{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:27:38Z","timestamp":1792006058562,"version":"4.4.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31601910 and U1603232"],"award-info":[{"award-number":["31601910 and U1603232"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ningxia Academy of Agricultural and Forestry Sciences Project","award":["2017-NXKY05"],"award-info":[{"award-number":["2017-NXKY05"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0235426","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T13:45:08Z","timestamp":1597931108000},"page":"e0235426","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Genomic mapping identifies two genetic variants in the MC1R gene for coat colour variation in Chinese Tan sheep"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7323-7135","authenticated-orcid":true,"given":"Gebremedhin","family":"Gebreselassie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benmeng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haile","family":"Berihulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Abied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,8,20]]},"reference":[{"issue":"2","key":"pone.0235426.ref001","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5194\/aab-61-173-2018","article-title":"Genetic background of coat colour in sheep","volume":"61","author":"A Koseniuk","year":"2018","journal-title":"Archives Animal Breeding"},{"issue":"3","key":"pone.0235426.ref002","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ajpa.10263","article-title":"Geographic distribution of environmental factors influencing human skin coloration","volume":"125","author":"G Chaplin","year":"2004","journal-title":"American Journal of Physical Anthropology: The Official Publication of the American Association of Physical Anthropologists"},{"issue":"1","key":"pone.0235426.ref003","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1006\/jhev.2000.0403","article-title":"The evolution of human skin coloration","volume":"39","author":"NG Jablonski","year":"2000","journal-title":"Journal of human evolution"},{"issue":"8","key":"pone.0235426.ref004","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1101\/gr.072090.107","article-title":"A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sheep","volume":"18","author":"BJ Norris","year":"2008","journal-title":"Genome research"},{"issue":"2\u20133","key":"pone.0235426.ref005","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.smallrumres.2010.03.015","article-title":"Sequence characterization of the melanocortin 1 receptor (MC1R) gene in sheep with different coat colours and identification of the putative e allele at the ovine Extension locus","volume":"91","author":"L Fontanesi","year":"2010","journal-title":"Small Ruminant Research"},{"issue":"4","key":"pone.0235426.ref006","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1469-185X.2011.00177.x","article-title":"Colours of domestication","volume":"86","author":"M Cieslak","year":"2011","journal-title":"Biological Reviews"},{"issue":"6","key":"pone.0235426.ref007","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0092-8674(93)90572-8","article-title":"Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function","volume":"72","author":"LS Robbins","year":"1993","journal-title":"Cell"},{"issue":"11","key":"pone.0235426.ref008","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.4238\/2012.May.22.5","article-title":"Identification of the e allele at the Extension locus (MC1R) in Brazilian Creole sheep and its role in wool color variation","volume":"11","author":"D Hepp","year":"2012","journal-title":"Genet Mol Res"},{"key":"pone.0235426.ref009","article-title":"Sequence characterization of the MC1R gene in yak (Poephagus grunniens) breeds with different coat colors","volume":"2009","author":"S-Y Chen","year":"2009","journal-title":"BioMed Research International"},{"issue":"1","key":"pone.0235426.ref010","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1749-6632.2003.tb03197.x","article-title":"Pigmentary switches in domestic animal species","volume":"994","author":"H Klungland","year":"2003","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"6","key":"pone.0235426.ref011","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/jhered\/esw037","article-title":"Epistatic interaction of the Melanocortin 1 Receptor and Agouti Signaling Protein genes modulates wool color in the Brazilian Creole Sheep","volume":"107","author":"D Hepp","year":"2016","journal-title":"Journal of Heredity"},{"key":"pone.0235426.ref012","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3389\/fgene.2018.00105","article-title":"Genome-wide association studies