{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:49:18Z","timestamp":1783662558538,"version":"3.55.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["R44DK060302"],"award-info":[{"award-number":["R44DK060302"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"crossref","award":["UL1RR024134"],"award-info":[{"award-number":["UL1RR024134"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1TR000003"],"award-info":[{"award-number":["UL1TR000003"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0232685","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T17:31:00Z","timestamp":1588959060000},"page":"e0232685","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Improved residual fat malabsorption and growth in children with cystic fibrosis treated with a novel oral structured lipid supplement: A randomized controlled trial"],"prefix":"10.1371","volume":"15","author":[{"given":"Virginia A.","family":"Stallings","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa M.","family":"Tindall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R.","family":"Mascarenhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim","family":"Maqbool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan I.","family":"Schall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"issue":"3","key":"pone.0232685.ref001","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.clnu.2016.03.004","article-title":"ESPEN-ESPGHAN-ECFS guidelines on nutrition care for infants, children, and adults with cystic fibrosis","volume":"35","author":"D Turck","year":"2016","journal-title":"Clin Nutr"},{"issue":"1","key":"pone.0232685.ref002","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s10620-015-3834-2","article-title":"Nutritional Status Improved in Cystic Fibrosis Patients with the G551D Mutation After Treatment with Ivacaftor","volume":"61","author":"D Borowitz","year":"2016","journal-title":"Dig Dis Sci"},{"key":"pone.0232685.ref003","article-title":"Type of infant formula increases early weight gain and impacts energy balance: an RCT","author":"JA Mennella","year":"2018","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"pone.0232685.ref004","first-page":"585","article-title":"Persistence of essential fatty acid deficiency in cystic fibrosis despite nutritional therapy","volume":"66","author":"L Aldamiz-Echevarria","year":"2009","journal-title":"PediatrRes"},{"issue":"4","key":"pone.0232685.ref005","doi-asserted-by":"crossref","first-page":"G646","DOI":"10.1152\/ajpgi.00295.2004","article-title":"Fat absorption in cystic fibrosis mice is impeded by defective lipolysis and post-lipolytic events","volume":"288","author":"MJ Bijvelds","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"pone.0232685.ref006","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/ajcn\/69.1.127","article-title":"Fat malabsorption in cystic fibrosis patients receiving enzyme replacement therapy is due to impaired intestinal uptake of long-chain fatty acids","volume":"69","author":"M Kalivianakis","year":"1999","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"pone.0232685.ref007","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/ajcn\/72.1.174","article-title":"Detection of impaired intestinal absorption of long-chain fatty acids: validation studies of a novel test in a rat model of fat malabsorption","volume":"72","author":"M Kalivianakis","year":"2000","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"pone.0232685.ref008","first-page":"167","article-title":"The mechanisms of fat malabsorption in cystic fibrosis patients","volume":"15","author":"M Kalivianakis","year":"1999","journal-title":"Nutrition"},{"issue":"2","key":"pone.0232685.ref009","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1067\/mpd.2002.124305","article-title":"Effect of an organized lipid matrix on lipid absorption and clinical outcomes in patients with cystic fibrosis","volume":"141","author":"G Lepage","year":"2002","journal-title":"Journal of Pediatrics"},{"issue":"4","key":"pone.0232685.ref010","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1097\/MPG.0000000000001004","article-title":"Choline supplementation with a structured lipid in children with cystic fibrosis: a randomized placebo-controlled trial","volume":"62","author":"JI Schall","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"pone.0232685.ref011","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1097\/MPG.0000000000001213","article-title":"Effect of oral lipid matrix supplementation on fat absorption in cystic fibrosis: a randomized placebo-controlled trial","volume":"63","author":"VA Stallings","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"4","key":"pone.0232685.ref012","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/MPG.0000000000000272","article-title":"Fat-soluble vitamins in cystic fibrosis and pancreatic insufficiency: efficacy of a nutrition intervention","volume":"58","author":"C Bertolaso","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"pone.0232685.ref013","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-1-4757-1364-0_7","volume-title":"Phospholipids","author":"DW Yesair","year":"1990"},{"issue":"2","key":"pone.0232685.ref014","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/ppul.1950150204","article-title":"Pulmonary function between 6 and 18 years of age","volume":"15","author":"X Wang","year":"1993","journal-title":"Pediatr Pulmonol"},{"issue":"1","key":"pone.0232685.ref015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1164\/ajrccm.159.1.9712108","article-title":"Spirometric reference values from a sample of the general U.S. population","volume":"159","author":"JL Hankinson","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"issue":"314","key":"pone.0232685.ref016","first-page":"1","article-title":"CDC growth charts: