{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:05:42Z","timestamp":1790679942315,"version":"4.1.0"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0234772","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T18:05:06Z","timestamp":1592503506000},"page":"e0234772","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Feasibility of intratumoral 165Holmium siloxane delivery to induced U87 glioblastoma in a large animal model, the Yucatan minipig"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0609-0898","authenticated-orcid":true,"given":"Mehrdad","family":"Khoshnevis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Carozzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6989-9200","authenticated-orcid":true,"given":"Richard","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Bardi\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Bonnefont-Rebeix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Belluco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Nennig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Marcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Tillement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Gehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilyes","family":"Zahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Buronfosse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Roger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-0654","authenticated-orcid":true,"given":"Fr\u00e9d\u00e9rique","family":"Ponce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,6,18]]},"reference":[{"issue":"32","key":"pone.0234772.ref001","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1200\/JCO.2013.49.6968","article-title":"Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial","volume":"31","author":"MR Gilbert","year":"2013","journal-title":"J Clin Oncol"},{"issue":"10","key":"pone.0234772.ref002","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma","volume":"352","author":"R Stupp","year":"2005","journal-title":"N Engl J Med"},{"key":"pone.0234772.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drup.2015.02.002","article-title":"Overcoming the blood\u2013brain tumor barrier for effective glioblastoma treatment","volume":"19","author":"O van Tellingen","year":"2015","journal-title":"Drug Resist Updat"},{"key":"pone.0234772.ref004","doi-asserted-by":"crossref","DOI":"10.12703\/P6-46","article-title":"Advances in treating glioblastoma","volume":"6","author":"SP Weathers","year":"2014","journal-title":"F1000Prime Rep"},{"key":"pone.0234772.ref005","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pharmthera.2015.05.005","article-title":"Glioblastoma multiforme: Pathogenesis and treatment","volume":"152","author":"C Alifieris","year":"2015","journal-title":"Pharmacol Ther"},{"issue":"2","key":"pone.0234772.ref006","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.wneu.2009.06.001","article-title":"Evaluating the prognostic factors effective on the outcome of patients with glioblastoma multiformis: does maximal resection of the tumor lengthen the median survival?","volume":"73","author":"F Allahdini","year":"2010","journal-title":"World Neurosurg"},{"key":"pone.0234772.ref007","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jneumeth.2017.03.007","article-title":"Development of induced glioblastoma by implantation of a human xenograft in Yucatan minipig as a large animal model","volume":"282","author":"M Khoshnevis","year":"2017","journal-title":"J Neurosci Methods"},{"issue":"1","key":"pone.0234772.ref008","doi-asserted-by":"crossref","first-page":"32","DOI":"10.5732\/cjc.013.10207","article-title":"Standards of care and novel approaches in the management of glioblastoma multiforme","volume":"33","author":"AF Hottinger","year":"2014","journal-title":"Chin J Cancer"},{"issue":"5","key":"pone.0234772.ref009","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1188\/16.CJON.S1.2-8","article-title":"Glioblastoma: Overview of Disease and Treatment","volume":"20","author":"ME Davis","year":"2016","journal-title":"Clin J Oncol Nurs"},{"issue":"4","key":"pone.0234772.ref010","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.ncl.2007.07.002","article-title":"Epidemiology of Brain Tumors","volume":"25","author":"JL Fisher","year":"2007","journal-title":"Neurol