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Konishi","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"pone.0235295.ref074","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/cea.12486","article-title":"A panel of biomarkers for disease severity in atopic dermatitis","volume":"45","author":"JL Thijs","year":"2015","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"pone.0235295.ref075","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2015.07.007","article-title":"Barrier epithelial cells and the control of type 2 immunity","volume":"43","author":"H Hammad","year":"2015","journal-title":"Immunity"},{"issue":"13","key":"pone.0235295.ref076","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1084\/jem.20130351","article-title":"A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis","volume":"210","author":"M Salimi","year":"2013","journal-title":"J Exp Med"},{"issue":"170","key":"pone.0235295.ref077","first-page":"170","article-title":"TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation","volume":"5","author":"BS Kim","year":"2013","journal-title":"Sci Transl Med"},{"issue":"4","key":"pone.0235295.ref078","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1084\/jem.20041503","article-title":"Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin","volume":"202","author":"J Yoo","year":"2005","journal-title":"J Exp Med"},{"issue":"34","key":"pone.0235295.ref079","doi-asserted-by":"crossref","first-page":"13921","DOI":"10.1073\/pnas.1307321110","article-title":"Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice","volume":"110","author":"Y Imai","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"pone.0235295.ref080","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ni805","article-title":"Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP","volume":"3","author":"V Soumelis","year":"2002","journal-title":"Nat Immunol"},{"issue":"24","key":"pone.0235295.ref081","doi-asserted-by":"crossref","first-page":"9773","DOI":"10.1073\/pnas.0901206106","article-title":"The cytokine interleukin-33 mediates anaphylactic shock","volume":"106","author":"PN Pushparaj","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7703","key":"pone.0235295.ref082","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41586-018-0064-8","article-title":"LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis","volume":"557","author":"N Peltzer","year":"2018","journal-title":"Nature"},{"key":"pone.0235295.ref083","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.24.021605.090720","article-title":"The eosinophil","volume":"24","author":"ME Rothenberg","year":"2006","journal-title":"Annu Rev Immunol"},{"issue":"8","key":"pone.0235295.ref084","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.4049\/jimmunol.175.8.5341","article-title":"The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia","volume":"175","author":"SM Pope","year":"2005","journal-title":"J Immunol"},{"issue":"8","key":"pone.0235295.ref085","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.4049\/jimmunol.151.8.4266","article-title":"Induction by IL-9 and suppression by IL-3 and IL-4 of the levels of chromosome 14-derived transcripts that encode late-expressed mouse mast cell proteases","volume":"151","author":"KK Eklund","year":"1993","journal-title":"J Immunol"},{"issue":"5","key":"pone.0235295.ref086","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/eji.201747351","article-title":"Treatment of MCPT8(DTR) mice with high- or low-dose diphtheria toxin leads to differential depletion of basophils and granulocyte-macrophage progenitors","volume":"48","author":"C El Hachem","year":"2018","journal-title":"Eur J Immunol"},{"issue":"6","key":"pone.0235295.ref087","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.4049\/jimmunol.0900328","article-title":"IL-33 activates unprimed murine basophils directly in vitro and induces their in vivo expansion indirectly by promoting hematopoietic growth factor production","volume":"183","author":"E Schneider","year":"2009","journal-title":"J Immunol"},{"issue":"7363","key":"pone.0235295.ref088","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nature10329","article-title":"TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 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