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The transmission of distemper among ferrets and mink. Proceedings of the 90th Annual American Veterinary Medical Association Meeting. Toronto, Canada; 1953. pp. 129\u2013141."},{"key":"pone.0232705.ref049","first-page":"25","volume-title":"Infectious diseases of the dog and cat","author":"CE Greene","year":"2012"},{"key":"pone.0232705.ref050","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1098\/rstb.1998.0263","article-title":"Rabies in Zimbabwe: reservoir dogs and the implications for disease control","volume":"353","author":"CJ Rhodes","year":"1998","journal-title":"Philos Trans R Soc B"},{"key":"pone.0232705.ref051","first-page":"412","article-title":"The response of young mink to varying lengths of exposure to nebulized egg-adapted distemper virus (DV)","volume":"50","author":"R Farrell","year":"1955","journal-title":"Vet Med"},{"key":"pone.0232705.ref052","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/9780470344880.ch1","volume-title":"Infectious diseases of wild mammals","author":"CE Rupprecht","year":"2001","edition":"3"},{"key":"pone.0232705.ref053","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0140-6736(04)15792-9","article-title":"Rabies and other lyssavirus diseases","volume":"363","author":"MJ Warrell","year":"2004","journal-title":"The Lancet"},{"key":"pone.0232705.ref054","doi-asserted-by":"crossref","first-page":"28","DOI":"10.7589\/0090-3558-28.1.28","article-title":"Diseases diagnosed in gray foxes (Urocyon cinereoargenteus) from the southeastern United States","volume":"28","author":"WR Davidson","year":"1992","journal-title":"J Wildl Dis"},{"key":"pone.0232705.ref055","first-page":"1170","article-title":"Response of gray foxes to modified live-virus canine distemper vaccines","volume":"179","author":"RD Halbrooks","year":"1981","journal-title":"J Am Vet Med Assoc"},{"key":"pone.0232705.ref056","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0264-410X(99)00247-9","article-title":"Immunization of dogs with a DNA vaccine induces protection against rabies virus","volume":"18","author":"P Perrin","year":"1999","journal-title":"Vaccine"},{"key":"pone.0232705.ref057","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1638\/1042-7260(2003)34[0025:EOOASD]2.0.CO;2","article-title":"Evaluation of oral and subcutaneous delivery of an experimental canarypox recombinant canine distemper vaccine in the Siberian polecat (Mustela eversmanni)","volume":"34","author":"J Wimsatt","year":"2003","journal-title":"J Zoo Wildl Med"},{"key":"pone.0232705.ref058","doi-asserted-by":"crossref","first-page":"67","DOI":"10.20506\/rst.21.1.1321","article-title":"Surveillance and monitoring of wildlife diseases","volume":"21","author":"T M\u00f6rner","year":"2002","journal-title":"Rev Sci Tech Int Off Epizoot"},{"key":"pone.0232705.ref059","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/289765a0","article-title":"Population dynamics of fox rabies in Europe","volume":"289","author":"RM 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