{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T18:52:42Z","timestamp":1776538362093,"version":"3.51.2"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0232071","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T14:32:43Z","timestamp":1602685963000},"page":"e0232071","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Molecular investigations on a chimeric strain of Staphylococcus aureus sequence type 80"],"prefix":"10.1371","volume":"15","author":[{"given":"Darius","family":"Gawlik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Ruppelt-Lorz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annett","family":"Rei\u00dfig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Hotzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha D.","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"S\u00f6derquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht","family":"Ziegler-Cordts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8157-2753","authenticated-orcid":true,"given":"Mathias W.","family":"Pletz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Ehricht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4368-8709","authenticated-orcid":true,"given":"Stefan","family":"Monecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"issue":"24","key":"pone.0232071.ref001","doi-asserted-by":"crossref","first-page":"8312","DOI":"10.1128\/JB.187.24.8312-8321.2005","article-title":"Evolutionary Genetics of the Accessory Gene Regulator (agr) Locus in Staphylococcus aureus.","volume":"187","author":"DA Robinson","year":"2005","journal-title":"J Bacteriol"},{"issue":"5","key":"pone.0232071.ref002","doi-asserted-by":"crossref","first-page":"e5714","DOI":"10.1371\/journal.pone.0005714","article-title":"Genetic diversity of staphylocoagulase genes (coa): insight into the evolution of variable chromosomal virulence factors in Staphylococcus aureus.","volume":"4","author":"S Watanabe","year":"2009","journal-title":"PLoS ONE"},{"key":"pone.0232071.ref003","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1038\/ncomms4956","article-title":"Mobile elements drive recombination hotspots in the core genome of Staphylococcus aureus","volume":"5","author":"RG Everitt","year":"2014","journal-title":"Nature communications"},{"issue":"7","key":"pone.0232071.ref004","doi-asserted-by":"crossref","first-page":"e0130955","DOI":"10.1371\/journal.pone.0130955","article-title":"Using Whole Genome Analysis to Examine Recombination across Diverse Sequence Types of Staphylococcus aureus","volume":"10","author":"EM Driebe","year":"2015","journal-title":"PLOS ONE"},{"issue":"4","key":"pone.0232071.ref005","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1128\/JB.186.4.1060-1064.2004","article-title":"Evolution of Staphylococcus aureus by Large Chromosomal Replacements","volume":"186","author":"DA Robinson","year":"2004","journal-title":"J Bacteriol"},{"issue":"3","key":"pone.0232071.ref006","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1128\/JB.01255-09","article-title":"Genome Sequence of a Recently Emerged, Highly Transmissible, Multi-Antibiotic- and Antiseptic-Resistant Variant of Methicillin-Resistant Staphylococcus aureus, Sequence Type 239 (TW).","volume":"192","author":"MTG Holden","year":"2010","journal-title":"Journal of Bacteriology"},{"issue":"5","key":"pone.0232071.ref007","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.cmi.2014.12.018","article-title":"ST2249-MRSA-III: a second major recombinant methicillin-resistant Staphylococcus aureus clone causing healthcare infection in the 1970s","volume":"21","author":"GR Nimmo","year":"2015","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"pone.0232071.ref008","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/cid\/ciw687","article-title":"Turkey Meat as Source of CC9\/CC398 Methicillin-Resistant Staphylococcus aureus in Humans?","volume":"64","author":"A Fetsch","year":"2017","journal-title":"Clin Infect Dis"},{"key":"pone.0232071.ref009","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.vetmic.2018.02.024","article-title":"Variability of SCCmec elements in livestock-associated CC398 MRSA","volume":"217","author":"S Monecke","year":"2018","journal-title":"Veterinary Microbiology"},{"issue":"4","key":"pone.0232071.ref010","doi-asserted-by":"crossref","DOI":"10.1099\/mgen.0.000036","article-title":"Recombination-mediated remodelling of host\u2013pathogen interactions during Staphylococcus aureus niche adaptation","volume":"1","author":"LE Spoor","year":"2015","journal-title":"Microbial Genomics"},{"issue":"8","key":"pone.0232071.ref011","doi-asserted-by":"crossref","first-page":"e0134592","DOI":"10.1371\/journal.pone.0134592","article-title":"Extensive Genomic Diversity among Bovine-Adapted Staphylococcus aureus: Evidence for a Genomic Rearrangement within CC97.","volume":"10","author":"KE Budd","year":"2015","journal-title":"PLoS ONE."