{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:25:16Z","timestamp":1775075116341,"version":"3.50.1"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agreement concerning research and education of doctors, Sweden","award":["ALFGBG-11522, ALFGBG-136431, ALFGBG-426411, ALFGBG-507701, ALFGBG-671611 and ALFGBG-717501"],"award-info":[{"award-number":["ALFGBG-11522, ALFGBG-136431, ALFGBG-426411, ALFGBG-507701, ALFGBG-671611 and ALFGBG-717501"]}]},{"name":"The Health & Medical Care Committee of the Regional Executive Board, Region V\u00e4stra G\u00f6taland, Sweden","award":["VGFOUREG-231311, VGFOUREG-308151 and VGFOUREG-368351"],"award-info":[{"award-number":["VGFOUREG-231311, VGFOUREG-308151 and VGFOUREG-368351"]}]},{"name":"Sahlgrenska University Hospital Foundations, Sweden"},{"name":"The foundation \u201cAlice Swenzons Stiftelse f\u00f6r Vetenskaplig Forskning\u201d, Sweden"},{"name":"The foundation \u201cKungl och Hvitfeldtska Stiftelsen\u201d, Sweden"},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["AI133976 and AI45890"],"award-info":[{"award-number":["AI133976 and AI45890"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0232553","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T17:37:43Z","timestamp":1588873063000},"page":"e0232553","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mid-trimester amniotic fluid proteome\u2019s association with spontaneous preterm delivery and gestational duration"],"prefix":"10.1371","volume":"15","author":[{"given":"Maria","family":"Hallingstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-1897","authenticated-orcid":true,"given":"Petra","family":"Zedn\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vojt\u011bch","family":"Tambor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malin","family":"Barman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Vajrychov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juraj","family":"Len\u010do","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicia","family":"Viklund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Tancred","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hardis","family":"Rabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisa","family":"Kachikis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Staffan","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Kacerovsk\u00fd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6939-7224","authenticated-orcid":true,"given":"Kristina M.","family":"Adams Waldorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5079-2374","authenticated-orcid":true,"given":"Bo","family":"Jacobsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"pone.0232553.ref001","volume-title":"Executive Summary for Born Too Soon: The global action report on preterm birth","author":"Born Too Soon Executive Summary Group","year":"2012"},{"key":"pone.0232553.ref002","article-title":"Analysis of big data for prediction of provider-initiated preterm birth and spontaneous premature deliveries and ranking the predictive features","author":"T Khatibi","year":"2019","journal-title":"Arch Gynecol Obstet"},{"issue":"6","key":"pone.0232553.ref003","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.0001-6349.2005.00765.x","article-title":"Preterm birth in Sweden 1973\u20132001: rate, subgroups, and effect of changing patterns in multiple births, maternal age, and smoking","volume":"84","author":"NH Morken","year":"2005","journal-title":"Acta obstetricia et gynecologica Scandinavica"},{"issue":"9606","key":"pone.0232553.ref004","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"RL Goldenberg","year":"2008","journal-title":"Lancet"},{"issue":"6","key":"pone.0232553.ref005","doi-asserted-by":"crossref","first-page":"830 e1","DOI":"10.1016\/j.ajog.2015.08.028","article-title":"Uterine overdistention induces preterm labor mediated by inflammation: observations in pregnant women and nonhuman primates","volume":"213","author":"KM Adams Waldorf","year":"2015","journal-title":"American journal of obstetrics and gynecology"},{"issue":"6198","key":"pone.0232553.ref006","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.1251816","article-title":"Preterm labor: one syndrome, many causes","volume":"345","author":"R Romero","year":"2014","journal-title":"Science (New York, NY)"},{"issue":"10","key":"pone.0232553.ref007","doi-asserted-by":"crossref","first-page":"e022929","DOI":"10.1136\/bmjopen-2018-022929","article-title":"Uterine distention as a factor in birth timing: retrospective nationwide cohort study in Sweden","volume":"8","author":"J Bacelis","year":"2018","journal-title":"BMJ Open"},{"issue":"8","key":"pone.0232553.ref008","doi-asserted-by":"crossref","first-page":"e0160335","DOI":"10.1371\/journal.pone.0160335","article-title":"Literature-Informed Analysis of a Genome-Wide Association Study of Gestational Age in Norwegian Women and Children Suggests Involvement of Inflammatory Pathways","volume":"11","author":"J Bacelis","year":"2016","journal-title":"PLoS One"},{"key":"pone.0232553.ref009","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bpobgyn.2018.05.003","article-title":"Genetic studies of gestational duration and preterm birth","volume":"52","author":"G Zhang","year":"2018","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"5","key":"pone.0232553.ref010","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/sj.jp.7211290","article-title":"Amniotic fluid: not just fetal urine anymore","volume":"25","author":"MA Underwood","year":"2005","journal-title":"Journal of perinatology: official journal of the California Perinatal