Clin"},{"issue":"10","key":"pone.0234772.ref011","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1093\/brain\/awm204","article-title":"Long-term survival with glioblastoma multiforme","volume":"130","author":"D Krex","year":"2007","journal-title":"Brain"},{"issue":"17","key":"pone.0234772.ref012","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1001\/jama.2013.280319","article-title":"Glioblastoma and Other Malignant Gliomas","volume":"310","author":"A Omuro","year":"2013","journal-title":"JAMA"},{"issue":"2","key":"pone.0234772.ref013","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1023\/A:1012249216117","article-title":"Biological Mechanisms of Glioma Invasion and Potential Therapeutic Targets","volume":"53","author":"B B\u00f8lge Tysnes","year":"2001","journal-title":"J Neurooncol"},{"issue":"5","key":"pone.0234772.ref014","doi-asserted-by":"crossref","first-page":"307","DOI":"10.5114\/wo.2014.40559","article-title":"Glioblastoma multiforme\u2014An overview","volume":"18","author":"K Urbanska","year":"2014","journal-title":"Wspolczesna Onkol"},{"key":"pone.0234772.ref015","volume-title":"Seminars in Oncology","author":"S Kesari","year":"2011"},{"key":"pone.0234772.ref016","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2147\/OTT.S120662","article-title":"Strategies of temozolomide in future glioblastoma treatment","volume":"10","author":"CY Lee","year":"2017","journal-title":"Onco Targets Ther"},{"issue":"10","key":"pone.0234772.ref017","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1080\/14737140.2016.1229600","article-title":"Immunological effects of chemotherapy and radiotherapy against brain tumors","volume":"16","author":"T Weiss","year":"2016","journal-title":"Expert Rev Anticancer Ther"},{"issue":"1","key":"pone.0234772.ref018","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1158\/0008-5472.CAN-05-0077","article-title":"Distinct Transcription Profiles of Primary and Secondary Glioblastoma Subgroups","volume":"66","author":"C-L Tso","year":"2006","journal-title":"Cancer Res"},{"key":"pone.0234772.ref019","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.msec.2016.07.080","article-title":"Nano-structures mediated co-delivery of therapeutic agents for glioblastoma treatment: A review","volume":"69","author":"B Mujokoro","year":"2016","journal-title":"Mater Sci Eng C"},{"issue":"1","key":"pone.0234772.ref020","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/PPO.0b013e3182431a73","article-title":"Immunotherapy for the treatment of glioblastoma","volume":"18","author":"AA Thomas","year":"2012","journal-title":"Cancer J"},{"issue":"4","key":"pone.0234772.ref021","doi-asserted-by":"crossref","first-page":"45","DOI":"10.7812\/TPP\/08-027","article-title":"Prognostic factors for long-term survival after glioblastoma","volume":"12","author":"MS Walid","year":"2008","journal-title":"Perm J"},{"issue":"6","key":"pone.0234772.ref022","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/neuonc\/noq008","article-title":"Prolonged survival for patients with newly diagnosed, inoperable glioblastoma with 3-times daily ultrafractionated radiation therapy","volume":"12","author":"P Beauchesne","year":"2010","journal-title":"Neuro Oncol"},{"issue":"2","key":"pone.0234772.ref023","first-page":"719","article-title":"Medical treatment of high grade malignant gliomas in adults: an overview","volume":"11","author":"A Brandes","year":"1991","journal-title":"Anticancer Res"},{"issue":"1","key":"pone.0234772.ref024","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.clon.2016.09.015","article-title":"Radiotherapy in Glioblastoma: the Past, the Present and the Future","volume":"29","author":"C Gzell","year":"2017","journal-title":"Clin Oncol"},{"issue":"6","key":"pone.0234772.ref025","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/jjco\/hyg053","article-title":"Feasibility Study of the Simultaneous Integrated Boost (SIB) Method for Malignant Gliomas Using Intensity-modulated Radiotherapy (IMRT)","volume":"33","author":"M Suzuki","year":"2003","journal-title":"Jpn J Clin Oncol"},{"issue":"10","key":"pone.0234772.ref026","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/0360-3016(79)90553-4","article-title":"An analysis of dose-effect relationship in the radiotherapy of malignant gliomas","volume":"5","author":"MD Walker","year":"1979","journal-title":"Int J Radiat