{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:42:10Z","timestamp":1790674930008,"version":"4.1.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0232740","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T17:37:15Z","timestamp":1589305035000},"page":"e0232740","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Risk of colorectal cancer in patients with alcoholism: A nationwide, population-based nested case-control study"],"prefix":"10.1371","volume":"15","author":[{"given":"Tzu-Chiao","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Chien","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je-Ming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian-Sheng","family":"Tzeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hsiang","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta-Wei","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Wen","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,5,12]]},"reference":[{"issue":"9","key":"pone.0232740.ref001","doi-asserted-by":"crossref","first-page":"e0203410","DOI":"10.1371\/journal.pone.0203410","article-title":"Alcohol use disorder tied to development of chronic kidney disease: A nationwide database analysis","volume":"13","author":"CS Pan","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"pone.0232740.ref002","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12889-017-4587-y","article-title":"Alcohol use disorders and associated chronic disease\u2014a national retrospective cohort study from France","volume":"18","author":"M Schwarzinger","year":"2017","journal-title":"BMC Public Health"},{"key":"pone.0232740.ref003","article-title":"Alcohol use and burden for 195 countries and territories, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","year":"2018","journal-title":"The Lancet"},{"key":"pone.0232740.ref004","article-title":"No level of alcohol consumption improves health","author":"R Burton","year":"2018","journal-title":"The Lancet"},{"issue":"9","key":"pone.0232740.ref005","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.7314\/APJCP.2013.14.9.4965","article-title":"Alcohol Consumption and Risk of Cancer: a Systematic Literature Review","volume":"14","author":"RF de Menezes","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"pone.0232740.ref006","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1186\/1471-2407-14-420","article-title":"Attributable fraction of alcohol consumption on cancer using population-based nationwide cancer incidence and mortality data in the Republic of Korea","volume":"14","author":"S Park","year":"2014","journal-title":"BMC Cancer"},{"issue":"3","key":"pone.0232740.ref007","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00384-018-2965-2","article-title":"Risk of colorectal cancer in patients with periodontal disease severity: a nationwide, population-based cohort study.","volume":"33","author":"JM Hu","year":"2018","journal-title":"Int J Colorectal Dis."},{"key":"pone.0232740.ref008","unstructured":"Health Promotion Administration, Ministry of Health and Welfare,Taiwan. Health Promotion Administration Annual Report 2018.Available at: https:\/\/www.hpa.gov.tw\/Pages\/ashx\/File.ashx?FilePath=~\/File\/Attach\/10231\/File_11648.pdf."},{"key":"pone.0232740.ref009","doi-asserted-by":"crossref","first-page":"d6617","DOI":"10.1136\/bmj.d6617","article-title":"Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies","volume":"343","author":"D Aune","year":"2011","journal-title":"BMJ"},{"issue":"3","key":"pone.0232740.ref010","first-page":"105","article-title":"Epidemiology of colorectal cancer","volume":"7","author":"AR Marley","year":"2016","journal-title":"Int J Mol Epidemiol Genet"},{"issue":"2","key":"pone.0232740.ref011","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10020038","article-title":"Colorectal Cancer and Alcohol Consumption-Populations to Molecules.","volume":"10","author":"M Rossi","year":"2018","journal-title":"Cancers (Basel)."},{"issue":"9","key":"pone.0232740.ref012","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1093\/annonc\/mdq653","article-title":"Alcohol drinking and colorectal cancer risk: an overall and dose-response meta-analysis of published studies","volume":"22","author":"V Fedirko","year":"2011","journal-title":"Ann Oncol"},{"issue":"3","key":"pone.0232740.ref013","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/ijc.22299","article-title":"Alcohol intake and colorectal cancer risk: a dose-response meta-analysis of published cohort studies","volume":"120","author":"A Moskal","year":"2007","journal-title":"Int J Cancer"},{"issue":"8","key":"pone.0232740.ref014","doi-asserted-by":"crossref","first-page":"603","DOI":"10.7326\/0003-4819-140-8-200404200-00007","article-title":"Alcohol intake and colorectal cancer: a pooled analysis of 8 cohort studies","volume":"140","author":"E Cho","year":"2004","journal-title":"Ann Intern Med"},{"issue":"5","key":"pone.0232740.ref015","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.canep.2009.10.015","article-title":"Baseline alcohol consumption, type of alcoholic beverage and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition-Norfolk study.","volume":"33","author":"JY Park","year":"2009","journal-title":"Cancer Epidemiol."