{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:25:26Z","timestamp":1790799926384,"version":"4.1.0"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["F31 CA192891"],"award-info":[{"award-number":["F31 CA192891"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["PF-17-243-01-RMC"],"award-info":[{"award-number":["PF-17-243-01-RMC"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K99CA230195"],"award-info":[{"award-number":["K99CA230195"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA142783"],"award-info":[{"award-number":["R01 CA142783"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA164729"],"award-info":[{"award-number":["R01CA164729"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U54 CA209975"],"award-info":[{"award-number":["U54 CA209975"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL112626"],"award-info":[{"award-number":["R01 HL112626"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0233962","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T13:31:19Z","timestamp":1591882279000},"page":"e0233962","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Notch3 signaling promotes tumor cell adhesion and progression in a murine epithelial ovarian cancer model"],"prefix":"10.1371","volume":"15","author":[{"given":"Jessica C.","family":"Price","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Azizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5031-4804","authenticated-orcid":true,"given":"L. A.","family":"Naiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny G.","family":"Parvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seoyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill K.","family":"Slack-Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Pe\u2019er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan K.","family":"Kitajewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"issue":"1","key":"pone.0233962.ref001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21387","article-title":"Cancer Statistics, 2017","volume":"67","author":"RL Siegel","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"pone.0233962.ref002","doi-asserted-by":"crossref","first-page":"16061","DOI":"10.1038\/nrdp.2016.61","article-title":"Ovarian cancer","volume":"2","author":"UA Matulonis","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"11","key":"pone.0233962.ref003","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrc4019","article-title":"Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer","volume":"15","author":"DD Bowtell","year":"2015","journal-title":"Nat Rev Cancer"},{"issue":"11","key":"pone.0233962.ref004","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1158\/0008-5472.CAN-11-3911","article-title":"The changing view of high-grade serous ovarian cancer","volume":"72","author":"EM Berns","year":"2012","journal-title":"Cancer Res"},{"issue":"5","key":"pone.0233962.ref005","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrc1611","article-title":"Ovarian cancer metastasis: integrating insights from disparate model organisms","volume":"5","author":"H Naora","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"pone.0233962.ref006","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/978-0-387-98094-2_15","article-title":"Microenvironmental regulation of ovarian cancer metastasis","volume":"149","author":"MV Barbolina","year":"2009","journal-title":"Cancer Treat Res"},{"issue":"1\u20132","key":"pone.0233962.ref007","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10555-012-9351-2","article-title":"Cell-cell and cell-matrix dynamics in intraperitoneal cancer metastasis","volume":"31","author":"KL Sodek","year":"2012","journal-title":"Cancer Metastasis Rev"},{"key":"pone.0233962.ref008","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.2741\/3364","article-title":"Ovarian cancer: pathology, biology, and disease models","volume":"14","author":"DG Rosen","year":"2009","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"1","key":"pone.0233962.ref009","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/gyno.1996.0106","article-title":"The prognostic implication of ascites in advanced-stage ovarian cancer","volume":"61","author":"LE Puls","year":"1996","journal-title":"Gynecol Oncol"},{"issue":"9","key":"pone.0233962.ref010","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.034199","article-title":"Modeling the effect of ascites-induced compression on ovarian cancer multicellular aggregates","volume":"11","author":"Y Klymenko","year":"2018","journal-title":"Dis