identify candidate genes for coat color and mohair traits in the iranian markhoz goat","volume":"9","author":"A Nazari-Ghadikolaei","year":"2018","journal-title":"Frontiers in genetics"},{"issue":"7","key":"pone.0235426.ref013","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/S2095-3119(14)60928-X","article-title":"Molecular characterization of two candidate genes associated with coat color in Tibetan sheep (Ovis arise)","volume":"14","author":"J-l HAN","year":"2015","journal-title":"Journal of integrative agriculture"},{"issue":"7","key":"pone.0235426.ref014","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s11626-016-0042-0","article-title":"Endothelin-1 increases melanin synthesis in an established sheep skin melanocyte culture","volume":"52","author":"Y Pang","year":"2016","journal-title":"In Vitro Cellular & Developmental Biology-Animal"},{"key":"pone.0235426.ref015","first-page":"8","article-title":"Mutations in MC1R gene determine black coat color phenotype in Chinese sheep","author":"G-L Yang","year":"2013","journal-title":"The Scientific World Journal"},{"issue":"7","key":"pone.0235426.ref016","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0092-8674(05)80067-4","article-title":"Molecular characterization of the mouse agouti locus","volume":"71","author":"SJ Bultman","year":"1992","journal-title":"Cell"},{"issue":"1\u20133","key":"pone.0235426.ref017","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.smallrumres.2012.02.008","article-title":"Analysis of polymorphisms in the agouti signalling protein (ASIP) and melanocortin 1 receptor (MC1R) genes and association with coat colours in two Pramenka sheep types","volume":"105","author":"L Fontanesi","year":"2012","journal-title":"Small ruminant research"},{"issue":"12","key":"pone.0235426.ref018","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.chembiol.2006.10.006","article-title":"Structural and molecular evolutionary analysis of Agouti and Agouti-related proteins","volume":"13","author":"PJ Jackson","year":"2006","journal-title":"Chemistry & biology"},{"issue":"6500","key":"pone.0235426.ref019","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/371799a0","article-title":"Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor","volume":"371","author":"D Lu","year":"1994","journal-title":"Nature"},{"issue":"2","key":"pone.0235426.ref020","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/hmg\/4.2.223","article-title":"Structure and function of ASP, the human homolog of the mouse agouti gene","volume":"4","author":"BD Wilson","year":"1995","journal-title":"Human Molecular Genetics"},{"issue":"4","key":"pone.0235426.ref021","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/genetics\/146.4.1407","article-title":"Genetic studies of the mouse mutations mahogany and mahoganoid","volume":"146","author":"K Miller","year":"1997","journal-title":"Genetics"},{"issue":"4","key":"pone.0235426.ref022","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1034\/j.1600-0749.2003.00067.x","article-title":"The color loci of mice\u2013a genetic century","volume":"16","author":"DC Bennett","year":"2003","journal-title":"Pigment Cell Research"},{"issue":"2","key":"pone.0235426.ref023","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/hdy.2013.83","article-title":"A genome-wide scan study identifies a single nucleotide substitution in ASIP associated with white versus non-white coat-colour variation in sheep (Ovis aries)","volume":"112","author":"M Li","year":"2014","journal-title":"Heredity"},{"issue":"1","key":"pone.0235426.ref024","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1017\/S1751731110001382","article-title":"Coat colours in the Massese sheep breed are associated with mutations in the agouti signalling protein (ASIP) and melanocortin 1 receptor (MC1R) genes","volume":"5","author":"L Fontanesi","year":"2011","journal-title":"Animal"},{"issue":"2","key":"pone.0235426.ref025","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/hdy.2009.105","article-title":"The genetic basis of recessive self-colour pattern in a wild sheep population","volume":"104","author":"J Gratten","year":"2010","journal-title":"Heredity"},{"issue":"4","key":"pone.0235426.ref026","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s13353-013-0163-z","article-title":"Family of melanocortin receptor (MCR) genes in mammals\u2014mutations, polymorphisms and phenotypic effects","volume":"54","author":"M Switonski","year":"2013","journal-title":"Journal of applied genetics"},{"issue":"10","key":"pone.0235426.ref027","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.peptides.2004.11.041","article-title":"Regulatory elements of the melanocortin 1 