},{"issue":"4","key":"pone.0232071.ref012","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1128\/JCM.43.4.1836-1842.2005","article-title":"Epidemiology of emerging methicillin-resistant Staphylococcus aureus (MRSA) in Denmark: a nationwide study in a country with low prevalence of MRSA infection.","volume":"43","author":"NA Faria","year":"2005","journal-title":"J Clin Microbiol"},{"issue":"5","key":"pone.0232071.ref013","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1128\/JCM.43.5.2384-2390.2005","article-title":"Staphylococcus aureus isolates carrying Panton-Valentine leucocidin genes in England and Wales: frequency, characterization, and association with clinical disease","volume":"43","author":"A Holmes","year":"2005","journal-title":"J Clin Microbiol"},{"issue":"12","key":"pone.0232071.ref014","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s10096-007-0391-4","article-title":"PVL-positive MRSA in Austria","volume":"26","author":"K Krziwanek","year":"2007","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"7","key":"pone.0232071.ref015","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/apm.12181","article-title":"Characterization of PVL-positive MRSA from Norway","volume":"122","author":"S Monecke","year":"2014","journal-title":"Apmis"},{"issue":"8","key":"pone.0232071.ref016","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1469-0691.2006.01420.x","article-title":"Microarray-based characterisation of a Panton-Valentine leukocidin-positive community-acquired strain of methicillin-resistant Staphylococcus aureus","volume":"12","author":"S Monecke","year":"2006","journal-title":"Clin Microbiol Infect"},{"issue":"6","key":"pone.0232071.ref017","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1469-0691.2008.01986.x","article-title":"DNA microarray-based genotyping of methicillin-resistant Staphylococcus aureus strains from Eastern Saxony","volume":"14","author":"S Monecke","year":"2008","journal-title":"Clin Microbiol Infect"},{"issue":"7","key":"pone.0232071.ref018","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/j.1469-0691.2008.02017.x","article-title":"The emergence of community-associated methicillin-resistant Staphylococcus aureus at a London teaching hospital, 2000\u20132006","volume":"14","author":"JA Otter","year":"2008","journal-title":"Clin Microbiol Infect"},{"issue":"8","key":"pone.0232071.ref019","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1128\/JCM.00245-07","article-title":"The emergence and importation of diverse genotypes of methicillin-resistant Staphylococcus aureus (MRSA) harboring the Panton-Valentine leukocidin gene (pvl) reveal that pvl is a poor marker for community-acquired MRSA strains in Ireland.","volume":"45","author":"AS Rossney","year":"2007","journal-title":"J Clin Microbiol"},{"issue":"5","key":"pone.0232071.ref020","doi-asserted-by":"crossref","first-page":"e01044","DOI":"10.1128\/mBio.01044-14","article-title":"Origin and evolution of European community-acquired methicillin-resistant Staphylococcus aureus","volume":"5","author":"M Stegger","year":"2014","journal-title":"mbio"},{"issue":"5","key":"pone.0232071.ref021","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1128\/JCM.41.5.2027-2032.2003","article-title":"Two international methicillin-resistant Staphylococcus aureus clones endemic in a university hospital in Patras, Greece","volume":"41","author":"M Aires de Sousa","year":"2003","journal-title":"J Clin Microbiol"},{"issue":"5","key":"pone.0232071.ref022","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2807\/esm.10.05.00537-en","article-title":"Community acquired MRSA infections in a paediatric population in Greece.","volume":"10","author":"S Vourli","year":"2005","journal-title":"Euro Surveill"},{"issue":"9","key":"pone.0232071.ref023","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s10096-005-0008-8","article-title":"Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus in Germany associated with travel or foreign family origin","volume":"24","author":"J Maier","year":"2005","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"5","key":"pone.0232071.ref024","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1017\/S0950268810000440","article-title":"Molecular characterization of Staphylococcus aureus in Lebanon","volume":"138","author":"ST Tokajian","year":"2010","journal-title":"Epidemiol Infect"},{"issue":"2","key":"pone.0232071.ref025","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10096-009-0834-1","article-title":"Characterisation of MRSA from Malta and the description of a Maltese epidemic MRSA strain","volume":"29","author":"E Scicluna","year":"2010","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"pone.0232071.ref026","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.diagmicrobio.2008.02.010","article-title":"Characterization of ST80 Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus clone in Tunisia","volume":"77","author":"M Ben Nejma","year":"2013","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"4","key":"pone.0232071.ref027","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s10096-010-1109-6","article-title":"Nasal carriage of Staphylococcus aureus in healthy humans with different levels of contact with animals in Tunisia: genetic lineages, methicillin resistance, and virulence factors","volume":"30","author":"K Ben Slama","year":"2011","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"4","key":"pone.0232071.ref028","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1469-0691.2010.03273.x","article-title":"High prevalence of methicillin-resistant Staphylococcus aureus clone ST80-IV in hospital and community settings in Algiers","volume":"17","author":"K Antri","year":"2011","journal-title":"Clin Microbiol Infect"},{"issue":"2","key":"pone.0232071.ref029","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3855\/jidc.4620","article-title":"Changing molecular epidemiology of methicillin-resistant Staphylococcus aureus in an Algerian hospital.","volume":"9","author":"P Basset","year":"2015","journal-title":"J Infect Dev Ctries"},{"issue":"1","key":"pone.0232071.ref030","first-page":"49","article-title":"Panton-Valentine leukocidin positive sequence type 80 methicillin-resistant Staphylococcus aureus carrying a staphylococcal cassette chromosome mec type IVc is dominant in neonates and children in an Algiers hospital.","volume":"36","author":"F Djoudi","year":"2013","journal-title":"New Microbiol"},{"issue":"9","key":"pone.0232071.ref031","doi-asserted-by":"crossref","first-page":"e0162744","DOI":"10.1371\/journal.pone.0162744","article-title":"Shifts in the Clonal Distribution of Methicillin-Resistant Staphylococcus aureus in Kuwait Hospitals: 1992\u20132010.","volume":"11","author":"SS Boswihi","year":"2016","journal-title":"PLoS ONE."