{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:27:37Z","timestamp":1788838057029,"version":"build-2803163510"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0234413","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T17:24:06Z","timestamp":1591637046000},"page":"e0234413","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Azithromycin decreases Chlamydia pneumoniae-mediated Interleukin-4 responses but not Immunoglobulin E responses"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8204-6728","authenticated-orcid":true,"given":"Tamar A.","family":"Smith-Norowitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Loeffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitzchok M.","family":"Norowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret R.","family":"Hammerschlag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rauno","family":"Joks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kohlhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"pone.0234413.ref001","first-page":"2174","volume-title":"Principles and Practice of Infectious Diseases","author":"MR Hammerschlag","year":"2014"},{"key":"pone.0234413.ref002","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1164\/rccm.200412-1743PP","article-title":"Chlamydophila pneumoniae and Mycoplasma pneumoniae a role in asthma pathogenesis?","volume":"172","author":"SL Johnston","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"pone.0234413.ref003","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1001\/archpedi.1994.02170070065013","article-title":"The association of Chlamydia pneumoniae infection and reactive airway disease in children","volume":"148","author":"U Emre","year":"1994","journal-title":"Arch Pediatr Adolesc Med"},{"key":"pone.0234413.ref004","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/clinids\/14.1.178","article-title":"Persistent infection with Chlamydia pneumoniae following acute respiratory illness","volume":"14","author":"MR Hammerschlag","year":"1992","journal-title":"Clin Infect Dis"},{"key":"pone.0234413.ref005","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1067\/mai.2001.113563","article-title":"A link between chronic asthma and chronic infection","volume":"107","author":"RJ Martin","year":"2001","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"pone.0234413.ref006","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2739\/kurumemedj.48.165","article-title":"Prevalence of Chlamydia pneumoniae in acute respiratory tract infection and detection of anti-Chlamydia pneumoniae-specific IgE in Japanese children with reactive airway disease","volume":"48","author":"S Ikezawa","year":"2001","journal-title":"Kurume Med J"},{"key":"pone.0234413.ref007","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1517\/14656566.2015.999041","article-title":"Treatment of chlamydial infections: 2014 update","volume":"16","author":"SA Kohlhoff","year":"2015","journal-title":"Expert Opin Pharmacother"},{"key":"pone.0234413.ref008","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0924-8579(98)00091-0","article-title":"Effect of clarithromycin and azithromycin on production of cytokines by human monocytes","volume":"11","author":"AA Khan","year":"1999","journal-title":"Int J Antimicrobial Agents"},{"key":"pone.0234413.ref009","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-6143.2006.01586.x","article-title":"Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells","volume":"7","author":"BM Vanaudenaerde","year":"2007","journal-title":"Am J Transplant"},{"key":"pone.0234413.ref010","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.lab.2004.03.012","article-title":"Azithromycin inhibits interleukin-6 but not fibrinogen production in hepatocytes infected with cytomegalovirus and chlamydia pneumoniae","volume":"144","author":"JJM Bouwman","year":"2004","journal-title":"J Lab Clin Med"},{"key":"pone.0234413.ref011","doi-asserted-by":"crossref","first-page":"286","DOI":"10.2500\/aap.2008.29.3121","article-title":"Minocycline treatment results in reduced oral steroid requirements in adults","volume":"29","author":"A Daoud","year":"2008","journal-title":"Asthma Allergy Asthma Proc"},{"issue":"issue 4","key":"pone.0234413.ref012","first-page":"CD002997","article-title":"Macrolides for chronic asthma","author":"L Richeldi","year":"2005","journal-title":"Cochrane database Syst Rev"},{"key":"pone.0234413.ref013","first-page":"2363","article-title":"Doxycycline suppresses Chlamydia pneumoniae-mediated increases in ongoing immunoglobulin E and interleukin-4 responses by peripheral blood mononuclear cells of patients with allergic asthma","volume":"68","author":"MS Dzhindzhikhashvili","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"pone.0234413.ref014","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jiac.2018.02.004","article-title":"Doxycycline suppresses Chlamydia pneumoniae induced interferon gamma responses in peripheral blood mononuclear cells in children with allergic asthma","volume":"24","author":"TA Smith-Norowitz","year":"2018","journal-title":"J Infect Chemother"},{"key":"pone.0234413.ref015","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1080\/02770900701595576","article-title":"Classifying asthma severity: objective versus subjective measures","volume":"44","author":"MK Cowen","year":"2007","journal-title":"J Asthma"},{"key":"pone.0234413.ref016","first-page":"329","volume-title":"Chlamydial infections: Proceedings of the Sixth International Symposium on Human Chlamydial Infections","author":"SP Wang","year":"1986"},{"key":"pone.0234413.ref017","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1128\/JCM.30.8.1968-1971.1992","article-title":"1992. Use of HEp-2 cells for improved isolation and passage of Chlamydia pneumoniae","volume":"30","author":"PM Roblin","year":"1992","journal-title":"J Clin Microbiol"},{"key":"pone.0234413.ref018","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1128\/JCM.41.2.592-600.2003","article-title":"Comparison of a new quantitative ompA-based real-time PCR TaqMan assay for detection of Chlamydia pneumoniae DNA in respiratory specimens with four conventional PCR assays","volume":"41","author":"P Apfalter","year":"2003","journal-title":"J Clin Microbiol"},{"key":"pone.0234413.ref019","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1128\/JCM.39.4.1385-1390.2001","article-title":"Development of a genomics-based PCR assay for detection of Mycoplasma pneumoniae in a large outbreak in New York State","volume":"39","author":"AL Waring","year":"2001","journal-title":"J Clin Microbiol"},{"key":"pone.0234413.ref020","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1128\/AAC.46.2.409-412.2002","article-title":"Effect of prolonged treatment with azithromycin, clarithromycin, or levofloxacin on Chlamydia pneumoniae in a continuous-infection model","volume":"46","author":"A Kutlin","year":"2002","journal-title":"Antimicrob Agents Chemother"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0234413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T17:24:15Z","timestamp":1591637055000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0234413"}},"subtitle":[],"editor":[{"given":"David M.","family":"Ojcius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,8]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0234413","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,8]]}}}