},{"issue":"6","key":"pone.0232740.ref016","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1136\/gut.52.6.861","article-title":"Relations between amount and type of alcohol and colon and rectal cancer in a Danish population based cohort study","volume":"52","author":"A Pedersen","year":"2003","journal-title":"Gut"},{"issue":"9","key":"pone.0232740.ref017","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1001\/jamainternmed.2015.3540","article-title":"Nationwide Population Science: Lessons From the Taiwan National Health Insurance Research Database.","volume":"175","author":"AW Hsing","year":"2015","journal-title":"JAMA internal medicine"},{"issue":"9","key":"pone.0232740.ref018","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrclinonc.2016.50","article-title":"Population-based screening for cancer: hope and hype","volume":"13","author":"Y Shieh","year":"2016","journal-title":"Nat Rev Clin Oncol"},{"key":"pone.0232740.ref019","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jad.2016.09.057","article-title":"Antidepressants and colorectal cancer: A population-based nested case-control study","volume":"207","author":"HC Lee","year":"2017","journal-title":"J Affect Disord"},{"issue":"10","key":"pone.0232740.ref020","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1002\/ijc.24191","article-title":"Cigarette smoking and colorectal cancer incidence and mortality: systematic review and meta-analysis","volume":"124","author":"PS Liang","year":"2009","journal-title":"Int J Cancer"},{"issue":"12","key":"pone.0232740.ref021","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1158\/1055-9965.EPI-07-0708","article-title":"Obesity and risk of colorectal cancer: a meta-analysis of 31 studies with 70,000 events","volume":"16","author":"AA Moghaddam","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"pone.0232740.ref022","article-title":"Meta-analysis of 16 studies of the association of alcohol with colorectal cancer","author":"S McNabb","year":"2019","journal-title":"Int J Cancer"},{"issue":"6","key":"pone.0232740.ref023","doi-asserted-by":"crossref","first-page":"e1002585","DOI":"10.1371\/journal.pmed.1002585","article-title":"The association of lifetime alcohol use with mortality and cancer risk in older adults: A cohort study","volume":"15","author":"AT Kunzmann","year":"2018","journal-title":"PLoS Med"},{"issue":"6","key":"pone.0232740.ref024","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/CEJ.0000000000000076","article-title":"Alcohol drinking and the risk of colorectal cancer death: a meta-analysis","volume":"23","author":"S Cai","year":"2014","journal-title":"Eur J Cancer Prev"},{"issue":"3","key":"pone.0232740.ref025","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/bjc.2014.579","article-title":"Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis","volume":"112","author":"V Bagnardi","year":"2015","journal-title":"Br J Cancer"},{"issue":"6","key":"pone.0232740.ref026","doi-asserted-by":"crossref","first-page":"400","DOI":"10.18632\/oncoscience.59","article-title":"Genetic pathways, prevention, and treatment of sporadic colorectal cancer","volume":"1","author":"R Mundade","year":"2014","journal-title":"Oncoscience"},{"issue":"6","key":"pone.0232740.ref027","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1053\/j.gastro.2009.12.065","article-title":"The chromosomal instability pathway in colon cancer","volume":"138","author":"MS Pino","year":"2010","journal-title":"Gastroenterology"},{"issue":"5","key":"pone.0232740.ref028","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.bpg.2017.09.012","article-title":"Alcohol, smoking and the risk of premalignant and malignant colorectal neoplasms.","volume":"31","author":"IO Fagunwa","year":"2017","journal-title":"Best Pract Res Clin Gastroenterol."},{"issue":"1","key":"pone.0232740.ref029","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1053\/j.gastro.2016.09.003","article-title":"Lifestyle Risk Factors for Serrated Colorectal Polyps: A Systematic Review and Meta-analysis","volume":"152","author":"L Bailie","year":"2017","journal-title":"Gastroenterology"},{"issue":"1","key":"pone.0232740.ref030","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.alcohol.2011.08.004","article-title":"Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human large bowel: association of the functional polymorphisms of ADH and ALDH genes with hemorrhoids and colorectal cancer","volume":"46","author":"CP Chiang","year":"2012","journal-title":"Alcohol"},{"issue":"1","key":"pone.0232740.ref031","first-page":"25","article-title":"Alcohol, DNA methylation, and cancer.","volume":"35","author":"M Varela-Rey","year":"2013","journal-title":"Alcohol research: current reviews."},{"issue":"2","key":"pone.0232740.ref032","first-page":"163","article-title":"Alcohol and Gut-Derived Inflammation.","volume":"38","author":"F Bishehsari","year":"2017","journal-title":"Alcohol research: current reviews"},{"issue":"12","key":"pone.0232740.ref033","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.3390\/ijms17122017","article-title":"Light\/Dark Shifting Promotes Alcohol-Induced Colon Carcinogenesis: Possible Role of Intestinal Inflammatory Milieu and Microbiota.","volume":"17","author":"F Bishehsari","year":"2016","journal-title":"Int J Mol Sci"},{"key":"pone.0232740.ref034","doi-asserted-by":"crossref","first-page":"27923","DOI":"10.1038\/srep27923","article-title":"Ecophysiological consequences of alcoholism on human gut microbiota: implications for ethanol-related pathogenesis of colon cancer","volume":"6","author":"A Tsuruya","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"pone.0232740.ref035","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/CEJ.0000000000000245","article-title":"Dietary patterns and colorectal cancer risk: a meta-analysis","volume":"26","author":"YL Feng","year":"2017","journal-title":"Eur J Cancer Prev"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0232740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T15:20:15Z","timestamp":1666538415000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0232740"}},"subtitle":[],"editor":[{"given":"Yu Ru","family":"Kou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,5,12]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0232740","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,12]]}}}