Model Mech"},{"issue":"2","key":"pone.0233962.ref011","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1158\/2159-8290.CD-14-0650","article-title":"NOTCH decoys that selectively block DLL\/NOTCH or JAG\/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth","volume":"5","author":"T Kangsamaksin","year":"2015","journal-title":"Cancer Discov"},{"key":"pone.0233962.ref012","doi-asserted-by":"crossref","first-page":"16449","DOI":"10.1038\/srep16449","article-title":"Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations","volume":"5","author":"NM Kofler","year":"2015","journal-title":"Sci Rep"},{"issue":"7353","key":"pone.0233962.ref013","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","author":"Cancer Genome Atlas Research N","year":"2011","journal-title":"Nature"},{"issue":"12","key":"pone.0233962.ref014","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1158\/0008-5472.CAN-13-2066","article-title":"Notch3 pathway alterations in ovarian cancer","volume":"74","author":"W Hu","year":"2014","journal-title":"Cancer Res"},{"issue":"10","key":"pone.0233962.ref015","doi-asserted-by":"crossref","first-page":"e1004751","DOI":"10.1371\/journal.pgen.1004751","article-title":"Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer","volume":"10","author":"JG Jung","year":"2014","journal-title":"PLoS Genet"},{"issue":"10","key":"pone.0233962.ref016","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1158\/1078-0432.CCR-03-0409","article-title":"Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis","volume":"10","author":"KH Lu","year":"2004","journal-title":"Clin Cancer Res"},{"issue":"12","key":"pone.0233962.ref017","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1002\/ijc.22609","article-title":"Amplicon profiles in ovarian serous carcinomas","volume":"120","author":"K Nakayama","year":"2007","journal-title":"Int J Cancer"},{"issue":"12","key":"pone.0233962.ref018","doi-asserted-by":"crossref","first-page":"6312","DOI":"10.1158\/0008-5472.CAN-05-3610","article-title":"Notch3 gene amplification in ovarian cancer","volume":"66","author":"JT Park","year":"2006","journal-title":"Cancer Res"},{"issue":"5","key":"pone.0233962.ref019","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/modpathol.2010.230","article-title":"Amplification of the ch19p13.2 NACC1 locus in ovarian high-grade serous carcinoma","volume":"24","author":"M Shih Ie","year":"2011","journal-title":"Mod Pathol"},{"issue":"9","key":"pone.0233962.ref020","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1111\/j.1349-7006.2010.01641.x","article-title":"Prognostic significance of Notch 3 gene expression in ovarian serous carcinoma","volume":"101","author":"SG Jung","year":"2010","journal-title":"Cancer Sci"},{"key":"pone.0233962.ref021","first-page":"5953498","article-title":"Overexpression of Notch3 and pS6 Is Associated with Poor Prognosis in Human Ovarian Epithelial Cancer","volume":"2016","author":"Z Liu","year":"2016","journal-title":"Mediators Inflamm"},{"issue":"3","key":"pone.0233962.ref022","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ygyno.2011.11.044","article-title":"Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin A","volume":"124","author":"X Zhang","year":"2012","journal-title":"Gynecol Oncol"},{"issue":"5","key":"pone.0233962.ref023","first-page":"818","article-title":"The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression","volume":"19","author":"J Zhang","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"pone.0233962.ref024","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ygyno.2013.03.019","article-title":"Notch3 induces epithelial-mesenchymal transition and attenuates carboplatin-induced apoptosis in ovarian cancer cells","volume":"130","author":"N Gupta","year":"2013","journal-title":"Gynecol Oncol"},{"issue":"1","key":"pone.0233962.ref025","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1158\/1541-7786.MCR-14-0334","article-title":"Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2","volume":"13","author":"CW Brown","year":"2015","journal-title":"Mol Cancer Res"},{"issue":"4","key":"pone.0233962.ref026","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/carcin\/21.4.585","article-title":"Development of a syngeneic mouse model for events related to ovarian cancer","volume":"21","author":"KF Roby","year":"2000","journal-title":"Carcinogenesis"},{"issue":"4","key":"pone.0233962.ref027","first-page":"1317","article-title":"Characterization and evaluation of pre-clinical suitability of a syngeneic orthotopic mouse ovarian