{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:29:54Z","timestamp":1776745794196,"version":"3.51.2"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T00:00:00Z","timestamp":1588550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS085238"],"award-info":[{"award-number":["NS085238"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0232300","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T17:37:00Z","timestamp":1588613820000},"page":"e0232300","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["A new linear regression-like residual for survival analysis, with application to genome wide association studies of time-to-event data"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3004-3840","authenticated-orcid":true,"given":"Veronica J.","family":"Vieland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Cheol","family":"Seok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C. L.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"issue":"3","key":"pone.0232300.ref001","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/ana.23528","article-title":"Evidence-based path to newborn screening for Duchenne muscular dystrophy","volume":"71","author":"JR Mendell","year":"2012","journal-title":"Ann Neurol"},{"issue":"10","key":"pone.0232300.ref002","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ejhg.2012.301","article-title":"Newborn bloodspot screening for Duchenne muscular dystrophy: 21 years experience in Wales (UK)","volume":"21","author":"SJ Moat","year":"2013","journal-title":"Eur J Hum Genet"},{"issue":"12","key":"pone.0232300.ref003","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1172\/JCI39845","article-title":"Latent TGF-beta-binding protein 4 modifies muscular dystrophy in mice","volume":"119","author":"A Heydemann","year":"2009","journal-title":"J Clin Invest"},{"issue":"5","key":"pone.0232300.ref004","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2015.10.049","article-title":"Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype","volume":"163","author":"NM Vieira","year":"2015","journal-title":"Cell"},{"issue":"3","key":"pone.0232300.ref005","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1212\/WNL.0b013e318207afeb","article-title":"SPP1 genotype is a determinant of disease severity in Duchenne muscular dystrophy","volume":"76","author":"E Pegoraro","year":"2011","journal-title":"Neurology"},{"issue":"4","key":"pone.0232300.ref006","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/ana.23819","article-title":"LTBP4 genotype predicts age of ambulatory loss in Duchenne muscular dystrophy","volume":"73","author":"KM Flanigan","year":"2013","journal-title":"Ann Neurol"},{"issue":"5","key":"pone.0232300.ref007","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.ajhg.2016.08.023","article-title":"Association Study of Exon Variants in the NF-kappaB and TGFbeta Pathways Identifies CD40 as a Modifier of Duchenne Muscular Dystrophy","volume":"99","author":"L Bello","year":"2016","journal-title":"Am J Hum Genet"},{"issue":"2","key":"pone.0232300.ref008","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/ana.25283","article-title":"Long-range genomic regulators of THBS1 and LTBP4 modify disease severity in duchenne muscular dystrophy","volume":"84","author":"RB Weiss","year":"2018","journal-title":"Ann Neurol"},{"issue":"12","key":"pone.0232300.ref009","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1002\/humu.21114","article-title":"Mutational spectrum of DMD mutations in dystrophinopathy patients: application of modern diagnostic techniques to a large cohort","volume":"30","author":"KM Flanigan","year":"2009","journal-title":"Hum Mutat"},{"issue":"3","key":"pone.0232300.ref010","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/humu.21426","article-title":"Nonsense mutation-associated Becker muscular dystrophy: interplay between exon definition and splicing regulatory elements within the DMD gene","volume":"32","author":"KM Flanigan","year":"2011","journal-title":"Hum Mutat"},{"issue":"8","key":"pone.0232300.ref011","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.nmd.2010.05.010","article-title":"Clinical and genetic characterization of manifesting carriers of DMD mutations","volume":"20","author":"P Soltanzadeh","year":"2010","journal-title":"Neuromuscul Disord"},{"issue":"2","key":"pone.0232300.ref012","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression Models and Life-Tables","volume":"34","author":"DR Cox","year":"1972","journal-title":"J Royal Stat Soc, Series B"},{"issue":"408","key":"pone.0232300.ref013","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1080\/01621459.1989.10478873","article-title":"Regression