Association"},{"issue":"5","key":"pone.0232553.ref011","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nm0595-460","article-title":"A placental clock controlling the length of human pregnancy","volume":"1","author":"M McLean","year":"1995","journal-title":"Nature medicine"},{"issue":"3","key":"pone.0232553.ref012","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1046\/j.1365-3083.2001.00872.x","article-title":"Cytokine levels in midtrimester amniotic fluid in normal pregnancy and in the prediction of pre-eclampsia","volume":"53","author":"J Heikkinen","year":"2001","journal-title":"Scandinavian journal of immunology"},{"issue":"1","key":"pone.0232553.ref013","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-2006-956773","article-title":"The role of inflammation and infection in preterm birth","volume":"25","author":"R Romero","year":"2007","journal-title":"Seminars in reproductive medicine"},{"key":"pone.0232553.ref014","article-title":"Preterm delivery: an overview on prediction, prevention and treatment","volume":"116","author":"B Jacobsson","year":"2019","journal-title":"Lakartidningen"},{"issue":"2","key":"pone.0232553.ref015","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1471-0528.2010.02765.x","article-title":"Prediction of microbial invasion of the amniotic cavity in women with preterm labour: analysis of multiple proteins in amniotic and cervical fluids","volume":"118","author":"RM Holst","year":"2011","journal-title":"BJOG: an international journal of obstetrics and gynaecology"},{"issue":"7","key":"pone.0232553.ref016","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/j.1471-0528.2012.03328.x","article-title":"Prediction of spontaneous preterm delivery in women with threatened preterm labour: a prospective cohort study of multiple proteins in maternal serum","volume":"119","author":"P Tsiartas","year":"2012","journal-title":"BJOG: an international journal of obstetrics and gynaecology"},{"issue":"Suppl 3","key":"pone.0232553.ref017","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1471-0528.2006.01150.x","article-title":"The use of high-dimensional biology (genomics, transcriptomics, proteomics, and metabolomics) to understand the preterm parturition syndrome","volume":"113","author":"R Romero","year":"2006","journal-title":"BJOG: an international journal of obstetrics and gynaecology"},{"issue":"9306","key":"pone.0232553.ref018","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(02)07746-2","article-title":"Use of proteomic patterns in serum to identify ovarian cancer","volume":"359","author":"EF Petricoin","year":"2002","journal-title":"Lancet"},{"issue":"6928","key":"pone.0232553.ref019","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nature01512","article-title":"Protein analysis on a proteomic scale","volume":"422","author":"E Phizicky","year":"2003","journal-title":"Nature"},{"issue":"4","key":"pone.0232553.ref020","doi-asserted-by":"crossref","first-page":"471","DOI":"10.33549\/physiolres.931758","article-title":"Application of proteomics in biomarker discovery: a primer for the clinician","volume":"59","author":"V Tambor","year":"2010","journal-title":"Physiol Res"},{"issue":"2","key":"pone.0232553.ref021","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.3390\/s120202284","article-title":"Biomarker discovery by novel sensors based on nanoproteomics approaches","volume":"12","author":"N Dasilva","year":"2012","journal-title":"Sensors (Basel)"},{"issue":"1","key":"pone.0232553.ref022","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1371\/journal.pmed.0040018","article-title":"Proteomic profiling of the amniotic fluid to detect inflammation, infection, and neonatal sepsis","volume":"4","author":"CS Buhimschi","year":"2007","journal-title":"PLoS Med"},{"issue":"2","key":"pone.0232553.ref023","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1471-0528.2004.00340.x","article-title":"Proteomic biomarker analysis of amniotic fluid for identification of intra-amniotic inflammation","volume":"112","author":"IA Buhimschi","year":"2005","journal-title":"BJOG: an international journal of obstetrics and gynaecology"},{"issue":"6","key":"pone.0232553.ref024","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1021\/pr050139e","article-title":"Proteomic analysis using protein chips to detect biomarkers in cervical and amniotic fluid in women with intra-amniotic inflammation","volume":"4","author":"U Ruetschi","year":"2005","journal-title":"Journal of proteome research"},{"issue":"4","key":"pone.0232553.ref025","doi-asserted-by":"crossref","first-page":"e2049","DOI":"10.1371\/journal.pone.0002049","article-title":"Multidimensional proteomics analysis of amniotic fluid to provide insight into the mechanisms of idiopathic preterm birth","volume":"3","author":"IA Buhimschi","year":"2008","journal-title":"PLoS One"},{"issue":"8","key":"pone.0232553.ref026","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1002\/pmic.200300455","article-title":"Identification of biologic markers of the premature rupture of fetal membranes: proteomic approach","volume":"3","author":"F Vuadens","year":"2003","journal-title":"Proteomics"},{"issue":"2","key":"pone.0232553.ref027","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.placenta.2012.11.028","article-title":"Proteomics and bioinformatics analysis reveal underlying pathways of infection associated histologic chorioamnionitis in pPROM","volume":"34","author":"V Tambor","year":"2013","journal-title":"Placenta"},{"issue":"12","key":"pone.0232553.ref028","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.3109\/14767058.2012.712565","article-title":"Proteomic analysis of midtrimester amniotic fluid to identify novel biomarkers for preterm