Oncol"},{"issue":"10","key":"pone.0234772.ref027","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/0360-3016(79)90554-6","article-title":"High dose radiation therapy in the treatment of malignant gliomas: Final Report","volume":"5","author":"OM Salazar","year":"1979","journal-title":"Int J Radiat Oncol"},{"issue":"3","key":"pone.0234772.ref028","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3171\/jns.1978.49.3.0333","article-title":"Evaluation of BCNU and\/or radiotherapy in the treatment of anaplastic gliomas","volume":"49","author":"MD Walker","year":"1978","journal-title":"J Neurosurg"},{"issue":"11","key":"pone.0234772.ref029","first-page":"894","article-title":"Radiotherapy and radiosensitizers in the treatment of glioblastoma multiforme","volume":"5","author":"JE Chang","year":"2007","journal-title":"Clin Adv Hematol Oncol"},{"issue":"2","key":"pone.0234772.ref030","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10143-016-0727-6","article-title":"The role of brachytherapy in the treatment of glioblastoma multiforme","volume":"40","author":"E Barbarite","year":"2017","journal-title":"Neurosurg Rev"},{"issue":"3","key":"pone.0234772.ref031","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11060-013-1139-x","article-title":"Immediate post-operative brachytherapy prior to irradiation and temozolomide for newly diagnosed glioblastoma","volume":"113","author":"JD Waters","year":"2013","journal-title":"J Neurooncol"},{"issue":"2","key":"pone.0234772.ref032","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0360-3016(98)00215-6","article-title":"Dosimetric properties of a novel brachytherapy balloon applicator for the treatment of malignant brain-tumor resection-cavity margins","volume":"42","author":"JF Dempsey","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"pone.0234772.ref033","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3171\/jns.2003.99.2.0297","article-title":"An inflatable balloon catheter and liquid 125I radiation source (GliaSite Radiation Therapy System) for treatment of recurrent malignant glioma: Multicenter safety and feasibility trial","volume":"99","author":"SB Tatter","year":"2003","journal-title":"J Neurosurg"},{"issue":"5","key":"pone.0234772.ref034","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.cdip.2006.06.007","article-title":"Molecular pathology of gliomas","volume":"12","author":"NN Nupponen","year":"2006","journal-title":"Curr Diagnostic Pathol"},{"issue":"4","key":"pone.0234772.ref035","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/cancers8040042","article-title":"Radioresistance of Brain Tumors","volume":"8","author":"K Kelley","year":"2016","journal-title":"Cancers (Basel)"},{"issue":"4","key":"pone.0234772.ref036","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1052-5149(02)00032-1","article-title":"Importance of hypoxia in the biology and treatment of brain tumors","volume":"12","author":"JPS Knisely","year":"2002","journal-title":"Neuroimaging Clin N Am"},{"issue":"2","key":"pone.0234772.ref037","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0167-8140(99)00121-8","article-title":"Polarographic measurements of oxygen tension in human glioma and surrounding peritumoural brain tissue","volume":"53","author":"DR Collingridge","year":"1999","journal-title":"Radiother Oncol"},{"issue":"5","key":"pone.0234772.ref038","doi-asserted-by":"crossref","first-page":"e95885","DOI":"10.1371\/journal.pone.0095885","article-title":"Semapimod sensitizes glioblastoma tumors to ionizing radiation by targeting microglia","volume":"9","author":"IS Miller","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"pone.0234772.ref039","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/neuonc\/not233","article-title":"Getting more out of radiation therapy in glioblastoma","volume":"16","author":"BA Castro","year":"2014","journal-title":"Neuro Oncol"},{"issue":"1","key":"pone.0234772.ref040","doi-asserted-by":"crossref","first-page":"25","DOI":"10.5732\/cjc.013.10216","article-title":"Radiation and concomitant chemotherapy for patients with glioblastoma multiforme","volume":"33","author":"S Vill\u00e0","year":"2014","journal-title":"Chin J Cancer"},{"issue":"3","key":"pone.0234772.ref041","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0167-8140(02)00078-6","article-title":"Radiotherapy for newly diagnosed malignant glioma in adults: A systematic review","volume":"64","author":"N