receptor","volume":"26","author":"F Rouzaud","year":"2005","journal-title":"Peptides"},{"issue":"4","key":"pone.0235426.ref028","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1134\/S1022795418040026","article-title":"Molecular Study of the Extension Locus in Association with Coat Colour Variation of Iranian Indigenous Sheep Breeds","volume":"54","author":"M Amin","year":"2018","journal-title":"Russian journal of genetics"},{"issue":"8","key":"pone.0235426.ref029","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1590\/s0100-204x2017000800007","article-title":"Genetic characterization of coat color genes in Brazilian Crioula sheep from a conservation nucleus","volume":"52","author":"LCG Cavalcanti","year":"2017","journal-title":"Pesquisa Agropecu\u00e1ria Brasileira"},{"issue":"6","key":"pone.0235426.ref030","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/jbg.12048","article-title":"Genomewide association for a dominant pigmentation gene in sheep","volume":"130","author":"J Kijas","year":"2013","journal-title":"Journal of animal breeding and genetics"},{"issue":"3","key":"pone.0235426.ref031","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1365-2052.2008.01712.x","article-title":"Differences in the expression of the ASIP gene are involved in the recessive black coat colour pattern in sheep: evidence from the rare Xalda sheep breed","volume":"39","author":"LJ Royo","year":"2008","journal-title":"Animal Genetics"},{"issue":"1","key":"pone.0235426.ref032","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s003359900939","article-title":"Molecular and pharmacological characterization of dominant black coat color in sheep","volume":"10","author":"DI V\u00e5ge","year":"1999","journal-title":"Mammalian Genome"},{"issue":"1","key":"pone.0235426.ref033","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s12864-015-1384-9","article-title":"Genome-wide analysis reveals population structure and selection in Chinese indigenous sheep breeds","volume":"16","author":"C Wei","year":"2015","journal-title":"Bmc Genomics"},{"issue":"1","key":"pone.0235426.ref034","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s41598-017-00847-9","article-title":"Genome-wide detection of copy number variation in Chinese indigenous sheep using an ovine high-density 600 K SNP array","volume":"7","author":"Q Ma","year":"2017","journal-title":"Scientific reports"},{"issue":"12","key":"pone.0235426.ref035","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1111\/j.1365-294X.2011.05076.x","article-title":"Genome\u2010wide association mapping identifies the genetic basis of discrete and quantitative variation in sexual weaponry in a wild sheep population","volume":"20","author":"SE Johnston","year":"2011","journal-title":"Molecular Ecology"},{"issue":"7","key":"pone.0235426.ref036","doi-asserted-by":"crossref","first-page":"e21739","DOI":"10.1371\/journal.pone.0021739","article-title":"A novel nonsense mutation in the DMP1 gene identified by a genome-wide association study is responsible for inherited rickets in Corriedale sheep","volume":"6","author":"X Zhao","year":"2011","journal-title":"PLoS One"},{"key":"pone.0235426.ref037","author":"C Zhu","year":"2019","journal-title":"GWAS and post-GWAS to Identification of Genes Associated with Sheep Tail Fat Deposition"},{"issue":"3","key":"pone.0235426.ref038","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"The American journal of human genetics"},{"issue":"1","key":"pone.0235426.ref039","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2156-10-47","article-title":"Missense and nonsense mutations in melanocortin 1 receptor (MC1R) gene of different goat breeds: association with red and black coat colour phenotypes but with unexpected evidences","volume":"10","author":"L Fontanesi","year":"2009","journal-title":"BMC genetics"},{"key":"pone.0235426.ref040","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.livsci.2016.06.006","article-title":"Application of genomic data to assist a community-based breeding program: a preliminary study of coat color genetics in Morada Nova sheep","volume":"190","author":"MMM Muniz","year":"2016","journal-title":"Livestock Science"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0245674","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0235426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T19:07:38Z","timestamp":1616958458000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0235426"}},"subtitle":[],"editor":[{"given":"Raluca","family":"Mateescu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,20]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0235426","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,20]]}}}