{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:59:27Z","timestamp":1776401967467,"version":"3.51.2"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0233261","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T18:25:08Z","timestamp":1589567108000},"page":"e0233261","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice"],"prefix":"10.1371","volume":"15","author":[{"given":"Stephan","family":"Settelmeier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-3158","authenticated-orcid":true,"given":"Timm","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joni","family":"M\u00e4ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadiya","family":"Byts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peppi","family":"Koivunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Myllyharju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-0531","authenticated-orcid":true,"given":"Joachim","family":"Fandrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Winning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"issue":"1","key":"pone.0233261.ref001","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4049\/jimmunol.1103779","article-title":"Myeloid hypoxia-inducible factor-1alpha is essential for skeletal muscle regeneration in mice","volume":"191","author":"N Scheerer","year":"2013","journal-title":"J Immunol"},{"issue":"5","key":"pone.0233261.ref002","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1097\/PRS.0000000000001699","article-title":"Fibroblast-Specific Deletion of Hypoxia Inducible Factor-1 Critically Impairs Murine Cutaneous Neovascularization and Wound Healing","volume":"136","author":"D Duscher","year":"2015","journal-title":"Plast Reconstr Surg"},{"issue":"5","key":"pone.0233261.ref003","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1096\/fj.201600878R","article-title":"Activation of the hypoxia-inducible factor 1alpha promotes myogenesis through the noncanonical Wnt pathway, leading to hypertrophic myotubes","volume":"31","author":"F Cirillo","year":"2017","journal-title":"FASEB J"},{"issue":"2","key":"pone.0233261.ref004","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0955-0674(00)00194-0","article-title":"HIF-1 and mechanisms of hypoxia sensing","volume":"13","author":"GL Semenza","year":"2001","journal-title":"Curr Opin Cell Biol"},{"issue":"4","key":"pone.0233261.ref005","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":". Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"WG Kaelin","year":"2008","journal-title":"Mol Cell"},{"issue":"4","key":"pone.0233261.ref006","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1515\/hsz-2012-0328","article-title":"Hypoxia-inducible factor prolyl 4-hydroxylases: common and specific roles","volume":"394","author":"J Myllyharju","year":"2013","journal-title":"Biol Chem"},{"issue":"1","key":"pone.0233261.ref007","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1152\/physrev.00003.2019","article-title":"Mechanisms and Consequences of Oxygen and Carbon Dioxide Sensing in Mammals","volume":"100","author":"EP Cummins","year":"2020","journal-title":"Physiol Rev"},{"issue":"Pt 7","key":"pone.0233261.ref008","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1242\/jcs.00318","article-title":"Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing","volume":"116","author":"E Metzen","year":"2003","journal-title":"J Cell Sci"},{"issue":"4","key":"pone.0233261.ref009","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cardiores.2006.05.005","article-title":"Regulating cellular oxygen sensing by hydroxylation","volume":"71","author":"J Fandrey","year":"2006","journal-title":"Cardiovasc Res"},{"issue":"6","key":"pone.0233261.ref010","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1080\/07853890801986594","article-title":"Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets","volume":"40","author":"J Myllyharju","year":"2008","journal-title":"Ann Med"},{"issue":"22","key":"pone.0233261.ref011","doi-asserted-by":"crossref","first-page":"8336","DOI":"10.1128\/MCB.00425-06","article-title":"Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2","volume":"26","author":"K Takeda","year":"2006","journal-title":"Mol Cell Biol"},{"issue":"18","key":"pone.0233261.ref012","doi-asserted-by":"crossref","first-page":"13646","DOI":"10.1074\/jbc.M109.084855","article-title":"Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury","volume":"285","author":"J Hyvarinen","year":"2010","journal-title":"J Biol Chem"},{"issue":"3","key":"pone.0233261.ref013","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00109-015-1349-0","article-title":"HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury","volume":"94","author":"S Karsikas","year":"2016","journal-title":"J Mol Med (Berl)"},{"issue":"4","key":"pone.0233261.ref014","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1161\/ATVBAHA.115.307136","article-title":"Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis","volume":"36","author":"L