{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:59:49Z","timestamp":1785473989899,"version":"3.56.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0232604","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T18:46:02Z","timestamp":1589481962000},"page":"e0232604","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Associations of dog and cat ownership with wheezing and asthma in children: Pilot study of the Japan Environment and children's study"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2442-2406","authenticated-orcid":true,"given":"Yu","family":"Taniguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2298-5133","authenticated-orcid":true,"given":"Takehiro","family":"Michikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji F.","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Sekiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Mezawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayako","family":"Saito-Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mitsubuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Sanefuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouichi","family":"Ohga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Mise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Ikegami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Shimono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Suga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,5,14]]},"reference":[{"issue":"4","key":"pone.0232604.ref001","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1164\/ajrccm\/146.4.888","article-title":"A community-based study of the epidemiology of asthma. Incidence rates, 1964\u20131983","volume":"146","author":"JW Yunginger","year":"1992","journal-title":"The American review of respiratory disease"},{"issue":"9239","key":"pone.0232604.ref002","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/S0140-6736(00)02842-7","article-title":"Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. Multicentre Allergy Study Group","volume":"356","author":"S Lau","year":"2000","journal-title":"Lancet (London, England)"},{"key":"pone.0232604.ref003","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fimmu.2014.00076","article-title":"Animal allergens and their presence in the environment","volume":"5","author":"E Zahradnik","year":"2014","journal-title":"Frontiers in immunology"},{"issue":"5","key":"pone.0232604.ref004","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1046\/j.1365-2222.1999.00534.x","article-title":"Does early exposure to cat or dog protect against later allergy development?","volume":"29","author":"B Hesselmar","year":"1999","journal-title":"Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology"},{"issue":"9","key":"pone.0232604.ref005","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1046\/j.1365-2222.2003.01764.x","article-title":"Direct and indirect exposure to pets\u2014risk of sensitization and asthma at 4 years in a birth cohort","volume":"33","author":"C Almqvist","year":"2003","journal-title":"Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology"},{"issue":"7","key":"pone.0232604.ref006","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1398-9995.2008.01732.x","article-title":"Exposure to furry pets and the risk of asthma and allergic rhinitis: a meta-analysis","volume":"63","author":"B Takkouche","year":"2008","journal-title":"Allergy"},{"key":"pone.0232604.ref007","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-35245-2","article-title":"Dog characteristics and future risk of asthma in children growing up with dogs","volume":"8","author":"T Fall","year":"2018","journal-title":"Scientific reports"},{"issue":"5","key":"pone.0232604.ref008","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.jaci.2005.02.035","article-title":"Allergen exposure in infancy and the development of sensitization, wheeze, and asthma at 4 years","volume":"115","author":"JE Brussee","year":"2005","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"7012","key":"pone.0232604.ref009","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1136\/bmj.311.7012.1053","article-title":"Home environment and severe asthma in adolescence: a population based case-control study","volume":"311","author":"DP Strachan","year":"1995","journal-title":"Bmj"},{"issue":"5","key":"pone.0232604.ref010","doi-asserted-by":"crossref","first-page":"e0197274","DOI":"10.1371\/journal.pone.0197274","article-title":"Pet keeping in childhood and asthma and allergy among children in Tianjin area, China","volume":"13","author":"S Luo","year":"2018","journal-title":"PloS one"},{"issue":"3","key":"pone.0232604.ref011","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1067\/mai.2001.113240","article-title":"Systematic review: Exposure to pets and risk of asthma and asthma-like symptoms","volume":"107","author":"BJ Apelberg","year":"2001","journal-title":"The Journal of allergy and clinical immunology"},{"key":"pone.0232604.ref012","unstructured":"Japan Pet Food Association. https:\/\/petfood.or.jp\/English\/message\/index.html. Accessed February, 2020."},{"key":"pone.0232604.ref013","article-title":"Extent of protective or allergy-inducing effects in cats and dogs","volume":"25","author":"E Krzych-Fa\u0142ta","year":"2017","journal-title":"Annals of Agricultural and Environmental Medicine"},{"issue":"6","key":"pone.0232604.ref014","doi-asserted-by":"crossref","first-page":"e0127756","DOI":"10.1371\/journal.pone.0127756","article-title":"Associations of Pet Ownership with Wheezing and Lung Function in Childhood: Findings from a UK Birth Cohort","volume":"10","author":"SM Collin","year":"2015","journal-title":"PloS one"},{"issue":"4","key":"pone.0232604.ref015","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1136\/adc.62.4.345","article-title":"Prodromal features of asthma","volume":"62","author":"S Beer","year":"1987","journal-title":"Arch Dis Child"},{"issue":"5","key":"pone.0232604.ref016","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/ped.12818","article-title":"Relieving pain and distress during venipuncture: Pilot study of the Japan Environment and Children's Study (JECS)","volume":"57","author":"K Yamamoto-Hanada","year":"2015","journal-title":"Pediatrics international: official journal of the Japan Pediatric Society"},{"issue":"1","key":"pone.0232604.ref017","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/ped.13410","article-title":"Regional differences in infant 25-Hydroxyvitamin D: Pilot study of the Japan Environment and Children's Study","volume":"60","author":"T Ayabe","year":"2018","journal-title":"Pediatrics international: official journal of the Japan Pediatric Society"},{"issue":"9111","key":"pone.0232604.ref018","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0140-6736(97)07302-9","article-title":"Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee","volume":"351","year":"1998","journal-title":"Lancet (London, England)"},{"issue":"4","key":"pone.0232604.ref019","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1398-9995.2005.00938.x","article-title":"Asthma in every fifth child in Oslo, Norway: a 10-year follow up of a birth cohort study","volume":"61","author":"KC Lodrup Carlsen","year":"2006","journal-title":"Allergy"},{"issue":"8","key":"pone.0232604.ref020","doi-asserted-by":"crossref","first-page":"e43214","DOI":"10.1371\/journal.pone.0043214","article-title":"Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts","volume":"7","author":"KC Lodrup Carlsen","year":"2012","journal-title":"PloS one"},{"issue":"4","key":"pone.0232604.ref021","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/jes.2014.15","article-title":"Association between traffic-related air pollution and development of asthma in school children: cohort study in Japan","volume":"24","author":"S Yamazaki","year":"2014","journal-title":"Journal of exposure science & environmental epidemiology"},{"issue":"8","key":"pone.0232604.ref022","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/oxfordjournals.aje.a116745","article-title":"Childhood asthma and indoor environmental risk factors","volume":"137","author":"C. Infante-Rivard","year":"1993","journal-title":"Am J Epidemiol"},{"issue":"1","key":"pone.0232604.ref023","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1399-3038.1998.tb00297.x","article-title":"Cat and dog allergen in mattresses and textile covered floors of homes which do or do not have pets, either in the past or currently","volume":"9","author":"AC Egmar","year":"1998","journal-title":"Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology"},{"issue":"6200","key":"pone.0232604.ref024","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1126\/science.1254529","article-title":"Longitudinal analysis of microbial interaction between humans and the indoor environment","volume":"345","author":"S Lax","year":"2014","journal-title":"Science"},{"issue":"7728","key":"pone.0232604.ref025","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-018-0617-x","article-title":"Temporal development of the gut microbiome in early childhood from the TEDDY study","volume":"562","author":"CJ Stewart","year":"2018","journal-title":"Nature"},{"key":"pone.0232604.ref026","article-title":"Birth Mode, Breastfeeding, Pet Exposure, and Antibiotic Use: Associations With the Gut Microbiome and Sensitization in Children","volume":"19","author":"H Kim","year":"2019","journal-title":"Current Allergy and Asthma Reports"},{"issue":"5","key":"pone.0232604.ref027","doi-asserted-by":"crossref","first-page":"e64133","DOI":"10.1371\/journal.pone.0064133","article-title":"Home life: factors structuring the bacterial diversity found within and between homes","volume":"8","author":"RR Dunn","year":"2013","journal-title":"PloS one"},{"key":"pone.0232604.ref028","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.envres.2015.02.003","article-title":"Key determinants of the fungal and bacterial microbiomes in homes","volume":"138","author":"EM Kettleson","year":"2015","journal-title":"Environmental research"},{"issue":"8","key":"pone.0232604.ref029","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1128\/AEM.01665-09","article-title":"Environmental determinants of and impact on childhood asthma by the bacterial community in household dust","volume":"76","author":"RM Maier","year":"2010","journal-title":"Applied and environmental microbiology"},{"issue":"2","key":"pone.0232604.ref030","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/ina.12205","article-title":"Influence of housing characteristics on bacterial and fungal communities in homes of asthmatic children","volume":"26","author":"KC Dannemiller","year":"2016","journal-title":"Indoor air"},{"issue":"1","key":"pone.0232604.ref031","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40168-017-0254-x","article-title":"Exposure to household furry pets influences the gut microbiota of infant at 3\u20134 months following various birth scenarios","volume":"5","author":"HM Tun","year":"2017","journal-title":"Microbiome"},{"key":"pone.0232604.ref032","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.scitotenv.2017.12.333","article-title":"Is the association between pet ownership and indoor endotoxin levels confounded or modified by outdoor residential greenspace?","volume":"625","author":"E Fuertes","year":"2018","journal-title":"The Science of the total environment"},{"issue":"6252","key":"pone.0232604.ref033","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1126\/science.aac6623","article-title":"Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells","volume":"349","author":"MJ Schuijs","year":"2015","journal-title":"Science (New York, NY)"},{"issue":"1","key":"pone.0232604.ref034","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/01.mcp.0000145791.13714.ae","article-title":"The hygiene hypothesis and asthma","volume":"11","author":"CD Ramsey","year":"2005","journal-title":"Current Opinion in Pulmonary Medicine"},{"issue":"11","key":"pone.0232604.ref035","doi-asserted-by":"crossref","first-page":"e0206399","DOI":"10.1371\/journal.pone.0206399","article-title":"Physical, social, and psychological characteristics of community-dwelling elderly Japanese dog and cat owners","volume":"13","author":"Y Taniguchi","year":"2018","journal-title":"PloS one"},{"issue":"3","key":"pone.0232604.ref036","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0091-6749(96)70088-X","article-title":"Cat and dog allergy and total IgE as risk factors of laboratory animal allergy","volume":"98","author":"A Hollander","year":"1996","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"4","key":"pone.0232604.ref037","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1067\/mai.2003.1334","article-title":"Heredity, pet ownership, and confounding control in a population-based birth cohort","volume":"111","author":"C Almqvist","year":"2003","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"11","key":"pone.0232604.ref038","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1111\/j.1398-9995.2008.01790.x","article-title":"Meta-analysis of determinants for pet ownership in 12 European birth cohorts on asthma and allergies: a GA2LEN initiative","volume":"63","author":"E Eller","year":"2008","journal-title":"Allergy"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0232604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T18:46:22Z","timestamp":1589481982000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0232604"}},"subtitle":[],"editor":[{"given":"Alexander","family":"Larcombe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,5,14]]},"references-count":38,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0232604","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,14]]}}}