},{"issue":"1","key":"pone.0232071.ref032","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/1471-2180-12-146","article-title":"Characterisation of MRSA strains isolated from patients in a hospital in Riyadh, Kingdom of Saudi Arabia","volume":"12","author":"S Monecke","year":"2012","journal-title":"BMC Microbiol"},{"issue":"4","key":"pone.0232071.ref033","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/nmi2.47","article-title":"Genotyping of methicillin-resistant Staphylococcus aureus in the Sultan Qaboos University Hospital, Oman reveals the dominance of Panton\u2013Valentine leucocidin-negative ST6-IV\/t304 clone.","volume":"2","author":"EE Udo","year":"2014","journal-title":"New Microbes and New Infections"},{"issue":"Pt 2","key":"pone.0232071.ref034","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1099\/jmm.0.013268-0","article-title":"Genetic analysis of high-level mupirocin resistance in the ST80 clone of community-associated meticillin-resistant Staphylococcus aureus","volume":"59","author":"EE Udo","year":"2010","journal-title":"J Med Microbiol"},{"key":"pone.0232071.ref035","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2015.01160","article-title":"An assessment on DNA microarray and sequence-based methods for the characterization of methicillin-susceptible Staphylococcus aureus from Nigeria","volume":"6","author":"AO Shittu","year":"2015","journal-title":"Frontiers in Microbiology"},{"issue":"9","key":"pone.0232071.ref036","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1128\/JCM.00648-09","article-title":"Emergence of a community-associated methicillin-resistant Staphylococcus aureus strain with a unique resistance profile in Southwest Nigeria","volume":"47","author":"B Ghebremedhin","year":"2009","journal-title":"J Clin Microbiol"},{"issue":"5","key":"pone.0232071.ref037","doi-asserted-by":"crossref","first-page":"e1150","DOI":"10.1371\/journal.pntd.0001150","article-title":"Population structure of Staphylococcus aureus from remote African Babongo Pygmies","volume":"5","author":"F Schaumburg","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"pone.0232071.ref038","doi-asserted-by":"crossref","first-page":"e17936","DOI":"10.1371\/journal.pone.0017936","article-title":"A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus.","volume":"6","author":"S Monecke","year":"2011","journal-title":"PLoS ONE"},{"issue":"9","key":"pone.0232071.ref039","doi-asserted-by":"crossref","first-page":"e0162654","DOI":"10.1371\/journal.pone.0162654","article-title":"Diversity of SCCmec elements in Staphylococcus aureus as observed in South-Eastern Germany.","volume":"11","author":"S Monecke","year":"2016","journal-title":"PLoS ONE"},{"key":"pone.0232071.ref040","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1574-695X.2008.00426.x","article-title":"Assignment of Staphylococcus aureus isolates to clonal complexes based on microarray analysis and pattern recognition","volume":"53","author":"S Monecke","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"1","key":"pone.0232071.ref041","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.1038\/s41598-020-62751-z","article-title":"Genomic characterization and outcome of prosthetic joint infections caused by Staphylococcus aureus.","volume":"10","author":"P Wildeman","year":"2020","journal-title":"Sci Rep."},{"issue":"1436","key":"pone.0232071.ref042","article-title":"Molecular typing of ST239-MRSA-III from diverse geographic locations and the evolution of the SCCmec III element during its intercontinental spread","volume":"9","author":"S Monecke","year":"2018","journal-title":"Frontiers in Microbiology"},{"issue":"1","key":"pone.0232071.ref043","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2217\/fmb.12.126","article-title":"Staphylococcal disease in Africa: another neglected 'tropical' disease.","volume":"8","author":"M Herrmann","year":"2013","journal-title":"Future Microbiol"},{"issue":"4","key":"pone.0232071.ref044","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/JCM.03022-15","article-title":"Detecting Staphylococcus aureus Virulence and Resistance Genes: a Comparison of Whole-Genome Sequencing and DNA Microarray Technology","volume":"54","author":"L Strau\u00df","year":"2016","journal-title":"Journal of Clinical Microbiology"},{"key":"pone.0232071.ref045","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.meegid.2017.09.019","article-title":"Epidemiology of transmissible diseases: Array hybridization and next generation sequencing as universal nucleic acid-mediated typing tools","volume":"63","author":"WM Dunne","year":"2018","journal-title":"Infection Genetics and Evolution"},{"issue":"11","key":"pone.0232071.ref046","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1128\/JB.185.11.3307-3316.2003","article-title":"How clonal is Staphylococcus aureus?","volume":"185","author":"EJ Feil","year":"2003","journal-title":"J Bacteriol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0232071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T14:33:25Z","timestamp":1602686005000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0232071"}},"subtitle":[],"editor":[{"given":"D. Ashley","family":"Robinson","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,14]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0232071","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.04.08.031591","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,14]]}}}