cancer model","volume":"33","author":"S Cho","year":"2013","journal-title":"Anticancer Res"},{"issue":"20","key":"pone.0233962.ref028","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1158\/0008-5472.CAN-16-1272","article-title":"CRISPR\/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma","volume":"76","author":"J Walton","year":"2016","journal-title":"Cancer Res"},{"issue":"3","key":"pone.0233962.ref029","doi-asserted-by":"crossref","first-page":"e0120071","DOI":"10.1371\/journal.pone.0120071","article-title":"Decreased peritoneal ovarian cancer growth in mice lacking expression of lipid phosphate phosphohydrolase 1","volume":"10","author":"J Nakayama","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"pone.0233962.ref030","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ygyno.2007.10.035","article-title":"Epithelial-stromal interaction increases cell proliferation, survival and tumorigenicity in a mouse model of human epithelial ovarian cancer","volume":"108","author":"J Greenaway","year":"2008","journal-title":"Gynecol Oncol"},{"issue":"6","key":"pone.0233962.ref031","doi-asserted-by":"crossref","first-page":"e1006853","DOI":"10.1371\/journal.pgen.1006853","article-title":"Integrative analysis of genomic alterations in triple-negative breast cancer in association with homologous recombination deficiency","volume":"13","author":"M Kawazu","year":"2017","journal-title":"PLoS Genet"},{"issue":"6","key":"pone.0233962.ref032","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1158\/0008-5472.CAN-16-1022","article-title":"Constitutive NOTCH3 Signaling Promotes the Growth of Basal Breast Cancers","volume":"77","author":"L Choy","year":"2017","journal-title":"Cancer Res"},{"issue":"17","key":"pone.0233962.ref033","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1242\/dev.126.17.3925","article-title":"The notch 3 intracellular domain represses notch 1-mediated activation through Hairy\/Enhancer of split (HES) promoters","volume":"126","author":"P Beatus","year":"1999","journal-title":"Development"},{"issue":"1\u20132","key":"pone.0233962.ref034","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0925-4773(01)00373-2","article-title":"The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity","volume":"104","author":"P Beatus","year":"2001","journal-title":"Mech Dev"},{"issue":"3","key":"pone.0233962.ref035","first-page":"319","article-title":"Body condition scoring: a rapid and accurate method for assessing health status in mice","volume":"49","author":"MH Ullman-Cullere","year":"1999","journal-title":"Lab Anim Sci"},{"issue":"1","key":"pone.0233962.ref036","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/biomet\/64.1.156","article-title":"Distribution-Free Tests for Equality of Survival Distributions","volume":"64","author":"RE Tarone","year":"1977","journal-title":"Biometrika"},{"issue":"2","key":"pone.0233962.ref037","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF03263529","article-title":"A pretest for choosing between logrank and wilcoxon tests in the two-sample problem","volume":"68","author":"RLMC Martinez","year":"2010","journal-title":"METRON"},{"issue":"1","key":"pone.0233962.ref038","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"W Huang da","year":"2009","journal-title":"Nat Protoc"},{"issue":"3","key":"pone.0233962.ref039","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"VK Mootha","year":"2003","journal-title":"Nat Genet"},{"issue":"43","key":"pone.0233962.ref040","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"14","key":"pone.0233962.ref041","doi-asserted-by":"crossref","first-page":"5716","DOI":"10.1158\/0008-5472.CAN-08-0001","article-title":"Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion","volume":"68","author":"JH Choi","year":"2008","journal-title":"Cancer Res"},{"issue":"8","key":"pone.0233962.ref042","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1097\/IGC.0b013e318263ef34","article-title":"Fibrillar type I collagen matrices enhance metastasis\/invasion of ovarian epithelial cancer via beta1 integrin and PTEN signals","volume":"22","author":"Y Shen","year":"2012","journal-title":"Int J Gynecol Cancer"},{"issue":"3","key":"pone.0233962.ref043","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","article-title":"Ovarian cancer development and metastasis","volume":"177","author":"E Lengyel","year":"2010","journal-title":"Am J Pathol"},{"issue":"3","key":"pone.0233962.ref044","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.matbio.2006.10.007","article-title":"Mammalian