Rahtu-Korpela","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"pone.0233261.ref015","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.2337\/db14-0472","article-title":"HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction","volume":"63","author":"L Rahtu-Korpela","year":"2014","journal-title":"Diabetes"},{"issue":"2","key":"pone.0233261.ref016","first-page":"209","article-title":"Secondary injury after musculoskeletal trauma: a review and update","volume":"37","author":"MA Merrick","year":"2002","journal-title":"J Athl Train"},{"issue":"6","key":"pone.0233261.ref017","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/SHK.0b013e3182111f3d","article-title":"Activation of hypoxia-inducible factor 1 in skeletal muscle cells after exposure to damaged muscle cell debris","volume":"35","author":"N Dehne","year":"2011","journal-title":"Shock"},{"issue":"8","key":"pone.0233261.ref018","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S1357-2725(03)00042-6","article-title":"Muscle satellite cells","volume":"35","author":"JE Morgan","year":"2003","journal-title":"Int J Biochem Cell Biol"},{"issue":"3","key":"pone.0233261.ref019","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/cphy.c140068","article-title":"Satellite Cells and Skeletal Muscle Regeneration","volume":"5","author":"NA Dumont","year":"2015","journal-title":"Compr Physiol"},{"issue":"9","key":"pone.0233261.ref020","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1242\/dev.114223","article-title":"Intrinsic and extrinsic mechanisms regulating satellite cell function","volume":"142","author":"NA Dumont","year":"2015","journal-title":"Development"},{"issue":"1","key":"pone.0233261.ref021","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1083\/jcb.200508001","article-title":"Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis","volume":"172","author":"S Kuang","year":"2006","journal-title":"J Cell Biol"},{"issue":"17","key":"pone.0233261.ref022","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1242\/dev.067595","article-title":"An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration","volume":"138","author":"C Lepper","year":"2011","journal-title":"Development"},{"issue":"2","key":"pone.0233261.ref023","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.cell.2005.05.010","article-title":"Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche","volume":"122","author":"CA Collins","year":"2005","journal-title":"Cell"},{"issue":"1","key":"pone.0233261.ref024","first-page":"1","article-title":"Muscle satellite cell heterogeneity and self-renewal","volume":"2","author":"N Motohashi","year":"2014","journal-title":"Front Cell Dev Biol"},{"issue":"12","key":"pone.0233261.ref025","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1242\/dev.01874","article-title":"The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription","volume":"132","author":"SJ Tapscott","year":"2005","journal-title":"Development"},{"issue":"7","key":"pone.0233261.ref026","doi-asserted-by":"crossref","first-page":"8321","DOI":"10.1096\/fj.201801794R","article-title":"Hypoxia-inducible factor 1alpha (HIF-1alpha) is a major determinant in the enhanced function of muscle-derived progenitors from MRL\/MpJ mice","volume":"33","author":"KM Sinha","year":"2019","journal-title":"FASEB J"},{"issue":"11","key":"pone.0233261.ref027","doi-asserted-by":"crossref","first-page":"e0207040","DOI":"10.1371\/journal.pone.0207040","article-title":"Influence of hypoxic stimulation on angiogenesis and satellite cells in mouse skeletal muscle","volume":"13","author":"H Nagahisa","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"pone.0233261.ref028","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/jcp.22127","article-title":"Regulatory factors and cell populations involved in skeletal muscle regeneration","volume":"224","author":"RW Ten Broek","year":"2010","journal-title":"J Cell Physiol"},{"key":"pone.0233261.ref029","doi-asserted-by":"crossref","first-page":"491497","DOI":"10.1155\/2013\/491497","article-title":"Macrophage plasticity and the role of inflammation in skeletal muscle repair","volume":"2013","author":"Y Kharraz","year":"2013","journal-title":"Mediators Inflamm"},{"issue":"5","key":"pone.0233261.ref030","doi-asserted-by":"crossref","first-page":"E453","DOI":"10.1152\/ajpendo.00553.2012","article-title":"Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications","volume":"304","author":"NJ Pillon","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"pone.0233261.ref031","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/cbin.10705","article-title":"Macrophage depletion impairs skeletal muscle regeneration: The roles of regulatory factors for muscle regeneration","volume":"41","author":"X Liu","year":"2017","journal-title":"Cell Biol Int"},{"issue":"10","key":"pone.0233261.ref032","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/0021-9290(96)00047-4","article-title":"Maximal contraction lessens impact response in a muscle contusion model","volume":"29","author":"JJ Crisco","year":"1996","journal-title":"J Biomech"},{"issue":"2","key":"pone.0233261.ref033","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000092609","article-title":"Screening