Analysis of Multivariate Incomplete Failure Time Data by Modeling Marginal Distributions","volume":"84","author":"LJ Wei","year":"1989","journal-title":"J Amer Statist Assoc"},{"issue":"4","key":"pone.0232300.ref014","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1159\/000330634","article-title":"KELVIN: a software package for rigorous measurement of statistical evidence in human genetics","volume":"72","author":"V. J. Vieland","year":"2011","journal-title":"Human Heredity"},{"key":"pone.0232300.ref015","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/gepi.20193","article-title":"Accumulating quantitative trait linkage evidence across multiple datasets using the posterior probability of linkage","volume":"31","author":"CW Bartlett","year":"2006","journal-title":"Genet Epi"},{"issue":"8","key":"pone.0232300.ref016","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/gepi.20537","article-title":"Association statistics under the PPL framework","volume":"34","author":"Y Huang","year":"2010","journal-title":"Genet Epidemiol"},{"key":"pone.0232300.ref017","volume-title":"Statistical Evidence: A likelihood paradigm","author":"R Royall","year":"1997"},{"key":"pone.0232300.ref018","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1086\/499065","article-title":"Review of Statistical Evidence: A Likelihood Paradigm","volume":"63","author":"VJ Vieland","year":"1998","journal-title":"Am J Hum Genet"},{"issue":"9","key":"pone.0232300.ref019","doi-asserted-by":"crossref","first-page":"e0203860","DOI":"10.1371\/journal.pone.0203860","article-title":"Non-parametric estimation of survival in age-dependent genetic disease and application to the transthyretin-related hereditary amyloidosis","volume":"13","author":"F Alarcon","year":"2018","journal-title":"PLoS One"},{"key":"pone.0232300.ref020","unstructured":"S.A.G.E. Statistical Analysis for Genetic Epidemiology. Release 64: http:\/\/darwincwruedu 2016."},{"key":"pone.0232300.ref021","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/sim.981","article-title":"Residual-Based Tree-Structured Survival Analysis","volume":"21","author":"S Keles","year":"2002","journal-title":"Statistics in Medicine"},{"key":"pone.0232300.ref022","author":"T Therneau","year":"1988","journal-title":"Martingale Based Residuals for Survival Models"},{"issue":"1","key":"pone.0232300.ref023","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/biomet\/75.1.65","article-title":"Residuals for Relative Risk Regression","volume":"75","author":"WE Barlow","year":"1988","journal-title":"Biometrika"},{"key":"pone.0232300.ref024","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000086699","article-title":"The posterior probability of linkage allowing for linkage disequilibrium and a new estimate of disequilibrium between a trait and a marker","volume":"59","author":"X Yang","year":"2005","journal-title":"Hum Hered"},{"key":"pone.0232300.ref025","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1469-1809.1963.tb00210.x","article-title":"Testing for heterogeneity of recombination fraction values in human genetics","volume":"27","author":"CAB Smith","year":"1963","journal-title":"Ann Hum Genet"},{"issue":"5","key":"pone.0232300.ref026","first-page":"1072","article-title":"The problem of ascertainment for linkage analysis","volume":"58","author":"VJ Vieland","year":"1996","journal-title":"Am J Hum Genet"},{"issue":"430","key":"pone.0232300.ref027","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1080\/01621459.1995.10476572","article-title":"Bayes Factors","volume":"90","author":"R.E. Kass","year":"1995","journal-title":"Journal of the American Statistical Association"},{"issue":"5","key":"pone.0232300.ref028","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1089\/cmb.2008.0175","article-title":"Fast and accurate calculation of a computationally intensive statistic for mapping disease genes","volume":"16","author":"S-C Seok","year":"2009","journal-title":"J Comput Biol"},{"issue":"6","key":"pone.0232300.ref029","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1159\/000152448","article-title":"A general model for the genetic analysis of pedigree data","volume":"21","author":"RC Elston","year":"1971","journal-title":"Hum Hered"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0232300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T06:16:16Z","timestamp":1722838576000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0232300"}},"subtitle":[],"editor":[{"given":"Fengfeng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,5,4]]},"references-count":29,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0232300","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,4]]}}}