collagen receptors","volume":"26","author":"B Leitinger","year":"2007","journal-title":"Matrix Biol"},{"issue":"5","key":"pone.0233962.ref045","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1071-5576(01)00122-8","article-title":"Composition of the extracellular matrix of the peritoneum","volume":"8","author":"CA Witz","year":"2001","journal-title":"J Soc Gynecol Investig"},{"issue":"12","key":"pone.0233962.ref046","first-page":"3239","article-title":"A rapid in vitro assay for quantitating the invasive potential of tumor cells","volume":"47","author":"A Albini","year":"1987","journal-title":"Cancer Res"},{"issue":"9","key":"pone.0233962.ref047","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/pmic.200900758","article-title":"Matrigel: a complex protein mixture required for optimal growth of cell culture","volume":"10","author":"CS Hughes","year":"2010","journal-title":"Proteomics"},{"key":"pone.0233962.ref048","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.addr.2014.07.003","article-title":"Three-dimensional modeling of ovarian cancer","volume":"79\u201380","author":"EA White","year":"2014","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"pone.0233962.ref049","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1158\/2159-8290.CD-11-0117","article-title":"The first line of intra-abdominal metastatic attack: breaching the mesothelial cell layer","volume":"1","author":"HA Kenny","year":"2011","journal-title":"Cancer Discov"},{"issue":"1","key":"pone.0233962.ref050","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2014.05.002","article-title":"Hematogenous metastasis of ovarian cancer: rethinking mode of spread","volume":"26","author":"S Pradeep","year":"2014","journal-title":"Cancer Cell"},{"issue":"5","key":"pone.0233962.ref051","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.2353\/ajpath.2006.051222","article-title":"Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth","volume":"169","author":"SA Gerber","year":"2006","journal-title":"Am J Pathol"},{"issue":"8","key":"pone.0233962.ref052","first-page":"3584","article-title":"Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts","volume":"44","author":"D Tarin","year":"1984","journal-title":"Cancer Res"},{"key":"pone.0233962.ref053","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-0-387-98094-2_16","article-title":"Organotypic models of metastasis: A three-dimensional culture mimicking the human peritoneum and omentum for the study of the early steps of ovarian cancer metastasis","volume":"149","author":"HA Kenny","year":"2009","journal-title":"Cancer Treat Res"},{"issue":"2","key":"pone.0233962.ref054","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0014-4827(85)90197-1","article-title":"Interactions of human ovarian tumor cells with human mesothelial cells grown on extracellular matrix. An in vitro model system for studying tumor cell adhesion and invasion","volume":"160","author":"MJ Niedbala","year":"1985","journal-title":"Exp Cell Res"},{"issue":"2\u20133","key":"pone.0233962.ref055","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12026-009-8100-2","article-title":"Omental immune aggregates and tumor metastasis within the peritoneal cavity","volume":"45","author":"EW Sorensen","year":"2009","journal-title":"Immunol Res"},{"issue":"2","key":"pone.0233962.ref056","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1158\/2159-8274.CD-11-0010","article-title":"Ovarian cancer spheroids use myosin-generated force to clear the mesothelium","volume":"1","author":"MP Iwanicki","year":"2011","journal-title":"Cancer Discov"},{"issue":"4","key":"pone.0233962.ref057","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.molcel.2015.07.008","article-title":"SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers","volume":"59","author":"MR Hass","year":"2015","journal-title":"Mol Cell"},{"issue":"6","key":"pone.0233962.ref058","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"RO Hynes","year":"2002","journal-title":"Cell"},{"issue":"3","key":"pone.0233962.ref059","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1158\/1078-0432.CCR-13-1256","article-title":"A collagen-remodeling gene signature regulated by TGF-beta signaling is associated with metastasis and poor survival in serous ovarian cancer","volume":"20","author":"DJ Cheon","year":"2014","journal-title":"Clin Cancer Res"},{"issue":"3","key":"pone.0233962.ref060","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/ijc.23963","article-title":"Autocrine VEGF-A\/KDR loop protects epithelial