volume":"9","author":"S.H. Loosen","year":"2019","journal-title":"Sci Rep"},{"issue":"11","key":"pone.0231701.ref010","doi-asserted-by":"crossref","DOI":"10.3390\/jcm7110390","article-title":"Circulating Levels of Osteopontin Predict Patients\u2019 Outcome after Resection of Colorectal Liver Metastases","volume":"7","author":"S.H. Loosen","year":"2018","journal-title":"J Clin Med"},{"issue":"1\u20132","key":"pone.0231701.ref011","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jneuroim.2013.07.005","article-title":"Plasma osteopontin levels are associated with disease activity in the patients with multiple sclerosis and neuromyelitis optica","volume":"263","author":"Y. Shimizu","year":"2013","journal-title":"J Neuroimmunol"},{"issue":"5","key":"pone.0231701.ref012","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/rheumatology\/keh558","article-title":"Elevation of plasma osteopontin concentration is correlated with disease activity in patients with systemic lupus erythematosus","volume":"44","author":"C.K. Wong","year":"2005","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"pone.0231701.ref013","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/MCG.0b013e31802d6268","article-title":"High plasma osteopontin levels in patients with inflammatory bowel disease","volume":"41","author":"R. Mishima","year":"2007","journal-title":"J Clin Gastroenterol"},{"issue":"271","key":"pone.0231701.ref014","first-page":"015","article-title":"Persistently elevated osteopontin serum levels predict mortality in critically ill patients","volume":"19","author":"C. Roderburg","year":"2015","journal-title":"Crit Care"},{"issue":"3","key":"pone.0231701.ref015","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nrc2345","article-title":"Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer","volume":"8","author":"A. Bellahcene","year":"2008","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"pone.0231701.ref016","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jhep.2014.09.032","article-title":"CXCL9 is a prognostic marker in patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt","volume":"62","author":"M.L. Berres","year":"2015","journal-title":"J Hepatol"},{"issue":"5","key":"pone.0231701.ref017","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/liv.13610","article-title":"Circulating CXCL10 in cirrhotic portal hypertension might reflect systemic inflammation and predict ACLF and mortality","volume":"38","author":"J.M. Lehmann","year":"2018","journal-title":"Liver Int"},{"issue":"3","key":"pone.0231701.ref018","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/liv.12922","article-title":"Chemokine (C-X-C motif) ligand 11 levels predict survival in cirrhotic patients with transjugular intrahepatic portosystemic shunt","volume":"36","author":"M.L. Berres","year":"2016","journal-title":"Liver Int"},{"issue":"1","key":"pone.0231701.ref019","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/hep.23922","article-title":"Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis","volume":"53","author":"C. Roderburg","year":"2011","journal-title":"Hepatology"},{"issue":"12","key":"pone.0231701.ref020","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.3748\/wjg.v22.i12.3441","article-title":"Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis","volume":"22","author":"R. Bruha","year":"2016","journal-title":"World J Gastroenterol"},{"issue":"4","key":"pone.0231701.ref021","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3390\/jcm2040264","article-title":"The Roles of Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal-to-Epithelial Transition (MET) in Breast Cancer Bone Metastasis: Potential Targets for Prevention and Treatment","volume":"2","author":"B. Demirkan","year":"2013","journal-title":"J Clin Med"},{"issue":"11","key":"pone.0231701.ref022","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1051\/medsci\/20132911019","article-title":"SIBLING proteins: molecular tools for tumor progression and angiogenesis","volume":"29","author":"V. Lamour","year":"2013","journal-title":"Med Sci (Paris)"},{"issue":"12","key":"pone.0231701.ref023","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1177\/0022034515605270","article-title":"Osteopontin in Immune-mediated Diseases","volume":"94","author":"S.R. Rittling","year":"2015","journal-title":"J Dent Res"},{"issue":"8","key":"pone.0231701.ref024","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080815","article-title":"Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight","volume":"8","author":"A.S. Lamort","year":"2019","journal-title":"Cells"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0231701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T17:31:38Z","timestamp":1587144698000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0231701"}},"subtitle":[],"editor":[{"given":"Pavel","family":"Strnad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,17]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0231701","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,17]]}}}