for the formation of reactive oxygen species and of NO in muscle tissue and remote organs upon mechanical trauma to the mouse hind limb","volume":"38","author":"U Kerkweg","year":"2006","journal-title":"Eur Surg Res"},{"issue":"1","key":"pone.0233261.ref034","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"P Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"issue":"1","key":"pone.0233261.ref035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/abio.1999.4085","article-title":"Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro","volume":"270","author":"J Winer","year":"1999","journal-title":"Anal Biochem"},{"issue":"2","key":"pone.0233261.ref036","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/mi.2015.67","article-title":"Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis","volume":"9","author":"K Fluck","year":"2016","journal-title":"Mucosal Immunol"},{"issue":"12","key":"pone.0233261.ref037","doi-asserted-by":"crossref","first-page":"e0190074","DOI":"10.1371\/journal.pone.0190074","article-title":"Knockdown of myeloid cell hypoxia-inducible factor-1alpha ameliorates the acute pathology in DSS-induced colitis","volume":"12","author":"V Backer","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"pone.0233261.ref038","doi-asserted-by":"crossref","first-page":"C475","DOI":"10.1152\/ajpcell.00088.2004","article-title":"The COX-2 pathway is essential during early stages of skeletal muscle regeneration","volume":"287","author":"BA Bondesen","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"pone.0233261.ref039","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/jcp.21212","article-title":"Interaction between macrophages, TGF-beta1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury","volume":"214","author":"W Shen","year":"2008","journal-title":"J Cell Physiol"},{"issue":"5","key":"pone.0233261.ref040","doi-asserted-by":"crossref","DOI":"10.3390\/cells8050384","article-title":"Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?","volume":"8","author":"MJ Strowitzki","year":"2019","journal-title":"Cells"},{"issue":"3","key":"pone.0233261.ref041","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.4049\/jimmunol.0903244","article-title":"Acute hypoxia induces HIF-independent monocyte adhesion to endothelial cells through increased intercellular adhesion molecule-1 expression: the role of hypoxic inhibition of prolyl hydroxylase activity for the induction of NF-kappa B","volume":"185","author":"S Winning","year":"2010","journal-title":"J Immunol"},{"issue":"3","key":"pone.0233261.ref042","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1006\/bbrc.1999.1889","article-title":"Angiogenesis: how a tumor adapts to hypoxia","volume":"266","author":"DE Richard","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"pone.0233261.ref043","doi-asserted-by":"crossref","first-page":"633","DOI":"10.33549\/physiolres.930811","article-title":"Sequential expression of vascular endothelial growth factor, Flt-1, and KDR\/Flk-1 in regenerating mouse skeletal muscle","volume":"55","author":"A Wagatsuma","year":"2006","journal-title":"Physiol Res"},{"issue":"1","key":"pone.0233261.ref044","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/apha.12751","article-title":"Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice","volume":"220","author":"A Nunomiya","year":"2017","journal-title":"Acta Physiol (Oxf)"},{"issue":"2","key":"pone.0233261.ref045","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/jcp.1041650211","article-title":"Hepatocyte growth factor activates quiescent skeletal muscle satellite cells in vitro","volume":"165","author":"RE Allen","year":"1995","journal-title":"J Cell Physiol"},{"issue":"1","key":"pone.0233261.ref046","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1006\/dbio.1997.8803","article-title":"HGF\/SF is present in normal adult skeletal muscle and is capable of activating satellite cells","volume":"194","author":"R Tatsumi","year":"1998","journal-title":"Dev Biol"},{"issue":"7","key":"pone.0233261.ref047","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1007\/s11033-008-9406-1","article-title":"Stabilization of hepatocyte growth factor mRNA by hypoxia-inducible factor 1","volume":"36","author":"SH Chu","year":"2009","journal-title":"Mol Biol Rep"},{"issue":"5","key":"pone.0233261.ref048","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1101\/gad.1881410","article-title":"Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis","volume":"24","author":"N Takeda","year":"2010","journal-title":"Genes Dev"},{"issue":"1","key":"pone.0233261.ref049","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13395-018-0179-5","article-title":"HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury","volume":"8","author":"AN Billin","year":"2018","journal-title":"Skelet Muscle"},{"issue":"13\u201314","key":"pone.0233261.ref050","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1089\/ten.tea.2010.0624","article-title":"Hypoxia promotes proliferation of human myogenic satellite cells: a