{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T20:32:41Z","timestamp":1785184361953,"version":"3.55.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1C1B5077093"],"award-info":[{"award-number":["2017R1C1B5077093"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0233596","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T17:58:22Z","timestamp":1590775102000},"page":"e0233596","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical factors predicting the successful discontinuation of hormone replacement therapy in patients diagnosed with primary hypothyroidism"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4029-6312","authenticated-orcid":true,"given":"Kyong Yeun","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7202-7777","authenticated-orcid":true,"given":"Hoon Sung","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hyun","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7394-3830","authenticated-orcid":true,"given":"Sun Wook","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Jeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3671-6364","authenticated-orcid":true,"given":"Young Joo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"key":"pone.0233596.ref001","volume-title":"Thyroid, Hashimoto Thyroiditis","author":"DL Mincer","year":"2018"},{"issue":"2","key":"pone.0233596.ref002","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1210\/jcem.87.2.8182","article-title":"Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)","volume":"87","author":"JG Hollowell","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"pone.0233596.ref003","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1210\/jc.2013-2409","article-title":"The incidence and prevalence of thyroid dysfunction in Europe: a meta-analysis","volume":"99","author":"A Garmendia Madariaga","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"pone.0233596.ref004","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1089\/thy.2006.0235","article-title":"Serum TSH and total T4 in the United States population and their association with participant characteristics: National Health and Nutrition Examination Survey (NHANES 1999\u20132002)","volume":"17","author":"Y Aoki","year":"2007","journal-title":"Thyroid"},{"key":"pone.0233596.ref005","first-page":"32","article-title":"Prevalence of Subclinical Hypothyroidism in Two Population Based-cohort: Ansung and KLoSHA Cohort in Korea","volume":"3","author":"PY Choi HS","year":"2010","journal-title":"J Korean Thyroid Assoc"},{"issue":"4","key":"pone.0233596.ref006","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1001\/archinte.160.4.526","article-title":"The Colorado thyroid disease prevalence study","volume":"160","author":"GJ Canaris","year":"2000","journal-title":"Arch Intern Med"},{"issue":"4","key":"pone.0233596.ref007","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S2213-8587(16)30276-5","article-title":"Levothyroxine overuse: time for an about face","volume":"5","author":"R Rodriguez-Gutierrez","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"pone.0233596.ref008","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00000441-198901000-00005","article-title":"Recovery of thyroid function in primary hypothyroidism","volume":"297","author":"TF Nikolai","year":"1989","journal-title":"Am J Med Sci"},{"key":"pone.0233596.ref009","volume-title":"Greenspan's Basic & Clinical Endocrinology","author":"DG Gardner","year":"2011","edition":"9"},{"issue":"6394","key":"pone.0233596.ref010","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1136\/bmj.287.6394.720","article-title":"Clinical importance of reversibility in primary goitrous hypothyroidism","volume":"287","author":"M Yoshinari","year":"1983","journal-title":"Br Med J (Clin Res Ed)"},{"issue":"3","key":"pone.0233596.ref011","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1365-2265.1988.tb01220.x","article-title":"TSH dependent elevation of serum thyroglobulin in reversible primary hypothyroidism","volume":"29","author":"K Sato","year":"1988","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"6","key":"pone.0233596.ref012","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1089\/105072503322238827","article-title":"Effect of iodine restriction on thyroid function in patients with primary hypothyroidism","volume":"13","author":"K Kasagi","year":"2003","journal-title":"Thyroid"},{"issue":"8","key":"pone.0233596.ref013","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJM199202203260803","article-title":"Disappearance of thyrotropin-blocking antibodies and spontaneous recovery from hypothyroidism in autoimmune thyroiditis","volume":"326","author":"N Takasu","year":"1992","journal-title":"N Engl J Med"},{"issue":"8723","key":"pone.0233596.ref014","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/0140-6736(90)92567-2","article-title":"Test for recovery from hypothyroidism during thyroxine therapy in Hashimoto's thyroiditis","volume":"336","author":"N Takasu","year":"1990","journal-title":"Lancet"},{"issue":"5","key":"pone.0233596.ref015","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1365-2265.2009.03711.x","article-title":"Levothyroxine in subclinical hypothyroidism: a lifelong therapy?","volume":"72","author":"PW Rosario","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"pone.0233596.ref016","article-title":"Levothyroxine Replacement Therapy and Overuse: A Timely Diagnostic Approach","author":"S