Laperriere","year":"2002","journal-title":"Radiother Oncol"},{"issue":"1","key":"pone.0234772.ref042","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3390\/cancers4010257","article-title":"Radiation therapy for the treatment of recurrent glioblastoma: an overview","volume":"4","author":"D Amelio","year":"2012","journal-title":"Cancers (Basel)"},{"issue":"3","key":"pone.0234772.ref043","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.radonc.2010.08.020","article-title":"Patterns of failure and comparison of different target volume delineations in patients with glioblastoma treated with conformal radiotherapy plus concomitant and adjuvant temozolomide","volume":"97","author":"G Minniti","year":"2010","journal-title":"Radiother Oncol"},{"issue":"2","key":"pone.0234772.ref044","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1148\/radiol.2312030594","article-title":"Liver Tumors: MR Imaging of Radioactive Holmium Microspheres\u2014Phantom and Rabbit Study","volume":"231","author":"JFW Nijsen","year":"2004","journal-title":"Radiology"},{"issue":"4","key":"pone.0234772.ref045","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1007\/s00330-009-1613-1","article-title":"Holmium-166 poly(L-lactic acid) microsphere radioembolisation of the liver: Technical aspects studied in a large animal model","volume":"20","author":"MAD Vente","year":"2010","journal-title":"Eur Radiol"},{"issue":"1","key":"pone.0234772.ref046","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/vco.12319","article-title":"Intratumoral injection of radioactive holmium (166 Ho) microspheres for treatment of oral squamous cell carcinoma in cats","volume":"16","author":"SA van Nimwegen","year":"2018","journal-title":"Vet Comp Oncol"},{"issue":"31","key":"pone.0234772.ref047","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1016\/j.biomaterials.2007.07.012","article-title":"Long-term toxicity of holmium-loaded poly(l-lactic acid) microspheres in rats","volume":"28","author":"SW Zielhuis","year":"2007","journal-title":"Biomaterials"},{"issue":"8","key":"pone.0234772.ref048","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0969-8051(02)00329-3","article-title":"Holmium-166-DTPA as a liquid source for endovascular brachytherapy","volume":"29","author":"YD Hong","year":"2002","journal-title":"Nucl Med Biol"},{"issue":"1","key":"pone.0234772.ref049","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3349\/ymj.2005.46.1.51","article-title":"Therapeutic effects of Holmium-166 chitosan complex in rat brain tumor model","volume":"46","author":"R Huh","year":"2005","journal-title":"Yonsei Med J"},{"issue":"5","key":"pone.0234772.ref050","first-page":"460","article-title":"Synthesis of Highly-loaded Holmium-165 Siloxane Particles for Brachytherapy of Brain Cancer and Injectability Evaluation in Healthy Pig","volume":"8","author":"L Marcon","year":"2017","journal-title":"J Nanomed Nanotechnol"},{"key":"pone.0234772.ref051","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jneumeth.2013.10.002","article-title":"Imaging and histological characterization of a human brain xenograft in pig: The first induced glioma model in a large animal","volume":"221","author":"L Selek","year":"2014","journal-title":"J Neurosci Methods"},{"key":"pone.0234772.ref052","unstructured":"U-87 MG ATCC \u00ae HTB-14TM Homo sapiens brain Likely glioblastom [Internet]. Available from: https:\/\/www.lgcstandards-atcc.org\/en\/Products\/All\/HTB-14.aspx#documentation"},{"key":"pone.0234772.ref053","first-page":"450","volume-title":"Treatment planning of microbrachytherapy with 3D NSGA-IIIFMBE Proceedings","author":"R Brown","year":"2017"},{"issue":"3","key":"pone.0234772.ref054","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1162\/evco.1994.2.3.221","article-title":"Muiltiobjective Optimization Using Nondominated Sorting in Genetic Algorithms","volume":"2","author":"N Srinivas","year":"1994","journal-title":"Evol Comput"},{"issue":"1","key":"pone.0234772.ref055","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.critrevonc.2010.09.001","article-title":"A comprehensive outlook on intracerebral therapy of malignant gliomas","volume":"80","author":"C Buonerba","year":"2011","journal-title":"Crit Rev Oncol Hematol"},{"issue":"2","key":"pone.0234772.ref056","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3171\/jns.1999.90.2.0315","article-title":"Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration, and