United States","author":"RJ Kuczmarski","year":"2000","journal-title":"Adv Data"},{"key":"pone.0232685.ref017","volume-title":"Dietary DRI Reference Intakes: The Essential Guide to Nutrient Requirements","author":"JJ Otten","year":"2006"},{"issue":"1","key":"pone.0232685.ref018","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/ajcn\/85.1.144","article-title":"Evaluation of formulas for calculating total energy requirements of preadolescent children with cystic fibrosis","volume":"85","author":"J Trabulsi","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"pone.0232685.ref019","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/01.MPG.0000158222.23181.1C","article-title":"Pancreatic status verification in children with cystic fibrosis: fecal elastase status predicts prospective changes in nutritional status","volume":"40","author":"J Cohen","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"pone.0232685.ref020","first-page":"38","article-title":"Quantitative determination of plasma c8-c26 total fatty acids for the biochemical diagnosis of nutritional and metabolic disorders","volume":"73","author":"SA Lagerstedt","year":"2001","journal-title":"Mol GenetMetab"},{"issue":"5","key":"pone.0232685.ref021","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.nutres.2015.12.014","article-title":"Choline supplementation alters some amino acid concentrations with no change in homocysteine in children with cystic fiborosis and pancreatic insufficiency","volume":"36","author":"B Alshaikh","year":"2016","journal-title":"Nutr Res"},{"issue":"11","key":"pone.0232685.ref022","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/S0022-2275(20)35102-6","article-title":"Absorption and distribution of arachidonate in rats receiving lysophospholipids by oral route","volume":"34","author":"G Viola","year":"1993","journal-title":"J Lipid Res"},{"issue":"6","key":"pone.0232685.ref023","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0022-2275(20)32544-X","article-title":"Phospholipase A2 relieves phosphatidylcholine inhibition of micellar cholesterol absorption and transport by human intestinal cell line Caco-2","volume":"39","author":"R Homan","year":"1998","journal-title":"J Lipid Res"},{"issue":"1","key":"pone.0232685.ref024","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1743-7075-2-11","article-title":"Mechanisms of lipid malabsorption in Cystic Fibrosis: the impact of essential fatty acids deficiency","volume":"2","author":"N Peretti","year":"2005","journal-title":"Nutr Metab (Lond)"},{"issue":"6","key":"pone.0232685.ref025","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/MCP.0000000000000629","article-title":"Prevention of malnutrition in cystic fibrosis","volume":"25","author":"M Slae","year":"2019","journal-title":"Curr Opin Pulm Med"},{"issue":"3","key":"pone.0232685.ref026","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/00005176-200209000-00004","article-title":"Consensus report on nutrition for pediatric patients with cystic fibrosis","volume":"35","author":"D Borowitz","year":"2002","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"pone.0232685.ref027","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000406.pub2","article-title":"Oral calorie supplements for cystic fibrosis (review)","author":"R Smyth","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"pone.0232685.ref028","unstructured":"Cystic Fibrosis Foundation Patient Registry: 2012 Annual Data Report. Bethesda, MD: Cystic Fibrosis Foundation; 2013 2013."},{"issue":"1","key":"pone.0232685.ref029","first-page":"57","article-title":"Systematic review: efficacy and safety of pancreatic enzyme supplements for exocrine pancreatic insufficiency","volume":"31","author":"JR Taylor","year":"2010","journal-title":"AlimentPharmacolTher"},{"issue":"1","key":"pone.0232685.ref030","first-page":"47","article-title":"Coefficients of fat and nitrogen absorption in healthy subjects and individuals with cystic fibrosis","volume":"12","author":"D Borowitz","year":"2007","journal-title":"J Pediatr PharmacolTher"},{"key":"pone.0232685.ref031","article-title":"Pancreatic Enzyme Replacement Therapy and Coefficient of Fat Absorption in Children and Adolescents with Cystic Fibrosis","author":"JW Woestenenk","year":"2015","journal-title":"JPediatrGastroenterolNutr"},{"issue":"8","key":"pone.0232685.ref032","first-page":"CD003424","article-title":"Drug therapies for reducing gastric acidity in people with cystic fibrosis","author":"SM Ng","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"pone.0232685.ref033","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/MPG.0000000000002110","article-title":"Absorption and Safety With Sustained Use of RELiZORB Evaluation (ASSURE) Study in Patients With Cystic Fibrosis Receiving Enteral Feeding","volume":"67","author":"J Stevens","year":"2018","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"pone.0232685.ref034","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2016.05.049","article-title":"Safety and Efficacy of a Novel Microbial Lipase in Patients with Exocrine Pancreatic Insufficiency due to Cystic Fibrosis: A Randomized Controlled Clinical Trial","volume":"176","author":"JE Heubi","year":"2016","journal-title":"J Pediatr"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0239642","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0232685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T11:48:43Z","timestamp":1615636123000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0232685"}},"subtitle":[],"editor":[{"given":"Maret G.","family":"Traber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,5,8]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0232685","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0239642","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,8]]}}}