Livadas","year":"2018","journal-title":"Thyroid"},{"issue":"6","key":"pone.0233596.ref017","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1159\/000339156","article-title":"Comparative evaluation of therapy with L-thyroxine versus no treatment in children with idiopathic and mild subclinical hypothyroidism","volume":"77","author":"M Wasniewska","year":"2012","journal-title":"Horm Res Paediatr"},{"issue":"4","key":"pone.0233596.ref018","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1530\/EC-17-0023","article-title":"Thyroid function in children and adolescents with Hashimoto's thyroiditis after l-thyroxine discontinuation","volume":"6","author":"G Radetti","year":"2017","journal-title":"Endocr Connect"},{"issue":"9","key":"pone.0233596.ref019","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1089\/thy.2014.0046","article-title":"Effect of iodine restriction on thyroid function in subclinical hypothyroid patients in an iodine-replete area: a long period observation in a large-scale cohort","volume":"24","author":"JY Joung","year":"2014","journal-title":"Thyroid"},{"issue":"4","key":"pone.0233596.ref020","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1530\/acta.0.1020531","article-title":"Recovery of thyroid function with a decreased titre of antimicrosomal antibody in a hypothyroid man with Hashimoto's thyroiditis","volume":"102","author":"M Yamamoto","year":"1983","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"1","key":"pone.0233596.ref021","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1089\/thy.2008.0221","article-title":"Natural history of mild subclinical hypothyroidism: prognostic value of ultrasound","volume":"19","author":"PW Rosario","year":"2009","journal-title":"Thyroid"},{"issue":"11","key":"pone.0233596.ref022","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1089\/thy.2010.0411","article-title":"Risk for progression to overt hypothyroidism in an elderly Japanese population with subclinical hypothyroidism","volume":"21","author":"M Imaizumi","year":"2011","journal-title":"Thyroid"},{"issue":"11","key":"pone.0233596.ref023","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.7863\/ultra.32.11.1979","article-title":"Correlation between sonography and antibody activity in patients with Hashimoto thyroiditis","volume":"32","author":"A Willms","year":"2013","journal-title":"J Ultrasound Med"},{"issue":"5","key":"pone.0233596.ref024","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/cen.13174","article-title":"Levothyroxine therapy in the subclinical hypothyroidism: a lifelong therapy? A long-term study","volume":"85","author":"PW Rosario","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"pone.0233596.ref025","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1365-2265.2009.03711.x","article-title":"Levothyroxine in subclinical hypothyroidism: a lifelong therapy?","volume":"72","author":"PW Rosario","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"pone.0233596.ref026","first-page":"30","article-title":"Spontaneous Recovery from Hypothyroidism in Autoimmune Thyroiditis","volume":"11","author":"JH Chung","year":"1996","journal-title":"J Kor Soc Endocrinol"},{"issue":"1","key":"pone.0233596.ref027","doi-asserted-by":"crossref","first-page":"35","DOI":"10.7326\/M14-1456","article-title":"Screening and treatment of thyroid dysfunction: an evidence review for the U.S. Preventive Services Task Force","volume":"162","author":"JB Rugge","year":"2015","journal-title":"Ann Intern Med"},{"issue":"4","key":"pone.0233596.ref028","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1056\/NEJM200107263450406","article-title":"Clinical practice. Subclinical hypothyroidism","volume":"345","author":"DS Cooper","year":"2001","journal-title":"N Engl J Med"},{"issue":"26","key":"pone.0233596.ref029","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1056\/NEJMoa054022","article-title":"Effect of iodine intake on thyroid diseases in China","volume":"354","author":"W Teng","year":"2006","journal-title":"N Engl J Med"},{"issue":"5","key":"pone.0233596.ref030","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1046\/j.1365-2265.1996.00858.x","article-title":"Immunological and chemical types of reversible hypothyroidism; clinical characteristics and long-term prognosis","volume":"45","author":"K Sato","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"pone.0233596.ref031","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3349\/ymj.2003.44.2.227","article-title":"The effect of iodine restriction on thyroid function in patients with hypothyroidism due to Hashimoto's thyroiditis","volume":"44","author":"SJ Yoon","year":"2003","journal-title":"Yonsei Med J"},{"issue":"6","key":"pone.0233596.ref032","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/cen.12939","article-title":"Natural history of subclinical hypothyroidism with TSH <\/ = 10 mIU\/l: a prospective study","volume":"84","author":"PW Rosario","year":"2016","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0233596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T17:58:36Z","timestamp":1590775116000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0233596"}},"subtitle":[],"editor":[{"given":"Sun Young","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,5,29]]},"references-count":32,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0233596","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,29]]}}}