potential benefactor in tissue engineering of skeletal muscle","volume":"17","author":"M Koning","year":"2011","journal-title":"Tissue Eng Part A"},{"issue":"11","key":"pone.0233261.ref051","doi-asserted-by":"crossref","first-page":"e49860","DOI":"10.1371\/journal.pone.0049860","article-title":"Hypoxia increases mouse satellite cell clone proliferation maintaining both in vitro and in vivo heterogeneity and myogenic potential","volume":"7","author":"L Urbani","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"pone.0233261.ref052","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/jcb.20804","article-title":"Knockdown of hypoxia-inducible factor-1alpha by siRNA inhibits C2C12 myoblast differentiation","volume":"98","author":"Y Ono","year":"2006","journal-title":"J Cell Biochem"},{"issue":"8","key":"pone.0233261.ref053","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cellbi.2008.03.017","article-title":"Hypoxia affects positively the proliferation of bovine satellite cells and their myogenic differentiation through up-regulation of MyoD","volume":"32","author":"SH Kook","year":"2008","journal-title":"Cell Biol Int"},{"issue":"1\u20132","key":"pone.0233261.ref054","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11010-010-0622-3","article-title":"Spatial and temporal expression of hypoxia-inducible factor-1alpha during myogenesis in vivo and in vitro","volume":"347","author":"A Wagatsuma","year":"2011","journal-title":"Mol Cell Biochem"},{"issue":"16","key":"pone.0233261.ref055","doi-asserted-by":"crossref","first-page":"16332","DOI":"10.1074\/jbc.M313931200","article-title":"Hypoxia inhibits myogenic differentiation through accelerated MyoD degradation","volume":"279","author":"A Di Carlo","year":"2004","journal-title":"J Biol Chem"},{"issue":"6","key":"pone.0233261.ref056","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1172\/JCI96208","article-title":"Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration","volume":"128","author":"L Xie","year":"2018","journal-title":"J Clin Invest"},{"issue":"3","key":"pone.0233261.ref057","doi-asserted-by":"crossref","first-page":"R832","DOI":"10.1152\/ajpregu.00797.2009","article-title":"Regulation of skeletal muscle regeneration by CCR2-activating chemokines is directly related to macrophage recruitment","volume":"299","author":"CO Martinez","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"3","key":"pone.0233261.ref058","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1096\/fj.04-2421fje","article-title":"Chemokine receptor CCR2 involvement in skeletal muscle regeneration","volume":"19","author":"GL Warren","year":"2005","journal-title":"FASEB J"},{"issue":"2","key":"pone.0233261.ref059","doi-asserted-by":"crossref","first-page":"R651","DOI":"10.1152\/ajpregu.00069.2007","article-title":"Delayed angiogenesis and VEGF production in CCR2-\/- mice during impaired skeletal muscle regeneration","volume":"293","author":"O Ochoa","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"pone.0233261.ref060","doi-asserted-by":"crossref","first-page":"17236","DOI":"10.1038\/s41598-017-17324-y","article-title":"Hypoxia-inducible factor 1alpha is Essential for Macrophage-mediated Erythroblast Proliferation in Acute Friend Retrovirus Infection","volume":"7","author":"T Schreiber","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"pone.0233261.ref061","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"148","author":"GL Semenza","year":"2012","journal-title":"Cell"},{"issue":"4","key":"pone.0233261.ref062","doi-asserted-by":"crossref","first-page":"E855","DOI":"10.1152\/ajpendo.2000.279.4.E855","article-title":"GLUT-3 expression in human skeletal muscle","volume":"279","author":"CA Stuart","year":"2000","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"16","key":"pone.0233261.ref063","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1242\/dev.079665","article-title":"Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation","volume":"139","author":"W Liu","year":"2012","journal-title":"Development"},{"issue":"6","key":"pone.0233261.ref064","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1159\/000489652","article-title":"FG-4592 Accelerates Cutaneous Wound Healing by Epidermal Stem Cell Activation via HIF-1alpha Stabilization","volume":"46","author":"D Tang","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"5","key":"pone.0233261.ref065","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s40265-019-01077-1","article-title":"Roxadustat: First Global Approval","volume":"79","author":"S Dhillon","year":"2019","journal-title":"Drugs"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0233261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T21:59:12Z","timestamp":1722895152000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0233261"}},"subtitle":[],"editor":[{"given":"J\u00f6rn","family":"Karhausen","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,5,15]]},"references-count":65,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0233261","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,15]]}}}