ovarian carcinoma cells from anoikis","volume":"124","author":"I Sher","year":"2009","journal-title":"Int J Cancer"},{"key":"pone.0233962.ref061","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13048-014-0095-1","article-title":"Notch signaling in serous ovarian cancer","volume":"7","author":"JW Groeneweg","year":"2014","journal-title":"J Ovarian Res"},{"issue":"7","key":"pone.0233962.ref062","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1093\/carcin\/bgt127","article-title":"The Notch signaling pathway as a mediator of tumor survival","volume":"34","author":"KM Capaccione","year":"2013","journal-title":"Carcinogenesis"},{"issue":"3","key":"pone.0233962.ref063","doi-asserted-by":"crossref","first-page":"210","DOI":"10.18632\/oncotarget.127","article-title":"Jagged1 expression regulated by Notch3 and Wnt\/beta-catenin signaling pathways in ovarian cancer","volume":"1","author":"X Chen","year":"2010","journal-title":"Oncotarget"},{"issue":"17","key":"pone.0233962.ref064","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1158\/1078-0432.CCR-11-0432","article-title":"Targeting the notch ligand JAGGED1 in both tumor cells and stroma in ovarian cancer","volume":"17","author":"AD Steg","year":"2011","journal-title":"Clin Cancer Res"},{"issue":"4","key":"pone.0233962.ref065","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1158\/0008-5472.CAN-06-3700","article-title":"Gene alterations identified by expression profiling in tumor-associated endothelial cells from invasive ovarian carcinoma","volume":"67","author":"C Lu","year":"2007","journal-title":"Cancer Res"},{"issue":"2","key":"pone.0233962.ref066","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s11912-006-0043-3","article-title":"Integrins: molecular targets in cancer therapy","volume":"8","author":"GC Tucker","year":"2006","journal-title":"Curr Oncol Rep"},{"issue":"8","key":"pone.0233962.ref067","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nrc2353","article-title":"Integrins in angiogenesis and lymphangiogenesis","volume":"8","author":"CJ Avraamides","year":"2008","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"pone.0233962.ref068","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1158\/0008-5472.CAN-05-3071","article-title":"Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo","volume":"66","author":"CC Park","year":"2006","journal-title":"Cancer Res"},{"issue":"6","key":"pone.0233962.ref069","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/S0002-9440(10)63058-1","article-title":"Beta 1-integrins regulate the formation and adhesion of ovarian carcinoma multicellular spheroids","volume":"159","author":"RC Casey","year":"2001","journal-title":"Am J Pathol"},{"issue":"10","key":"pone.0233962.ref070","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1158\/0008-5472.CAN-04-2427","article-title":"Endogenous inhibitors of angiogenesis","volume":"65","author":"P Nyberg","year":"2005","journal-title":"Cancer Res"},{"issue":"3","key":"pone.0233962.ref071","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2310\/7290.2009.00007","article-title":"In vivo pharmacodynamic imaging of proteasome inhibition","volume":"8","author":"EA Kimbrel","year":"2009","journal-title":"Mol Imaging"},{"issue":"2","key":"pone.0233962.ref072","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1530\/ERC-11-0329","article-title":"Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients","volume":"19","author":"B Gyorffy","year":"2012","journal-title":"Endocr Relat Cancer"},{"issue":"3","key":"pone.0233962.ref073","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"C Trapnell","year":"2012","journal-title":"Nat Protoc"},{"issue":"10","key":"pone.0233962.ref074","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"S Anders","year":"2010","journal-title":"Genome Biol"},{"issue":"1","key":"pone.0233962.ref075","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society: Series B (Methodological)"},{"issue":"7","key":"pone.0233962.ref076","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nat Methods"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0233962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T08:43:24Z","timestamp":1723020204000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0233962"}},"subtitle":[],"editor":[{"given":"Khalid","family":"Sossey-Alaoui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,11]]},"references-count":76,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0233962","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,11]]}}}