delivery","volume":"25","author":"C Fotopoulou","year":"2012","journal-title":"The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet"},{"issue":"5","key":"pone.0232553.ref029","doi-asserted-by":"crossref","first-page":"e0155164","DOI":"10.1371\/journal.pone.0155164","article-title":"Proteomic Analysis of Early Mid-Trimester Amniotic Fluid Does Not Predict Spontaneous Preterm Delivery","volume":"11","author":"M Hallingstrom","year":"2016","journal-title":"PloS one"},{"issue":"5","key":"pone.0232553.ref030","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1067\/mob.2001.117678","article-title":"An elevated amniotic fluid matrix metalloproteinase-8 level at the time of mid-trimester genetic amniocentesis is a risk factor for spontaneous preterm delivery","volume":"185","author":"BH Yoon","year":"2001","journal-title":"American journal of obstetrics and gynecology"},{"issue":"1","key":"pone.0232553.ref031","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jri.2008.04.002","article-title":"Inflammatory processes in preterm and term parturition","volume":"79","author":"I Christiaens","year":"2008","journal-title":"Journal of reproductive immunology"},{"issue":"5","key":"pone.0232553.ref032","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.siny.2006.05.001","article-title":"Inflammation in preterm and term labour and delivery","volume":"11","author":"R Romero","year":"2006","journal-title":"Semin Fetal Neonatal Med"},{"issue":"Suppl 3","key":"pone.0232553.ref033","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1471-0528.2006.01120.x","article-title":"The preterm parturition syndrome","volume":"113","author":"R Romero","year":"2006","journal-title":"BJOG: an international journal of obstetrics and gynaecology"},{"issue":"1","key":"pone.0232553.ref034","first-page":"129","article-title":"The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer","volume":"1826","author":"S Chakraborty","year":"2012","journal-title":"Biochimica et biophysica acta"},{"issue":"7","key":"pone.0232553.ref035","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1023\/A:1003708808934","article-title":"Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression","volume":"31","author":"A Friedl","year":"1999","journal-title":"Histochem J"},{"issue":"1","key":"pone.0232553.ref036","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3109\/14767058.2014.991305","article-title":"Microbial invasion and histological chorioamnionitis upregulate neutrophil-gelatinase associated lipocalin in preterm prelabor rupture of membranes","volume":"29","author":"M Vajrychova","year":"2016","journal-title":"The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet"},{"issue":"8","key":"pone.0232553.ref037","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1177\/1933719110396722","article-title":"Intra-amniotic infection upregulates neutrophil gelatinase-associated lipocalin (NGAL) expression at the maternal-fetal interface at term: implications for infection-related preterm birth","volume":"18","author":"S Tadesse","year":"2011","journal-title":"Reprod Sci"},{"issue":"5","key":"pone.0232553.ref038","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1097-2765(02)00710-4","article-title":"An iron delivery pathway mediated by a lipocalin","volume":"10","author":"J Yang","year":"2002","journal-title":"Mol Cell"},{"issue":"10","key":"pone.0232553.ref039","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1128\/IAI.00602-13","article-title":"Sequestration and scavenging of iron in infection","volume":"81","author":"NL Parrow","year":"2013","journal-title":"Infection and immunity"},{"issue":"4","key":"pone.0232553.ref040","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1542\/peds.2005-0870","article-title":"High concentrations of plasminogen activator inhibitor-1 in lungs of preterm infants with respiratory distress syndrome","volume":"117","author":"K Cederqvist","year":"2006","journal-title":"Pediatrics"},{"issue":"10","key":"pone.0232553.ref041","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1002\/j.1460-2075.1986.tb04532.x","article-title":"Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family","volume":"5","author":"H Pannekoek","year":"1986","journal-title":"The EMBO journal"},{"key":"pone.0232553.ref042","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fendo.2018.00053","article-title":"IGF Binding Protein-5 Induces Cell Senescence","volume":"9","author":"F Sanada","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"10","key":"pone.0232553.ref043","doi-asserted-by":"crossref","first-page":"e005133","DOI":"10.1161\/CIRCHEARTFAILURE.118.005133","article-title":"IGFBP7 (Insulin-Like Growth Factor-Binding Protein-7) and Neprilysin Inhibition in Patients With Heart Failure","volume":"11","author":"JL Januzzi","year":"2018","journal-title":"Circ Heart Fail"},{"issue":"9","key":"pone.0232553.ref044","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.placenta.2015.05.003","article-title":"Aging of intrauterine tissues in spontaneous preterm birth and preterm premature rupture of the membranes: A systematic review of the literature","volume":"36","author":"J Polettini","year":"2015","journal-title":"Placenta"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0232553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T08:20:52Z","timestamp":1615623652000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0232553"}},"subtitle":[],"editor":[{"given":"Kang","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,5,7]]},"references-count":44,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0232553","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,7]]}}}