tissue\u2014cannula sealing time","volume":"90","author":"MY Chen","year":"1999","journal-title":"J Neurosurg"},{"key":"pone.0234772.ref057","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2013.04.001","article-title":"Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species","volume":"106\u2013107","author":"BD Semple","year":"2013","journal-title":"Prog Neurobiol"},{"issue":"8","key":"pone.0234772.ref058","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/jcbfm.2010.66","article-title":"Different Strokes for Different Folks: The Rich Diversity of Animal Models of Focal Cerebral Ischemia","volume":"30","author":"DW Howells","year":"2010","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"pone.0234772.ref059","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.bbcan.2013.04.003","article-title":"Vertebrate animal models of glioma: Understanding the mechanisms and developing new therapies","volume":"1836","author":"L Chen","year":"2013","journal-title":"Biochim Biophys Acta\u2014Rev Cancer"},{"issue":"3","key":"pone.0234772.ref060","doi-asserted-by":"crossref","first-page":"e00063","DOI":"10.1042\/AN20110014","article-title":"Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model","volume":"3","author":"VL Jacobs","year":"2011","journal-title":"ASN Neuro"},{"issue":"2","key":"pone.0234772.ref061","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11060-007-9400-9","article-title":"Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression","volume":"85","author":"M Candolfi","year":"2007","journal-title":"J Neurooncol"},{"issue":"2","key":"pone.0234772.ref062","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1227\/00006123-198708000-00012","article-title":"Effect of the Extent of Surgical Resection on Survival and Quality of Life in Patients with Supratentorial Glioblastomas and Anaplastic Astrocytomas","volume":"21","author":"M Ammirati","year":"1987","journal-title":"Neurosurgery"},{"issue":"3","key":"pone.0234772.ref063","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1215\/15228517-2008-008","article-title":"Disease progression or pseudoprogression after concomitant radiochemotherapy treatment: Pitfalls in neurooncology","volume":"10","author":"AA Brandes","year":"2008","journal-title":"Neuro Oncol"},{"issue":"3","key":"pone.0234772.ref064","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/02688699943655","article-title":"Stereotactic radiosurgery VIII. The classification of postradiation reactions","volume":"13","author":"PN Plowman","year":"1999","journal-title":"Br J Neurosurg"},{"issue":"5","key":"pone.0234772.ref065","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1097\/00006123-200005000-00019","article-title":"Permanent Iodine-125 Interstitial Implants for the Treatment of Recurrent Glioblastoma Multiforme","volume":"46","author":"S Patel","year":"2000","journal-title":"Neurosurgery"},{"issue":"1","key":"pone.0234772.ref066","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3348\/jkrs.1998.38.1.83","article-title":"Effect of Holmium-166 Injection into Hepatocellular Carcinomas (SK-HEP1) Heterotransplanted in Mice","volume":"38","author":"YH Lee","year":"1998","journal-title":"J Korean Radiol Soc"},{"issue":"1","key":"pone.0234772.ref067","doi-asserted-by":"crossref","first-page":"e52178","DOI":"10.1371\/journal.pone.0052178","article-title":"Intratumoral Administration of Holmium-166 Acetylacetonate Microspheres: Antitumor Efficacy and Feasibility of Multimodality Imaging in Renal Cancer","volume":"8","author":"W Bult","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"pone.0234772.ref068","first-page":"2161","article-title":"Biodistribution and kinetics of holmium-166-chitosan complex (DW-166HC) in rats and mice","volume":"39","author":"YS Suzuki","year":"1998","journal-title":"J Nucl Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0234772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T18:06:10Z","timestamp":1592503570000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0234772"}},"subtitle":[],"editor":[{"given":"Jonathan H.","family":"Sherman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,18]]},"references-count":68,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0234772","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,18]]}}}